ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000638

rCBF Changes Associated with PPN Stimulation in a Patient with Parkinson's disease : A PET Study

Identifieur interne : 000638 ( PascalFrancis/Corpus ); précédent : 000637; suivant : 000639

rCBF Changes Associated with PPN Stimulation in a Patient with Parkinson's disease : A PET Study

Auteurs : Antonio P. Strafella ; Andres M. Lozano ; Benedicte Ballanger ; Yu-Yan Poon ; Anthony E. Lang ; Elena Moro

Source :

Movement disorders [ 0885-3185 ] ; 2008.

RBID : Pascal:08-0305163

Descripteurs français

Pascal (Inist)
- Maladie de Parkinson, Pathologie du système nerveux, Homme, Tomoscintigraphie, Tomographie par émission de positons, Imagerie fonctionnelle, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Deep brain stimulation, Emission tomography, Functional imaging, Human, Nervous system diseases, Parkinson disease, Positron emission tomography.

Abstract

Gait disturbances and akinesia are disabling symptoms in advanced Parkinson's disease (PD). The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement (REM) sleep]. Some reports have suggested that modulation of the activity of the PPN with deep brain stimulation (DBS) may be beneficial in the treatment of gait dysfunction and akinesia. To gain some insights on effects of PPN-DBS in the human brain, we used [¹⁵O] H₂O positron emission tomography (PET) to measure changes in regional cerebral blood flow (rCBF) at rest during Off and On stimulation in an advanced PD patient with unilateral PPN-DBS. PPN-DBS increased rCBF in different subcortical areas most notably the thalamus, bilaterally. Double-blinded clinical evaluation revealed an improvement in motor function by ∼20%. The PET changes provide for the first time evidence in the human brain that PPN-DBS may be able to influence and modify rCBF of closely connected subcortical structures. Given the importance of the PPN in locomotion, control of posture, and behavioral states, DBS may have significant implication for more complicated forms of movement disorders where deterioration of gait, postural instability, and REM sleep behavior disorders are very disabling.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Mov. disord.`
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A11	`01`	`1`		`@1 STRAFELLA (Antonio P.)`
A11	`02`	`1`		`@1 LOZANO (Andres M.)`
A11	`03`	`1`		`@1 BALLANGER (Benedicte)`
A11	`04`	`1`		`@1 POON (Yu-Yan)`
A11	`05`	`1`		`@1 LANG (Anthony E.)`
A11	`06`	`1`		`@1 MORO (Elena)`
A14	`01`			`@1 Movement Disorders Center, Toronto Western Hospital, Division of Neurology, University of Toronto @2 Toronto, Ontario @3 CAN @Z 1 aut. @Z 4 aut. @Z 5 aut. @Z 6 aut.`
A14	`02`			`@1 PET Imaging Centre, Center of Addiction Mental Health, University of Toronto @2 Toronto, Ontario @3 CAN @Z 1 aut. @Z 3 aut.`
A14	`03`			`@1 Department of Neurosurgery, Toronto Western Hospital, University of Toronto @2 Toronto, Ontario @3 CAN @Z 2 aut.`
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A21				`@1 2008`
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A44				`@0 0000 @1 © 2008 INIST-CNRS. All rights reserved.`
A45				`@0 23 ref.`
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A60				`@1 P @3 CC`
A61				`@0 A`
A64	`01`	`1`		`@0 Movement disorders`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 Gait disturbances and akinesia are disabling symptoms in advanced Parkinson's disease (PD). The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement (REM) sleep]. Some reports have suggested that modulation of the activity of the PPN with deep brain stimulation (DBS) may be beneficial in the treatment of gait dysfunction and akinesia. To gain some insights on effects of PPN-DBS in the human brain, we used [¹⁵O] H₂O positron emission tomography (PET) to measure changes in regional cerebral blood flow (rCBF) at rest during Off and On stimulation in an advanced PD patient with unilateral PPN-DBS. PPN-DBS increased rCBF in different subcortical areas most notably the thalamus, bilaterally. Double-blinded clinical evaluation revealed an improvement in motor function by ∼20%. The PET changes provide for the first time evidence in the human brain that PPN-DBS may be able to influence and modify rCBF of closely connected subcortical structures. Given the importance of the PPN in locomotion, control of posture, and behavioral states, DBS may have significant implication for more complicated forms of movement disorders where deterioration of gait, postural instability, and REM sleep behavior disorders are very disabling.
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C03	`04`	`X`	`SPA`	`@0 Tomocentelleografía @5 10`
C03	`05`	`X`	`FRE`	`@0 Tomographie par émission de positons @5 11`
C03	`05`	`X`	`ENG`	`@0 Positron emission tomography @5 11`
C03	`05`	`X`	`SPA`	`@0 Tomografía emisión positrones @5 11`
C03	`06`	`X`	`FRE`	`@0 Imagerie fonctionnelle @5 12`
C03	`06`	`X`	`ENG`	`@0 Functional imaging @5 12`
C03	`06`	`X`	`SPA`	`@0 Imaginería funcional @5 12`
C03	`07`	`X`	`FRE`	`@0 Stimulation cérébrale profonde @4 CD @5 96`
C03	`07`	`X`	`ENG`	`@0 Deep brain stimulation @4 CD @5 96`
C07	`01`	`X`	`FRE`	`@0 Pathologie de l'encéphale @5 37`
C07	`01`	`X`	`ENG`	`@0 Cerebral disorder @5 37`
C07	`01`	`X`	`SPA`	`@0 Encéfalo patología @5 37`
C07	`02`	`X`	`FRE`	`@0 Syndrome extrapyramidal @5 38`
C07	`02`	`X`	`ENG`	`@0 Extrapyramidal syndrome @5 38`
C07	`02`	`X`	`SPA`	`@0 Extrapiramidal síndrome @5 38`
C07	`03`	`X`	`FRE`	`@0 Maladie dégénérative @5 39`
C07	`03`	`X`	`ENG`	`@0 Degenerative disease @5 39`
C07	`03`	`X`	`SPA`	`@0 Enfermedad degenerativa @5 39`
C07	`04`	`X`	`FRE`	`@0 Pathologie du système nerveux central @5 40`
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N44	`01`			`@1 OTO`
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Format Inist (serveur)

NO :	PASCAL 08-0305163 INIST
ET :	rCBF Changes Associated with PPN Stimulation in a Patient with Parkinson's disease : A PET Study
AU :	STRAFELLA (Antonio P.); LOZANO (Andres M.); BALLANGER (Benedicte); POON (Yu-Yan); LANG (Anthony E.); MORO (Elena)
AF :	Movement Disorders Center, Toronto Western Hospital, Division of Neurology, University of Toronto/Toronto, Ontario/Canada (1 aut., 4 aut., 5 aut., 6 aut.); PET Imaging Centre, Center of Addiction Mental Health, University of Toronto/Toronto, Ontario/Canada (1 aut., 3 aut.); Department of Neurosurgery, Toronto Western Hospital, University of Toronto/Toronto, Ontario/Canada (2 aut.)
DT :	Publication en série; Courte communication, note brève; Niveau analytique
SO :	Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 7; Pp. 1051-1054; Bibl. 23 ref.
LA :	Anglais
EA :	Gait disturbances and akinesia are disabling symptoms in advanced Parkinson's disease (PD). The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement (REM) sleep]. Some reports have suggested that modulation of the activity of the PPN with deep brain stimulation (DBS) may be beneficial in the treatment of gait dysfunction and akinesia. To gain some insights on effects of PPN-DBS in the human brain, we used [¹⁵O] H₂O positron emission tomography (PET) to measure changes in regional cerebral blood flow (rCBF) at rest during Off and On stimulation in an advanced PD patient with unilateral PPN-DBS. PPN-DBS increased rCBF in different subcortical areas most notably the thalamus, bilaterally. Double-blinded clinical evaluation revealed an improvement in motor function by ∼20%. The PET changes provide for the first time evidence in the human brain that PPN-DBS may be able to influence and modify rCBF of closely connected subcortical structures. Given the importance of the PPN in locomotion, control of posture, and behavioral states, DBS may have significant implication for more complicated forms of movement disorders where deterioration of gait, postural instability, and REM sleep behavior disorders are very disabling.
CC :	002B17; 002B17G
FD :	Maladie de Parkinson; Pathologie du système nerveux; Homme; Tomoscintigraphie; Tomographie par émission de positons; Imagerie fonctionnelle; Stimulation cérébrale profonde
FG :	Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED :	Parkinson disease; Nervous system diseases; Human; Emission tomography; Positron emission tomography; Functional imaging; Deep brain stimulation
EG :	Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD :	Parkinson enfermedad; Sistema nervioso patología; Hombre; Tomocentelleografía; Tomografía emisión positrones; Imaginería funcional
LO :	INIST-20953.354000200276040210
ID :	08-0305163

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Pascal:08-0305163

Le document en format XML

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<front><div type="abstract" xml:lang="en">Gait disturbances and akinesia are disabling symptoms in advanced Parkinson's disease (PD). The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement (REM) sleep]. Some reports have suggested that modulation of the activity of the PPN with deep brain stimulation (DBS) may be beneficial in the treatment of gait dysfunction and akinesia. To gain some insights on effects of PPN-DBS in the human brain, we used [<sup>15</sup>
O] H<sub>2</sub>
O positron emission tomography (PET) to measure changes in regional cerebral blood flow (rCBF) at rest during Off and On stimulation in an advanced PD patient with unilateral PPN-DBS. PPN-DBS increased rCBF in different subcortical areas most notably the thalamus, bilaterally. Double-blinded clinical evaluation revealed an improvement in motor function by ∼20%. The PET changes provide for the first time evidence in the human brain that PPN-DBS may be able to influence and modify rCBF of closely connected subcortical structures. Given the importance of the PPN in locomotion, control of posture, and behavioral states, DBS may have significant implication for more complicated forms of movement disorders where deterioration of gait, postural instability, and REM sleep behavior disorders are very disabling.</div>
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O] H<sub>2</sub>
O positron emission tomography (PET) to measure changes in regional cerebral blood flow (rCBF) at rest during Off and On stimulation in an advanced PD patient with unilateral PPN-DBS. PPN-DBS increased rCBF in different subcortical areas most notably the thalamus, bilaterally. Double-blinded clinical evaluation revealed an improvement in motor function by ∼20%. The PET changes provide for the first time evidence in the human brain that PPN-DBS may be able to influence and modify rCBF of closely connected subcortical structures. Given the importance of the PPN in locomotion, control of posture, and behavioral states, DBS may have significant implication for more complicated forms of movement disorders where deterioration of gait, postural instability, and REM sleep behavior disorders are very disabling.</s0>
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<fC03 i1="07" i2="X" l="ENG"><s0>Deep brain stimulation</s0>
<s4>CD</s4>
<s5>96</s5>
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<s5>38</s5>
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<fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
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<fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
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<fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>39</s5>
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<s5>39</s5>
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<s5>39</s5>
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<fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
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</fC07>
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<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>40</s5>
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<server><NO>PASCAL 08-0305163 INIST</NO>
<ET>rCBF Changes Associated with PPN Stimulation in a Patient with Parkinson's disease : A PET Study</ET>
<AU>STRAFELLA (Antonio P.); LOZANO (Andres M.); BALLANGER (Benedicte); POON (Yu-Yan); LANG (Anthony E.); MORO (Elena)</AU>
<AF>Movement Disorders Center, Toronto Western Hospital, Division of Neurology, University of Toronto/Toronto, Ontario/Canada (1 aut., 4 aut., 5 aut., 6 aut.); PET Imaging Centre, Center of Addiction Mental Health, University of Toronto/Toronto, Ontario/Canada (1 aut., 3 aut.); Department of Neurosurgery, Toronto Western Hospital, University of Toronto/Toronto, Ontario/Canada (2 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 7; Pp. 1051-1054; Bibl. 23 ref.</SO>
<LA>Anglais</LA>
<EA>Gait disturbances and akinesia are disabling symptoms in advanced Parkinson's disease (PD). The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement (REM) sleep]. Some reports have suggested that modulation of the activity of the PPN with deep brain stimulation (DBS) may be beneficial in the treatment of gait dysfunction and akinesia. To gain some insights on effects of PPN-DBS in the human brain, we used [<sup>15</sup>
O] H<sub>2</sub>
O positron emission tomography (PET) to measure changes in regional cerebral blood flow (rCBF) at rest during Off and On stimulation in an advanced PD patient with unilateral PPN-DBS. PPN-DBS increased rCBF in different subcortical areas most notably the thalamus, bilaterally. Double-blinded clinical evaluation revealed an improvement in motor function by ∼20%. The PET changes provide for the first time evidence in the human brain that PPN-DBS may be able to influence and modify rCBF of closely connected subcortical structures. Given the importance of the PPN in locomotion, control of posture, and behavioral states, DBS may have significant implication for more complicated forms of movement disorders where deterioration of gait, postural instability, and REM sleep behavior disorders are very disabling.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du   système nerveux; Homme; Tomoscintigraphie; Tomographie par émission de positons; Imagerie fonctionnelle; Stimulation cérébrale profonde</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Human; Emission tomography; Positron emission tomography; Functional imaging; Deep brain stimulation</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Hombre; Tomocentelleografía; Tomografía emisión positrones; Imaginería funcional</SD>
<LO>INIST-20953.354000200276040210</LO>
<ID>08-0305163</ID>
</server>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

rCBF Changes Associated with PPN Stimulation in a Patient with Parkinson's disease : A PET Study

rCBF Changes Associated with PPN Stimulation in a Patient with Parkinson's disease : A PET Study

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