ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000388

Involvement of the human pedunculopontine nucleus region in voluntary movements

Identifieur interne : 000388 ( PascalFrancis/Corpus ); précédent : 000387; suivant : 000389

Involvement of the human pedunculopontine nucleus region in voluntary movements

Auteurs : E. W. Tsang ; C. Hamani ; E. Moro ; F. Mazzella ; Y. Y. Poon ; A. M. Lozano ; R. Chen

Source :

Neurology [ 0028-3878 ] ; 2010.

RBID : Pascal:10-0453740

Descripteurs français

Pascal (Inist)
- Pathologie du système nerveux, Homme.

English descriptors

KwdEn :
- Human, Nervous system diseases.

Abstract

Objective: The pedunculopontine nucleus region (PPNR) is being investigated as a target for deep brain stimulation (DBS) in Parkinson disease (PD), particularly for gait and postural impairment. A greater understanding of how PPNR activities and oscillations are modulated with voluntary movements is crucial to the development of neuromodulation strategies. Methods: We studied 7 patients with PD who underwent DBS electrode implantations in the PPNR. PPNR local field potential and EEG were recorded while patients performed self-paced wrist and ankle movements. Results: Back-averaging of the PPNR recording showed movement-related potentials before electromyography onset. Frequency analysis showed 2 discrete movement-related frequency bands in the theta (6- to 10-Hz) and beta (14- to 30-Hz) ranges. The PPNR theta band showed greater event-related desynchronization with movements in the ON than in the OFF medication state and was coupled with the sensorimotor cortices in the ON state only. Beta event-related desynchronization was observed in the PPNR during the premovement and movement execution phases in the OFF state. In contrast, premovement PPNR beta event-related synchronization occurred in the ON state. Moreover, beta band coherence between the PPNR and the midline prefrontal region was observed during movement preparation in the ON but not the OFF state. Conclusions: Activities of PPNR change during movement preparation and execution in patients with PD. Dopaminergic medications modulate PPNR activities and promote the interactions between the cortex and PPNR. Beta oscillations may have different functions in the basal ganglia and PPNR, and may be prokinetic rather than antikinetic in the PPNR.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03		`1`		`@0 Neurology`
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A08	`01`	`1`	`ENG`	`@1 Involvement of the human pedunculopontine nucleus region in voluntary movements`
A11	`01`	`1`		`@1 TSANG (E. W.)`
A11	`02`	`1`		`@1 HAMANI (C.)`
A11	`03`	`1`		`@1 MORO (E.)`
A11	`04`	`1`		`@1 MAZZELLA (F.)`
A11	`05`	`1`		`@1 POON (Y. Y.)`
A11	`06`	`1`		`@1 LOZANO (A. M.)`
A11	`07`	`1`		`@1 CHEN (R.)`
A14	`01`			`@1 Division of Brain Imaging & Behaviour Systems-Neuroscience, Toronto Western Research Institute, University Health Network @3 CAN @Z 1 aut. @Z 2 aut. @Z 3 aut. @Z 6 aut. @Z 7 aut.`
A14	`02`			`@1 Division of Neurology, Department of Medicine, University of Toronto @2 Ontario @3 CAN @Z 1 aut. @Z 4 aut. @Z 5 aut. @Z 7 aut.`
A14	`03`			`@1 Division of Neurosurgery, Department of Surgery, University of Toronto @2 Ontario @3 CAN @Z 2 aut. @Z 6 aut.`
A14	`04`			`@1 Institute of Medical Science, University of Toronto @2 Ontario @3 CAN @Z 1 aut. @Z 6 aut. @Z 7 aut.`
A20				`@1 950-959`
A21				`@1 2010`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 6345 @5 354000191283970040`
A44				`@0 0000 @1 © 2010 INIST-CNRS. All rights reserved.`
A45				`@0 40 ref.`
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A64	`01`	`1`		`@0 Neurology`
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C01	`01`		`ENG`	@0 Objective: The pedunculopontine nucleus region (PPNR) is being investigated as a target for deep brain stimulation (DBS) in Parkinson disease (PD), particularly for gait and postural impairment. A greater understanding of how PPNR activities and oscillations are modulated with voluntary movements is crucial to the development of neuromodulation strategies. Methods: We studied 7 patients with PD who underwent DBS electrode implantations in the PPNR. PPNR local field potential and EEG were recorded while patients performed self-paced wrist and ankle movements. Results: Back-averaging of the PPNR recording showed movement-related potentials before electromyography onset. Frequency analysis showed 2 discrete movement-related frequency bands in the theta (6- to 10-Hz) and beta (14- to 30-Hz) ranges. The PPNR theta band showed greater event-related desynchronization with movements in the ON than in the OFF medication state and was coupled with the sensorimotor cortices in the ON state only. Beta event-related desynchronization was observed in the PPNR during the premovement and movement execution phases in the OFF state. In contrast, premovement PPNR beta event-related synchronization occurred in the ON state. Moreover, beta band coherence between the PPNR and the midline prefrontal region was observed during movement preparation in the ON but not the OFF state. Conclusions: Activities of PPNR change during movement preparation and execution in patients with PD. Dopaminergic medications modulate PPNR activities and promote the interactions between the cortex and PPNR. Beta oscillations may have different functions in the basal ganglia and PPNR, and may be prokinetic rather than antikinetic in the PPNR.
C02	`01`	`X`		`@0 002B17`
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C03	`01`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 01`
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C03	`01`	`X`	`SPA`	`@0 Sistema nervioso patología @5 01`
C03	`02`	`X`	`FRE`	`@0 Homme @5 09`
C03	`02`	`X`	`ENG`	`@0 Human @5 09`
C03	`02`	`X`	`SPA`	`@0 Hombre @5 09`
N21				`@1 298`
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Format Inist (serveur)

NO :	PASCAL 10-0453740 INIST
ET :	Involvement of the human pedunculopontine nucleus region in voluntary movements
AU :	TSANG (E. W.); HAMANI (C.); MORO (E.); MAZZELLA (F.); POON (Y. Y.); LOZANO (A. M.); CHEN (R.)
AF :	Division of Brain Imaging & Behaviour Systems-Neuroscience, Toronto Western Research Institute, University Health Network/Canada (1 aut., 2 aut., 3 aut., 6 aut., 7 aut.); Division of Neurology, Department of Medicine, University of Toronto/Ontario/Canada (1 aut., 4 aut., 5 aut., 7 aut.); Division of Neurosurgery, Department of Surgery, University of Toronto/Ontario/Canada (2 aut., 6 aut.); Institute of Medical Science, University of Toronto/Ontario/Canada (1 aut., 6 aut., 7 aut.)
DT :	Publication en série; Niveau analytique
SO :	Neurology; ISSN 0028-3878; Coden NEURAI; Etats-Unis; Da. 2010; Vol. 75; No. 11; Pp. 950-959; Bibl. 40 ref.
LA :	Anglais
EA :	Objective: The pedunculopontine nucleus region (PPNR) is being investigated as a target for deep brain stimulation (DBS) in Parkinson disease (PD), particularly for gait and postural impairment. A greater understanding of how PPNR activities and oscillations are modulated with voluntary movements is crucial to the development of neuromodulation strategies. Methods: We studied 7 patients with PD who underwent DBS electrode implantations in the PPNR. PPNR local field potential and EEG were recorded while patients performed self-paced wrist and ankle movements. Results: Back-averaging of the PPNR recording showed movement-related potentials before electromyography onset. Frequency analysis showed 2 discrete movement-related frequency bands in the theta (6- to 10-Hz) and beta (14- to 30-Hz) ranges. The PPNR theta band showed greater event-related desynchronization with movements in the ON than in the OFF medication state and was coupled with the sensorimotor cortices in the ON state only. Beta event-related desynchronization was observed in the PPNR during the premovement and movement execution phases in the OFF state. In contrast, premovement PPNR beta event-related synchronization occurred in the ON state. Moreover, beta band coherence between the PPNR and the midline prefrontal region was observed during movement preparation in the ON but not the OFF state. Conclusions: Activities of PPNR change during movement preparation and execution in patients with PD. Dopaminergic medications modulate PPNR activities and promote the interactions between the cortex and PPNR. Beta oscillations may have different functions in the basal ganglia and PPNR, and may be prokinetic rather than antikinetic in the PPNR.
CC :	002B17; 002B05C02D
FD :	Pathologie du système nerveux; Homme
ED :	Nervous system diseases; Human
SD :	Sistema nervioso patología; Hombre
LO :	INIST-6345.354000191283970040
ID :	10-0453740

Links to Exploration step

Pascal:10-0453740

Le document en format XML

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<front><div type="abstract" xml:lang="en">Objective: The pedunculopontine nucleus region (PPNR) is being investigated as a target for deep brain stimulation (DBS) in Parkinson disease (PD), particularly for gait and postural impairment. A greater understanding of how PPNR activities and oscillations are modulated with voluntary movements is crucial to the development of neuromodulation strategies. Methods: We studied 7 patients with PD who underwent DBS electrode implantations in the PPNR. PPNR local field potential and EEG were recorded while patients performed self-paced wrist and ankle movements. Results: Back-averaging of the PPNR recording showed movement-related potentials before electromyography onset. Frequency analysis showed 2 discrete movement-related frequency bands in the theta (6- to 10-Hz) and beta (14- to 30-Hz) ranges. The PPNR theta band showed greater event-related desynchronization with movements in the ON than in the OFF medication state and was coupled with the sensorimotor cortices in the ON state only. Beta event-related desynchronization was observed in the PPNR during the premovement and movement execution phases in the OFF state. In contrast, premovement PPNR beta event-related synchronization occurred in the ON state. Moreover, beta band coherence between the PPNR and the midline prefrontal region was observed during movement preparation in the ON but not the OFF state. Conclusions: Activities of PPNR change during movement preparation and execution in patients with PD. Dopaminergic medications modulate PPNR activities and promote the interactions between the cortex and PPNR. Beta oscillations may have different functions in the basal ganglia and PPNR, and may be prokinetic rather than antikinetic in the PPNR.</div>
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<fA14 i1="02"><s1>Division of Neurology, Department of Medicine, University of Toronto</s1>
<s2>Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>7 aut.</sZ>
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<fA14 i1="03"><s1>Division of Neurosurgery, Department of Surgery, University of Toronto</s1>
<s2>Ontario</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
<sZ>6 aut.</sZ>
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<fA14 i1="04"><s1>Institute of Medical Science, University of Toronto</s1>
<s2>Ontario</s2>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
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<fC01 i1="01" l="ENG"><s0>Objective: The pedunculopontine nucleus region (PPNR) is being investigated as a target for deep brain stimulation (DBS) in Parkinson disease (PD), particularly for gait and postural impairment. A greater understanding of how PPNR activities and oscillations are modulated with voluntary movements is crucial to the development of neuromodulation strategies. Methods: We studied 7 patients with PD who underwent DBS electrode implantations in the PPNR. PPNR local field potential and EEG were recorded while patients performed self-paced wrist and ankle movements. Results: Back-averaging of the PPNR recording showed movement-related potentials before electromyography onset. Frequency analysis showed 2 discrete movement-related frequency bands in the theta (6- to 10-Hz) and beta (14- to 30-Hz) ranges. The PPNR theta band showed greater event-related desynchronization with movements in the ON than in the OFF medication state and was coupled with the sensorimotor cortices in the ON state only. Beta event-related desynchronization was observed in the PPNR during the premovement and movement execution phases in the OFF state. In contrast, premovement PPNR beta event-related synchronization occurred in the ON state. Moreover, beta band coherence between the PPNR and the midline prefrontal region was observed during movement preparation in the ON but not the OFF state. Conclusions: Activities of PPNR change during movement preparation and execution in patients with PD. Dopaminergic medications modulate PPNR activities and promote the interactions between the cortex and PPNR. Beta oscillations may have different functions in the basal ganglia and PPNR, and may be prokinetic rather than antikinetic in the PPNR.</s0>
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<server><NO>PASCAL 10-0453740 INIST</NO>
<ET>Involvement of the human pedunculopontine nucleus region in voluntary movements</ET>
<AU>TSANG (E. W.); HAMANI (C.); MORO (E.); MAZZELLA (F.); POON (Y. Y.); LOZANO (A. M.); CHEN (R.)</AU>
<AF>Division of Brain Imaging & Behaviour Systems-Neuroscience, Toronto Western Research Institute, University Health Network/Canada (1 aut., 2 aut., 3 aut., 6 aut., 7 aut.); Division of Neurology, Department of Medicine, University of Toronto/Ontario/Canada (1 aut., 4 aut., 5 aut., 7 aut.); Division of Neurosurgery, Department of Surgery, University of Toronto/Ontario/Canada (2 aut., 6 aut.); Institute of Medical Science, University of Toronto/Ontario/Canada (1 aut., 6 aut., 7 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neurology; ISSN 0028-3878; Coden NEURAI; Etats-Unis; Da. 2010; Vol. 75; No. 11; Pp. 950-959; Bibl. 40 ref.</SO>
<LA>Anglais</LA>
<EA>Objective: The pedunculopontine nucleus region (PPNR) is being investigated as a target for deep brain stimulation (DBS) in Parkinson disease (PD), particularly for gait and postural impairment. A greater understanding of how PPNR activities and oscillations are modulated with voluntary movements is crucial to the development of neuromodulation strategies. Methods: We studied 7 patients with PD who underwent DBS electrode implantations in the PPNR. PPNR local field potential and EEG were recorded while patients performed self-paced wrist and ankle movements. Results: Back-averaging of the PPNR recording showed movement-related potentials before electromyography onset. Frequency analysis showed 2 discrete movement-related frequency bands in the theta (6- to 10-Hz) and beta (14- to 30-Hz) ranges. The PPNR theta band showed greater event-related desynchronization with movements in the ON than in the OFF medication state and was coupled with the sensorimotor cortices in the ON state only. Beta event-related desynchronization was observed in the PPNR during the premovement and movement execution phases in the OFF state. In contrast, premovement PPNR beta event-related synchronization occurred in the ON state. Moreover, beta band coherence between the PPNR and the midline prefrontal region was observed during movement preparation in the ON but not the OFF state. Conclusions: Activities of PPNR change during movement preparation and execution in patients with PD. Dopaminergic medications modulate PPNR activities and promote the interactions between the cortex and PPNR. Beta oscillations may have different functions in the basal ganglia and PPNR, and may be prokinetic rather than antikinetic in the PPNR.</EA>
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<ED>Nervous system diseases; Human</ED>
<SD>Sistema nervioso patología; Hombre</SD>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Involvement of the human pedunculopontine nucleus region in voluntary movements

Involvement of the human pedunculopontine nucleus region in voluntary movements

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