ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000778

Acute stressor-selective effects on homocysteine metabolism and oxidative stress parameters in female rats

Identifieur interne : 000778 ( PascalFrancis/Corpus ); précédent : 000777; suivant : 000779

Acute stressor-selective effects on homocysteine metabolism and oxidative stress parameters in female rats

Auteurs : Fernanda G. De Souza ; Mayra D. B. Rodrigues ; Sergio Tufik ; José N. Nobrega ; Vania D'Almeida

Source :

Pharmacology, biochemistry and behavior [ 0091-3057 ] ; 2006.

RBID : Pascal:07-0075841

Descripteurs français

Pascal (Inist)
- Aigu, Stress oxydatif, Homocystéine, Métabolisme, Femelle, Rat, Animal.

English descriptors

KwdEn :
- Acute, Animal, Female, Homocystein, Metabolism, Oxidative stress, Rat.

Abstract

Homocysteine levels are affected by diet factors such as vitamin deficiencies, non-diet factors such as genetic disorders, and stress exposure. Hyperhomocysteinemia has been implicated in several disorders, including cardiovascular disease, depression, schizophrenia, Alzheimer's and Parkinson's disease. Since sex differences play a role both in stress responses and in susceptibility to various diseases, the objective of this study was to evaluate possible alterations in homocysteine metabolism including cysteine, folate, and vitamin B₆, and oxidative stress markers in female rats exposed to different types of acute stress. Female rats were randomly distributed into eight groups according to stress manipulation (restraint, swimming, cold and control) and estrous cycle (diestrus and estrus). In general no significant differences were seen between rats in estrus and diestrus. Restraint stress was the only type of stress that altered homocysteine concentrations (+33% relative to controls). An increase in levels of thiobarbituric acid reactive substances (TBARS) and a decrease in total glutathione (GSHt) concentration were also observed in animals subjected to restraint and swimming stress, suggesting the possibility of oxidative damage. Thus, both the homocysteine results and the oxidative stress data indicated that restraint stress was the most powerful stress manipulation in female rats, as previously observed in male rats. These findings indicate that hormonal and gonadal differences do not interfere with stress responses related to homocysteine metabolism and suggest that putative gender-related differences in homocysteine responses are probably not involved in the differential prevalence of some diseases in human males and females.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A02	`01`			`@0 PBBHAU`
A03		`1`		`@0 Pharmacol. biochem. behav.`
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A11	`02`	`1`		`@1 RODRIGUES (Mayra D. B.)`
A11	`03`	`1`		`@1 TUFIK (Sergio)`
A11	`04`	`1`		`@1 NOBREGA (José N.)`
A11	`05`	`1`		`@1 D'ALMEIDA (Vania)`
A14	`01`			`@1 Department of Pediatrics of Universidade Fédéral de São Paulo-UNIFESP @2 São Paulo @3 BRA @Z 1 aut. @Z 2 aut. @Z 5 aut.`
A14	`02`			`@1 Department of Psychobiology of Universidade Fédéral de Sào Paulo-UNIFESP @2 São Paulo @3 BRA @Z 3 aut. @Z 5 aut.`
A14	`03`			`@1 Neuroimaging Research Section, Centre for Addiction and Mental Health @2 Toronto @3 CAN @Z 4 aut.`
A14	`04`			`@1 Department of Health Sciences of Universidade Fédéral de São Paulo-UNIFESP @2 São Paulo @3 BRA @Z 5 aut.`
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A23	`01`			`@0 ENG`
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C01	`01`		`ENG`	@0 Homocysteine levels are affected by diet factors such as vitamin deficiencies, non-diet factors such as genetic disorders, and stress exposure. Hyperhomocysteinemia has been implicated in several disorders, including cardiovascular disease, depression, schizophrenia, Alzheimer's and Parkinson's disease. Since sex differences play a role both in stress responses and in susceptibility to various diseases, the objective of this study was to evaluate possible alterations in homocysteine metabolism including cysteine, folate, and vitamin B₆, and oxidative stress markers in female rats exposed to different types of acute stress. Female rats were randomly distributed into eight groups according to stress manipulation (restraint, swimming, cold and control) and estrous cycle (diestrus and estrus). In general no significant differences were seen between rats in estrus and diestrus. Restraint stress was the only type of stress that altered homocysteine concentrations (+33% relative to controls). An increase in levels of thiobarbituric acid reactive substances (TBARS) and a decrease in total glutathione (GSHt) concentration were also observed in animals subjected to restraint and swimming stress, suggesting the possibility of oxidative damage. Thus, both the homocysteine results and the oxidative stress data indicated that restraint stress was the most powerful stress manipulation in female rats, as previously observed in male rats. These findings indicate that hormonal and gonadal differences do not interfere with stress responses related to homocysteine metabolism and suggest that putative gender-related differences in homocysteine responses are probably not involved in the differential prevalence of some diseases in human males and females.
C02	`01`	`X`		`@0 002B`
C03	`01`	`X`	`FRE`	`@0 Aigu @5 01`
C03	`01`	`X`	`ENG`	`@0 Acute @5 01`
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C03	`02`	`X`	`FRE`	`@0 Stress oxydatif @5 02`
C03	`02`	`X`	`ENG`	`@0 Oxidative stress @5 02`
C03	`02`	`X`	`SPA`	`@0 Estrés oxidativo @5 02`
C03	`03`	`X`	`FRE`	`@0 Homocystéine @2 NK @2 FR @5 03`
C03	`03`	`X`	`ENG`	`@0 Homocystein @2 NK @2 FR @5 03`
C03	`03`	`X`	`SPA`	`@0 Homocisteína @2 NK @2 FR @5 03`
C03	`04`	`X`	`FRE`	`@0 Métabolisme @5 04`
C03	`04`	`X`	`ENG`	`@0 Metabolism @5 04`
C03	`04`	`X`	`SPA`	`@0 Metabolismo @5 04`
C03	`05`	`X`	`FRE`	`@0 Femelle @5 05`
C03	`05`	`X`	`ENG`	`@0 Female @5 05`
C03	`05`	`X`	`SPA`	`@0 Hembra @5 05`
C03	`06`	`X`	`FRE`	`@0 Rat @5 06`
C03	`06`	`X`	`ENG`	`@0 Rat @5 06`
C03	`06`	`X`	`SPA`	`@0 Rata @5 06`
C03	`07`	`X`	`FRE`	`@0 Animal @5 07`
C03	`07`	`X`	`ENG`	`@0 Animal @5 07`
C03	`07`	`X`	`SPA`	`@0 Animal @5 07`
C07	`01`	`X`	`FRE`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`ENG`	`@0 Rodentia @2 NS`
C07	`01`	`X`	`SPA`	`@0 Rodentia @2 NS`
C07	`02`	`X`	`FRE`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`ENG`	`@0 Mammalia @2 NS`
C07	`02`	`X`	`SPA`	`@0 Mammalia @2 NS`
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C07	`04`	`X`	`FRE`	`@0 Aminoacide soufré @5 37`
C07	`04`	`X`	`ENG`	`@0 Sulfur containing aminoacid @5 37`
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C07	`06`	`X`	`SPA`	`@0 Farmacocinética @5 39`
N21				`@1 050`
N44	`01`			`@1 OTO`
N82				`@1 OTO`

Format Inist (serveur)

NO :	PASCAL 07-0075841 INIST
ET :	Acute stressor-selective effects on homocysteine metabolism and oxidative stress parameters in female rats
AU :	DE SOUZA (Fernanda G.); RODRIGUES (Mayra D. B.); TUFIK (Sergio); NOBREGA (José N.); D'ALMEIDA (Vania)
AF :	Department of Pediatrics of Universidade Fédéral de São Paulo-UNIFESP/São Paulo/Brésil (1 aut., 2 aut., 5 aut.); Department of Psychobiology of Universidade Fédéral de Sào Paulo-UNIFESP/São Paulo/Brésil (3 aut., 5 aut.); Neuroimaging Research Section, Centre for Addiction and Mental Health/Toronto/Canada (4 aut.); Department of Health Sciences of Universidade Fédéral de São Paulo-UNIFESP/São Paulo/Brésil (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Pharmacology, biochemistry and behavior; ISSN 0091-3057; Coden PBBHAU; Etats-Unis; Da. 2006; Vol. 85; No. 2; Pp. 400-407; Bibl. 1 p.1/4
LA :	Anglais
EA :	Homocysteine levels are affected by diet factors such as vitamin deficiencies, non-diet factors such as genetic disorders, and stress exposure. Hyperhomocysteinemia has been implicated in several disorders, including cardiovascular disease, depression, schizophrenia, Alzheimer's and Parkinson's disease. Since sex differences play a role both in stress responses and in susceptibility to various diseases, the objective of this study was to evaluate possible alterations in homocysteine metabolism including cysteine, folate, and vitamin B₆, and oxidative stress markers in female rats exposed to different types of acute stress. Female rats were randomly distributed into eight groups according to stress manipulation (restraint, swimming, cold and control) and estrous cycle (diestrus and estrus). In general no significant differences were seen between rats in estrus and diestrus. Restraint stress was the only type of stress that altered homocysteine concentrations (+33% relative to controls). An increase in levels of thiobarbituric acid reactive substances (TBARS) and a decrease in total glutathione (GSHt) concentration were also observed in animals subjected to restraint and swimming stress, suggesting the possibility of oxidative damage. Thus, both the homocysteine results and the oxidative stress data indicated that restraint stress was the most powerful stress manipulation in female rats, as previously observed in male rats. These findings indicate that hormonal and gonadal differences do not interfere with stress responses related to homocysteine metabolism and suggest that putative gender-related differences in homocysteine responses are probably not involved in the differential prevalence of some diseases in human males and females.
CC :	002B
FD :	Aigu; Stress oxydatif; Homocystéine; Métabolisme; Femelle; Rat; Animal
FG :	Rodentia; Mammalia; Vertebrata; Aminoacide soufré; Thiol; Pharmacocinétique
ED :	Acute; Oxidative stress; Homocystein; Metabolism; Female; Rat; Animal
EG :	Rodentia; Mammalia; Vertebrata; Sulfur containing aminoacid; Thiol; Pharmacokinetics
SD :	Agudo; Estrés oxidativo; Homocisteína; Metabolismo; Hembra; Rata; Animal
LO :	INIST-16578.354000145263060160
ID :	07-0075841

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Pascal:07-0075841

Le document en format XML

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<front><div type="abstract" xml:lang="en">Homocysteine levels are affected by diet factors such as vitamin deficiencies, non-diet factors such as genetic disorders, and stress exposure. Hyperhomocysteinemia has been implicated in several disorders, including cardiovascular disease, depression, schizophrenia, Alzheimer's and Parkinson's disease. Since sex differences play a role both in stress responses and in susceptibility to various diseases, the objective of this study was to evaluate possible alterations in homocysteine metabolism including cysteine, folate, and vitamin B<sub>6</sub>
, and oxidative stress markers in female rats exposed to different types of acute stress. Female rats were randomly distributed into eight groups according to stress manipulation (restraint, swimming, cold and control) and estrous cycle (diestrus and estrus). In general no significant differences were seen between rats in estrus and diestrus. Restraint stress was the only type of stress that altered homocysteine concentrations (+33% relative to controls). An increase in levels of thiobarbituric acid reactive substances (TBARS) and a decrease in total glutathione (GSHt) concentration were also observed in animals subjected to restraint and swimming stress, suggesting the possibility of oxidative damage. Thus, both the homocysteine results and the oxidative stress data indicated that restraint stress was the most powerful stress manipulation in female rats, as previously observed in male rats. These findings indicate that hormonal and gonadal differences do not interfere with stress responses related to homocysteine metabolism and suggest that putative gender-related differences in homocysteine responses are probably not involved in the differential prevalence of some diseases in human males and females.</div>
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<fC01 i1="01" l="ENG"><s0>Homocysteine levels are affected by diet factors such as vitamin deficiencies, non-diet factors such as genetic disorders, and stress exposure. Hyperhomocysteinemia has been implicated in several disorders, including cardiovascular disease, depression, schizophrenia, Alzheimer's and Parkinson's disease. Since sex differences play a role both in stress responses and in susceptibility to various diseases, the objective of this study was to evaluate possible alterations in homocysteine metabolism including cysteine, folate, and vitamin B<sub>6</sub>
, and oxidative stress markers in female rats exposed to different types of acute stress. Female rats were randomly distributed into eight groups according to stress manipulation (restraint, swimming, cold and control) and estrous cycle (diestrus and estrus). In general no significant differences were seen between rats in estrus and diestrus. Restraint stress was the only type of stress that altered homocysteine concentrations (+33% relative to controls). An increase in levels of thiobarbituric acid reactive substances (TBARS) and a decrease in total glutathione (GSHt) concentration were also observed in animals subjected to restraint and swimming stress, suggesting the possibility of oxidative damage. Thus, both the homocysteine results and the oxidative stress data indicated that restraint stress was the most powerful stress manipulation in female rats, as previously observed in male rats. These findings indicate that hormonal and gonadal differences do not interfere with stress responses related to homocysteine metabolism and suggest that putative gender-related differences in homocysteine responses are probably not involved in the differential prevalence of some diseases in human males and females.</s0>
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<s2>NS</s2>
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<s2>NS</s2>
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<fC07 i1="03" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
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<s2>NS</s2>
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<s2>NS</s2>
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<s5>37</s5>
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<s5>37</s5>
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<s5>37</s5>
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<s5>38</s5>
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<s5>38</s5>
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<fC07 i1="05" i2="X" l="SPA"><s0>Tiol</s0>
<s5>38</s5>
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<s5>39</s5>
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<s5>39</s5>
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<s5>39</s5>
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<fN82><s1>OTO</s1>
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<server><NO>PASCAL 07-0075841 INIST</NO>
<ET>Acute stressor-selective effects on homocysteine metabolism and oxidative stress parameters in female rats</ET>
<AU>DE SOUZA (Fernanda G.); RODRIGUES (Mayra D. B.); TUFIK (Sergio); NOBREGA (José N.); D'ALMEIDA (Vania)</AU>
<AF>Department of Pediatrics of Universidade Fédéral de São Paulo-UNIFESP/São Paulo/Brésil (1 aut., 2 aut., 5 aut.); Department of Psychobiology of Universidade Fédéral de Sào Paulo-UNIFESP/São Paulo/Brésil (3 aut., 5 aut.); Neuroimaging Research Section, Centre for Addiction and Mental Health/Toronto/Canada (4 aut.); Department of Health Sciences of Universidade Fédéral de São Paulo-UNIFESP/São Paulo/Brésil (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Pharmacology, biochemistry and behavior; ISSN 0091-3057; Coden PBBHAU; Etats-Unis; Da. 2006; Vol. 85; No. 2; Pp. 400-407; Bibl. 1 p.1/4</SO>
<LA>Anglais</LA>
<EA>Homocysteine levels are affected by diet factors such as vitamin deficiencies, non-diet factors such as genetic disorders, and stress exposure. Hyperhomocysteinemia has been implicated in several disorders, including cardiovascular disease, depression, schizophrenia, Alzheimer's and Parkinson's disease. Since sex differences play a role both in stress responses and in susceptibility to various diseases, the objective of this study was to evaluate possible alterations in homocysteine metabolism including cysteine, folate, and vitamin B<sub>6</sub>
, and oxidative stress markers in female rats exposed to different types of acute stress. Female rats were randomly distributed into eight groups according to stress manipulation (restraint, swimming, cold and control) and estrous cycle (diestrus and estrus). In general no significant differences were seen between rats in estrus and diestrus. Restraint stress was the only type of stress that altered homocysteine concentrations (+33% relative to controls). An increase in levels of thiobarbituric acid reactive substances (TBARS) and a decrease in total glutathione (GSHt) concentration were also observed in animals subjected to restraint and swimming stress, suggesting the possibility of oxidative damage. Thus, both the homocysteine results and the oxidative stress data indicated that restraint stress was the most powerful stress manipulation in female rats, as previously observed in male rats. These findings indicate that hormonal and gonadal differences do not interfere with stress responses related to homocysteine metabolism and suggest that putative gender-related differences in homocysteine responses are probably not involved in the differential prevalence of some diseases in human males and females.</EA>
<CC>002B</CC>
<FD>Aigu; Stress oxydatif; Homocystéine; Métabolisme; Femelle; Rat; Animal</FD>
<FG>Rodentia; Mammalia; Vertebrata; Aminoacide soufré; Thiol; Pharmacocinétique</FG>
<ED>Acute; Oxidative stress; Homocystein; Metabolism; Female; Rat; Animal</ED>
<EG>Rodentia; Mammalia; Vertebrata; Sulfur containing aminoacid; Thiol; Pharmacokinetics</EG>
<SD>Agudo; Estrés oxidativo; Homocisteína; Metabolismo; Hembra; Rata; Animal</SD>
<LO>INIST-16578.354000145263060160</LO>
<ID>07-0075841</ID>
</server>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Acute stressor-selective effects on homocysteine metabolism and oxidative stress parameters in female rats

Acute stressor-selective effects on homocysteine metabolism and oxidative stress parameters in female rats

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