The Course of Depressive Symptoms in Early Parkinson's Disease
Identifieur interne : 000524 ( PascalFrancis/Corpus ); précédent : 000523; suivant : 000525The Course of Depressive Symptoms in Early Parkinson's Disease
Auteurs : Bernard Ravina ; Jordan Elm ; Richard Camicioli ; Peter G. Como ; Laura Marsh ; Joseph Jankovic ; Daniel WeintraubSource :
- Movement disorders [ 0885-3185 ] ; 2009.
Descripteurs français
- Pascal (Inist)
English descriptors
Abstract
Little is known about the course of depressive symptoms in Parkinson's disease (PD). We studied the course of clinically significant depressive symptoms using data from two clinical trials that followed 413 early, untreated PD subjects for 12 to 18 months. We measured depressive symptoms with the 15-item geriatric depression scale (GDS-15); a score of ≥5 indicates clinically significant depressive symptoms. We used a time-dependent Cox model to examine the association between demographic variables, PD severity, and medication use on the time to resolution of depressive symptoms. One hundred fourteen of 413 (27.6%) subjects were screened positive for depression during the study, with a median GDS-15 score of 6, indicating mild symptoms. Within 6 months, 47% of subjects experienced remission of clinically significant depressive symptoms. Subjects with mild depressive symptoms were more likely to develop moderate to severe depressive symptoms (GDS ≥ 10) than those without prior symptoms (relative risk = 6.16). Increasing severity of depressive symptoms, older age, and longer PD duration predicted a lower likelihood of symptom resolution (hazard ratios 0.83-0.92). Mild depressive symptoms have a variable course, with remission and development of more sustained and severe symptoms occurring over time. More severe depressive symptoms may herald a protracted course.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
pA |
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Format Inist (serveur)
NO : | PASCAL 09-0349965 INIST |
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ET : | The Course of Depressive Symptoms in Early Parkinson's Disease |
AU : | RAVINA (Bernard); ELM (Jordan); CAMICIOLI (Richard); COMO (Peter G.); MARSH (Laura); JANKOVIC (Joseph); WEINTRAUB (Daniel) |
AF : | Department of Neurology, University of Rochester School of Medicine and Dentistry/Rochester, New York/Etats-Unis (1 aut., 4 aut.); Department of Biostatistics, Medical University of South Carolina/Charleston, South Carolina/Etats-Unis (2 aut.); Department of Neurology, University of Alberta/Edmonton/Canada (3 aut.); Department of Psychiatry, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (5 aut.); Department of Neurology, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (5 aut.); Department of Neurology, Baylor College of Medicine/Houston, Texas/Etats-Unis (6 aut.); Department of Psychiatry, University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (7 aut.); Department of Neurology, University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (7 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 9; Pp. 1306-1311; Bibl. 28 ref. |
LA : | Anglais |
EA : | Little is known about the course of depressive symptoms in Parkinson's disease (PD). We studied the course of clinically significant depressive symptoms using data from two clinical trials that followed 413 early, untreated PD subjects for 12 to 18 months. We measured depressive symptoms with the 15-item geriatric depression scale (GDS-15); a score of ≥5 indicates clinically significant depressive symptoms. We used a time-dependent Cox model to examine the association between demographic variables, PD severity, and medication use on the time to resolution of depressive symptoms. One hundred fourteen of 413 (27.6%) subjects were screened positive for depression during the study, with a median GDS-15 score of 6, indicating mild symptoms. Within 6 months, 47% of subjects experienced remission of clinically significant depressive symptoms. Subjects with mild depressive symptoms were more likely to develop moderate to severe depressive symptoms (GDS ≥ 10) than those without prior symptoms (relative risk = 6.16). Increasing severity of depressive symptoms, older age, and longer PD duration predicted a lower likelihood of symptom resolution (hazard ratios 0.83-0.92). Mild depressive symptoms have a variable course, with remission and development of more sustained and severe symptoms occurring over time. More severe depressive symptoms may herald a protracted course. |
CC : | 002B17; 002B17G |
FD : | Etat dépressif; Maladie de Parkinson; Pathologie du système nerveux; Pronostic |
FG : | Trouble de l'humeur; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
ED : | Depression; Parkinson disease; Nervous system diseases; Prognosis |
EG : | Mood disorder; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
SD : | Estado depresivo; Parkinson enfermedad; Sistema nervioso patología; Pronóstico |
LO : | INIST-20953.354000170902500070 |
ID : | 09-0349965 |
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Pascal:09-0349965Le document en format XML
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<front><div type="abstract" xml:lang="en">Little is known about the course of depressive symptoms in Parkinson's disease (PD). We studied the course of clinically significant depressive symptoms using data from two clinical trials that followed 413 early, untreated PD subjects for 12 to 18 months. We measured depressive symptoms with the 15-item geriatric depression scale (GDS-15); a score of ≥5 indicates clinically significant depressive symptoms. We used a time-dependent Cox model to examine the association between demographic variables, PD severity, and medication use on the time to resolution of depressive symptoms. One hundred fourteen of 413 (27.6%) subjects were screened positive for depression during the study, with a median GDS-15 score of 6, indicating mild symptoms. Within 6 months, 47% of subjects experienced remission of clinically significant depressive symptoms. Subjects with mild depressive symptoms were more likely to develop moderate to severe depressive symptoms (GDS ≥ 10) than those without prior symptoms (relative risk = 6.16). Increasing severity of depressive symptoms, older age, and longer PD duration predicted a lower likelihood of symptom resolution (hazard ratios 0.83-0.92). Mild depressive symptoms have a variable course, with remission and development of more sustained and severe symptoms occurring over time. More severe depressive symptoms may herald a protracted course.</div>
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<ET>The Course of Depressive Symptoms in Early Parkinson's Disease</ET>
<AU>RAVINA (Bernard); ELM (Jordan); CAMICIOLI (Richard); COMO (Peter G.); MARSH (Laura); JANKOVIC (Joseph); WEINTRAUB (Daniel)</AU>
<AF>Department of Neurology, University of Rochester School of Medicine and Dentistry/Rochester, New York/Etats-Unis (1 aut., 4 aut.); Department of Biostatistics, Medical University of South Carolina/Charleston, South Carolina/Etats-Unis (2 aut.); Department of Neurology, University of Alberta/Edmonton/Canada (3 aut.); Department of Psychiatry, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (5 aut.); Department of Neurology, Johns Hopkins University/Baltimore, Maryland/Etats-Unis (5 aut.); Department of Neurology, Baylor College of Medicine/Houston, Texas/Etats-Unis (6 aut.); Department of Psychiatry, University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (7 aut.); Department of Neurology, University of Pennsylvania/Philadelphia, Pennsylvania/Etats-Unis (7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2009; Vol. 24; No. 9; Pp. 1306-1311; Bibl. 28 ref.</SO>
<LA>Anglais</LA>
<EA>Little is known about the course of depressive symptoms in Parkinson's disease (PD). We studied the course of clinically significant depressive symptoms using data from two clinical trials that followed 413 early, untreated PD subjects for 12 to 18 months. We measured depressive symptoms with the 15-item geriatric depression scale (GDS-15); a score of ≥5 indicates clinically significant depressive symptoms. We used a time-dependent Cox model to examine the association between demographic variables, PD severity, and medication use on the time to resolution of depressive symptoms. One hundred fourteen of 413 (27.6%) subjects were screened positive for depression during the study, with a median GDS-15 score of 6, indicating mild symptoms. Within 6 months, 47% of subjects experienced remission of clinically significant depressive symptoms. Subjects with mild depressive symptoms were more likely to develop moderate to severe depressive symptoms (GDS ≥ 10) than those without prior symptoms (relative risk = 6.16). Increasing severity of depressive symptoms, older age, and longer PD duration predicted a lower likelihood of symptom resolution (hazard ratios 0.83-0.92). Mild depressive symptoms have a variable course, with remission and development of more sustained and severe symptoms occurring over time. More severe depressive symptoms may herald a protracted course.</EA>
<CC>002B17; 002B17G</CC>
<FD>Etat dépressif; Maladie de Parkinson; Pathologie du système nerveux; Pronostic</FD>
<FG>Trouble de l'humeur; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central</FG>
<ED>Depression; Parkinson disease; Nervous system diseases; Prognosis</ED>
<EG>Mood disorder; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Estado depresivo; Parkinson enfermedad; Sistema nervioso patología; Pronóstico</SD>
<LO>INIST-20953.354000170902500070</LO>
<ID>09-0349965</ID>
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