ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000720

Differential effects of glial cell line-derived neurotrophic factor on A9 and A10 dopamine neuron survival in vitro

Identifieur interne : 000720 ( PascalFrancis/Corpus ); précédent : 000719; suivant : 000721

Differential effects of glial cell line-derived neurotrophic factor on A9 and A10 dopamine neuron survival in vitro

Auteurs : L. Borgal ; M. Hong ; D. Sadi ; I. Mendez

Source :

Neuroscience [ 0306-4522 ] ; 2007.

RBID : Pascal:07-0370668

Descripteurs français

Pascal (Inist)
- Facteur GDNF, Neurone dopaminergique, In vitro, Locus niger, Dopamine, Transplantation.

English descriptors

KwdEn :
- Dopamine, Dopaminergic neuron, Glial cell line derived neurotrophic factor, In vitro, Locus niger, Transplantation.

Abstract

-Glial cell-line derived neurotrophic factor (GDNF) enhances dopamine (DA) cell survival and fiber outgrowth, and may be beneficial in enhancing cell restorative strategies for Parkinson's disease (PD). However, GDNF may have different roles for transplanted DA cell sub-types. The present in vitro study investigated the effect of GDNF on the survival of rat DA cells displaying a phenotype consistent with either the substantia nigra [A9 cells immunopositive for tyrosine hydroxylase (TH) and G-protein-gated inwardly rectifying potassium channel subunit 2 (GIRK2)] or with the ventral tegmental area [A10 cells immunopositive for TH and calbindin]. It was found that a single exposure of GDNF enhanced the number of DA cells of an A9 phenotype, without affecting DA cells of an A10 phenotype. Conversely, repeated GDNF exposure did not alter the survival of A9 phenotypic cells, but doubled the percentage of A10 cells. It was concluded that GDNF administration may affect dopaminergic cells differently depending on time and degree of GDNF exposure. For cell transplantation in PD, long-term GDNF administration may result in detrimental effects for transplanted A9 TH+ cells as this may introduce competition with A10 TH+ cells for survival and fiber outgrowth into the host striatum. These results may have important implications for clinical neural transplantation in PD.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 -Glial cell-line derived neurotrophic factor (GDNF) enhances dopamine (DA) cell survival and fiber outgrowth, and may be beneficial in enhancing cell restorative strategies for Parkinson's disease (PD). However, GDNF may have different roles for transplanted DA cell sub-types. The present in vitro study investigated the effect of GDNF on the survival of rat DA cells displaying a phenotype consistent with either the substantia nigra [A9 cells immunopositive for tyrosine hydroxylase (TH) and G-protein-gated inwardly rectifying potassium channel subunit 2 (GIRK2)] or with the ventral tegmental area [A10 cells immunopositive for TH and calbindin]. It was found that a single exposure of GDNF enhanced the number of DA cells of an A9 phenotype, without affecting DA cells of an A10 phenotype. Conversely, repeated GDNF exposure did not alter the survival of A9 phenotypic cells, but doubled the percentage of A10 cells. It was concluded that GDNF administration may affect dopaminergic cells differently depending on time and degree of GDNF exposure. For cell transplantation in PD, long-term GDNF administration may result in detrimental effects for transplanted A9 TH+ cells as this may introduce competition with A10 TH+ cells for survival and fiber outgrowth into the host striatum. These results may have important implications for clinical neural transplantation in PD.
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C07	`03`	`X`	`FRE`	`@0 Catécholamine @5 22`
C07	`03`	`X`	`ENG`	`@0 Catecholamine @5 22`
C07	`03`	`X`	`SPA`	`@0 Catecolamina @5 22`
C07	`04`	`X`	`FRE`	`@0 Neurotransmetteur @5 23`
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Format Inist (serveur)

NO :	PASCAL 07-0370668 INIST
ET :	Differential effects of glial cell line-derived neurotrophic factor on A9 and A10 dopamine neuron survival in vitro
AU :	BORGAL (L.); HONG (M.); SADI (D.); MENDEZ (I.)
AF :	Cell Restoration Laboratory, Brain Repair Centre, Tupper Medical Building, Room 12-H, Dalhousie University, 5850 College Street/Halifax, NS, B3H 1X5/Canada (1 aut., 2 aut., 3 aut., 4 aut.)
DT :	Publication en série; Niveau analytique
SO :	Neuroscience; ISSN 0306-4522; Coden NRSCDN; Royaume-Uni; Da. 2007; Vol. 147; No. 3; Pp. 712-719; Bibl. 2 p.
LA :	Anglais
EA :	-Glial cell-line derived neurotrophic factor (GDNF) enhances dopamine (DA) cell survival and fiber outgrowth, and may be beneficial in enhancing cell restorative strategies for Parkinson's disease (PD). However, GDNF may have different roles for transplanted DA cell sub-types. The present in vitro study investigated the effect of GDNF on the survival of rat DA cells displaying a phenotype consistent with either the substantia nigra [A9 cells immunopositive for tyrosine hydroxylase (TH) and G-protein-gated inwardly rectifying potassium channel subunit 2 (GIRK2)] or with the ventral tegmental area [A10 cells immunopositive for TH and calbindin]. It was found that a single exposure of GDNF enhanced the number of DA cells of an A9 phenotype, without affecting DA cells of an A10 phenotype. Conversely, repeated GDNF exposure did not alter the survival of A9 phenotypic cells, but doubled the percentage of A10 cells. It was concluded that GDNF administration may affect dopaminergic cells differently depending on time and degree of GDNF exposure. For cell transplantation in PD, long-term GDNF administration may result in detrimental effects for transplanted A9 TH+ cells as this may introduce competition with A10 TH+ cells for survival and fiber outgrowth into the host striatum. These results may have important implications for clinical neural transplantation in PD.
CC :	002A25
FD :	Facteur GDNF; Neurone dopaminergique; In vitro; Locus niger; Dopamine; Transplantation
FG :	Encéphale; Système nerveux central; Catécholamine; Neurotransmetteur
ED :	Glial cell line derived neurotrophic factor; Dopaminergic neuron; In vitro; Locus niger; Dopamine; Transplantation
EG :	Encephalon; Central nervous system; Catecholamine; Neurotransmitter
SD :	Factor GDNF; Neurona dopaminérgica; In vitro; Locus níger; Dopamina; Trasplantación
LO :	INIST-17194.354000162395360160
ID :	07-0370668

Links to Exploration step

Pascal:07-0370668

Le document en format XML

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<front><div type="abstract" xml:lang="en">-Glial cell-line derived neurotrophic factor (GDNF) enhances dopamine (DA) cell survival and fiber outgrowth, and may be beneficial in enhancing cell restorative strategies for Parkinson's disease (PD). However, GDNF may have different roles for transplanted DA cell sub-types. The present in vitro study investigated the effect of GDNF on the survival of rat DA cells displaying a phenotype consistent with either the substantia nigra [A9 cells immunopositive for tyrosine hydroxylase (TH) and G-protein-gated inwardly rectifying potassium channel subunit 2 (GIRK2)] or with the ventral tegmental area [A10 cells immunopositive for TH and calbindin]. It was found that a single exposure of GDNF enhanced the number of DA cells of an A9 phenotype, without affecting DA cells of an A10 phenotype. Conversely, repeated GDNF exposure did not alter the survival of A9 phenotypic cells, but doubled the percentage of A10 cells. It was concluded that GDNF administration may affect dopaminergic cells differently depending on time and degree of GDNF exposure. For cell transplantation in PD, long-term GDNF administration may result in detrimental effects for transplanted A9 TH+ cells as this may introduce competition with A10 TH+ cells for survival and fiber outgrowth into the host striatum. These results may have important implications for clinical neural transplantation in PD.</div>
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<ET>Differential effects of glial cell line-derived neurotrophic factor on A9 and A10 dopamine neuron survival in vitro</ET>
<AU>BORGAL (L.); HONG (M.); SADI (D.); MENDEZ (I.)</AU>
<AF>Cell Restoration Laboratory, Brain Repair Centre, Tupper Medical Building, Room 12-H, Dalhousie University, 5850 College Street/Halifax, NS, B3H 1X5/Canada (1 aut., 2 aut., 3 aut., 4 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neuroscience; ISSN 0306-4522; Coden NRSCDN; Royaume-Uni; Da. 2007; Vol. 147; No. 3; Pp. 712-719; Bibl. 2 p.</SO>
<LA>Anglais</LA>
<EA>-Glial cell-line derived neurotrophic factor (GDNF) enhances dopamine (DA) cell survival and fiber outgrowth, and may be beneficial in enhancing cell restorative strategies for Parkinson's disease (PD). However, GDNF may have different roles for transplanted DA cell sub-types. The present in vitro study investigated the effect of GDNF on the survival of rat DA cells displaying a phenotype consistent with either the substantia nigra [A9 cells immunopositive for tyrosine hydroxylase (TH) and G-protein-gated inwardly rectifying potassium channel subunit 2 (GIRK2)] or with the ventral tegmental area [A10 cells immunopositive for TH and calbindin]. It was found that a single exposure of GDNF enhanced the number of DA cells of an A9 phenotype, without affecting DA cells of an A10 phenotype. Conversely, repeated GDNF exposure did not alter the survival of A9 phenotypic cells, but doubled the percentage of A10 cells. It was concluded that GDNF administration may affect dopaminergic cells differently depending on time and degree of GDNF exposure. For cell transplantation in PD, long-term GDNF administration may result in detrimental effects for transplanted A9 TH+ cells as this may introduce competition with A10 TH+ cells for survival and fiber outgrowth into the host striatum. These results may have important implications for clinical neural transplantation in PD.</EA>
<CC>002A25</CC>
<FD>Facteur GDNF; Neurone dopaminergique; In vitro; Locus niger; Dopamine; Transplantation</FD>
<FG>Encéphale; Système nerveux central; Catécholamine; Neurotransmetteur</FG>
<ED>Glial cell line derived neurotrophic factor; Dopaminergic neuron; In vitro; Locus niger; Dopamine; Transplantation</ED>
<EG>Encephalon; Central nervous system; Catecholamine; Neurotransmitter</EG>
<SD>Factor GDNF; Neurona dopaminérgica; In vitro; Locus níger; Dopamina; Trasplantación</SD>
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<ID>07-0370668</ID>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Differential effects of glial cell line-derived neurotrophic factor on A9 and A10 dopamine neuron survival in vitro

Differential effects of glial cell line-derived neurotrophic factor on A9 and A10 dopamine neuron survival in vitro

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