ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000666

Sensorimotor adaptation in Parkinson's disease : evidence for a dopamine dependent remapping disturbance

Identifieur interne : 000666 ( PascalFrancis/Corpus ); précédent : 000665; suivant : 000667

Sensorimotor adaptation in Parkinson's disease : evidence for a dopamine dependent remapping disturbance

Auteurs : F. Paquet ; M. A. Bedard ; M. Levesque ; P. L. Tremblay ; M. Lemay ; P. J. Blanchet ; P. Scherzer ; S. Chouinard ; J. Filion

Source :

Experimental brain research [ 0014-4819 ] ; 2008.

RBID : Pascal:08-0135368

Descripteurs français

Pascal (Inist)
- Cinématique, Apprentissage, Déplétion, Lévodopa, Mouvement orienté, Corps strié, Perception, Maladie de Parkinson, Homme, Tâche pointage.

English descriptors

KwdEn :
- Corpus striatum, Depletion, Goal directed movement, Human, Kinematics, Learning, Levodopa, Parkinson disease, Perception, Pointing task.

Abstract

Sensorimotor adaptation is thought to involve a remapping of the kinematic and kinetic parameters associated with movements performed within a changing environment. Patients with Parkinson's disease (PD) are known to be affected on this type of learning process, although the specific role of dopamine depletion in these deficits has not yet been elucidated. The present study was an attempt to clarify whether dopamine depletion in PD may directly affect the capacity to internally reorganize the visuomotor remapping of a distorted environment. Fourteen PD patients were tested twice, while they were treated and while they were withdrawn from their regular levodopa treatment. Fourteen control subjects were also enrolled and tested twice. Two parallel forms of the Computed Mirror Pointing Task (CMPT), requiring making a reaching movement in a visually transformed environment (mirror inversion), were administered to each participant. Each of tnem had to perform 40 trials at each of the 2 testing sessions. At each trial, sensorimotor adaptation was evaluated by the initial direction angle (IDA), which reflects the direction of movement before any visually guided readjustment. Results revealed no IDA difference at baseline, between control subject and PD patients, whether they were treated or not. In all group, IDA values at that time were large, reflecting a tendency to make movements according to the real life visuomotor mapping (based on the natural direct vision). However, striking differences appeared during sensorimotor learning, in that IDA reduction along trials was poorer in patient not treated with levodopa than both control subjects and the same PD patient treated with levodopa. No difference was observed between the treated PD patients and control subjects. Given that IDA is thought to reflect the internal representation of the visuomotor mapping, it is concluded that dopamine depletion in PD would affects sensorimotor adaptation, in that it facilitates old and poorly adapted movements (real life mapping), instead of new and more adapted ones (mirror transformed mapping).

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 08-0135368 INIST
ET :	Sensorimotor adaptation in Parkinson's disease : evidence for a dopamine dependent remapping disturbance
AU :	PAQUET (F.); BEDARD (M. A.); LEVESQUE (M.); TREMBLAY (P. L.); LEMAY (M.); BLANCHET (P. J.); SCHERZER (P.); CHOUINARD (S.); FILION (J.)
AF :	Department of Psychology, Neuropsychology Division, University of Quebec in Montreal (UQAM), Station Downtown, P.O. Box 8888/Montreal, QC/Canada (1 aut., 2 aut., 4 aut., 5 aut., 7 aut.); Marie-Enfant readaptation Center, CHU Sainte-Justine, Bélanger Est/5200 Montreal/Canada (3 aut.); Movement Disorder Unit, CHUM/Montreal/Canada (6 aut., 8 aut.); Department of Stomatology, Faculty of Dental Medicine, University of Montreal/Montreal/Canada (6 aut., 9 aut.)
DT :	Publication en série; Niveau analytique
SO :	Experimental brain research; ISSN 0014-4819; Coden EXBRAP; Allemagne; Da. 2008; Vol. 185; No. 2; Pp. 227-236; Bibl. 1 p.1/4
LA :	Anglais
EA :	Sensorimotor adaptation is thought to involve a remapping of the kinematic and kinetic parameters associated with movements performed within a changing environment. Patients with Parkinson's disease (PD) are known to be affected on this type of learning process, although the specific role of dopamine depletion in these deficits has not yet been elucidated. The present study was an attempt to clarify whether dopamine depletion in PD may directly affect the capacity to internally reorganize the visuomotor remapping of a distorted environment. Fourteen PD patients were tested twice, while they were treated and while they were withdrawn from their regular levodopa treatment. Fourteen control subjects were also enrolled and tested twice. Two parallel forms of the Computed Mirror Pointing Task (CMPT), requiring making a reaching movement in a visually transformed environment (mirror inversion), were administered to each participant. Each of tnem had to perform 40 trials at each of the 2 testing sessions. At each trial, sensorimotor adaptation was evaluated by the initial direction angle (IDA), which reflects the direction of movement before any visually guided readjustment. Results revealed no IDA difference at baseline, between control subject and PD patients, whether they were treated or not. In all group, IDA values at that time were large, reflecting a tendency to make movements according to the real life visuomotor mapping (based on the natural direct vision). However, striking differences appeared during sensorimotor learning, in that IDA reduction along trials was poorer in patient not treated with levodopa than both control subjects and the same PD patient treated with levodopa. No difference was observed between the treated PD patients and control subjects. Given that IDA is thought to reflect the internal representation of the visuomotor mapping, it is concluded that dopamine depletion in PD would affects sensorimotor adaptation, in that it facilitates old and poorly adapted movements (real life mapping), instead of new and more adapted ones (mirror transformed mapping).
CC :	002B17G; 002A25E
FD :	Cinématique; Apprentissage; Déplétion; Lévodopa; Mouvement orienté; Corps strié; Perception; Maladie de Parkinson; Homme; Tâche pointage
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Pathologie du système nerveux; Processus acquisition; Encéphale; Noyau gris central; Système nerveux central
ED :	Kinematics; Learning; Depletion; Levodopa; Goal directed movement; Corpus striatum; Perception; Parkinson disease; Human; Pointing task
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Nervous system diseases; Acquisition process; Encephalon; Basal ganglion; Central nervous system
SD :	Cinemática; Aprendizaje; Depleción; Levodopa; Movimiento orientado; Cuerpo estriado; Percepción; Parkinson enfermedad; Hombre
LO :	INIST-12535.354000175080380060
ID :	08-0135368

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Pascal:08-0135368

Le document en format XML

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<term>Learning</term>
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<term>Parkinson disease</term>
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<front><div type="abstract" xml:lang="en">Sensorimotor adaptation is thought to involve a remapping of the kinematic and kinetic parameters associated with movements performed within a changing environment. Patients with Parkinson's disease (PD) are known to be affected on this type of learning process, although the specific role of dopamine depletion in these deficits has not yet been elucidated. The present study was an attempt to clarify whether dopamine depletion in PD may directly affect the capacity to internally reorganize the visuomotor remapping of a distorted environment. Fourteen PD patients were tested twice, while they were treated and while they were withdrawn from their regular levodopa treatment. Fourteen control subjects were also enrolled and tested twice. Two parallel forms of the Computed Mirror Pointing Task (CMPT), requiring making a reaching movement in a visually transformed environment (mirror inversion), were administered to each participant. Each of tnem had to perform 40 trials at each of the 2 testing sessions. At each trial, sensorimotor adaptation was evaluated by the initial direction angle (IDA), which reflects the direction of movement before any visually guided readjustment. Results revealed no IDA difference at baseline, between control subject and PD patients, whether they were treated or not. In all group, IDA values at that time were large, reflecting a tendency to make movements according to the real life visuomotor mapping (based on the natural direct vision). However, striking differences appeared during sensorimotor learning, in that IDA reduction along trials was poorer in patient not treated with levodopa than both control subjects and the same PD patient treated with levodopa. No difference was observed between the treated PD patients and control subjects. Given that IDA is thought to reflect the internal representation of the visuomotor mapping, it is concluded that dopamine depletion in PD would affects sensorimotor adaptation, in that it facilitates old and poorly adapted movements (real life mapping), instead of new and more adapted ones (mirror transformed mapping).</div>
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<ET>Sensorimotor adaptation in Parkinson's disease : evidence for a dopamine dependent remapping disturbance</ET>
<AU>PAQUET (F.); BEDARD (M. A.); LEVESQUE (M.); TREMBLAY (P. L.); LEMAY (M.); BLANCHET (P. J.); SCHERZER (P.); CHOUINARD (S.); FILION (J.)</AU>
<AF>Department of Psychology, Neuropsychology Division, University of Quebec in Montreal (UQAM), Station Downtown, P.O. Box 8888/Montreal, QC/Canada (1 aut., 2 aut., 4 aut., 5 aut., 7 aut.); Marie-Enfant readaptation Center, CHU Sainte-Justine, Bélanger Est/5200 Montreal/Canada (3 aut.); Movement Disorder Unit, CHUM/Montreal/Canada (6 aut., 8 aut.); Department of Stomatology, Faculty of Dental Medicine, University of Montreal/Montreal/Canada (6 aut., 9 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Experimental brain research; ISSN 0014-4819; Coden EXBRAP; Allemagne; Da. 2008; Vol. 185; No. 2; Pp. 227-236; Bibl. 1 p.1/4</SO>
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<EA>Sensorimotor adaptation is thought to involve a remapping of the kinematic and kinetic parameters associated with movements performed within a changing environment. Patients with Parkinson's disease (PD) are known to be affected on this type of learning process, although the specific role of dopamine depletion in these deficits has not yet been elucidated. The present study was an attempt to clarify whether dopamine depletion in PD may directly affect the capacity to internally reorganize the visuomotor remapping of a distorted environment. Fourteen PD patients were tested twice, while they were treated and while they were withdrawn from their regular levodopa treatment. Fourteen control subjects were also enrolled and tested twice. Two parallel forms of the Computed Mirror Pointing Task (CMPT), requiring making a reaching movement in a visually transformed environment (mirror inversion), were administered to each participant. Each of tnem had to perform 40 trials at each of the 2 testing sessions. At each trial, sensorimotor adaptation was evaluated by the initial direction angle (IDA), which reflects the direction of movement before any visually guided readjustment. Results revealed no IDA difference at baseline, between control subject and PD patients, whether they were treated or not. In all group, IDA values at that time were large, reflecting a tendency to make movements according to the real life visuomotor mapping (based on the natural direct vision). However, striking differences appeared during sensorimotor learning, in that IDA reduction along trials was poorer in patient not treated with levodopa than both control subjects and the same PD patient treated with levodopa. No difference was observed between the treated PD patients and control subjects. Given that IDA is thought to reflect the internal representation of the visuomotor mapping, it is concluded that dopamine depletion in PD would affects sensorimotor adaptation, in that it facilitates old and poorly adapted movements (real life mapping), instead of new and more adapted ones (mirror transformed mapping).</EA>
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<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central; Pathologie du   système nerveux; Processus acquisition; Encéphale; Noyau gris central; Système nerveux central</FG>
<ED>Kinematics; Learning; Depletion; Levodopa; Goal directed movement; Corpus striatum; Perception; Parkinson disease; Human; Pointing task</ED>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Sensorimotor adaptation in Parkinson's disease : evidence for a dopamine dependent remapping disturbance

Sensorimotor adaptation in Parkinson's disease : evidence for a dopamine dependent remapping disturbance

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