Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson's Disease
Identifieur interne : 000441 ( PascalFrancis/Corpus ); précédent : 000440; suivant : 000442Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson's Disease
Auteurs : Elena Moro ; Andres M. Lozano ; Pierre Pollak ; Yves Agid ; Stig Rehncrona ; Jens Volkmann ; Jaime Kulisevsky ; Jose A. Obeso ; Alberto Albanese ; Marwan I. Hariz ; Niall P. Quinn ; Jans D. Speelman ; Alim L. Benabid ; Valerie Fraix ; Alexandre Mendes ; Marie-Laure Welter ; Jean-Luc Houeto ; Philippe Cornu ; Didier Dormont ; Annalena L. Tornqvist ; Ron Ekberg ; Alfons Schnitzler ; Lars Timmermann ; Lars Wojtecki ; Andres Gironell ; Maria C. Rodriguez-Oroz ; Jorge Guridi ; Anna R. Bentivoglio ; Maria F. Contarino ; Luigi Romito ; Massimo Scerrati ; Marc Janssens ; Anthony E. LangSource :
- Movement disorders [ 0885-3185 ] ; 2010.
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Abstract
We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus intemus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off-and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off-stimulation, regardless of the sequence of stimulation. In open assessment, both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group.
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NO : | PASCAL 10-0233216 INIST |
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ET : | Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson's Disease |
AU : | MORO (Elena); LOZANO (Andres M.); POLLAK (Pierre); AGID (Yves); REHNCRONA (Stig); VOLKMANN (Jens); KULISEVSKY (Jaime); OBESO (Jose A.); ALBANESE (Alberto); HARIZ (Marwan I.); QUINN (Niall P.); SPEELMAN (Jans D.); BENABID (Alim L.); FRAIX (Valerie); MENDES (Alexandre); WELTER (Marie-Laure); HOUETO (Jean-Luc); CORNU (Philippe); DORMONT (Didier); TORNQVIST (Annalena L.); EKBERG (Ron); SCHNITZLER (Alfons); TIMMERMANN (Lars); WOJTECKI (Lars); GIRONELL (Andres); RODRIGUEZ-OROZ (Maria C.); GURIDI (Jorge); BENTIVOGLIO (Anna R.); CONTARINO (Maria F.); ROMITO (Luigi); SCERRATI (Massimo); JANSSENS (Marc); LANG (Anthony E.) |
AF : | Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network/Toronto, Ontario/Canada (1 aut., 11 aut., 33 aut.); Division of Neurosurgery, University of Toronto and University Health Network/Toronto, Ontario/Canada (2 aut.); Service de Neurologie, CHU de Grenoble/Grenoble/France (3 aut., 13 aut., 14 aut., 15 aut.); Hôpital de la Salpêtrière, Fédération de Neurologie/Paris/France (4 aut., 16 aut., 17 aut., 18 aut., 19 aut.); Neurosurgery Service, Lund University Hospital/Lund/Suède (5 aut., 20 aut., 21 aut.); Neurologische Klinik der Christian-Albrect-Universitat/Kiel/Allemagne (6 aut.); Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED/Barcelona/Espagne (7 aut., 25 aut.); Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED/Pamplona/Espagne (8 aut., 26 aut., 27 aut.); Istituto Nazionale Neurologico C. Besta and Università Cattolica/Milano/Italie (9 aut., 30 aut.); Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore/Roma/Italie (9 aut., 28 aut., 29 aut., 31 aut.); Institute of Neurology, Queen Square/London/Royaume-Uni (10 aut.); Department of Neurosurgery, University Hospital of Northern Sweden/Umeå/Suède (10 aut.); Department of Neurology, Academic Medical Center/Amsterdam/Pays-Bas (12 aut., 29 aut.); Service de Neurologie, CHU de Poitiers, University of Poitiers/Poitiers/France (17 aut.); Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf/Duesseldorf/Allemagne (22 aut., 23 aut., 24 aut.); Department of Neurology, University Hospital/Cologne/Allemagne (23 aut.); Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Universitd Politecnica delle Marche/Ancona/Italie (31 aut.); Bakken Research Center/Maastricht/Pays-Bas (32 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 5; Pp. 578-586; Bibl. 25 ref. |
LA : | Anglais |
EA : | We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus intemus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off-and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off-stimulation, regardless of the sequence of stimulation. In open assessment, both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group. |
CC : | 002B17; 002B17G |
FD : | Maladie de Parkinson; Pathologie du système nerveux; Long terme; Etude multicentrique; Noyau sousthalamique; Stimulation cérébrale profonde |
FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Encéphale; Système nerveux central |
ED : | Parkinson disease; Nervous system diseases; Long term; Multicenter study; Subthalamic nucleus; Deep brain stimulation |
EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Encephalon; Central nervous system |
SD : | Parkinson enfermedad; Sistema nervioso patología; Largo plazo; Estudio multicéntrico; Núcleo subtalámico |
LO : | INIST-20953.354000181079390090 |
ID : | 10-0233216 |
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Pascal:10-0233216Le document en format XML
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<affiliation><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1>
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<author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name>
<affiliation><inist:fA14 i1="09"><s1>Istituto Nazionale Neurologico C. Besta and Università Cattolica</s1>
<s2>Milano</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name>
<affiliation><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="17"><s1>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Universitd Politecnica delle Marche</s1>
<s2>Ancona</s2>
<s3>ITA</s3>
<sZ>31 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name>
<affiliation><inist:fA14 i1="18"><s1>Bakken Research Center</s1>
<s2>Maastricht</s2>
<s3>NLD</s3>
<sZ>32 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<affiliation><inist:fA14 i1="01"><s1>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0233216</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0233216 INIST</idno>
<idno type="RBID">Pascal:10-0233216</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000441</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson's Disease</title>
<author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name>
<affiliation><inist:fA14 i1="01"><s1>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name>
<affiliation><inist:fA14 i1="02"><s1>Division of Neurosurgery, University of Toronto and University Health Network</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Pollak, Pierre" sort="Pollak, Pierre" uniqKey="Pollak P" first="Pierre" last="Pollak">Pierre Pollak</name>
<affiliation><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Agid, Yves" sort="Agid, Yves" uniqKey="Agid Y" first="Yves" last="Agid">Yves Agid</name>
<affiliation><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Rehncrona, Stig" sort="Rehncrona, Stig" uniqKey="Rehncrona S" first="Stig" last="Rehncrona">Stig Rehncrona</name>
<affiliation><inist:fA14 i1="05"><s1>Neurosurgery Service, Lund University Hospital</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Volkmann, Jens" sort="Volkmann, Jens" uniqKey="Volkmann J" first="Jens" last="Volkmann">Jens Volkmann</name>
<affiliation><inist:fA14 i1="06"><s1>Neurologische Klinik der Christian-Albrect-Universitat</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Kulisevsky, Jaime" sort="Kulisevsky, Jaime" uniqKey="Kulisevsky J" first="Jaime" last="Kulisevsky">Jaime Kulisevsky</name>
<affiliation><inist:fA14 i1="07"><s1>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>7 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Obeso, Jose A" sort="Obeso, Jose A" uniqKey="Obeso J" first="Jose A." last="Obeso">Jose A. Obeso</name>
<affiliation><inist:fA14 i1="08"><s1>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Albanese, Alberto" sort="Albanese, Alberto" uniqKey="Albanese A" first="Alberto" last="Albanese">Alberto Albanese</name>
<affiliation><inist:fA14 i1="09"><s1>Istituto Nazionale Neurologico C. Besta and Università Cattolica</s1>
<s2>Milano</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Hariz, Marwan I" sort="Hariz, Marwan I" uniqKey="Hariz M" first="Marwan I." last="Hariz">Marwan I. Hariz</name>
<affiliation><inist:fA14 i1="11"><s1>Institute of Neurology, Queen Square</s1>
<s2>London</s2>
<s3>GBR</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="12"><s1>Department of Neurosurgery, University Hospital of Northern Sweden</s1>
<s2>Umeå</s2>
<s3>SWE</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Quinn, Niall P" sort="Quinn, Niall P" uniqKey="Quinn N" first="Niall P." last="Quinn">Niall P. Quinn</name>
<affiliation><inist:fA14 i1="01"><s1>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Speelman, Jans D" sort="Speelman, Jans D" uniqKey="Speelman J" first="Jans D." last="Speelman">Jans D. Speelman</name>
<affiliation><inist:fA14 i1="13"><s1>Department of Neurology, Academic Medical Center</s1>
<s2>Amsterdam</s2>
<s3>NLD</s3>
<sZ>12 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Benabid, Alim L" sort="Benabid, Alim L" uniqKey="Benabid A" first="Alim L." last="Benabid">Alim L. Benabid</name>
<affiliation><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Fraix, Valerie" sort="Fraix, Valerie" uniqKey="Fraix V" first="Valerie" last="Fraix">Valerie Fraix</name>
<affiliation><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Mendes, Alexandre" sort="Mendes, Alexandre" uniqKey="Mendes A" first="Alexandre" last="Mendes">Alexandre Mendes</name>
<affiliation><inist:fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Welter, Marie Laure" sort="Welter, Marie Laure" uniqKey="Welter M" first="Marie-Laure" last="Welter">Marie-Laure Welter</name>
<affiliation><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Houeto, Jean Luc" sort="Houeto, Jean Luc" uniqKey="Houeto J" first="Jean-Luc" last="Houeto">Jean-Luc Houeto</name>
<affiliation><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="14"><s1>Service de Neurologie, CHU de Poitiers, University of Poitiers</s1>
<s2>Poitiers</s2>
<s3>FRA</s3>
<sZ>17 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Cornu, Philippe" sort="Cornu, Philippe" uniqKey="Cornu P" first="Philippe" last="Cornu">Philippe Cornu</name>
<affiliation><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Dormont, Didier" sort="Dormont, Didier" uniqKey="Dormont D" first="Didier" last="Dormont">Didier Dormont</name>
<affiliation><inist:fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Tornqvist, Annalena L" sort="Tornqvist, Annalena L" uniqKey="Tornqvist A" first="Annalena L." last="Tornqvist">Annalena L. Tornqvist</name>
<affiliation><inist:fA14 i1="05"><s1>Neurosurgery Service, Lund University Hospital</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Ekberg, Ron" sort="Ekberg, Ron" uniqKey="Ekberg R" first="Ron" last="Ekberg">Ron Ekberg</name>
<affiliation><inist:fA14 i1="05"><s1>Neurosurgery Service, Lund University Hospital</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Schnitzler, Alfons" sort="Schnitzler, Alfons" uniqKey="Schnitzler A" first="Alfons" last="Schnitzler">Alfons Schnitzler</name>
<affiliation><inist:fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1>
<s2>Duesseldorf</s2>
<s3>DEU</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Timmermann, Lars" sort="Timmermann, Lars" uniqKey="Timmermann L" first="Lars" last="Timmermann">Lars Timmermann</name>
<affiliation><inist:fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1>
<s2>Duesseldorf</s2>
<s3>DEU</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="16"><s1>Department of Neurology, University Hospital</s1>
<s2>Cologne</s2>
<s3>DEU</s3>
<sZ>23 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Wojtecki, Lars" sort="Wojtecki, Lars" uniqKey="Wojtecki L" first="Lars" last="Wojtecki">Lars Wojtecki</name>
<affiliation><inist:fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1>
<s2>Duesseldorf</s2>
<s3>DEU</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Gironell, Andres" sort="Gironell, Andres" uniqKey="Gironell A" first="Andres" last="Gironell">Andres Gironell</name>
<affiliation><inist:fA14 i1="07"><s1>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>7 aut.</sZ>
<sZ>25 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Rodriguez Oroz, Maria C" sort="Rodriguez Oroz, Maria C" uniqKey="Rodriguez Oroz M" first="Maria C." last="Rodriguez-Oroz">Maria C. Rodriguez-Oroz</name>
<affiliation><inist:fA14 i1="08"><s1>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Guridi, Jorge" sort="Guridi, Jorge" uniqKey="Guridi J" first="Jorge" last="Guridi">Jorge Guridi</name>
<affiliation><inist:fA14 i1="08"><s1>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Bentivoglio, Anna R" sort="Bentivoglio, Anna R" uniqKey="Bentivoglio A" first="Anna R." last="Bentivoglio">Anna R. Bentivoglio</name>
<affiliation><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Contarino, Maria F" sort="Contarino, Maria F" uniqKey="Contarino M" first="Maria F." last="Contarino">Maria F. Contarino</name>
<affiliation><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="13"><s1>Department of Neurology, Academic Medical Center</s1>
<s2>Amsterdam</s2>
<s3>NLD</s3>
<sZ>12 aut.</sZ>
<sZ>29 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Romito, Luigi" sort="Romito, Luigi" uniqKey="Romito L" first="Luigi" last="Romito">Luigi Romito</name>
<affiliation><inist:fA14 i1="09"><s1>Istituto Nazionale Neurologico C. Besta and Università Cattolica</s1>
<s2>Milano</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>30 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Scerrati, Massimo" sort="Scerrati, Massimo" uniqKey="Scerrati M" first="Massimo" last="Scerrati">Massimo Scerrati</name>
<affiliation><inist:fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>31 aut.</sZ>
</inist:fA14>
</affiliation>
<affiliation><inist:fA14 i1="17"><s1>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Universitd Politecnica delle Marche</s1>
<s2>Ancona</s2>
<s3>ITA</s3>
<sZ>31 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Janssens, Marc" sort="Janssens, Marc" uniqKey="Janssens M" first="Marc" last="Janssens">Marc Janssens</name>
<affiliation><inist:fA14 i1="18"><s1>Bakken Research Center</s1>
<s2>Maastricht</s2>
<s3>NLD</s3>
<sZ>32 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
<author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E." last="Lang">Anthony E. Lang</name>
<affiliation><inist:fA14 i1="01"><s1>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>33 aut.</sZ>
</inist:fA14>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Movement disorders</title>
<title level="j" type="abbreviated">Mov. disord.</title>
<idno type="ISSN">0885-3185</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
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<seriesStmt><title level="j" type="main">Movement disorders</title>
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<idno type="ISSN">0885-3185</idno>
</seriesStmt>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Deep brain stimulation</term>
<term>Long term</term>
<term>Multicenter study</term>
<term>Nervous system diseases</term>
<term>Parkinson disease</term>
<term>Subthalamic nucleus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term>
<term>Pathologie du système nerveux</term>
<term>Long terme</term>
<term>Etude multicentrique</term>
<term>Noyau sousthalamique</term>
<term>Stimulation cérébrale profonde</term>
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<front><div type="abstract" xml:lang="en">We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus intemus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off-and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off-stimulation, regardless of the sequence of stimulation. In open assessment, both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group.</div>
</front>
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<fA08 i1="01" i2="1" l="ENG"><s1>Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson's Disease</s1>
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<fA11 i1="01" i2="1"><s1>MORO (Elena)</s1>
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<fA11 i1="02" i2="1"><s1>LOZANO (Andres M.)</s1>
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<fA11 i1="13" i2="1"><s1>BENABID (Alim L.)</s1>
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<fA11 i1="15" i2="1"><s1>MENDES (Alexandre)</s1>
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<fA11 i1="16" i2="1"><s1>WELTER (Marie-Laure)</s1>
</fA11>
<fA11 i1="17" i2="1"><s1>HOUETO (Jean-Luc)</s1>
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<fA11 i1="18" i2="1"><s1>CORNU (Philippe)</s1>
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<fA11 i1="19" i2="1"><s1>DORMONT (Didier)</s1>
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<fA11 i1="20" i2="1"><s1>TORNQVIST (Annalena L.)</s1>
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<fA11 i1="28" i2="1"><s1>BENTIVOGLIO (Anna R.)</s1>
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<fA11 i1="33" i2="1"><s1>LANG (Anthony E.)</s1>
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<fA14 i1="01"><s1>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>33 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Division of Neurosurgery, University of Toronto and University Health Network</s1>
<s2>Toronto, Ontario</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Service de Neurologie, CHU de Grenoble</s1>
<s2>Grenoble</s2>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
<sZ>14 aut.</sZ>
<sZ>15 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Hôpital de la Salpêtrière, Fédération de Neurologie</s1>
<s2>Paris</s2>
<s3>FRA</s3>
<sZ>4 aut.</sZ>
<sZ>16 aut.</sZ>
<sZ>17 aut.</sZ>
<sZ>18 aut.</sZ>
<sZ>19 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Neurosurgery Service, Lund University Hospital</s1>
<s2>Lund</s2>
<s3>SWE</s3>
<sZ>5 aut.</sZ>
<sZ>20 aut.</sZ>
<sZ>21 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Neurologische Klinik der Christian-Albrect-Universitat</s1>
<s2>Kiel</s2>
<s3>DEU</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED</s1>
<s2>Barcelona</s2>
<s3>ESP</s3>
<sZ>7 aut.</sZ>
<sZ>25 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED</s1>
<s2>Pamplona</s2>
<s3>ESP</s3>
<sZ>8 aut.</sZ>
<sZ>26 aut.</sZ>
<sZ>27 aut.</sZ>
</fA14>
<fA14 i1="09"><s1>Istituto Nazionale Neurologico C. Besta and Università Cattolica</s1>
<s2>Milano</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>30 aut.</sZ>
</fA14>
<fA14 i1="10"><s1>Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore</s1>
<s2>Roma</s2>
<s3>ITA</s3>
<sZ>9 aut.</sZ>
<sZ>28 aut.</sZ>
<sZ>29 aut.</sZ>
<sZ>31 aut.</sZ>
</fA14>
<fA14 i1="11"><s1>Institute of Neurology, Queen Square</s1>
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<sZ>10 aut.</sZ>
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<fA14 i1="12"><s1>Department of Neurosurgery, University Hospital of Northern Sweden</s1>
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<s3>SWE</s3>
<sZ>10 aut.</sZ>
</fA14>
<fA14 i1="13"><s1>Department of Neurology, Academic Medical Center</s1>
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<s3>NLD</s3>
<sZ>12 aut.</sZ>
<sZ>29 aut.</sZ>
</fA14>
<fA14 i1="14"><s1>Service de Neurologie, CHU de Poitiers, University of Poitiers</s1>
<s2>Poitiers</s2>
<s3>FRA</s3>
<sZ>17 aut.</sZ>
</fA14>
<fA14 i1="15"><s1>Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf</s1>
<s2>Duesseldorf</s2>
<s3>DEU</s3>
<sZ>22 aut.</sZ>
<sZ>23 aut.</sZ>
<sZ>24 aut.</sZ>
</fA14>
<fA14 i1="16"><s1>Department of Neurology, University Hospital</s1>
<s2>Cologne</s2>
<s3>DEU</s3>
<sZ>23 aut.</sZ>
</fA14>
<fA14 i1="17"><s1>Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Universitd Politecnica delle Marche</s1>
<s2>Ancona</s2>
<s3>ITA</s3>
<sZ>31 aut.</sZ>
</fA14>
<fA14 i1="18"><s1>Bakken Research Center</s1>
<s2>Maastricht</s2>
<s3>NLD</s3>
<sZ>32 aut.</sZ>
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<fA20><s1>578-586</s1>
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<fC01 i1="01" l="ENG"><s0>We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus intemus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off-and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off-stimulation, regardless of the sequence of stimulation. In open assessment, both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group.</s0>
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<s5>02</s5>
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<fC03 i1="03" i2="X" l="ENG"><s0>Long term</s0>
<s5>09</s5>
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<s5>40</s5>
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<server><NO>PASCAL 10-0233216 INIST</NO>
<ET>Long-Term Results of a Multicenter Study on Subthalamic and Pallidal Stimulation in Parkinson's Disease</ET>
<AU>MORO (Elena); LOZANO (Andres M.); POLLAK (Pierre); AGID (Yves); REHNCRONA (Stig); VOLKMANN (Jens); KULISEVSKY (Jaime); OBESO (Jose A.); ALBANESE (Alberto); HARIZ (Marwan I.); QUINN (Niall P.); SPEELMAN (Jans D.); BENABID (Alim L.); FRAIX (Valerie); MENDES (Alexandre); WELTER (Marie-Laure); HOUETO (Jean-Luc); CORNU (Philippe); DORMONT (Didier); TORNQVIST (Annalena L.); EKBERG (Ron); SCHNITZLER (Alfons); TIMMERMANN (Lars); WOJTECKI (Lars); GIRONELL (Andres); RODRIGUEZ-OROZ (Maria C.); GURIDI (Jorge); BENTIVOGLIO (Anna R.); CONTARINO (Maria F.); ROMITO (Luigi); SCERRATI (Massimo); JANSSENS (Marc); LANG (Anthony E.)</AU>
<AF>Toronto Western Hospital, Movement Disorders Center, University of Toronto and University Health Network/Toronto, Ontario/Canada (1 aut., 11 aut., 33 aut.); Division of Neurosurgery, University of Toronto and University Health Network/Toronto, Ontario/Canada (2 aut.); Service de Neurologie, CHU de Grenoble/Grenoble/France (3 aut., 13 aut., 14 aut., 15 aut.); Hôpital de la Salpêtrière, Fédération de Neurologie/Paris/France (4 aut., 16 aut., 17 aut., 18 aut., 19 aut.); Neurosurgery Service, Lund University Hospital/Lund/Suède (5 aut., 20 aut., 21 aut.); Neurologische Klinik der Christian-Albrect-Universitat/Kiel/Allemagne (6 aut.); Department of Neurology, Sant Pau Hospital, Autonomous University of Barcelona, CIBERNED/Barcelona/Espagne (7 aut., 25 aut.); Department of Neurology and Neurosurgery, Clinica Universitaria and Medical School, University of Navarra, CIBERNED/Pamplona/Espagne (8 aut., 26 aut., 27 aut.); Istituto Nazionale Neurologico C. Besta and Università Cattolica/Milano/Italie (9 aut., 30 aut.); Dipartimento di Neuroscienze, Università Cattolica del Sacro Cuore/Roma/Italie (9 aut., 28 aut., 29 aut., 31 aut.); Institute of Neurology, Queen Square/London/Royaume-Uni (10 aut.); Department of Neurosurgery, University Hospital of Northern Sweden/Umeå/Suède (10 aut.); Department of Neurology, Academic Medical Center/Amsterdam/Pays-Bas (12 aut., 29 aut.); Service de Neurologie, CHU de Poitiers, University of Poitiers/Poitiers/France (17 aut.); Department of Neurology and Institute of Clinical Neurosciences, Heinrich-Heine-Universitat Duesseldorf/Duesseldorf/Allemagne (22 aut., 23 aut., 24 aut.); Department of Neurology, University Hospital/Cologne/Allemagne (23 aut.); Dipartimento di Neuroscienze, Sezione di Neurochirurgia, Universitd Politecnica delle Marche/Ancona/Italie (31 aut.); Bakken Research Center/Maastricht/Pays-Bas (32 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Movement disorders; ISSN 0885-3185; Etats-Unis; Da. 2010; Vol. 25; No. 5; Pp. 578-586; Bibl. 25 ref.</SO>
<LA>Anglais</LA>
<EA>We report the 5 to 6 year follow-up of a multicenter study of bilateral subthalamic nucleus (STN) and globus pallidus intemus (GPi) deep brain stimulation (DBS) in advanced Parkinson's disease (PD) patients. Thirty-five STN patients and 16 GPi patients were assessed at 5 to 6 years after DBS surgery. Primary outcome measure was the stimulation effect on the motor Unified Parkinson's Disease Rating Scale (UPDRS) assessed with a prospective cross-over double-blind assessment without medications (stimulation was randomly switched on or off). Secondary outcomes were motor UPDRS changes with unblinded assessments in off-and on-medication states with and without stimulation, activities of daily living (ADL), anti-PD medications, and dyskinesias. In double-blind assessment, both STN and GPi DBS were significantly effective in improving the motor UPDRS scores (STN, P < 0.0001, 45.4%; GPi, P = 0.008, 20.0%) compared with off-stimulation, regardless of the sequence of stimulation. In open assessment, both STN- and GPi-DBS significantly improved the off-medication motor UPDRS when compared with before surgery (STN, P < 0.001, 50.5%; GPi, P = 0.002, 35.6%). Dyskinesias and ADL were significantly improved in both groups. Anti-PD medications were significantly reduced only in the STN group. Adverse events were more frequent in the STN group. These results confirm the long-term efficacy of STN and GPi DBS in advanced PD. Although the surgical targets were not randomized, there was a trend to a better outcome of motor signs in the STN-DBS patients and fewer adverse events in the GPi-DBS group.</EA>
<CC>002B17; 002B17G</CC>
<FD>Maladie de Parkinson; Pathologie du système nerveux; Long terme; Etude multicentrique; Noyau sousthalamique; Stimulation cérébrale profonde</FD>
<FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Encéphale; Système nerveux central</FG>
<ED>Parkinson disease; Nervous system diseases; Long term; Multicenter study; Subthalamic nucleus; Deep brain stimulation</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Encephalon; Central nervous system</EG>
<SD>Parkinson enfermedad; Sistema nervioso patología; Largo plazo; Estudio multicéntrico; Núcleo subtalámico</SD>
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