The effect of dopamine therapy on ventral and dorsal striatum-mediated cognition in Parkinson's disease: support from functional MRI
Identifieur interne : 000318 ( PascalFrancis/Corpus ); précédent : 000317; suivant : 000319The effect of dopamine therapy on ventral and dorsal striatum-mediated cognition in Parkinson's disease: support from functional MRI
Auteurs : Penny A. Macdonald ; Alex A. Macdonald ; Ken N. Seergobin ; Ruzbeh Tamjeedi ; Hooman Ganjavi ; Jean-Sebastien Provost ; Oury MonchiSource :
- Brain [ 0006-8950 ] ; 2011.
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- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
The central aim of our study was to elucidate functions mediated by the ventral and dorsal striatum, respectively, to better understand the cognitive effects of dopamine replacement in Parkinson's disease. We proposed that the ventral striatum underlies general learning of stimulus associations, whereas the dorsal striatum promotes integration of various influences on selecting. In Parkinson's disease, dopamine depletion is substantially less notable in the ventral relative to the dorsal striatum, and therefore greater improvements are expected for dorsal striatum-mediated functions with dopamine replacement. Using a simple selection task, we found that dopamine replacement impaired encoding and facilitation of consistent stimulus-stimulus relations across trials. This finding was in line with our contention that ventral striatum mediates learning stimulus associations, even when explicit feedback or reward is not provided. In contrast, dopamine replacement enhanced interference related to assimilating conflicting influences on selection across trials, consistent with our hypothesis that the dorsal striatum supports deciding in ambiguous contexts. We further confirmed these separable roles for the ventral and dorsal striatum in our selection task with healthy young volunteers using functional magnetic resonance imaging. In summary, we present a within-subject, double dissociation of the effects of dopamine replacement in patients with Parkinson's disease for ventral striatum-mediated facilitation and dorsal striatum-mediated interference, confirmed in a separate functional magnetic resonance imaging experiment. Defining the distinct functions of the ventral and dorsal striatum will have direct clinical implications. Titration of therapy in Parkinson's disease is generally geared towards optimizing dorsal striatum-mediated motor symptoms, possibly at the expense of ventral striatum operations, a consequence that is only beginning to be recognized. Enhanced awareness of these different processes will translate into medication strategies that take into account those symptoms that dopamine replacement might hinder, as well as improve. Here, we show impairments in learning new stimulus associations compared with improvements in integrating varied influences related to selection. Ultimately, this knowledge will lead clinicians to survey a broader range of symptoms in determining optimal therapy based on individual patient priorities.
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Format Inist (serveur)
| NO : | PASCAL 11-0254712 INIST |
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| ET : | The effect of dopamine therapy on ventral and dorsal striatum-mediated cognition in Parkinson's disease: support from functional MRI |
| AU : | MACDONALD (Penny A.); MACDONALD (Alex A.); SEERGOBIN (Ken N.); TAMJEEDI (Ruzbeh); GANJAVI (Hooman); PROVOST (Jean-Sebastien); MONCHI (Oury) |
| AF : | Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University/Montreal, Quebec, H3A 2B5/Canada (1 aut.); Functional Neuroimaging Unit, Centre de Recherche, Institut Universitaire de Gériatrie de Montréal/Montreal, Quebec, H3W 1W4/Canada (1 aut., 6 aut., 7 aut.); Department of Psychology, McGill University/Montreal, Quebec, H3A 1B1/Canada (2 aut.); Centre for Biological Timing and Cognition, University of Toronto/Toronto, Ontario, M5S 3G3/Canada (3 aut.); Department of Philosophy, McGill University/Montreal, Quebec, H3A 2T7/Canada (4 aut.); Department of Psychiatry, McGill University/Montreal, Quebec, H3A 1A1/Canada (5 aut.); Department of Radiology, University of Montreal/Montreal, Quebec, H3C 3J7/Canada (6 aut., 7 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Brain; ISSN 0006-8950; Royaume-Uni; Da. 2011; Vol. 134; No. p. 5; Pp. 1447-1463; Bibl. 2 p.3/4 |
| LA : | Anglais |
| EA : | The central aim of our study was to elucidate functions mediated by the ventral and dorsal striatum, respectively, to better understand the cognitive effects of dopamine replacement in Parkinson's disease. We proposed that the ventral striatum underlies general learning of stimulus associations, whereas the dorsal striatum promotes integration of various influences on selecting. In Parkinson's disease, dopamine depletion is substantially less notable in the ventral relative to the dorsal striatum, and therefore greater improvements are expected for dorsal striatum-mediated functions with dopamine replacement. Using a simple selection task, we found that dopamine replacement impaired encoding and facilitation of consistent stimulus-stimulus relations across trials. This finding was in line with our contention that ventral striatum mediates learning stimulus associations, even when explicit feedback or reward is not provided. In contrast, dopamine replacement enhanced interference related to assimilating conflicting influences on selection across trials, consistent with our hypothesis that the dorsal striatum supports deciding in ambiguous contexts. We further confirmed these separable roles for the ventral and dorsal striatum in our selection task with healthy young volunteers using functional magnetic resonance imaging. In summary, we present a within-subject, double dissociation of the effects of dopamine replacement in patients with Parkinson's disease for ventral striatum-mediated facilitation and dorsal striatum-mediated interference, confirmed in a separate functional magnetic resonance imaging experiment. Defining the distinct functions of the ventral and dorsal striatum will have direct clinical implications. Titration of therapy in Parkinson's disease is generally geared towards optimizing dorsal striatum-mediated motor symptoms, possibly at the expense of ventral striatum operations, a consequence that is only beginning to be recognized. Enhanced awareness of these different processes will translate into medication strategies that take into account those symptoms that dopamine replacement might hinder, as well as improve. Here, we show impairments in learning new stimulus associations compared with improvements in integrating varied influences related to selection. Ultimately, this knowledge will lead clinicians to survey a broader range of symptoms in determining optimal therapy based on individual patient priorities. |
| CC : | 002B17; 002B17G |
| FD : | Maladie de Parkinson; Trouble cognitif; Pathologie du système nerveux; Dopamine; Traitement; Cognition; Imagerie RMN |
| FG : | Catécholamine; Neurotransmetteur; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central |
| ED : | Parkinson disease; Cognitive disorder; Nervous system diseases; Dopamine; Treatment; Cognition; Nuclear magnetic resonance imaging |
| EG : | Catecholamine; Neurotransmitter; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease |
| SD : | Parkinson enfermedad; Trastorno cognitivo; Sistema nervioso patología; Dopamina; Tratamiento; Cognición; Imaginería RMN |
| LO : | INIST-998.354000192112840160 |
| ID : | 11-0254712 |
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We proposed that the ventral striatum underlies general learning of stimulus associations, whereas the dorsal striatum promotes integration of various influences on selecting. In Parkinson's disease, dopamine depletion is substantially less notable in the ventral relative to the dorsal striatum, and therefore greater improvements are expected for dorsal striatum-mediated functions with dopamine replacement. Using a simple selection task, we found that dopamine replacement impaired encoding and facilitation of consistent stimulus-stimulus relations across trials. This finding was in line with our contention that ventral striatum mediates learning stimulus associations, even when explicit feedback or reward is not provided. In contrast, dopamine replacement enhanced interference related to assimilating conflicting influences on selection across trials, consistent with our hypothesis that the dorsal striatum supports deciding in ambiguous contexts. We further confirmed these separable roles for the ventral and dorsal striatum in our selection task with healthy young volunteers using functional magnetic resonance imaging. In summary, we present a within-subject, double dissociation of the effects of dopamine replacement in patients with Parkinson's disease for ventral striatum-mediated facilitation and dorsal striatum-mediated interference, confirmed in a separate functional magnetic resonance imaging experiment. Defining the distinct functions of the ventral and dorsal striatum will have direct clinical implications. Titration of therapy in Parkinson's disease is generally geared towards optimizing dorsal striatum-mediated motor symptoms, possibly at the expense of ventral striatum operations, a consequence that is only beginning to be recognized. Enhanced awareness of these different processes will translate into medication strategies that take into account those symptoms that dopamine replacement might hinder, as well as improve. Here, we show impairments in learning new stimulus associations compared with improvements in integrating varied influences related to selection. Ultimately, this knowledge will lead clinicians to survey a broader range of symptoms in determining optimal therapy based on individual patient priorities.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0006-8950</s0></fA01><fA03 i2="1"><s0>Brain</s0></fA03><fA05><s2>134</s2></fA05><fA06><s3>p. 5</s3></fA06><fA08 i1="01" i2="1" l="ENG"><s1>The effect of dopamine therapy on ventral and dorsal striatum-mediated cognition in Parkinson's disease: support from functional MRI</s1></fA08><fA11 i1="01" i2="1"><s1>MACDONALD (Penny A.)</s1></fA11><fA11 i1="02" i2="1"><s1>MACDONALD (Alex A.)</s1></fA11><fA11 i1="03" i2="1"><s1>SEERGOBIN (Ken N.)</s1></fA11><fA11 i1="04" i2="1"><s1>TAMJEEDI (Ruzbeh)</s1></fA11><fA11 i1="05" i2="1"><s1>GANJAVI (Hooman)</s1></fA11><fA11 i1="06" i2="1"><s1>PROVOST (Jean-Sebastien)</s1></fA11><fA11 i1="07" i2="1"><s1>MONCHI (Oury)</s1></fA11><fA14 i1="01"><s1>Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University</s1><s2>Montreal, Quebec, H3A 2B5</s2><s3>CAN</s3><sZ>1 aut.</sZ></fA14><fA14 i1="02"><s1>Functional Neuroimaging Unit, Centre de Recherche, Institut Universitaire de Gériatrie de Montréal</s1><s2>Montreal, Quebec, H3W 1W4</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Psychology, McGill University</s1><s2>Montreal, Quebec, H3A 1B1</s2><s3>CAN</s3><sZ>2 aut.</sZ></fA14><fA14 i1="04"><s1>Centre for Biological Timing and Cognition, University of Toronto</s1><s2>Toronto, Ontario, M5S 3G3</s2><s3>CAN</s3><sZ>3 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Philosophy, McGill University</s1><s2>Montreal, Quebec, H3A 2T7</s2><s3>CAN</s3><sZ>4 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Psychiatry, McGill University</s1><s2>Montreal, Quebec, H3A 1A1</s2><s3>CAN</s3><sZ>5 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Radiology, University of Montreal</s1><s2>Montreal, Quebec, H3C 3J7</s2><s3>CAN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></fA14><fA20><s1>1447-1463</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>998</s2><s5>354000192112840160</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>2 p.3/4</s0></fA45><fA47 i1="01" i2="1"><s0>11-0254712</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Brain</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>The central aim of our study was to elucidate functions mediated by the ventral and dorsal striatum, respectively, to better understand the cognitive effects of dopamine replacement in Parkinson's disease. We proposed that the ventral striatum underlies general learning of stimulus associations, whereas the dorsal striatum promotes integration of various influences on selecting. In Parkinson's disease, dopamine depletion is substantially less notable in the ventral relative to the dorsal striatum, and therefore greater improvements are expected for dorsal striatum-mediated functions with dopamine replacement. Using a simple selection task, we found that dopamine replacement impaired encoding and facilitation of consistent stimulus-stimulus relations across trials. This finding was in line with our contention that ventral striatum mediates learning stimulus associations, even when explicit feedback or reward is not provided. In contrast, dopamine replacement enhanced interference related to assimilating conflicting influences on selection across trials, consistent with our hypothesis that the dorsal striatum supports deciding in ambiguous contexts. We further confirmed these separable roles for the ventral and dorsal striatum in our selection task with healthy young volunteers using functional magnetic resonance imaging. In summary, we present a within-subject, double dissociation of the effects of dopamine replacement in patients with Parkinson's disease for ventral striatum-mediated facilitation and dorsal striatum-mediated interference, confirmed in a separate functional magnetic resonance imaging experiment. Defining the distinct functions of the ventral and dorsal striatum will have direct clinical implications. Titration of therapy in Parkinson's disease is generally geared towards optimizing dorsal striatum-mediated motor symptoms, possibly at the expense of ventral striatum operations, a consequence that is only beginning to be recognized. Enhanced awareness of these different processes will translate into medication strategies that take into account those symptoms that dopamine replacement might hinder, as well as improve. Here, we show impairments in learning new stimulus associations compared with improvements in integrating varied influences related to selection. Ultimately, this knowledge will lead clinicians to survey a broader range of symptoms in determining optimal therapy based on individual patient priorities.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Trouble cognitif</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Cognitive disorder</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Trastorno cognitivo</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Dopamine</s0><s2>NK</s2><s2>FR</s2><s5>09</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Dopamine</s0><s2>NK</s2><s2>FR</s2><s5>09</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Dopamina</s0><s2>NK</s2><s2>FR</s2><s5>09</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Traitement</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Treatment</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Tratamiento</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Cognition</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Cognition</s0><s5>11</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Cognición</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Imagerie RMN</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Nuclear magnetic resonance imaging</s0><s5>12</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Imaginería RMN</s0><s5>12</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Catécholamine</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Catecholamine</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Catecolamina</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Neurotransmetteur</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Neurotransmitter</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Neurotransmisor</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>42</s5></fC07><fN21><s1>171</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 11-0254712 INIST</NO><ET>The effect of dopamine therapy on ventral and dorsal striatum-mediated cognition in Parkinson's disease: support from functional MRI</ET><AU>MACDONALD (Penny A.); MACDONALD (Alex A.); SEERGOBIN (Ken N.); TAMJEEDI (Ruzbeh); GANJAVI (Hooman); PROVOST (Jean-Sebastien); MONCHI (Oury)</AU><AF>Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University/Montreal, Quebec, H3A 2B5/Canada (1 aut.); Functional Neuroimaging Unit, Centre de Recherche, Institut Universitaire de Gériatrie de Montréal/Montreal, Quebec, H3W 1W4/Canada (1 aut., 6 aut., 7 aut.); Department of Psychology, McGill University/Montreal, Quebec, H3A 1B1/Canada (2 aut.); Centre for Biological Timing and Cognition, University of Toronto/Toronto, Ontario, M5S 3G3/Canada (3 aut.); Department of Philosophy, McGill University/Montreal, Quebec, H3A 2T7/Canada (4 aut.); Department of Psychiatry, McGill University/Montreal, Quebec, H3A 1A1/Canada (5 aut.); Department of Radiology, University of Montreal/Montreal, Quebec, H3C 3J7/Canada (6 aut., 7 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Brain; ISSN 0006-8950; Royaume-Uni; Da. 2011; Vol. 134; No. p. 5; Pp. 1447-1463; Bibl. 2 p.3/4</SO><LA>Anglais</LA><EA>The central aim of our study was to elucidate functions mediated by the ventral and dorsal striatum, respectively, to better understand the cognitive effects of dopamine replacement in Parkinson's disease. We proposed that the ventral striatum underlies general learning of stimulus associations, whereas the dorsal striatum promotes integration of various influences on selecting. In Parkinson's disease, dopamine depletion is substantially less notable in the ventral relative to the dorsal striatum, and therefore greater improvements are expected for dorsal striatum-mediated functions with dopamine replacement. Using a simple selection task, we found that dopamine replacement impaired encoding and facilitation of consistent stimulus-stimulus relations across trials. This finding was in line with our contention that ventral striatum mediates learning stimulus associations, even when explicit feedback or reward is not provided. In contrast, dopamine replacement enhanced interference related to assimilating conflicting influences on selection across trials, consistent with our hypothesis that the dorsal striatum supports deciding in ambiguous contexts. We further confirmed these separable roles for the ventral and dorsal striatum in our selection task with healthy young volunteers using functional magnetic resonance imaging. In summary, we present a within-subject, double dissociation of the effects of dopamine replacement in patients with Parkinson's disease for ventral striatum-mediated facilitation and dorsal striatum-mediated interference, confirmed in a separate functional magnetic resonance imaging experiment. Defining the distinct functions of the ventral and dorsal striatum will have direct clinical implications. Titration of therapy in Parkinson's disease is generally geared towards optimizing dorsal striatum-mediated motor symptoms, possibly at the expense of ventral striatum operations, a consequence that is only beginning to be recognized. Enhanced awareness of these different processes will translate into medication strategies that take into account those symptoms that dopamine replacement might hinder, as well as improve. Here, we show impairments in learning new stimulus associations compared with improvements in integrating varied influences related to selection. Ultimately, this knowledge will lead clinicians to survey a broader range of symptoms in determining optimal therapy based on individual patient priorities.</EA><CC>002B17; 002B17G</CC><FD>Maladie de Parkinson; Trouble cognitif; Pathologie du système nerveux; Dopamine; Traitement; Cognition; Imagerie RMN</FD><FG>Catécholamine; Neurotransmetteur; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central</FG><ED>Parkinson disease; Cognitive disorder; Nervous system diseases; Dopamine; Treatment; Cognition; Nuclear magnetic resonance imaging</ED><EG>Catecholamine; Neurotransmitter; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease</EG><SD>Parkinson enfermedad; Trastorno cognitivo; Sistema nervioso patología; Dopamina; Tratamiento; Cognición; Imaginería RMN</SD><LO>INIST-998.354000192112840160</LO><ID>11-0254712</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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