Behavior and cognition in corticobasal degeneration and progressive supranuclear palsy
Identifieur interne : 000458 ( PascalFrancis/Corpus ); précédent : 000457; suivant : 000459Behavior and cognition in corticobasal degeneration and progressive supranuclear palsy
Auteurs : Andrew Kertesz ; Paul McmonagleSource :
- Journal of the neurological sciences [ 0022-510X ] ; 2010.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), previously described as Parkinsonian syndromes are also cognitive disorders, and biologically related to the frontotemporal dementia or Pick's disease. PSP and CBD overlap clinically, pathologically and genetically, sharing tau haplotypes and mutations. In our series of CBD/PSP patients with cognitive presentation (n=36), primary progressive aphasia (PPA) was particularly common, but behavioral onset occurred also. CBD or PSP as motor presentations developed significant language disorder in 17/19. The underlying pathology is predictably tau positive in these clinical combinations, regardless of the presentation. Other cognitive features of CBDS include apraxia, alien hand and apathy, but often frontal lobe dementia with disinhibition develops also. CBDS also has visuospatial deficit, because of the parietal involvement. PSP was considered the prototype of subcortical dementia, with bradyphrenia, poor recall and executive deficit, but cortical features were recognized to be important also. Language testing and a behavioral inventory should be part of neuropsychological tests to facilitate diagnosis and to quantify the deficit. The clinical, genetic and pathological relationship is strong between CBD /PSP and the aphasic and behavioral components of the Pick complex.
Notice en format standard (ISO 2709)
Pour connaître la documentation sur le format Inist Standard.
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Format Inist (serveur)
NO : | PASCAL 10-0131742 INIST |
---|---|
ET : | Behavior and cognition in corticobasal degeneration and progressive supranuclear palsy |
AU : | KERTESZ (Andrew); MCMONAGLE (Paul); REICHMANN (Heinz); KORCZYN (Amos D.) |
AF : | Dept of Cognitive Neurology, University of Western Ontario, St Joseph's Hospital, 268 Grosvenor St/London, Ontario, N6A 4V2/Canada (1 aut.); Dept of Neurology, The Royal Victoria Hospital, 274 Grosvenor Road/Belfast BT12 6BA/Royaume-Uni (2 aut.); Department of Neurology, Dresden University Medical School/Dresden/Allemagne (1 aut.); Department of Neurology, Tel Aviv University Medical School/Ramat Aviv/Israël (2 aut.) |
DT : | Publication en série; Congrès; Niveau analytique |
SO : | Journal of the neurological sciences; ISSN 0022-510X; Coden JNSCAG; Irlande; Da. 2010; Vol. 289; No. 1-2; Pp. 138-143; Bibl. 104 ref. |
LA : | Anglais |
EA : | Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), previously described as Parkinsonian syndromes are also cognitive disorders, and biologically related to the frontotemporal dementia or Pick's disease. PSP and CBD overlap clinically, pathologically and genetically, sharing tau haplotypes and mutations. In our series of CBD/PSP patients with cognitive presentation (n=36), primary progressive aphasia (PPA) was particularly common, but behavioral onset occurred also. CBD or PSP as motor presentations developed significant language disorder in 17/19. The underlying pathology is predictably tau positive in these clinical combinations, regardless of the presentation. Other cognitive features of CBDS include apraxia, alien hand and apathy, but often frontal lobe dementia with disinhibition develops also. CBDS also has visuospatial deficit, because of the parietal involvement. PSP was considered the prototype of subcortical dementia, with bradyphrenia, poor recall and executive deficit, but cortical features were recognized to be important also. Language testing and a behavioral inventory should be part of neuropsychological tests to facilitate diagnosis and to quantify the deficit. The clinical, genetic and pathological relationship is strong between CBD /PSP and the aphasic and behavioral components of the Pick complex. |
CC : | 002B17; 002B17G |
FD : | Dégénérescence; Démence frontotemporale; Aphasie; Apraxie; Pathologie du système nerveux; Comportement; Cognition; Ophtalmoplégie supranucléaire |
FG : | Pathologie de l'encéphale; Maladie dégénérative; Syndrome oculomoteur; Pathologie de l'oeil; Pathologie du système nerveux central; Syndrome du tronc cérébral; Trouble de la communication; Trouble du langage; Trouble neurologique |
ED : | Degeneration; Frontotemporal dementia; Aphasia; Apraxia; Nervous system diseases; Behavior; Cognition; Supranuclear ophthalmoplegia |
EG : | Cerebral disorder; Degenerative disease; Oculomotor syndrome; Eye disease; Central nervous system disease; Brain stem syndrome; Communication disorder; Language disorder; Neurological disorder |
SD : | Degeneración; Demencia frontotemporal; Afasia; Apraxia; Sistema nervioso patología; Conducta; Cognición; Oftalmoplejía supranuclear |
LO : | INIST-12185.354000190042590260 |
ID : | 10-0131742 |
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Pascal:10-0131742Le document en format XML
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<front><div type="abstract" xml:lang="en">Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), previously described as Parkinsonian syndromes are also cognitive disorders, and biologically related to the frontotemporal dementia or Pick's disease. PSP and CBD overlap clinically, pathologically and genetically, sharing tau haplotypes and mutations. In our series of CBD/PSP patients with cognitive presentation (n=36), primary progressive aphasia (PPA) was particularly common, but behavioral onset occurred also. CBD or PSP as motor presentations developed significant language disorder in 17/19. The underlying pathology is predictably tau positive in these clinical combinations, regardless of the presentation. Other cognitive features of CBDS include apraxia, alien hand and apathy, but often frontal lobe dementia with disinhibition develops also. CBDS also has visuospatial deficit, because of the parietal involvement. PSP was considered the prototype of subcortical dementia, with bradyphrenia, poor recall and executive deficit, but cortical features were recognized to be important also. Language testing and a behavioral inventory should be part of neuropsychological tests to facilitate diagnosis and to quantify the deficit. The clinical, genetic and pathological relationship is strong between CBD /PSP and the aphasic and behavioral components of the Pick complex.</div>
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<server><NO>PASCAL 10-0131742 INIST</NO>
<ET>Behavior and cognition in corticobasal degeneration and progressive supranuclear palsy</ET>
<AU>KERTESZ (Andrew); MCMONAGLE (Paul); REICHMANN (Heinz); KORCZYN (Amos D.)</AU>
<AF>Dept of Cognitive Neurology, University of Western Ontario, St Joseph's Hospital, 268 Grosvenor St/London, Ontario, N6A 4V2/Canada (1 aut.); Dept of Neurology, The Royal Victoria Hospital, 274 Grosvenor Road/Belfast BT12 6BA/Royaume-Uni (2 aut.); Department of Neurology, Dresden University Medical School/Dresden/Allemagne (1 aut.); Department of Neurology, Tel Aviv University Medical School/Ramat Aviv/Israël (2 aut.)</AF>
<DT>Publication en série; Congrès; Niveau analytique</DT>
<SO>Journal of the neurological sciences; ISSN 0022-510X; Coden JNSCAG; Irlande; Da. 2010; Vol. 289; No. 1-2; Pp. 138-143; Bibl. 104 ref.</SO>
<LA>Anglais</LA>
<EA>Progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD), previously described as Parkinsonian syndromes are also cognitive disorders, and biologically related to the frontotemporal dementia or Pick's disease. PSP and CBD overlap clinically, pathologically and genetically, sharing tau haplotypes and mutations. In our series of CBD/PSP patients with cognitive presentation (n=36), primary progressive aphasia (PPA) was particularly common, but behavioral onset occurred also. CBD or PSP as motor presentations developed significant language disorder in 17/19. The underlying pathology is predictably tau positive in these clinical combinations, regardless of the presentation. Other cognitive features of CBDS include apraxia, alien hand and apathy, but often frontal lobe dementia with disinhibition develops also. CBDS also has visuospatial deficit, because of the parietal involvement. PSP was considered the prototype of subcortical dementia, with bradyphrenia, poor recall and executive deficit, but cortical features were recognized to be important also. Language testing and a behavioral inventory should be part of neuropsychological tests to facilitate diagnosis and to quantify the deficit. The clinical, genetic and pathological relationship is strong between CBD /PSP and the aphasic and behavioral components of the Pick complex.</EA>
<CC>002B17; 002B17G</CC>
<FD>Dégénérescence; Démence frontotemporale; Aphasie; Apraxie; Pathologie du système nerveux; Comportement; Cognition; Ophtalmoplégie supranucléaire</FD>
<FG>Pathologie de l'encéphale; Maladie dégénérative; Syndrome oculomoteur; Pathologie de l'oeil; Pathologie du système nerveux central; Syndrome du tronc cérébral; Trouble de la communication; Trouble du langage; Trouble neurologique</FG>
<ED>Degeneration; Frontotemporal dementia; Aphasia; Apraxia; Nervous system diseases; Behavior; Cognition; Supranuclear ophthalmoplegia</ED>
<EG>Cerebral disorder; Degenerative disease; Oculomotor syndrome; Eye disease; Central nervous system disease; Brain stem syndrome; Communication disorder; Language disorder; Neurological disorder</EG>
<SD>Degeneración; Demencia frontotemporal; Afasia; Apraxia; Sistema nervioso patología; Conducta; Cognición; Oftalmoplejía supranuclear</SD>
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