La maladie de Parkinson au Canada (serveur d'exploration)

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Amantadine Use Associated with Impulse Control Disorders in Parkinson Disease in Cross-Sectional Study

Identifieur interne : 000352 ( PascalFrancis/Corpus ); précédent : 000351; suivant : 000353

Amantadine Use Associated with Impulse Control Disorders in Parkinson Disease in Cross-Sectional Study

Auteurs : Daniel Weintraub ; Mandy Sohr ; Marc N. Potenza ; Andrew D. Siderowf ; Mark Stacy ; Valerie Voon ; Jacqueline Whetteckey ; Glen R. Wunderlich ; Anthony E. Lang

Source :

RBID : Pascal:11-0060434

Descripteurs français

English descriptors

Abstract

A recent controlled clinical trial suggested a role for amantadine as a treatment for pathological gambling in patients with Parkinson disease (PD). Analyzing data from a large cross-sectional study of impulse control disorders (ICDs) in PD, amantadine use (n = 728), vs no amantadine use (n = 2,357), was positively associated with a diagnosis of any ICD (17.6% vs 12.4%, p < 0.001) and compulsive gambling specifically (7.4% vs 4.2%, p < 0.001). This amantadine association remained after controlling for covariates of amantadine use, including both dopamine agonist use and levodopa dosage. Further research, including larger clinical trials, is needed to assess the role of amantadine in the development and treatment of ICDs in PD.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

pA  
A01 01  1    @0 0364-5134
A02 01      @0 ANNED3
A03   1    @0 Ann. neurol.
A05       @2 68
A06       @2 6
A08 01  1  ENG  @1 Amantadine Use Associated with Impulse Control Disorders in Parkinson Disease in Cross-Sectional Study
A11 01  1    @1 WEINTRAUB (Daniel)
A11 02  1    @1 SOHR (Mandy)
A11 03  1    @1 POTENZA (Marc N.)
A11 04  1    @1 SIDEROWF (Andrew D.)
A11 05  1    @1 STACY (Mark)
A11 06  1    @1 VOON (Valerie)
A11 07  1    @1 WHETTECKEY (Jacqueline)
A11 08  1    @1 WUNDERLICH (Glen R.)
A11 09  1    @1 LANG (Anthony E.)
A14 01      @1 Department of Psychiatry, University of Pennsylvania School of Medicine @2 Philadelphia, PA @3 USA @Z 1 aut.
A14 02      @1 Department of Neurology, University of Pennsylvania School of Medicine @2 Philadelphia, PA @3 USA @Z 1 aut. @Z 4 aut.
A14 03      @1 Philadelphia Veterans Affairs Medical Center @2 Philadelphia, PA; @3 USA @Z 1 aut.
A14 04      @1 Boehringer Ingelheim Pharma GmbH & Co. KG @2 Ingelheim @3 DEU @Z 2 aut.
A14 05      @1 Department of Psychiatry, Yale University School of Medicine @2 New Haven, CT @3 USA @Z 3 aut.
A14 06      @1 Department of Child Study, Yale University School of Medicine @2 New Haven, CT @3 USA @Z 3 aut.
A14 07      @1 Department of Neurobiology, Yale University School of Medicine @2 New Haven, CT @3 USA @Z 3 aut.
A14 08      @1 Department of Neurology, Duke University Medical Center @2 Durham, NC @3 USA @Z 5 aut.
A14 09      @1 University of Cambridge @2 Cambridge @3 GBR @Z 6 aut.
A14 10      @1 Boehringer Ingelheim Pharmaceuticals, Inc. @2 Ridgefield, CT @3 USA @Z 7 aut.
A14 11      @1 Boehringer Ingelheim (Canada) Ltd @2 Burlington, Ontario @3 CAN @Z 8 aut.
A14 12      @1 Department of Neurology, University of Toronto @2 Toronto, Ontario @3 CAN @Z 9 aut.
A20       @1 963-968
A21       @1 2010
A23 01      @0 ENG
A43 01      @1 INIST @2 16555 @5 354000193558180260
A44       @0 0000 @1 © 2011 INIST-CNRS. All rights reserved.
A45       @0 20 ref.
A47 01  1    @0 11-0060434
A60       @1 P @3 CC
A61       @0 A
A64 01  1    @0 Annals of neurology
A66 01      @0 USA
C01 01    ENG  @0 A recent controlled clinical trial suggested a role for amantadine as a treatment for pathological gambling in patients with Parkinson disease (PD). Analyzing data from a large cross-sectional study of impulse control disorders (ICDs) in PD, amantadine use (n = 728), vs no amantadine use (n = 2,357), was positively associated with a diagnosis of any ICD (17.6% vs 12.4%, p < 0.001) and compulsive gambling specifically (7.4% vs 4.2%, p < 0.001). This amantadine association remained after controlling for covariates of amantadine use, including both dopamine agonist use and levodopa dosage. Further research, including larger clinical trials, is needed to assess the role of amantadine in the development and treatment of ICDs in PD.
C02 01  X    @0 002B17
C02 02  X    @0 002B17G
C03 01  X  FRE  @0 Trouble du contrôle des impulsions @2 NM @5 01
C03 01  X  ENG  @0 Impulse control disorder @2 NM @5 01
C03 01  X  SPA  @0 Trastorno control impulso @2 NM @5 01
C03 02  X  FRE  @0 Maladie de Parkinson @2 NM @5 02
C03 02  X  ENG  @0 Parkinson disease @2 NM @5 02
C03 02  X  SPA  @0 Parkinson enfermedad @2 NM @5 02
C03 03  X  FRE  @0 Pathologie du système nerveux @5 03
C03 03  X  ENG  @0 Nervous system diseases @5 03
C03 03  X  SPA  @0 Sistema nervioso patología @5 03
C03 04  X  FRE  @0 Amantadine @2 NK @2 FR @5 09
C03 04  X  ENG  @0 Amantadine @2 NK @2 FR @5 09
C03 04  X  SPA  @0 Amantadina @2 NK @2 FR @5 09
C03 05  X  FRE  @0 Etude transversale @5 10
C03 05  X  ENG  @0 Cross sectional study @5 10
C03 05  X  SPA  @0 Estudio transversal @5 10
C07 01  X  FRE  @0 Pathologie de l'encéphale @5 37
C07 01  X  ENG  @0 Cerebral disorder @5 37
C07 01  X  SPA  @0 Encéfalo patología @5 37
C07 02  X  FRE  @0 Syndrome extrapyramidal @5 38
C07 02  X  ENG  @0 Extrapyramidal syndrome @5 38
C07 02  X  SPA  @0 Extrapiramidal síndrome @5 38
C07 03  X  FRE  @0 Maladie dégénérative @5 39
C07 03  X  ENG  @0 Degenerative disease @5 39
C07 03  X  SPA  @0 Enfermedad degenerativa @5 39
C07 04  X  FRE  @0 Pathologie du système nerveux central @5 40
C07 04  X  ENG  @0 Central nervous system disease @5 40
C07 04  X  SPA  @0 Sistema nervosio central patología @5 40
N21       @1 038
N44 01      @1 OTO
N82       @1 OTO

Format Inist (serveur)

NO : PASCAL 11-0060434 INIST
ET : Amantadine Use Associated with Impulse Control Disorders in Parkinson Disease in Cross-Sectional Study
AU : WEINTRAUB (Daniel); SOHR (Mandy); POTENZA (Marc N.); SIDEROWF (Andrew D.); STACY (Mark); VOON (Valerie); WHETTECKEY (Jacqueline); WUNDERLICH (Glen R.); LANG (Anthony E.)
AF : Department of Psychiatry, University of Pennsylvania School of Medicine/Philadelphia, PA/Etats-Unis (1 aut.); Department of Neurology, University of Pennsylvania School of Medicine/Philadelphia, PA/Etats-Unis (1 aut., 4 aut.); Philadelphia Veterans Affairs Medical Center/Philadelphia, PA;/Etats-Unis (1 aut.); Boehringer Ingelheim Pharma GmbH & Co. KG/Ingelheim/Allemagne (2 aut.); Department of Psychiatry, Yale University School of Medicine/New Haven, CT/Etats-Unis (3 aut.); Department of Child Study, Yale University School of Medicine/New Haven, CT/Etats-Unis (3 aut.); Department of Neurobiology, Yale University School of Medicine/New Haven, CT/Etats-Unis (3 aut.); Department of Neurology, Duke University Medical Center/Durham, NC/Etats-Unis (5 aut.); University of Cambridge/Cambridge/Royaume-Uni (6 aut.); Boehringer Ingelheim Pharmaceuticals, Inc./Ridgefield, CT/Etats-Unis (7 aut.); Boehringer Ingelheim (Canada) Ltd/Burlington, Ontario/Canada (8 aut.); Department of Neurology, University of Toronto/Toronto, Ontario/Canada (9 aut.)
DT : Publication en série; Courte communication, note brève; Niveau analytique
SO : Annals of neurology; ISSN 0364-5134; Coden ANNED3; Etats-Unis; Da. 2010; Vol. 68; No. 6; Pp. 963-968; Bibl. 20 ref.
LA : Anglais
EA : A recent controlled clinical trial suggested a role for amantadine as a treatment for pathological gambling in patients with Parkinson disease (PD). Analyzing data from a large cross-sectional study of impulse control disorders (ICDs) in PD, amantadine use (n = 728), vs no amantadine use (n = 2,357), was positively associated with a diagnosis of any ICD (17.6% vs 12.4%, p < 0.001) and compulsive gambling specifically (7.4% vs 4.2%, p < 0.001). This amantadine association remained after controlling for covariates of amantadine use, including both dopamine agonist use and levodopa dosage. Further research, including larger clinical trials, is needed to assess the role of amantadine in the development and treatment of ICDs in PD.
CC : 002B17; 002B17G
FD : Trouble du contrôle des impulsions; Maladie de Parkinson; Pathologie du système nerveux; Amantadine; Etude transversale
FG : Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central
ED : Impulse control disorder; Parkinson disease; Nervous system diseases; Amantadine; Cross sectional study
EG : Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease
SD : Trastorno control impulso; Parkinson enfermedad; Sistema nervioso patología; Amantadina; Estudio transversal
LO : INIST-16555.354000193558180260
ID : 11-0060434

Links to Exploration step

Pascal:11-0060434

Le document en format XML

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<div type="abstract" xml:lang="en">A recent controlled clinical trial suggested a role for amantadine as a treatment for pathological gambling in patients with Parkinson disease (PD). Analyzing data from a large cross-sectional study of impulse control disorders (ICDs) in PD, amantadine use (n = 728), vs no amantadine use (n = 2,357), was positively associated with a diagnosis of any ICD (17.6% vs 12.4%, p < 0.001) and compulsive gambling specifically (7.4% vs 4.2%, p < 0.001). This amantadine association remained after controlling for covariates of amantadine use, including both dopamine agonist use and levodopa dosage. Further research, including larger clinical trials, is needed to assess the role of amantadine in the development and treatment of ICDs in PD.</div>
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<ET>Amantadine Use Associated with Impulse Control Disorders in Parkinson Disease in Cross-Sectional Study</ET>
<AU>WEINTRAUB (Daniel); SOHR (Mandy); POTENZA (Marc N.); SIDEROWF (Andrew D.); STACY (Mark); VOON (Valerie); WHETTECKEY (Jacqueline); WUNDERLICH (Glen R.); LANG (Anthony E.)</AU>
<AF>Department of Psychiatry, University of Pennsylvania School of Medicine/Philadelphia, PA/Etats-Unis (1 aut.); Department of Neurology, University of Pennsylvania School of Medicine/Philadelphia, PA/Etats-Unis (1 aut., 4 aut.); Philadelphia Veterans Affairs Medical Center/Philadelphia, PA;/Etats-Unis (1 aut.); Boehringer Ingelheim Pharma GmbH & Co. KG/Ingelheim/Allemagne (2 aut.); Department of Psychiatry, Yale University School of Medicine/New Haven, CT/Etats-Unis (3 aut.); Department of Child Study, Yale University School of Medicine/New Haven, CT/Etats-Unis (3 aut.); Department of Neurobiology, Yale University School of Medicine/New Haven, CT/Etats-Unis (3 aut.); Department of Neurology, Duke University Medical Center/Durham, NC/Etats-Unis (5 aut.); University of Cambridge/Cambridge/Royaume-Uni (6 aut.); Boehringer Ingelheim Pharmaceuticals, Inc./Ridgefield, CT/Etats-Unis (7 aut.); Boehringer Ingelheim (Canada) Ltd/Burlington, Ontario/Canada (8 aut.); Department of Neurology, University of Toronto/Toronto, Ontario/Canada (9 aut.)</AF>
<DT>Publication en série; Courte communication, note brève; Niveau analytique</DT>
<SO>Annals of neurology; ISSN 0364-5134; Coden ANNED3; Etats-Unis; Da. 2010; Vol. 68; No. 6; Pp. 963-968; Bibl. 20 ref.</SO>
<LA>Anglais</LA>
<EA>A recent controlled clinical trial suggested a role for amantadine as a treatment for pathological gambling in patients with Parkinson disease (PD). Analyzing data from a large cross-sectional study of impulse control disorders (ICDs) in PD, amantadine use (n = 728), vs no amantadine use (n = 2,357), was positively associated with a diagnosis of any ICD (17.6% vs 12.4%, p < 0.001) and compulsive gambling specifically (7.4% vs 4.2%, p < 0.001). This amantadine association remained after controlling for covariates of amantadine use, including both dopamine agonist use and levodopa dosage. Further research, including larger clinical trials, is needed to assess the role of amantadine in the development and treatment of ICDs in PD.</EA>
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<ED>Impulse control disorder; Parkinson disease; Nervous system diseases; Amantadine; Cross sectional study</ED>
<EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG>
<SD>Trastorno control impulso; Parkinson enfermedad; Sistema nervioso patología; Amantadina; Estudio transversal</SD>
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