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The use of rodent skilled reaching as a translational model for investigating brain damage and disease

Identifieur interne : 000212 ( PascalFrancis/Corpus ); précédent : 000211; suivant : 000213

The use of rodent skilled reaching as a translational model for investigating brain damage and disease

Auteurs : Alexander Klein ; Lori-Ann R. Sacrey ; Ian Q. Whishaw ; Stephen B. Dunnett

Source :

RBID : Pascal:12-0159173

Descripteurs français

English descriptors

Abstract

Neurological diseases, including Parkinson's disease, Huntington's disease, and brain damage caused by stroke, cause severe motor impairments. Deficits in hand use are one of the most debilitating motor symptoms and include impairments in body posture, forelimb movements, and finger shaping for manipulating objects. Hand movements can be formally studied using reaching tasks, including the skilled reaching task, or reach-to-eat task. For skilled reaching, a subject reaches for a small food item, grasps it with the fingers, and places it in the mouth for eating. The human movement and its associated deficits can be modeled by experimental lesions to the same systems in rodents which in turn provide an avenue for investigating treatments of human impairments. Skilled reaching movements are scored using three methods: (1) end point measures of attempts and success, (2) biometric measures, and (3) movement element rating scales derived from formal descriptions of movement. The striking similarities between human and rodent reaching movements allow the analysis of the reach-to-eat movement to serve as a powerful tool to generalize preclinical research to clinical conditions.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A03   1    @0 Neurosci. biobehav. rev.
A05       @2 36
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A08 01  1  ENG  @1 The use of rodent skilled reaching as a translational model for investigating brain damage and disease
A11 01  1    @1 KLEIN (Alexander)
A11 02  1    @1 SACREY (Lori-Ann R.)
A11 03  1    @1 WHISHAW (Ian Q.)
A11 04  1    @1 DUNNETT (Stephen B.)
A14 01      @1 Brain Repair Group, School of Biosciences, Cardiff University @2 Cardiff, Wales @3 GBR @Z 1 aut. @Z 4 aut.
A14 02      @1 Canadian Centre for Behavioural Neuroscience, University of Lethbridge @2 Lethbridge, Alberta @3 CAN @Z 2 aut. @Z 3 aut.
A20       @1 1030-1042
A21       @1 2012
A23 01      @0 ENG
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A44       @0 0000 @1 © 2012 INIST-CNRS. All rights reserved.
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A47 01  1    @0 12-0159173
A60       @1 P
A61       @0 A
A64 01  1    @0 Neuroscience and biobehavioral reviews
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C01 01    ENG  @0 Neurological diseases, including Parkinson's disease, Huntington's disease, and brain damage caused by stroke, cause severe motor impairments. Deficits in hand use are one of the most debilitating motor symptoms and include impairments in body posture, forelimb movements, and finger shaping for manipulating objects. Hand movements can be formally studied using reaching tasks, including the skilled reaching task, or reach-to-eat task. For skilled reaching, a subject reaches for a small food item, grasps it with the fingers, and places it in the mouth for eating. The human movement and its associated deficits can be modeled by experimental lesions to the same systems in rodents which in turn provide an avenue for investigating treatments of human impairments. Skilled reaching movements are scored using three methods: (1) end point measures of attempts and success, (2) biometric measures, and (3) movement element rating scales derived from formal descriptions of movement. The striking similarities between human and rodent reaching movements allow the analysis of the reach-to-eat movement to serve as a powerful tool to generalize preclinical research to clinical conditions.
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C03 04  X  FRE  @0 Modèle @5 04
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C07 07  X  ENG  @0 Genetic disease @5 41
C07 07  X  SPA  @0 Enfermedad hereditaria @5 41
C07 08  X  FRE  @0 Pathologie de l'appareil circulatoire @5 42
C07 08  X  ENG  @0 Cardiovascular disease @5 42
C07 08  X  SPA  @0 Aparato circulatorio patología @5 42
C07 09  X  FRE  @0 Pathologie cérébrovasculaire @5 43
C07 09  X  ENG  @0 Cerebrovascular disease @5 43
C07 09  X  SPA  @0 Vaso sanguíneo encéfalo patología @5 43
C07 10  X  FRE  @0 Pathologie des vaisseaux sanguins @5 44
C07 10  X  ENG  @0 Vascular disease @5 44
C07 10  X  SPA  @0 Vaso sanguíneo patología @5 44
C07 11  X  FRE  @0 Trouble neurologique @5 45
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C07 11  X  SPA  @0 Trastorno neurológico @5 45
N21       @1 122
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Format Inist (serveur)

NO : PASCAL 12-0159173 INIST
ET : The use of rodent skilled reaching as a translational model for investigating brain damage and disease
AU : KLEIN (Alexander); SACREY (Lori-Ann R.); WHISHAW (Ian Q.); DUNNETT (Stephen B.)
AF : Brain Repair Group, School of Biosciences, Cardiff University/Cardiff, Wales/Royaume-Uni (1 aut., 4 aut.); Canadian Centre for Behavioural Neuroscience, University of Lethbridge/Lethbridge, Alberta/Canada (2 aut., 3 aut.)
DT : Publication en série; Niveau analytique
SO : Neuroscience and biobehavioral reviews; ISSN 0149-7634; Royaume-Uni; Da. 2012; Vol. 36; No. 3; Pp. 1030-1042; Bibl. 1 p.3/4
LA : Anglais
EA : Neurological diseases, including Parkinson's disease, Huntington's disease, and brain damage caused by stroke, cause severe motor impairments. Deficits in hand use are one of the most debilitating motor symptoms and include impairments in body posture, forelimb movements, and finger shaping for manipulating objects. Hand movements can be formally studied using reaching tasks, including the skilled reaching task, or reach-to-eat task. For skilled reaching, a subject reaches for a small food item, grasps it with the fingers, and places it in the mouth for eating. The human movement and its associated deficits can be modeled by experimental lesions to the same systems in rodents which in turn provide an avenue for investigating treatments of human impairments. Skilled reaching movements are scored using three methods: (1) end point measures of attempts and success, (2) biometric measures, and (3) movement element rating scales derived from formal descriptions of movement. The striking similarities between human and rodent reaching movements allow the analysis of the reach-to-eat movement to serve as a powerful tool to generalize preclinical research to clinical conditions.
CC : 002A26C; 002B17G; 002B18C13; 002B17C
FD : Habileté; Motricité; Mouvement orienté; Modèle; Pathologie de l'encéphale; Maladie de Parkinson; Chorée de Huntington; Accident cérébrovasculaire; Trouble moteur; Comportement; Article synthèse; Rodentia; Contrôle moteur
FG : Mammalia; Vertebrata; Pathologie du système nerveux central; Pathologie du système nerveux; Syndrome extrapyramidal; Maladie dégénérative; Maladie héréditaire; Pathologie de l'appareil circulatoire; Pathologie cérébrovasculaire; Pathologie des vaisseaux sanguins; Trouble neurologique
ED : Skill; Motricity; Goal directed movement; Models; Cerebral disorder; Parkinson disease; Huntington disease; Stroke; Motor system disorder; Behavior; Review; Rodentia; Motor control
EG : Mammalia; Vertebrata; Central nervous system disease; Nervous system diseases; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Cardiovascular disease; Cerebrovascular disease; Vascular disease; Neurological disorder
SD : Habilidad; Motricidad; Movimiento orientado; Modelo; Encéfalo patología; Parkinson enfermedad; Corea Huntington; Accidente cerebrovascular; Trastorno motor; Conducta; Artículo síntesis; Rodentia; Control motor
LO : INIST-18046.354000509609550040
ID : 12-0159173

Links to Exploration step

Pascal:12-0159173

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<s0>Modèle</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG">
<s0>Models</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA">
<s0>Modelo</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE">
<s0>Pathologie de l'encéphale</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG">
<s0>Cerebral disorder</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA">
<s0>Encéfalo patología</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE">
<s0>Maladie de Parkinson</s0>
<s2>NM</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG">
<s0>Parkinson disease</s0>
<s2>NM</s2>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA">
<s0>Parkinson enfermedad</s0>
<s2>NM</s2>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE">
<s0>Chorée de Huntington</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG">
<s0>Huntington disease</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA">
<s0>Corea Huntington</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE">
<s0>Accident cérébrovasculaire</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG">
<s0>Stroke</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA">
<s0>Accidente cerebrovascular</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE">
<s0>Trouble moteur</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG">
<s0>Motor system disorder</s0>
<s5>09</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA">
<s0>Trastorno motor</s0>
<s5>09</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE">
<s0>Comportement</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG">
<s0>Behavior</s0>
<s5>10</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA">
<s0>Conducta</s0>
<s5>10</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE">
<s0>Article synthèse</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG">
<s0>Review</s0>
<s5>11</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA">
<s0>Artículo síntesis</s0>
<s5>11</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE">
<s0>Rodentia</s0>
<s2>NS</s2>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG">
<s0>Rodentia</s0>
<s2>NS</s2>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA">
<s0>Rodentia</s0>
<s2>NS</s2>
<s5>18</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE">
<s0>Contrôle moteur</s0>
<s5>31</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG">
<s0>Motor control</s0>
<s5>31</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA">
<s0>Control motor</s0>
<s5>31</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Pathologie du système nerveux central</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Central nervous system disease</s0>
<s5>37</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Sistema nervosio central patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Pathologie du système nerveux</s0>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Nervous system diseases</s0>
<s5>38</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Sistema nervioso patología</s0>
<s5>38</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE">
<s0>Syndrome extrapyramidal</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Extrapyramidal syndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Extrapiramidal síndrome</s0>
<s5>39</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE">
<s0>Maladie dégénérative</s0>
<s5>40</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG">
<s0>Degenerative disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA">
<s0>Enfermedad degenerativa</s0>
<s5>40</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE">
<s0>Maladie héréditaire</s0>
<s5>41</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG">
<s0>Genetic disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA">
<s0>Enfermedad hereditaria</s0>
<s5>41</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE">
<s0>Pathologie de l'appareil circulatoire</s0>
<s5>42</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG">
<s0>Cardiovascular disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA">
<s0>Aparato circulatorio patología</s0>
<s5>42</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE">
<s0>Pathologie cérébrovasculaire</s0>
<s5>43</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG">
<s0>Cerebrovascular disease</s0>
<s5>43</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA">
<s0>Vaso sanguíneo encéfalo patología</s0>
<s5>43</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE">
<s0>Pathologie des vaisseaux sanguins</s0>
<s5>44</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG">
<s0>Vascular disease</s0>
<s5>44</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA">
<s0>Vaso sanguíneo patología</s0>
<s5>44</s5>
</fC07>
<fC07 i1="11" i2="X" l="FRE">
<s0>Trouble neurologique</s0>
<s5>45</s5>
</fC07>
<fC07 i1="11" i2="X" l="ENG">
<s0>Neurological disorder</s0>
<s5>45</s5>
</fC07>
<fC07 i1="11" i2="X" l="SPA">
<s0>Trastorno neurológico</s0>
<s5>45</s5>
</fC07>
<fN21>
<s1>122</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
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<server>
<NO>PASCAL 12-0159173 INIST</NO>
<ET>The use of rodent skilled reaching as a translational model for investigating brain damage and disease</ET>
<AU>KLEIN (Alexander); SACREY (Lori-Ann R.); WHISHAW (Ian Q.); DUNNETT (Stephen B.)</AU>
<AF>Brain Repair Group, School of Biosciences, Cardiff University/Cardiff, Wales/Royaume-Uni (1 aut., 4 aut.); Canadian Centre for Behavioural Neuroscience, University of Lethbridge/Lethbridge, Alberta/Canada (2 aut., 3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neuroscience and biobehavioral reviews; ISSN 0149-7634; Royaume-Uni; Da. 2012; Vol. 36; No. 3; Pp. 1030-1042; Bibl. 1 p.3/4</SO>
<LA>Anglais</LA>
<EA>Neurological diseases, including Parkinson's disease, Huntington's disease, and brain damage caused by stroke, cause severe motor impairments. Deficits in hand use are one of the most debilitating motor symptoms and include impairments in body posture, forelimb movements, and finger shaping for manipulating objects. Hand movements can be formally studied using reaching tasks, including the skilled reaching task, or reach-to-eat task. For skilled reaching, a subject reaches for a small food item, grasps it with the fingers, and places it in the mouth for eating. The human movement and its associated deficits can be modeled by experimental lesions to the same systems in rodents which in turn provide an avenue for investigating treatments of human impairments. Skilled reaching movements are scored using three methods: (1) end point measures of attempts and success, (2) biometric measures, and (3) movement element rating scales derived from formal descriptions of movement. The striking similarities between human and rodent reaching movements allow the analysis of the reach-to-eat movement to serve as a powerful tool to generalize preclinical research to clinical conditions.</EA>
<CC>002A26C; 002B17G; 002B18C13; 002B17C</CC>
<FD>Habileté; Motricité; Mouvement orienté; Modèle; Pathologie de l'encéphale; Maladie de Parkinson; Chorée de Huntington; Accident cérébrovasculaire; Trouble moteur; Comportement; Article synthèse; Rodentia; Contrôle moteur</FD>
<FG>Mammalia; Vertebrata; Pathologie du système nerveux central; Pathologie du système nerveux; Syndrome extrapyramidal; Maladie dégénérative; Maladie héréditaire; Pathologie de l'appareil circulatoire; Pathologie cérébrovasculaire; Pathologie des vaisseaux sanguins; Trouble neurologique</FG>
<ED>Skill; Motricity; Goal directed movement; Models; Cerebral disorder; Parkinson disease; Huntington disease; Stroke; Motor system disorder; Behavior; Review; Rodentia; Motor control</ED>
<EG>Mammalia; Vertebrata; Central nervous system disease; Nervous system diseases; Extrapyramidal syndrome; Degenerative disease; Genetic disease; Cardiovascular disease; Cerebrovascular disease; Vascular disease; Neurological disorder</EG>
<SD>Habilidad; Motricidad; Movimiento orientado; Modelo; Encéfalo patología; Parkinson enfermedad; Corea Huntington; Accidente cerebrovascular; Trastorno motor; Conducta; Artículo síntesis; Rodentia; Control motor</SD>
<LO>INIST-18046.354000509609550040</LO>
<ID>12-0159173</ID>
</server>
</inist>
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