BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study
Identifieur interne : 000871 ( PascalFrancis/Corpus ); précédent : 000870; suivant : 000872BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study
Auteurs : S. Karamohamed ; J. C. Latourelle ; B. A. Racette ; J. S. Perlmutter ; G. F. Wooten ; M. Lew ; C. Klein ; H. Shill ; L. I. Golbe ; M. H. Mark ; M. Guttman ; G. Nicholson ; J. B. Wilk ; M. Saint-Hilaire ; A. L. Destefano ; R. Prakash ; S. Tobin ; J. Williamson ; O. Suchowersky ; N. Labell ; B. N. J. Growdon ; C. Singer ; R. Watts ; S. Goldwurm ; G. Pezzoli ; K. B. Baker ; M. L. Giroux ; P. P. Pramstaller ; D. J. Burn ; P. Chinnery ; S. Sherman ; P. Vieregge ; I. Litvan ; J. F. Gusella ; R. H. Myers ; A. ParsianSource :
- Neurology [ 0028-3878 ] ; 2005.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.
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NO : | PASCAL 06-0054738 INIST |
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ET : | BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study |
AU : | KARAMOHAMED (S.); LATOURELLE (J. C.); RACETTE (B. A.); PERLMUTTER (J. S.); WOOTEN (G. F.); LEW (M.); KLEIN (C.); SHILL (H.); GOLBE (L. I.); MARK (M. H.); GUTTMAN (M.); NICHOLSON (G.); WILK (J. B.); SAINT-HILAIRE (M.); DESTEFANO (A. L.); PRAKASH (R.); TOBIN (S.); WILLIAMSON (J.); SUCHOWERSKY (O.); LABELL (N.); GROWDON (B. N. J.); SINGER (C.); WATTS (R.); GOLDWURM (S.); PEZZOLI (G.); BAKER (K. B.); GIROUX (M. L.); PRAMSTALLER (P. P.); BURN (D. J.); CHINNERY (P.); SHERMAN (S.); VIEREGGE (P.); LITVAN (I.); GUSELLA (J. F.); MYERS (R. H.); PARSIAN (A.) |
AF : | Department of Neurology, Boston University School of Medicine/Etats-Unis (1 aut., 2 aut., 13 aut., 14 aut., 15 aut., 16 aut., 17 aut., 18 aut., 35 aut.); Department of Neurology, Washington University School of Medicine/Saint Louis, MO/Etats-Unis (3 aut., 4 aut.); Department of Neurology, University of Virginia Health System/Charlottesville/Etats-Unis (5 aut.); De partment of Neurology, University of Southern California/Los Angeles/Etats-Unis (6 aut.); Department of Neurology, Medical University of Lübeck/Allemagne (7 aut.); Muhammad Ali Parkinson Research Center, Barrow Neurological Institute/Phoenix, AZ/Etats-Unis (8 aut.); Department of Neurology, University of Medicine and Dentistry of New Jersey- Robert Wood Johnson Medical School/New Brunswick/Etats-Unis (9 aut., 10 aut.); Department of Medicine, University of Toronto/Ontario/Canada (11 aut.); Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital/Australie (12 aut.); Department of Biostatistics, Boston University School of Public Health/MA/Etats-Unis (15 aut.); Departments of Clinical Neurosciences and Medical Genetics, University of Calgary/Canada (19 aut., 20 aut.); Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School/Boston/Etats-Unis (21 aut.); Department of Neurology, University of Miami/FL/Etats-Unis (22 aut.); Department of Neurology, Emory University/Atlanta, GA;/Etats-Unis (23 aut.); Medical Genetics Unit, Istituti Clinici di Perfezionamento/Milano/Italie (24 aut.); Parkinson Institute, Istituti Clinici di Perfezionamento/Milano/Italie (25 aut.); Departments of Neurology and Neuroscience, Cleveland Clinic Foundation/OH/Etats-Unis (26 aut., 27 aut.); Department of Neu rology, General Regional Hospital Bolzano/Italie (28 aut.); Re gional Neurosciences Centre, Newcastle General Hospital/Newcastle upon Tyne/Royaume-Uni (29 aut., 30 aut.); Department of Neurology, University of Arizona/Tucson/Etats-Unis (31 aut.); Klinik fur Neurologie, Klinikum Lippe-Lemgo/Lemgo/Allemagne (32 aut.); Department of Neurology, University of Louisville School of Medicine/KY/Etats-Unis (33 aut.); Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School/Boston/Etats-Unis (34 aut.); Department of Pediatrics, Human Genomics Laboratories, University of Arkansas for Medical Sciences/Little Rock/Etats-Unis (36 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Neurology; ISSN 0028-3878; Coden NEURAI; Etats-Unis; Da. 2005; Vol. 65; No. 11; Pp. 1823-1825; Bibl. 10 ref. |
LA : | Anglais |
EA : | Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age. |
CC : | 002B17; 002B17G; 002B17A03 |
FD : | Système nerveux pathologie; Parkinson maladie; Variant génétique; Age apparition; Maladie familiale |
FG : | Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie |
ED : | Nervous system diseases; Parkinson disease; Genetic variant; Age of onset; Familial disease |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Sistema nervioso patología; Parkinson enfermedad; Variante genética; Edad aparición; Enfermedad familiar |
LO : | INIST-6345.354000134415150310 |
ID : | 06-0054738 |
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Pascal:06-0054738Le document en format XML
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<author><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name>
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<author><name sortKey="Sherman, S" sort="Sherman, S" uniqKey="Sherman S" first="S." last="Sherman">S. Sherman</name>
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<author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name>
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<author><name sortKey="Parsian, A" sort="Parsian, A" uniqKey="Parsian A" first="A." last="Parsian">A. Parsian</name>
<affiliation><inist:fA14 i1="24"><s1>Department of Pediatrics, Human Genomics Laboratories, University of Arkansas for Medical Sciences</s1>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study</title>
<author><name sortKey="Karamohamed, S" sort="Karamohamed, S" uniqKey="Karamohamed S" first="S." last="Karamohamed">S. Karamohamed</name>
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<author><name sortKey="Latourelle, J C" sort="Latourelle, J C" uniqKey="Latourelle J" first="J. C." last="Latourelle">J. C. Latourelle</name>
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</author>
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<affiliation><inist:fA14 i1="02"><s1>Department of Neurology, Washington University School of Medicine</s1>
<s2>Saint Louis, MO</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
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<affiliation><inist:fA14 i1="02"><s1>Department of Neurology, Washington University School of Medicine</s1>
<s2>Saint Louis, MO</s2>
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<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
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</author>
<author><name sortKey="Wooten, G F" sort="Wooten, G F" uniqKey="Wooten G" first="G. F." last="Wooten">G. F. Wooten</name>
<affiliation><inist:fA14 i1="03"><s1>Department of Neurology, University of Virginia Health System</s1>
<s2>Charlottesville</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lew, M" sort="Lew, M" uniqKey="Lew M" first="M." last="Lew">M. Lew</name>
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</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C." last="Klein">C. Klein</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Neurology, Medical University of Lübeck</s1>
<s3>DEU</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Shill, H" sort="Shill, H" uniqKey="Shill H" first="H." last="Shill">H. Shill</name>
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<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L. I." last="Golbe">L. I. Golbe</name>
<affiliation><inist:fA14 i1="07"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey- Robert Wood Johnson Medical School</s1>
<s2>New Brunswick</s2>
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<author><name sortKey="Mark, M H" sort="Mark, M H" uniqKey="Mark M" first="M. H." last="Mark">M. H. Mark</name>
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<s2>New Brunswick</s2>
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<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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<author><name sortKey="Guttman, M" sort="Guttman, M" uniqKey="Guttman M" first="M." last="Guttman">M. Guttman</name>
<affiliation><inist:fA14 i1="08"><s1>Department of Medicine, University of Toronto</s1>
<s2>Ontario</s2>
<s3>CAN</s3>
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</inist:fA14>
</affiliation>
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<author><name sortKey="Nicholson, G" sort="Nicholson, G" uniqKey="Nicholson G" first="G." last="Nicholson">G. Nicholson</name>
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<sZ>12 aut.</sZ>
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</affiliation>
</author>
<author><name sortKey="Wilk, J B" sort="Wilk, J B" uniqKey="Wilk J" first="J. B." last="Wilk">J. B. Wilk</name>
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<author><name sortKey="Destefano, A L" sort="Destefano, A L" uniqKey="Destefano A" first="A. L." last="Destefano">A. L. Destefano</name>
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<affiliation><inist:fA14 i1="10"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
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</inist:fA14>
</affiliation>
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<author><name sortKey="Prakash, R" sort="Prakash, R" uniqKey="Prakash R" first="R." last="Prakash">R. Prakash</name>
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<author><name sortKey="Tobin, S" sort="Tobin, S" uniqKey="Tobin S" first="S." last="Tobin">S. Tobin</name>
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<author><name sortKey="Williamson, J" sort="Williamson, J" uniqKey="Williamson J" first="J." last="Williamson">J. Williamson</name>
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<author><name sortKey="Suchowersky, O" sort="Suchowersky, O" uniqKey="Suchowersky O" first="O." last="Suchowersky">O. Suchowersky</name>
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<sZ>19 aut.</sZ>
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</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Labell, N" sort="Labell, N" uniqKey="Labell N" first="N." last="Labell">N. Labell</name>
<affiliation><inist:fA14 i1="11"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1>
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<sZ>19 aut.</sZ>
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</inist:fA14>
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<author><name sortKey="Growdon, B N J" sort="Growdon, B N J" uniqKey="Growdon B" first="B. N. J." last="Growdon">B. N. J. Growdon</name>
<affiliation><inist:fA14 i1="12"><s1>Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1>
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<author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name>
<affiliation><inist:fA14 i1="13"><s1>Department of Neurology, University of Miami</s1>
<s2>FL</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Watts, R" sort="Watts, R" uniqKey="Watts R" first="R." last="Watts">R. Watts</name>
<affiliation><inist:fA14 i1="14"><s1>Department of Neurology, Emory University</s1>
<s2>Atlanta, GA;</s2>
<s3>USA</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Goldwurm, S" sort="Goldwurm, S" uniqKey="Goldwurm S" first="S." last="Goldwurm">S. Goldwurm</name>
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</inist:fA14>
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<s2>Milano</s2>
<s3>ITA</s3>
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<affiliation><inist:fA14 i1="17"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1>
<s2>OH</s2>
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<s3>ITA</s3>
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</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name>
<affiliation><inist:fA14 i1="19"><s1>Re gional Neurosciences Centre, Newcastle General Hospital</s1>
<s2>Newcastle upon Tyne</s2>
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<author><name sortKey="Chinnery, P" sort="Chinnery, P" uniqKey="Chinnery P" first="P." last="Chinnery">P. Chinnery</name>
<affiliation><inist:fA14 i1="19"><s1>Re gional Neurosciences Centre, Newcastle General Hospital</s1>
<s2>Newcastle upon Tyne</s2>
<s3>GBR</s3>
<sZ>29 aut.</sZ>
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</inist:fA14>
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</author>
<author><name sortKey="Sherman, S" sort="Sherman, S" uniqKey="Sherman S" first="S." last="Sherman">S. Sherman</name>
<affiliation><inist:fA14 i1="20"><s1>Department of Neurology, University of Arizona</s1>
<s2>Tucson</s2>
<s3>USA</s3>
<sZ>31 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
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<affiliation><inist:fA14 i1="21"><s1>Klinik fur Neurologie, Klinikum Lippe-Lemgo</s1>
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<s3>DEU</s3>
<sZ>32 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name>
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<s2>KY</s2>
<s3>USA</s3>
<sZ>33 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
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<s2>Boston</s2>
<s3>USA</s3>
<sZ>34 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R. H." last="Myers">R. H. Myers</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s3>USA</s3>
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<author><name sortKey="Parsian, A" sort="Parsian, A" uniqKey="Parsian A" first="A." last="Parsian">A. Parsian</name>
<affiliation><inist:fA14 i1="24"><s1>Department of Pediatrics, Human Genomics Laboratories, University of Arkansas for Medical Sciences</s1>
<s2>Little Rock</s2>
<s3>USA</s3>
<sZ>36 aut.</sZ>
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</analytic>
<series><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of onset</term>
<term>Familial disease</term>
<term>Genetic variant</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Parkinson maladie</term>
<term>Variant génétique</term>
<term>Age apparition</term>
<term>Maladie familiale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.</div>
</front>
</TEI>
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<fA08 i1="01" i2="1" l="ENG"><s1>BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study</s1>
</fA08>
<fA11 i1="01" i2="1"><s1>KARAMOHAMED (S.)</s1>
</fA11>
<fA11 i1="02" i2="1"><s1>LATOURELLE (J. C.)</s1>
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<fA11 i1="17" i2="1"><s1>TOBIN (S.)</s1>
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<fA11 i1="27" i2="1"><s1>GIROUX (M. L.)</s1>
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<fA11 i1="35" i2="1"><s1>MYERS (R. H.)</s1>
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<fA11 i1="36" i2="1"><s1>PARSIAN (A.)</s1>
</fA11>
<fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>35 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Neurology, Washington University School of Medicine</s1>
<s2>Saint Louis, MO</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Neurology, University of Virginia Health System</s1>
<s2>Charlottesville</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>De partment of Neurology, University of Southern California</s1>
<s2>Los Angeles</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Department of Neurology, Medical University of Lübeck</s1>
<s3>DEU</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Muhammad Ali Parkinson Research Center, Barrow Neurological Institute</s1>
<s2>Phoenix, AZ</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey- Robert Wood Johnson Medical School</s1>
<s2>New Brunswick</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Department of Medicine, University of Toronto</s1>
<s2>Ontario</s2>
<s3>CAN</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital</s1>
<s3>AUS</s3>
<sZ>12 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
<s2>MA</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1>
<s3>CAN</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</fA14>
<fA14 i1="12"><s1>Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
</fA14>
<fA14 i1="13"><s1>Department of Neurology, University of Miami</s1>
<s2>FL</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
</fA14>
<fA14 i1="14"><s1>Department of Neurology, Emory University</s1>
<s2>Atlanta, GA;</s2>
<s3>USA</s3>
<sZ>23 aut.</sZ>
</fA14>
<fA14 i1="15"><s1>Medical Genetics Unit, Istituti Clinici di Perfezionamento</s1>
<s2>Milano</s2>
<s3>ITA</s3>
<sZ>24 aut.</sZ>
</fA14>
<fA14 i1="16"><s1>Parkinson Institute, Istituti Clinici di Perfezionamento</s1>
<s2>Milano</s2>
<s3>ITA</s3>
<sZ>25 aut.</sZ>
</fA14>
<fA14 i1="17"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1>
<s2>OH</s2>
<s3>USA</s3>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</fA14>
<fA14 i1="18"><s1>Department of Neu rology, General Regional Hospital Bolzano</s1>
<s3>ITA</s3>
<sZ>28 aut.</sZ>
</fA14>
<fA14 i1="19"><s1>Re gional Neurosciences Centre, Newcastle General Hospital</s1>
<s2>Newcastle upon Tyne</s2>
<s3>GBR</s3>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</fA14>
<fA14 i1="20"><s1>Department of Neurology, University of Arizona</s1>
<s2>Tucson</s2>
<s3>USA</s3>
<sZ>31 aut.</sZ>
</fA14>
<fA14 i1="21"><s1>Klinik fur Neurologie, Klinikum Lippe-Lemgo</s1>
<s2>Lemgo</s2>
<s3>DEU</s3>
<sZ>32 aut.</sZ>
</fA14>
<fA14 i1="22"><s1>Department of Neurology, University of Louisville School of Medicine</s1>
<s2>KY</s2>
<s3>USA</s3>
<sZ>33 aut.</sZ>
</fA14>
<fA14 i1="23"><s1>Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>34 aut.</sZ>
</fA14>
<fA14 i1="24"><s1>Department of Pediatrics, Human Genomics Laboratories, University of Arkansas for Medical Sciences</s1>
<s2>Little Rock</s2>
<s3>USA</s3>
<sZ>36 aut.</sZ>
</fA14>
<fA20><s1>1823-1825</s1>
</fA20>
<fA21><s1>2005</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
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<s5>11</s5>
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<s2>NM</s2>
<s5>11</s5>
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<fC03 i1="05" i2="X" l="SPA"><s0>Enfermedad familiar</s0>
<s2>NM</s2>
<s5>11</s5>
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<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale pathologie</s0>
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<s5>38</s5>
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<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
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<fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>39</s5>
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<s5>39</s5>
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<fC07 i1="04" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>40</s5>
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<server><NO>PASCAL 06-0054738 INIST</NO>
<ET>BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study</ET>
<AU>KARAMOHAMED (S.); LATOURELLE (J. C.); RACETTE (B. A.); PERLMUTTER (J. S.); WOOTEN (G. F.); LEW (M.); KLEIN (C.); SHILL (H.); GOLBE (L. I.); MARK (M. H.); GUTTMAN (M.); NICHOLSON (G.); WILK (J. B.); SAINT-HILAIRE (M.); DESTEFANO (A. L.); PRAKASH (R.); TOBIN (S.); WILLIAMSON (J.); SUCHOWERSKY (O.); LABELL (N.); GROWDON (B. N. J.); SINGER (C.); WATTS (R.); GOLDWURM (S.); PEZZOLI (G.); BAKER (K. B.); GIROUX (M. L.); PRAMSTALLER (P. P.); BURN (D. J.); CHINNERY (P.); SHERMAN (S.); VIEREGGE (P.); LITVAN (I.); GUSELLA (J. F.); MYERS (R. H.); PARSIAN (A.)</AU>
<AF>Department of Neurology, Boston University School of Medicine/Etats-Unis (1 aut., 2 aut., 13 aut., 14 aut., 15 aut., 16 aut., 17 aut., 18 aut., 35 aut.); Department of Neurology, Washington University School of Medicine/Saint Louis, MO/Etats-Unis (3 aut., 4 aut.); Department of Neurology, University of Virginia Health System/Charlottesville/Etats-Unis (5 aut.); De partment of Neurology, University of Southern California/Los Angeles/Etats-Unis (6 aut.); Department of Neurology, Medical University of Lübeck/Allemagne (7 aut.); Muhammad Ali Parkinson Research Center, Barrow Neurological Institute/Phoenix, AZ/Etats-Unis (8 aut.); Department of Neurology, University of Medicine and Dentistry of New Jersey- Robert Wood Johnson Medical School/New Brunswick/Etats-Unis (9 aut., 10 aut.); Department of Medicine, University of Toronto/Ontario/Canada (11 aut.); Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital/Australie (12 aut.); Department of Biostatistics, Boston University School of Public Health/MA/Etats-Unis (15 aut.); Departments of Clinical Neurosciences and Medical Genetics, University of Calgary/Canada (19 aut., 20 aut.); Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School/Boston/Etats-Unis (21 aut.); Department of Neurology, University of Miami/FL/Etats-Unis (22 aut.); Department of Neurology, Emory University/Atlanta, GA;/Etats-Unis (23 aut.); Medical Genetics Unit, Istituti Clinici di Perfezionamento/Milano/Italie (24 aut.); Parkinson Institute, Istituti Clinici di Perfezionamento/Milano/Italie (25 aut.); Departments of Neurology and Neuroscience, Cleveland Clinic Foundation/OH/Etats-Unis (26 aut., 27 aut.); Department of Neu rology, General Regional Hospital Bolzano/Italie (28 aut.); Re gional Neurosciences Centre, Newcastle General Hospital/Newcastle upon Tyne/Royaume-Uni (29 aut., 30 aut.); Department of Neurology, University of Arizona/Tucson/Etats-Unis (31 aut.); Klinik fur Neurologie, Klinikum Lippe-Lemgo/Lemgo/Allemagne (32 aut.); Department of Neurology, University of Louisville School of Medicine/KY/Etats-Unis (33 aut.); Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School/Boston/Etats-Unis (34 aut.); Department of Pediatrics, Human Genomics Laboratories, University of Arkansas for Medical Sciences/Little Rock/Etats-Unis (36 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Neurology; ISSN 0028-3878; Coden NEURAI; Etats-Unis; Da. 2005; Vol. 65; No. 11; Pp. 1823-1825; Bibl. 10 ref.</SO>
<LA>Anglais</LA>
<EA>Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.</EA>
<CC>002B17; 002B17G; 002B17A03</CC>
<FD>Système nerveux pathologie; Parkinson maladie; Variant génétique; Age apparition; Maladie familiale</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Parkinson disease; Genetic variant; Age of onset; Familial disease</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Variante genética; Edad aparición; Enfermedad familiar</SD>
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