rCBF Changes Associated with PPN Stimulation in a Patient with Parkinson's disease : A PET Study
Identifieur interne : 000638 ( PascalFrancis/Corpus ); précédent : 000637; suivant : 000639rCBF Changes Associated with PPN Stimulation in a Patient with Parkinson's disease : A PET Study
Auteurs : Antonio P. Strafella ; Andres M. Lozano ; Benedicte Ballanger ; Yu-Yan Poon ; Anthony E. Lang ; Elena MoroSource :
- Movement disorders [ 0885-3185 ] ; 2008.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Gait disturbances and akinesia are disabling symptoms in advanced Parkinson's disease (PD). The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement (REM) sleep]. Some reports have suggested that modulation of the activity of the PPN with deep brain stimulation (DBS) may be beneficial in the treatment of gait dysfunction and akinesia. To gain some insights on effects of PPN-DBS in the human brain, we used [15O] H2O positron emission tomography (PET) to measure changes in regional cerebral blood flow (rCBF) at rest during Off and On stimulation in an advanced PD patient with unilateral PPN-DBS. PPN-DBS increased rCBF in different subcortical areas most notably the thalamus, bilaterally. Double-blinded clinical evaluation revealed an improvement in motor function by ∼20%. The PET changes provide for the first time evidence in the human brain that PPN-DBS may be able to influence and modify rCBF of closely connected subcortical structures. Given the importance of the PPN in locomotion, control of posture, and behavioral states, DBS may have significant implication for more complicated forms of movement disorders where deterioration of gait, postural instability, and REM sleep behavior disorders are very disabling.
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Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 08-0305163 INIST |
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ET : | rCBF Changes Associated with PPN Stimulation in a Patient with Parkinson's disease : A PET Study |
AU : | STRAFELLA (Antonio P.); LOZANO (Andres M.); BALLANGER (Benedicte); POON (Yu-Yan); LANG (Anthony E.); MORO (Elena) |
AF : | Movement Disorders Center, Toronto Western Hospital, Division of Neurology, University of Toronto/Toronto, Ontario/Canada (1 aut., 4 aut., 5 aut., 6 aut.); PET Imaging Centre, Center of Addiction Mental Health, University of Toronto/Toronto, Ontario/Canada (1 aut., 3 aut.); Department of Neurosurgery, Toronto Western Hospital, University of Toronto/Toronto, Ontario/Canada (2 aut.) |
DT : | Publication en série; Courte communication, note brève; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 7; Pp. 1051-1054; Bibl. 23 ref. |
LA : | Anglais |
EA : | Gait disturbances and akinesia are disabling symptoms in advanced Parkinson's disease (PD). The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement (REM) sleep]. Some reports have suggested that modulation of the activity of the PPN with deep brain stimulation (DBS) may be beneficial in the treatment of gait dysfunction and akinesia. To gain some insights on effects of PPN-DBS in the human brain, we used [15O] H2O positron emission tomography (PET) to measure changes in regional cerebral blood flow (rCBF) at rest during Off and On stimulation in an advanced PD patient with unilateral PPN-DBS. PPN-DBS increased rCBF in different subcortical areas most notably the thalamus, bilaterally. Double-blinded clinical evaluation revealed an improvement in motor function by ∼20%. The PET changes provide for the first time evidence in the human brain that PPN-DBS may be able to influence and modify rCBF of closely connected subcortical structures. Given the importance of the PPN in locomotion, control of posture, and behavioral states, DBS may have significant implication for more complicated forms of movement disorders where deterioration of gait, postural instability, and REM sleep behavior disorders are very disabling. |
CC : | 002B17; 002B17G |
FD : | Maladie de Parkinson; Pathologie du système nerveux; Homme; Tomoscintigraphie; Tomographie par émission de positons; Imagerie fonctionnelle; Stimulation cérébrale profonde |
FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
ED : | Parkinson disease; Nervous system diseases; Human; Emission tomography; Positron emission tomography; Functional imaging; Deep brain stimulation |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Parkinson enfermedad; Sistema nervioso patología; Hombre; Tomocentelleografía; Tomografía emisión positrones; Imaginería funcional |
LO : | INIST-20953.354000200276040210 |
ID : | 08-0305163 |
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Pascal:08-0305163Le document en format XML
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<front><div type="abstract" xml:lang="en">Gait disturbances and akinesia are disabling symptoms in advanced Parkinson's disease (PD). The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement (REM) sleep]. Some reports have suggested that modulation of the activity of the PPN with deep brain stimulation (DBS) may be beneficial in the treatment of gait dysfunction and akinesia. To gain some insights on effects of PPN-DBS in the human brain, we used [<sup>15</sup>
O] H<sub>2</sub>
O positron emission tomography (PET) to measure changes in regional cerebral blood flow (rCBF) at rest during Off and On stimulation in an advanced PD patient with unilateral PPN-DBS. PPN-DBS increased rCBF in different subcortical areas most notably the thalamus, bilaterally. Double-blinded clinical evaluation revealed an improvement in motor function by ∼20%. The PET changes provide for the first time evidence in the human brain that PPN-DBS may be able to influence and modify rCBF of closely connected subcortical structures. Given the importance of the PPN in locomotion, control of posture, and behavioral states, DBS may have significant implication for more complicated forms of movement disorders where deterioration of gait, postural instability, and REM sleep behavior disorders are very disabling.</div>
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<server><NO>PASCAL 08-0305163 INIST</NO>
<ET>rCBF Changes Associated with PPN Stimulation in a Patient with Parkinson's disease : A PET Study</ET>
<AU>STRAFELLA (Antonio P.); LOZANO (Andres M.); BALLANGER (Benedicte); POON (Yu-Yan); LANG (Anthony E.); MORO (Elena)</AU>
<AF>Movement Disorders Center, Toronto Western Hospital, Division of Neurology, University of Toronto/Toronto, Ontario/Canada (1 aut., 4 aut., 5 aut., 6 aut.); PET Imaging Centre, Center of Addiction Mental Health, University of Toronto/Toronto, Ontario/Canada (1 aut., 3 aut.); Department of Neurosurgery, Toronto Western Hospital, University of Toronto/Toronto, Ontario/Canada (2 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2008; Vol. 23; No. 7; Pp. 1051-1054; Bibl. 23 ref.</SO>
<LA>Anglais</LA>
<EA>Gait disturbances and akinesia are disabling symptoms in advanced Parkinson's disease (PD). The pedunculopontine nucleus (PPN) is involved in locomotion, control of posture, and behavioral states [i.e. wakefulness, rapid eye movement (REM) sleep]. Some reports have suggested that modulation of the activity of the PPN with deep brain stimulation (DBS) may be beneficial in the treatment of gait dysfunction and akinesia. To gain some insights on effects of PPN-DBS in the human brain, we used [<sup>15</sup>
O] H<sub>2</sub>
O positron emission tomography (PET) to measure changes in regional cerebral blood flow (rCBF) at rest during Off and On stimulation in an advanced PD patient with unilateral PPN-DBS. PPN-DBS increased rCBF in different subcortical areas most notably the thalamus, bilaterally. Double-blinded clinical evaluation revealed an improvement in motor function by ∼20%. The PET changes provide for the first time evidence in the human brain that PPN-DBS may be able to influence and modify rCBF of closely connected subcortical structures. Given the importance of the PPN in locomotion, control of posture, and behavioral states, DBS may have significant implication for more complicated forms of movement disorders where deterioration of gait, postural instability, and REM sleep behavior disorders are very disabling.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du système nerveux; Homme; Tomoscintigraphie; Tomographie par émission de positons; Imagerie fonctionnelle; Stimulation cérébrale profonde</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Human; Emission tomography; Positron emission tomography; Functional imaging; Deep brain stimulation</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Hombre; Tomocentelleografía; Tomografía emisión positrones; Imaginería funcional</SD>
<LO>INIST-20953.354000200276040210</LO>
<ID>08-0305163</ID>
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