ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000252

POSTERIOR HYPOTHALAMIC NUCLEUS DEEP BRAIN STIMULATION RESTORES LOCOMOTION IN RATS WITH HALOPERIDOL-INDUCED AKINESIA BUT NOT SKILLED FORELIMB USE IN PELLET REACHING AND LEVER PRESSING

Identifieur interne : 000252 ( PascalFrancis/Corpus ); précédent : 000251; suivant : 000253

POSTERIOR HYPOTHALAMIC NUCLEUS DEEP BRAIN STIMULATION RESTORES LOCOMOTION IN RATS WITH HALOPERIDOL-INDUCED AKINESIA BUT NOT SKILLED FORELIMB USE IN PELLET REACHING AND LEVER PRESSING

Auteurs : C. K. Young ; I. Q. Whishaw ; B. H. Bland

Source :

Neuroscience [ 0306-4522 ] ; 2011.

RBID : Pascal:12-0016583

Descripteurs français

Pascal (Inist)
- Hypothalamus, Locomotion, Halopéridol, Akinésie, Membre thoracique, Membre supérieur, Maladie de Parkinson, Rat, Animal, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Akinesia, Animal, Deep brain stimulation, Forelimb, Haloperidol, Hypothalamus, Locomotion, Parkinson disease, Rat, Upper limb.

Abstract

Recent studies have shown that electrical stimulation of the posterior hypothalamic nucleus (PH) facilitates locomotion in control rats, and rats were made akinetic by dopaminergic blockade via haloperidol or dopamine depletion by the neurotoxin 6-hydroxydopamine. These findings suggest that PH stimulation might be a promising treatment for akinesia associated with dopamine loss in Parkinson's disease. The present study further examined the positive effects of PH stimulation on behavior by characterizing its potential facilitatory effects on tasks that require skilled movements. Rats were trained to reach for food pellets with a forelimb (skilled reaching) or press a bar in an operant conditioning task for food. PH stimulation in undrugged rats not only facilitated locomotion in each of the tasks, but also impaired performance of the skilled movement components of the tasks. Haloperidol reduced locomotion and skilled movement, and PH stimulation only restored locomotion. The results are discussed in relation to the idea that PH stimulation selectively facilitates locomotor behavior and may have limited use in restoring impairments in skilled movements and consummatory behavior that results from dopaminergic depletion.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	PASCAL 12-0016583 INIST
ET :	POSTERIOR HYPOTHALAMIC NUCLEUS DEEP BRAIN STIMULATION RESTORES LOCOMOTION IN RATS WITH HALOPERIDOL-INDUCED AKINESIA BUT NOT SKILLED FORELIMB USE IN PELLET REACHING AND LEVER PRESSING
AU :	YOUNG (C. K.); WHISHAW (I. Q.); BLAND (B. H.)
AF :	Behavioural Neuroscience Group, Department of Psychology, Hotchkiss Brain Institute, University of Calgary/Calgary, AB/Canada (1 aut., 3 aut.); Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge/Lethbridge, AB/Canada (2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Neuroscience; ISSN 0306-4522; Coden NRSCDN; Pays-Bas; Da. 2011; Vol. 192; Pp. 452-458; Bibl. 1 p.1/4
LA :	Anglais
EA :	Recent studies have shown that electrical stimulation of the posterior hypothalamic nucleus (PH) facilitates locomotion in control rats, and rats were made akinetic by dopaminergic blockade via haloperidol or dopamine depletion by the neurotoxin 6-hydroxydopamine. These findings suggest that PH stimulation might be a promising treatment for akinesia associated with dopamine loss in Parkinson's disease. The present study further examined the positive effects of PH stimulation on behavior by characterizing its potential facilitatory effects on tasks that require skilled movements. Rats were trained to reach for food pellets with a forelimb (skilled reaching) or press a bar in an operant conditioning task for food. PH stimulation in undrugged rats not only facilitated locomotion in each of the tasks, but also impaired performance of the skilled movement components of the tasks. Haloperidol reduced locomotion and skilled movement, and PH stimulation only restored locomotion. The results are discussed in relation to the idea that PH stimulation selectively facilitates locomotor behavior and may have limited use in restoring impairments in skilled movements and consummatory behavior that results from dopaminergic depletion.
CC :	002A25; 002B17A01
FD :	Hypothalamus; Locomotion; Halopéridol; Akinésie; Membre thoracique; Membre supérieur; Maladie de Parkinson; Rat; Animal; Stimulation cérébrale profonde
FG :	Encéphale; Système nerveux central; Psychotrope; Neuroleptique; Pathologie de l'encéphale; Pathologie du système nerveux central; Pathologie du système nerveux; Trouble moteur; Trouble neurologique; Maladie dégénérative; Syndrome extrapyramidal; Rodentia; Mammalia; Vertebrata
ED :	Hypothalamus; Locomotion; Haloperidol; Akinesia; Forelimb; Upper limb; Parkinson disease; Rat; Animal; Deep brain stimulation
EG :	Encephalon; Central nervous system; Psychotropic; Neuroleptic; Cerebral disorder; Central nervous system disease; Nervous system diseases; Motor system disorder; Neurological disorder; Degenerative disease; Extrapyramidal syndrome; Rodentia; Mammalia; Vertebrata
SD :	Hipotálamo; Locomoción; Haloperidol; Aquinesia; Miembro torácico; Miembro superior; Parkinson enfermedad; Rata; Animal
LO :	INIST-17194.354000507316380420
ID :	12-0016583

Links to Exploration step

Pascal:12-0016583

Le document en format XML

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<front><div type="abstract" xml:lang="en">Recent studies have shown that electrical stimulation of the posterior hypothalamic nucleus (PH) facilitates locomotion in control rats, and rats were made akinetic by dopaminergic blockade via haloperidol or dopamine depletion by the neurotoxin 6-hydroxydopamine. These findings suggest that PH stimulation might be a promising treatment for akinesia associated with dopamine loss in Parkinson's disease. The present study further examined the positive effects of PH stimulation on behavior by characterizing its potential facilitatory effects on tasks that require skilled movements. Rats were trained to reach for food pellets with a forelimb (skilled reaching) or press a bar in an operant conditioning task for food. PH stimulation in undrugged rats not only facilitated locomotion in each of the tasks, but also impaired performance of the skilled movement components of the tasks. Haloperidol reduced locomotion and skilled movement, and PH stimulation only restored locomotion. The results are discussed in relation to the idea that PH stimulation selectively facilitates locomotor behavior and may have limited use in restoring impairments in skilled movements and consummatory behavior that results from dopaminergic depletion.</div>
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<fC03 i1="04" i2="X" l="FRE"><s0>Akinésie</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Akinesia</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Aquinesia</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Membre thoracique</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Forelimb</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Miembro torácico</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Membre supérieur</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Upper limb</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Miembro superior</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>09</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>09</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Rat</s0>
<s5>54</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Rat</s0>
<s5>54</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Rata</s0>
<s5>54</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Animal</s0>
<s5>69</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Animal</s0>
<s5>69</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Animal</s0>
<s5>69</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Stimulation cérébrale profonde</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Deep brain stimulation</s0>
<s4>CD</s4>
<s5>96</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Encéphale</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Encephalon</s0>
<s5>20</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo</s0>
<s5>20</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>21</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>21</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Psychotrope</s0>
<s2>FX</s2>
<s5>22</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Psychotropic</s0>
<s2>FX</s2>
<s5>22</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Psicotropo</s0>
<s2>FX</s2>
<s5>22</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Neuroleptique</s0>
<s5>23</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Neuroleptic</s0>
<s5>23</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Neuroléptico</s0>
<s5>23</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0>
<s5>24</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Cerebral disorder</s0>
<s5>24</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>24</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>25</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>25</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>25</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Pathologie du   système nerveux</s0>
<s5>26</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Nervous system diseases</s0>
<s5>26</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervioso patología</s0>
<s5>26</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Trouble moteur</s0>
<s5>27</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Motor system disorder</s0>
<s5>27</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Trastorno motor</s0>
<s5>27</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Trouble neurologique</s0>
<s5>28</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Neurological disorder</s0>
<s5>28</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Trastorno neurológico</s0>
<s5>28</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>29</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>29</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>29</s5>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>30</s5>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>30</s5>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>30</s5>
</fC07>
<fC07 i1="12" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="12" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="12" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="13" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="13" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="13" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="14" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="14" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="14" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>002</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
<server><NO>PASCAL 12-0016583 INIST</NO>
<ET>POSTERIOR HYPOTHALAMIC NUCLEUS DEEP BRAIN STIMULATION RESTORES LOCOMOTION IN RATS WITH HALOPERIDOL-INDUCED AKINESIA BUT NOT SKILLED FORELIMB USE IN PELLET REACHING AND LEVER PRESSING</ET>
<AU>YOUNG (C. K.); WHISHAW (I. Q.); BLAND (B. H.)</AU>
<AF>Behavioural Neuroscience Group, Department of Psychology, Hotchkiss Brain Institute, University of Calgary/Calgary, AB/Canada (1 aut., 3 aut.); Department of Neuroscience, Canadian Centre for Behavioural Neuroscience, University of Lethbridge/Lethbridge, AB/Canada (2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neuroscience; ISSN 0306-4522; Coden NRSCDN; Pays-Bas; Da. 2011; Vol. 192; Pp. 452-458; Bibl. 1 p.1/4</SO>
<LA>Anglais</LA>
<EA>Recent studies have shown that electrical stimulation of the posterior hypothalamic nucleus (PH) facilitates locomotion in control rats, and rats were made akinetic by dopaminergic blockade via haloperidol or dopamine depletion by the neurotoxin 6-hydroxydopamine. These findings suggest that PH stimulation might be a promising treatment for akinesia associated with dopamine loss in Parkinson's disease. The present study further examined the positive effects of PH stimulation on behavior by characterizing its potential facilitatory effects on tasks that require skilled movements. Rats were trained to reach for food pellets with a forelimb (skilled reaching) or press a bar in an operant conditioning task for food. PH stimulation in undrugged rats not only facilitated locomotion in each of the tasks, but also impaired performance of the skilled movement components of the tasks. Haloperidol reduced locomotion and skilled movement, and PH stimulation only restored locomotion. The results are discussed in relation to the idea that PH stimulation selectively facilitates locomotor behavior and may have limited use in restoring impairments in skilled movements and consummatory behavior that results from dopaminergic depletion.</EA>
<CC>002A25; 002B17A01</CC>
<FD>Hypothalamus; Locomotion; Halopéridol; Akinésie; Membre thoracique; Membre supérieur; Maladie de Parkinson; Rat; Animal; Stimulation cérébrale profonde</FD>
<FG>Encéphale; Système nerveux central; Psychotrope; Neuroleptique; Pathologie de l'encéphale; Pathologie du système nerveux central; Pathologie du   système nerveux; Trouble moteur; Trouble neurologique; Maladie dégénérative; Syndrome extrapyramidal; Rodentia; Mammalia; Vertebrata</FG>
<ED>Hypothalamus; Locomotion; Haloperidol; Akinesia; Forelimb; Upper limb; Parkinson disease; Rat; Animal; Deep brain stimulation</ED>
<EG>Encephalon; Central nervous system; Psychotropic; Neuroleptic; Cerebral disorder; Central nervous system disease; Nervous system diseases; Motor system disorder; Neurological disorder; Degenerative disease; Extrapyramidal syndrome; Rodentia; Mammalia; Vertebrata</EG>
<SD>Hipotálamo; Locomoción; Haloperidol; Aquinesia; Miembro torácico; Miembro superior; Parkinson enfermedad; Rata; Animal</SD>
<LO>INIST-17194.354000507316380420</LO>
<ID>12-0016583</ID>
</server>
</inist>
</record>

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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

POSTERIOR HYPOTHALAMIC NUCLEUS DEEP BRAIN STIMULATION RESTORES LOCOMOTION IN RATS WITH HALOPERIDOL-INDUCED AKINESIA BUT NOT SKILLED FORELIMB USE IN PELLET REACHING AND LEVER PRESSING

POSTERIOR HYPOTHALAMIC NUCLEUS DEEP BRAIN STIMULATION RESTORES LOCOMOTION IN RATS WITH HALOPERIDOL-INDUCED AKINESIA BUT NOT SKILLED FORELIMB USE IN PELLET REACHING AND LEVER PRESSING

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