Subdural Motor Cortex Stimulation in Parkinson's Disease Does Not Modify Movement-Related rCBF Pattern
Identifieur interne : 000675 ( PascalFrancis/Corpus ); précédent : 000674; suivant : 000676Subdural Motor Cortex Stimulation in Parkinson's Disease Does Not Modify Movement-Related rCBF Pattern
Auteurs : Antonio P. Strafella ; Andres M. Lozano ; Anthony E. Lang ; JI HYUN KO ; Yu-Yan Poon ; Elena MoroSource :
- Movement disorders [ 0885-3185 ] ; 2007.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
There has been some evidence that electrical stimulation of the primary motor cortex (MCS) may relieve motor symptoms of Parkinson's disease (PD). This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [15O] H2O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF-condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement-related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement-related activation pattern in patients with advanced PD.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 08-0069705 INIST |
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ET : | Subdural Motor Cortex Stimulation in Parkinson's Disease Does Not Modify Movement-Related rCBF Pattern |
AU : | STRAFELLA (Antonio P.); LOZANO (Andres M.); LANG (Anthony E.); JI HYUN KO; POON (Yu-Yan); MORO (Elena) |
AF : | Movement Disorders Center, Division of Neurology, Toronto Western Hospital, University of Toronto/Toronto, Ontario/Canada (1 aut., 3 aut., 5 aut., 6 aut.); PET Imaging Centre, Centre for Addiction Mental Health, University of Toronto/Toronto, Ontario/Canada (1 aut.); Department of Neurosurgery, Toronto Western Hospital, University of Toronto/Toronto, Ontario/Canada (2 aut.); Montreal Neurological Institute, McGill University/Montreal, Quebec/Canada (4 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 14; Pp. 2113-2116; Bibl. 27 ref. |
LA : | Anglais |
EA : | There has been some evidence that electrical stimulation of the primary motor cortex (MCS) may relieve motor symptoms of Parkinson's disease (PD). This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [15O] H2O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF-condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement-related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement-related activation pattern in patients with advanced PD. |
CC : | 002B17; 002B17G; 002B17A03 |
FD : | Pathologie du système nerveux; Maladie de Parkinson; Sousdural; Cortex moteur; Tomoscintigraphie; Positon; Tomographie par émission de positons; Imagerie fonctionnelle |
FG : | Encéphale; Système nerveux central; Voie motrice; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
ED : | Nervous system diseases; Parkinson disease; Subdural; Motor cortex; Emission tomography; Positron; Positron emission tomography; Functional imaging |
EG : | Encephalon; Central nervous system; Motor pathway; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Sistema nervioso patología; Parkinson enfermedad; Subdural; Corteza motora; Tomocentelleografía; Positrón; Tomografía emisión positrones; Imaginería funcional |
LO : | INIST-20953.354000174393170160 |
ID : | 08-0069705 |
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Pascal:08-0069705Le document en format XML
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<front><div type="abstract" xml:lang="en">There has been some evidence that electrical stimulation of the primary motor cortex (MCS) may relieve motor symptoms of Parkinson's disease (PD). This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [<sup>15</sup>
O] H<sub>2</sub>
O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF-condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement-related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement-related activation pattern in patients with advanced PD.</div>
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O] H<sub>2</sub>
O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF-condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement-related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement-related activation pattern in patients with advanced PD.</s0>
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<s5>43</s5>
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<server><NO>PASCAL 08-0069705 INIST</NO>
<ET>Subdural Motor Cortex Stimulation in Parkinson's Disease Does Not Modify Movement-Related rCBF Pattern</ET>
<AU>STRAFELLA (Antonio P.); LOZANO (Andres M.); LANG (Anthony E.); JI HYUN KO; POON (Yu-Yan); MORO (Elena)</AU>
<AF>Movement Disorders Center, Division of Neurology, Toronto Western Hospital, University of Toronto/Toronto, Ontario/Canada (1 aut., 3 aut., 5 aut., 6 aut.); PET Imaging Centre, Centre for Addiction Mental Health, University of Toronto/Toronto, Ontario/Canada (1 aut.); Department of Neurosurgery, Toronto Western Hospital, University of Toronto/Toronto, Ontario/Canada (2 aut.); Montreal Neurological Institute, McGill University/Montreal, Quebec/Canada (4 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2007; Vol. 22; No. 14; Pp. 2113-2116; Bibl. 27 ref.</SO>
<LA>Anglais</LA>
<EA>There has been some evidence that electrical stimulation of the primary motor cortex (MCS) may relieve motor symptoms of Parkinson's disease (PD). This surgical technique is being studied as alternative for PD patients who are considered poor candidates for deep brain stimulation (DBS) of subthalamic nucleus (STN). In 4 PD patients with unilateral MCS, we used [<sup>15</sup>
O] H<sub>2</sub>
O positron emission tomography to measure changes in regional cerebral blood flow (rCBF) while testing motor performance with a joystick motor task during different stimulation frequencies, OFF-condition, 50 and 130 Hz. We found that different stimulation settings did neither improve performance on joystick task nor modify the pattern of movement-related rCBF. Similarly, no changes were observed in UPDRS motor score between Off and On stimulation while off medication. We conclude that while MCS may be a simpler and safer surgical procedure than DBS of STN, it failed to provide evidence of clear effect on motor performance and movement-related activation pattern in patients with advanced PD.</EA>
<CC>002B17; 002B17G; 002B17A03</CC>
<FD>Pathologie du système nerveux; Maladie de Parkinson; Sousdural; Cortex moteur; Tomoscintigraphie; Positon; Tomographie par émission de positons; Imagerie fonctionnelle</FD>
<FG>Encéphale; Système nerveux central; Voie motrice; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central</FG>
<ED>Nervous system diseases; Parkinson disease; Subdural; Motor cortex; Emission tomography; Positron; Positron emission tomography; Functional imaging</ED>
<EG>Encephalon; Central nervous system; Motor pathway; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Sistema nervioso patología; Parkinson enfermedad; Subdural; Corteza motora; Tomocentelleografía; Positrón; Tomografía emisión positrones; Imaginería funcional</SD>
<LO>INIST-20953.354000174393170160</LO>
<ID>08-0069705</ID>
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