ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000871

BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study

Identifieur interne : 000871 ( PascalFrancis/Corpus ); précédent : 000870; suivant : 000872

BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study

Auteurs : S. Karamohamed ; J. C. Latourelle ; B. A. Racette ; J. S. Perlmutter ; G. F. Wooten ; M. Lew ; C. Klein ; H. Shill ; L. I. Golbe ; M. H. Mark ; M. Guttman ; G. Nicholson ; J. B. Wilk ; M. Saint-Hilaire ; A. L. Destefano ; R. Prakash ; S. Tobin ; J. Williamson ; O. Suchowersky ; N. Labell ; B. N. J. Growdon ; C. Singer ; R. Watts ; S. Goldwurm ; G. Pezzoli ; K. B. Baker ; M. L. Giroux ; P. P. Pramstaller ; D. J. Burn ; P. Chinnery ; S. Sherman ; P. Vieregge ; I. Litvan ; J. F. Gusella ; R. H. Myers ; A. Parsian

Source :

Neurology [ 0028-3878 ] ; 2005.

RBID : Pascal:06-0054738

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Variant génétique, Age apparition, Maladie familiale.

English descriptors

KwdEn :
- Age of onset, Familial disease, Genetic variant, Nervous system diseases, Parkinson disease.

Abstract

Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A14	`01`			`@1 Department of Neurology, Boston University School of Medicine @3 USA @Z 1 aut. @Z 2 aut. @Z 13 aut. @Z 14 aut. @Z 15 aut. @Z 16 aut. @Z 17 aut. @Z 18 aut. @Z 35 aut.`
A14	`02`			`@1 Department of Neurology, Washington University School of Medicine @2 Saint Louis, MO @3 USA @Z 3 aut. @Z 4 aut.`
A14	`03`			`@1 Department of Neurology, University of Virginia Health System @2 Charlottesville @3 USA @Z 5 aut.`
A14	`04`			`@1 De partment of Neurology, University of Southern California @2 Los Angeles @3 USA @Z 6 aut.`
A14	`05`			`@1 Department of Neurology, Medical University of Lübeck @3 DEU @Z 7 aut.`
A14	`06`			`@1 Muhammad Ali Parkinson Research Center, Barrow Neurological Institute @2 Phoenix, AZ @3 USA @Z 8 aut.`
A14	`07`			`@1 Department of Neurology, University of Medicine and Dentistry of New Jersey- Robert Wood Johnson Medical School @2 New Brunswick @3 USA @Z 9 aut. @Z 10 aut.`
A14	`08`			`@1 Department of Medicine, University of Toronto @2 Ontario @3 CAN @Z 11 aut.`
A14	`09`			`@1 Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital @3 AUS @Z 12 aut.`
A14	`10`			`@1 Department of Biostatistics, Boston University School of Public Health @2 MA @3 USA @Z 15 aut.`
A14	`11`			`@1 Departments of Clinical Neurosciences and Medical Genetics, University of Calgary @3 CAN @Z 19 aut. @Z 20 aut.`
A14	`12`			`@1 Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School @2 Boston @3 USA @Z 21 aut.`
A14	`13`			`@1 Department of Neurology, University of Miami @2 FL @3 USA @Z 22 aut.`
A14	`14`			`@1 Department of Neurology, Emory University @2 Atlanta, GA; @3 USA @Z 23 aut.`
A14	`15`			`@1 Medical Genetics Unit, Istituti Clinici di Perfezionamento @2 Milano @3 ITA @Z 24 aut.`
A14	`16`			`@1 Parkinson Institute, Istituti Clinici di Perfezionamento @2 Milano @3 ITA @Z 25 aut.`
A14	`17`			`@1 Departments of Neurology and Neuroscience, Cleveland Clinic Foundation @2 OH @3 USA @Z 26 aut. @Z 27 aut.`
A14	`18`			`@1 Department of Neu rology, General Regional Hospital Bolzano @3 ITA @Z 28 aut.`
A14	`19`			`@1 Re gional Neurosciences Centre, Newcastle General Hospital @2 Newcastle upon Tyne @3 GBR @Z 29 aut. @Z 30 aut.`
A14	`20`			`@1 Department of Neurology, University of Arizona @2 Tucson @3 USA @Z 31 aut.`
A14	`21`			`@1 Klinik fur Neurologie, Klinikum Lippe-Lemgo @2 Lemgo @3 DEU @Z 32 aut.`
A14	`22`			`@1 Department of Neurology, University of Louisville School of Medicine @2 KY @3 USA @Z 33 aut.`
A14	`23`			`@1 Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School @2 Boston @3 USA @Z 34 aut.`
A14	`24`			`@1 Department of Pediatrics, Human Genomics Laboratories, University of Arkansas for Medical Sciences @2 Little Rock @3 USA @Z 36 aut.`
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C01	`01`		`ENG`	`@0 Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.`
C02	`01`	`X`		`@0 002B17`
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Format Inist (serveur)

NO :	PASCAL 06-0054738 INIST
ET :	BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study
AU :	KARAMOHAMED (S.); LATOURELLE (J. C.); RACETTE (B. A.); PERLMUTTER (J. S.); WOOTEN (G. F.); LEW (M.); KLEIN (C.); SHILL (H.); GOLBE (L. I.); MARK (M. H.); GUTTMAN (M.); NICHOLSON (G.); WILK (J. B.); SAINT-HILAIRE (M.); DESTEFANO (A. L.); PRAKASH (R.); TOBIN (S.); WILLIAMSON (J.); SUCHOWERSKY (O.); LABELL (N.); GROWDON (B. N. J.); SINGER (C.); WATTS (R.); GOLDWURM (S.); PEZZOLI (G.); BAKER (K. B.); GIROUX (M. L.); PRAMSTALLER (P. P.); BURN (D. J.); CHINNERY (P.); SHERMAN (S.); VIEREGGE (P.); LITVAN (I.); GUSELLA (J. F.); MYERS (R. H.); PARSIAN (A.)
AF :	Department of Neurology, Boston University School of Medicine/Etats-Unis (1 aut., 2 aut., 13 aut., 14 aut., 15 aut., 16 aut., 17 aut., 18 aut., 35 aut.); Department of Neurology, Washington University School of Medicine/Saint Louis, MO/Etats-Unis (3 aut., 4 aut.); Department of Neurology, University of Virginia Health System/Charlottesville/Etats-Unis (5 aut.); De partment of Neurology, University of Southern California/Los Angeles/Etats-Unis (6 aut.); Department of Neurology, Medical University of Lübeck/Allemagne (7 aut.); Muhammad Ali Parkinson Research Center, Barrow Neurological Institute/Phoenix, AZ/Etats-Unis (8 aut.); Department of Neurology, University of Medicine and Dentistry of New Jersey- Robert Wood Johnson Medical School/New Brunswick/Etats-Unis (9 aut., 10 aut.); Department of Medicine, University of Toronto/Ontario/Canada (11 aut.); Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital/Australie (12 aut.); Department of Biostatistics, Boston University School of Public Health/MA/Etats-Unis (15 aut.); Departments of Clinical Neurosciences and Medical Genetics, University of Calgary/Canada (19 aut., 20 aut.); Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School/Boston/Etats-Unis (21 aut.); Department of Neurology, University of Miami/FL/Etats-Unis (22 aut.); Department of Neurology, Emory University/Atlanta, GA;/Etats-Unis (23 aut.); Medical Genetics Unit, Istituti Clinici di Perfezionamento/Milano/Italie (24 aut.); Parkinson Institute, Istituti Clinici di Perfezionamento/Milano/Italie (25 aut.); Departments of Neurology and Neuroscience, Cleveland Clinic Foundation/OH/Etats-Unis (26 aut., 27 aut.); Department of Neu rology, General Regional Hospital Bolzano/Italie (28 aut.); Re gional Neurosciences Centre, Newcastle General Hospital/Newcastle upon Tyne/Royaume-Uni (29 aut., 30 aut.); Department of Neurology, University of Arizona/Tucson/Etats-Unis (31 aut.); Klinik fur Neurologie, Klinikum Lippe-Lemgo/Lemgo/Allemagne (32 aut.); Department of Neurology, University of Louisville School of Medicine/KY/Etats-Unis (33 aut.); Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School/Boston/Etats-Unis (34 aut.); Department of Pediatrics, Human Genomics Laboratories, University of Arkansas for Medical Sciences/Little Rock/Etats-Unis (36 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Neurology; ISSN 0028-3878; Coden NEURAI; Etats-Unis; Da. 2005; Vol. 65; No. 11; Pp. 1823-1825; Bibl. 10 ref.
LA :	Anglais
EA :	Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.
CC :	002B17; 002B17G; 002B17A03
FD :	Système nerveux pathologie; Parkinson maladie; Variant génétique; Age apparition; Maladie familiale
FG :	Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie
ED :	Nervous system diseases; Parkinson disease; Genetic variant; Age of onset; Familial disease
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Sistema nervioso patología; Parkinson enfermedad; Variante genética; Edad aparición; Enfermedad familiar
LO :	INIST-6345.354000134415150310
ID :	06-0054738

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Pascal:06-0054738

Le document en format XML

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<author><name sortKey="Mark, M H" sort="Mark, M H" uniqKey="Mark M" first="M. H." last="Mark">M. H. Mark</name>
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<author><name sortKey="Guttman, M" sort="Guttman, M" uniqKey="Guttman M" first="M." last="Guttman">M. Guttman</name>
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<author><name sortKey="Nicholson, G" sort="Nicholson, G" uniqKey="Nicholson G" first="G." last="Nicholson">G. Nicholson</name>
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<author><name sortKey="Williamson, J" sort="Williamson, J" uniqKey="Williamson J" first="J." last="Williamson">J. Williamson</name>
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<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
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<author><name sortKey="Suchowersky, O" sort="Suchowersky, O" uniqKey="Suchowersky O" first="O." last="Suchowersky">O. Suchowersky</name>
<affiliation><inist:fA14 i1="11"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1>
<s3>CAN</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
</affiliation>
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<author><name sortKey="Labell, N" sort="Labell, N" uniqKey="Labell N" first="N." last="Labell">N. Labell</name>
<affiliation><inist:fA14 i1="11"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1>
<s3>CAN</s3>
<sZ>19 aut.</sZ>
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<author><name sortKey="Growdon, B N J" sort="Growdon, B N J" uniqKey="Growdon B" first="B. N. J." last="Growdon">B. N. J. Growdon</name>
<affiliation><inist:fA14 i1="12"><s1>Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
</affiliation>
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<author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name>
<affiliation><inist:fA14 i1="13"><s1>Department of Neurology, University of Miami</s1>
<s2>FL</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Watts, R" sort="Watts, R" uniqKey="Watts R" first="R." last="Watts">R. Watts</name>
<affiliation><inist:fA14 i1="14"><s1>Department of Neurology, Emory University</s1>
<s2>Atlanta, GA;</s2>
<s3>USA</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Goldwurm, S" sort="Goldwurm, S" uniqKey="Goldwurm S" first="S." last="Goldwurm">S. Goldwurm</name>
<affiliation><inist:fA14 i1="15"><s1>Medical Genetics Unit, Istituti Clinici di Perfezionamento</s1>
<s2>Milano</s2>
<s3>ITA</s3>
<sZ>24 aut.</sZ>
</inist:fA14>
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</author>
<author><name sortKey="Pezzoli, G" sort="Pezzoli, G" uniqKey="Pezzoli G" first="G." last="Pezzoli">G. Pezzoli</name>
<affiliation><inist:fA14 i1="16"><s1>Parkinson Institute, Istituti Clinici di Perfezionamento</s1>
<s2>Milano</s2>
<s3>ITA</s3>
<sZ>25 aut.</sZ>
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<author><name sortKey="Baker, K B" sort="Baker, K B" uniqKey="Baker K" first="K. B." last="Baker">K. B. Baker</name>
<affiliation><inist:fA14 i1="17"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1>
<s2>OH</s2>
<s3>USA</s3>
<sZ>26 aut.</sZ>
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<author><name sortKey="Giroux, M L" sort="Giroux, M L" uniqKey="Giroux M" first="M. L." last="Giroux">M. L. Giroux</name>
<affiliation><inist:fA14 i1="17"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1>
<s2>OH</s2>
<s3>USA</s3>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
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<author><name sortKey="Pramstaller, P P" sort="Pramstaller, P P" uniqKey="Pramstaller P" first="P. P." last="Pramstaller">P. P. Pramstaller</name>
<affiliation><inist:fA14 i1="18"><s1>Department of Neu rology, General Regional Hospital Bolzano</s1>
<s3>ITA</s3>
<sZ>28 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name>
<affiliation><inist:fA14 i1="19"><s1>Re gional Neurosciences Centre, Newcastle General Hospital</s1>
<s2>Newcastle upon Tyne</s2>
<s3>GBR</s3>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
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</author>
<author><name sortKey="Chinnery, P" sort="Chinnery, P" uniqKey="Chinnery P" first="P." last="Chinnery">P. Chinnery</name>
<affiliation><inist:fA14 i1="19"><s1>Re gional Neurosciences Centre, Newcastle General Hospital</s1>
<s2>Newcastle upon Tyne</s2>
<s3>GBR</s3>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Sherman, S" sort="Sherman, S" uniqKey="Sherman S" first="S." last="Sherman">S. Sherman</name>
<affiliation><inist:fA14 i1="20"><s1>Department of Neurology, University of Arizona</s1>
<s2>Tucson</s2>
<s3>USA</s3>
<sZ>31 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Vieregge, P" sort="Vieregge, P" uniqKey="Vieregge P" first="P." last="Vieregge">P. Vieregge</name>
<affiliation><inist:fA14 i1="21"><s1>Klinik fur Neurologie, Klinikum Lippe-Lemgo</s1>
<s2>Lemgo</s2>
<s3>DEU</s3>
<sZ>32 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name>
<affiliation><inist:fA14 i1="22"><s1>Department of Neurology, University of Louisville School of Medicine</s1>
<s2>KY</s2>
<s3>USA</s3>
<sZ>33 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Gusella, J F" sort="Gusella, J F" uniqKey="Gusella J" first="J. F." last="Gusella">J. F. Gusella</name>
<affiliation><inist:fA14 i1="23"><s1>Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>34 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R. H." last="Myers">R. H. Myers</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
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<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
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</author>
<author><name sortKey="Parsian, A" sort="Parsian, A" uniqKey="Parsian A" first="A." last="Parsian">A. Parsian</name>
<affiliation><inist:fA14 i1="24"><s1>Department of Pediatrics, Human Genomics Laboratories, University of Arkansas for Medical Sciences</s1>
<s2>Little Rock</s2>
<s3>USA</s3>
<sZ>36 aut.</sZ>
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</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">06-0054738</idno>
<date when="2005">2005</date>
<idno type="stanalyst">PASCAL 06-0054738 INIST</idno>
<idno type="RBID">Pascal:06-0054738</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000871</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study</title>
<author><name sortKey="Karamohamed, S" sort="Karamohamed, S" uniqKey="Karamohamed S" first="S." last="Karamohamed">S. Karamohamed</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>35 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Latourelle, J C" sort="Latourelle, J C" uniqKey="Latourelle J" first="J. C." last="Latourelle">J. C. Latourelle</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
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</affiliation>
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<author><name sortKey="Racette, B A" sort="Racette, B A" uniqKey="Racette B" first="B. A." last="Racette">B. A. Racette</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Neurology, Washington University School of Medicine</s1>
<s2>Saint Louis, MO</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Perlmutter, J S" sort="Perlmutter, J S" uniqKey="Perlmutter J" first="J. S." last="Perlmutter">J. S. Perlmutter</name>
<affiliation><inist:fA14 i1="02"><s1>Department of Neurology, Washington University School of Medicine</s1>
<s2>Saint Louis, MO</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
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</author>
<author><name sortKey="Wooten, G F" sort="Wooten, G F" uniqKey="Wooten G" first="G. F." last="Wooten">G. F. Wooten</name>
<affiliation><inist:fA14 i1="03"><s1>Department of Neurology, University of Virginia Health System</s1>
<s2>Charlottesville</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lew, M" sort="Lew, M" uniqKey="Lew M" first="M." last="Lew">M. Lew</name>
<affiliation><inist:fA14 i1="04"><s1>De partment of Neurology, University of Southern California</s1>
<s2>Los Angeles</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
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</affiliation>
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<author><name sortKey="Klein, C" sort="Klein, C" uniqKey="Klein C" first="C." last="Klein">C. Klein</name>
<affiliation><inist:fA14 i1="05"><s1>Department of Neurology, Medical University of Lübeck</s1>
<s3>DEU</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Shill, H" sort="Shill, H" uniqKey="Shill H" first="H." last="Shill">H. Shill</name>
<affiliation><inist:fA14 i1="06"><s1>Muhammad Ali Parkinson Research Center, Barrow Neurological Institute</s1>
<s2>Phoenix, AZ</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
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</affiliation>
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<author><name sortKey="Golbe, L I" sort="Golbe, L I" uniqKey="Golbe L" first="L. I." last="Golbe">L. I. Golbe</name>
<affiliation><inist:fA14 i1="07"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey- Robert Wood Johnson Medical School</s1>
<s2>New Brunswick</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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</affiliation>
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<author><name sortKey="Mark, M H" sort="Mark, M H" uniqKey="Mark M" first="M. H." last="Mark">M. H. Mark</name>
<affiliation><inist:fA14 i1="07"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey- Robert Wood Johnson Medical School</s1>
<s2>New Brunswick</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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<author><name sortKey="Guttman, M" sort="Guttman, M" uniqKey="Guttman M" first="M." last="Guttman">M. Guttman</name>
<affiliation><inist:fA14 i1="08"><s1>Department of Medicine, University of Toronto</s1>
<s2>Ontario</s2>
<s3>CAN</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Nicholson, G" sort="Nicholson, G" uniqKey="Nicholson G" first="G." last="Nicholson">G. Nicholson</name>
<affiliation><inist:fA14 i1="09"><s1>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital</s1>
<s3>AUS</s3>
<sZ>12 aut.</sZ>
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</affiliation>
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<author><name sortKey="Wilk, J B" sort="Wilk, J B" uniqKey="Wilk J" first="J. B." last="Wilk">J. B. Wilk</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
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<author><name sortKey="Saint Hilaire, M" sort="Saint Hilaire, M" uniqKey="Saint Hilaire M" first="M." last="Saint-Hilaire">M. Saint-Hilaire</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
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<author><name sortKey="Destefano, A L" sort="Destefano, A L" uniqKey="Destefano A" first="A. L." last="Destefano">A. L. Destefano</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
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<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>35 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="10"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
<s2>MA</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
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<author><name sortKey="Prakash, R" sort="Prakash, R" uniqKey="Prakash R" first="R." last="Prakash">R. Prakash</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
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<author><name sortKey="Tobin, S" sort="Tobin, S" uniqKey="Tobin S" first="S." last="Tobin">S. Tobin</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s3>USA</s3>
<sZ>1 aut.</sZ>
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<sZ>14 aut.</sZ>
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<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
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<author><name sortKey="Williamson, J" sort="Williamson, J" uniqKey="Williamson J" first="J." last="Williamson">J. Williamson</name>
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<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
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<sZ>16 aut.</sZ>
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<author><name sortKey="Suchowersky, O" sort="Suchowersky, O" uniqKey="Suchowersky O" first="O." last="Suchowersky">O. Suchowersky</name>
<affiliation><inist:fA14 i1="11"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1>
<s3>CAN</s3>
<sZ>19 aut.</sZ>
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</inist:fA14>
</affiliation>
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<author><name sortKey="Labell, N" sort="Labell, N" uniqKey="Labell N" first="N." last="Labell">N. Labell</name>
<affiliation><inist:fA14 i1="11"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1>
<s3>CAN</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Growdon, B N J" sort="Growdon, B N J" uniqKey="Growdon B" first="B. N. J." last="Growdon">B. N. J. Growdon</name>
<affiliation><inist:fA14 i1="12"><s1>Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>21 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Singer, C" sort="Singer, C" uniqKey="Singer C" first="C." last="Singer">C. Singer</name>
<affiliation><inist:fA14 i1="13"><s1>Department of Neurology, University of Miami</s1>
<s2>FL</s2>
<s3>USA</s3>
<sZ>22 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Watts, R" sort="Watts, R" uniqKey="Watts R" first="R." last="Watts">R. Watts</name>
<affiliation><inist:fA14 i1="14"><s1>Department of Neurology, Emory University</s1>
<s2>Atlanta, GA;</s2>
<s3>USA</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Goldwurm, S" sort="Goldwurm, S" uniqKey="Goldwurm S" first="S." last="Goldwurm">S. Goldwurm</name>
<affiliation><inist:fA14 i1="15"><s1>Medical Genetics Unit, Istituti Clinici di Perfezionamento</s1>
<s2>Milano</s2>
<s3>ITA</s3>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Pezzoli, G" sort="Pezzoli, G" uniqKey="Pezzoli G" first="G." last="Pezzoli">G. Pezzoli</name>
<affiliation><inist:fA14 i1="16"><s1>Parkinson Institute, Istituti Clinici di Perfezionamento</s1>
<s2>Milano</s2>
<s3>ITA</s3>
<sZ>25 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Baker, K B" sort="Baker, K B" uniqKey="Baker K" first="K. B." last="Baker">K. B. Baker</name>
<affiliation><inist:fA14 i1="17"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1>
<s2>OH</s2>
<s3>USA</s3>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
</affiliation>
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<author><name sortKey="Giroux, M L" sort="Giroux, M L" uniqKey="Giroux M" first="M. L." last="Giroux">M. L. Giroux</name>
<affiliation><inist:fA14 i1="17"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1>
<s2>OH</s2>
<s3>USA</s3>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Pramstaller, P P" sort="Pramstaller, P P" uniqKey="Pramstaller P" first="P. P." last="Pramstaller">P. P. Pramstaller</name>
<affiliation><inist:fA14 i1="18"><s1>Department of Neu rology, General Regional Hospital Bolzano</s1>
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<author><name sortKey="Burn, D J" sort="Burn, D J" uniqKey="Burn D" first="D. J." last="Burn">D. J. Burn</name>
<affiliation><inist:fA14 i1="19"><s1>Re gional Neurosciences Centre, Newcastle General Hospital</s1>
<s2>Newcastle upon Tyne</s2>
<s3>GBR</s3>
<sZ>29 aut.</sZ>
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<author><name sortKey="Chinnery, P" sort="Chinnery, P" uniqKey="Chinnery P" first="P." last="Chinnery">P. Chinnery</name>
<affiliation><inist:fA14 i1="19"><s1>Re gional Neurosciences Centre, Newcastle General Hospital</s1>
<s2>Newcastle upon Tyne</s2>
<s3>GBR</s3>
<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
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<author><name sortKey="Sherman, S" sort="Sherman, S" uniqKey="Sherman S" first="S." last="Sherman">S. Sherman</name>
<affiliation><inist:fA14 i1="20"><s1>Department of Neurology, University of Arizona</s1>
<s2>Tucson</s2>
<s3>USA</s3>
<sZ>31 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Vieregge, P" sort="Vieregge, P" uniqKey="Vieregge P" first="P." last="Vieregge">P. Vieregge</name>
<affiliation><inist:fA14 i1="21"><s1>Klinik fur Neurologie, Klinikum Lippe-Lemgo</s1>
<s2>Lemgo</s2>
<s3>DEU</s3>
<sZ>32 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Litvan, I" sort="Litvan, I" uniqKey="Litvan I" first="I." last="Litvan">I. Litvan</name>
<affiliation><inist:fA14 i1="22"><s1>Department of Neurology, University of Louisville School of Medicine</s1>
<s2>KY</s2>
<s3>USA</s3>
<sZ>33 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Gusella, J F" sort="Gusella, J F" uniqKey="Gusella J" first="J. F." last="Gusella">J. F. Gusella</name>
<affiliation><inist:fA14 i1="23"><s1>Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>34 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Myers, R H" sort="Myers, R H" uniqKey="Myers R" first="R. H." last="Myers">R. H. Myers</name>
<affiliation><inist:fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>35 aut.</sZ>
</inist:fA14>
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<author><name sortKey="Parsian, A" sort="Parsian, A" uniqKey="Parsian A" first="A." last="Parsian">A. Parsian</name>
<affiliation><inist:fA14 i1="24"><s1>Department of Pediatrics, Human Genomics Laboratories, University of Arkansas for Medical Sciences</s1>
<s2>Little Rock</s2>
<s3>USA</s3>
<sZ>36 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
<imprint><date when="2005">2005</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Neurology</title>
<title level="j" type="abbreviated">Neurology</title>
<idno type="ISSN">0028-3878</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age of onset</term>
<term>Familial disease</term>
<term>Genetic variant</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Système nerveux pathologie</term>
<term>Parkinson maladie</term>
<term>Variant génétique</term>
<term>Age apparition</term>
<term>Maladie familiale</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study</s1>
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<fA11 i1="01" i2="1"><s1>KARAMOHAMED (S.)</s1>
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<fA11 i1="36" i2="1"><s1>PARSIAN (A.)</s1>
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<fA14 i1="01"><s1>Department of Neurology, Boston University School of Medicine</s1>
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<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
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<fA14 i1="02"><s1>Department of Neurology, Washington University School of Medicine</s1>
<s2>Saint Louis, MO</s2>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
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<fA14 i1="03"><s1>Department of Neurology, University of Virginia Health System</s1>
<s2>Charlottesville</s2>
<s3>USA</s3>
<sZ>5 aut.</sZ>
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<fA14 i1="04"><s1>De partment of Neurology, University of Southern California</s1>
<s2>Los Angeles</s2>
<s3>USA</s3>
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<fA14 i1="05"><s1>Department of Neurology, Medical University of Lübeck</s1>
<s3>DEU</s3>
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<fA14 i1="06"><s1>Muhammad Ali Parkinson Research Center, Barrow Neurological Institute</s1>
<s2>Phoenix, AZ</s2>
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<fA14 i1="07"><s1>Department of Neurology, University of Medicine and Dentistry of New Jersey- Robert Wood Johnson Medical School</s1>
<s2>New Brunswick</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
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<fA14 i1="08"><s1>Department of Medicine, University of Toronto</s1>
<s2>Ontario</s2>
<s3>CAN</s3>
<sZ>11 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital</s1>
<s3>AUS</s3>
<sZ>12 aut.</sZ>
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<fA14 i1="10"><s1>Department of Biostatistics, Boston University School of Public Health</s1>
<s2>MA</s2>
<s3>USA</s3>
<sZ>15 aut.</sZ>
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<fA14 i1="11"><s1>Departments of Clinical Neurosciences and Medical Genetics, University of Calgary</s1>
<s3>CAN</s3>
<sZ>19 aut.</sZ>
<sZ>20 aut.</sZ>
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<fA14 i1="12"><s1>Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1>
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<s3>USA</s3>
<sZ>21 aut.</sZ>
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<fA14 i1="13"><s1>Department of Neurology, University of Miami</s1>
<s2>FL</s2>
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<fA14 i1="14"><s1>Department of Neurology, Emory University</s1>
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<fA14 i1="15"><s1>Medical Genetics Unit, Istituti Clinici di Perfezionamento</s1>
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<fA14 i1="16"><s1>Parkinson Institute, Istituti Clinici di Perfezionamento</s1>
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<fA14 i1="17"><s1>Departments of Neurology and Neuroscience, Cleveland Clinic Foundation</s1>
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<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
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<fA14 i1="18"><s1>Department of Neu rology, General Regional Hospital Bolzano</s1>
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<fA14 i1="19"><s1>Re gional Neurosciences Centre, Newcastle General Hospital</s1>
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<sZ>29 aut.</sZ>
<sZ>30 aut.</sZ>
</fA14>
<fA14 i1="20"><s1>Department of Neurology, University of Arizona</s1>
<s2>Tucson</s2>
<s3>USA</s3>
<sZ>31 aut.</sZ>
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<fA14 i1="21"><s1>Klinik fur Neurologie, Klinikum Lippe-Lemgo</s1>
<s2>Lemgo</s2>
<s3>DEU</s3>
<sZ>32 aut.</sZ>
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<fA14 i1="22"><s1>Department of Neurology, University of Louisville School of Medicine</s1>
<s2>KY</s2>
<s3>USA</s3>
<sZ>33 aut.</sZ>
</fA14>
<fA14 i1="23"><s1>Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School</s1>
<s2>Boston</s2>
<s3>USA</s3>
<sZ>34 aut.</sZ>
</fA14>
<fA14 i1="24"><s1>Department of Pediatrics, Human Genomics Laboratories, University of Arkansas for Medical Sciences</s1>
<s2>Little Rock</s2>
<s3>USA</s3>
<sZ>36 aut.</sZ>
</fA14>
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<server><NO>PASCAL 06-0054738 INIST</NO>
<ET>BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study</ET>
<AU>KARAMOHAMED (S.); LATOURELLE (J. C.); RACETTE (B. A.); PERLMUTTER (J. S.); WOOTEN (G. F.); LEW (M.); KLEIN (C.); SHILL (H.); GOLBE (L. I.); MARK (M. H.); GUTTMAN (M.); NICHOLSON (G.); WILK (J. B.); SAINT-HILAIRE (M.); DESTEFANO (A. L.); PRAKASH (R.); TOBIN (S.); WILLIAMSON (J.); SUCHOWERSKY (O.); LABELL (N.); GROWDON (B. N. J.); SINGER (C.); WATTS (R.); GOLDWURM (S.); PEZZOLI (G.); BAKER (K. B.); GIROUX (M. L.); PRAMSTALLER (P. P.); BURN (D. J.); CHINNERY (P.); SHERMAN (S.); VIEREGGE (P.); LITVAN (I.); GUSELLA (J. F.); MYERS (R. H.); PARSIAN (A.)</AU>
<AF>Department of Neurology, Boston University School of Medicine/Etats-Unis (1 aut., 2 aut., 13 aut., 14 aut., 15 aut., 16 aut., 17 aut., 18 aut., 35 aut.); Department of Neurology, Washington University School of Medicine/Saint Louis, MO/Etats-Unis (3 aut., 4 aut.); Department of Neurology, University of Virginia Health System/Charlottesville/Etats-Unis (5 aut.); De partment of Neurology, University of Southern California/Los Angeles/Etats-Unis (6 aut.); Department of Neurology, Medical University of Lübeck/Allemagne (7 aut.); Muhammad Ali Parkinson Research Center, Barrow Neurological Institute/Phoenix, AZ/Etats-Unis (8 aut.); Department of Neurology, University of Medicine and Dentistry of New Jersey- Robert Wood Johnson Medical School/New Brunswick/Etats-Unis (9 aut., 10 aut.); Department of Medicine, University of Toronto/Ontario/Canada (11 aut.); Neurology Department, University of Sydney ANZAC Research Institute, Concord Hospital/Australie (12 aut.); Department of Biostatistics, Boston University School of Public Health/MA/Etats-Unis (15 aut.); Departments of Clinical Neurosciences and Medical Genetics, University of Calgary/Canada (19 aut., 20 aut.); Department of Neurology, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School/Boston/Etats-Unis (21 aut.); Department of Neurology, University of Miami/FL/Etats-Unis (22 aut.); Department of Neurology, Emory University/Atlanta, GA;/Etats-Unis (23 aut.); Medical Genetics Unit, Istituti Clinici di Perfezionamento/Milano/Italie (24 aut.); Parkinson Institute, Istituti Clinici di Perfezionamento/Milano/Italie (25 aut.); Departments of Neurology and Neuroscience, Cleveland Clinic Foundation/OH/Etats-Unis (26 aut., 27 aut.); Department of Neu rology, General Regional Hospital Bolzano/Italie (28 aut.); Re gional Neurosciences Centre, Newcastle General Hospital/Newcastle upon Tyne/Royaume-Uni (29 aut., 30 aut.); Department of Neurology, University of Arizona/Tucson/Etats-Unis (31 aut.); Klinik fur Neurologie, Klinikum Lippe-Lemgo/Lemgo/Allemagne (32 aut.); Department of Neurology, University of Louisville School of Medicine/KY/Etats-Unis (33 aut.); Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School/Boston/Etats-Unis (34 aut.); Department of Pediatrics, Human Genomics Laboratories, University of Arkansas for Medical Sciences/Little Rock/Etats-Unis (36 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Neurology; ISSN 0028-3878; Coden NEURAI; Etats-Unis; Da. 2005; Vol. 65; No. 11; Pp. 1823-1825; Bibl. 10 ref.</SO>
<LA>Anglais</LA>
<EA>Brain-derived neurotrophic factor (BDNF) stimulates neuronal growth and protects nigral dopamine neurons in animal models of Parkinson disease (PD). Therefore, BDNF is a candidate gene for PD. The authors investigated five single-nucleotide polymorphisms in 597 cases of familial PD. Homozygosity for the rare allele of the functional BDNF G196A (Val66Met) variant was associated with a 5.3-year older onset age (p = 0.0001). These findings suggest that BDNF may influence PD onset age.</EA>
<CC>002B17; 002B17G; 002B17A03</CC>
<FD>Système nerveux pathologie; Parkinson maladie; Variant génétique; Age apparition; Maladie familiale</FD>
<FG>Encéphale pathologie; Extrapyramidal syndrome; Maladie dégénérative; Système nerveux central pathologie</FG>
<ED>Nervous system diseases; Parkinson disease; Genetic variant; Age of onset; Familial disease</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Variante genética; Edad aparición; Enfermedad familiar</SD>
<LO>INIST-6345.354000134415150310</LO>
<ID>06-0054738</ID>
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BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study

BDNF genetic variants are associated with onset age of familial Parkinson disease : GenePD Study

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