ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000148

Using a startling acoustic stimulus to investigate underlying mechanisms of bradykinesia in Parkinson's disease

Identifieur interne : 000148 ( PascalFrancis/Corpus ); précédent : 000147; suivant : 000149

Using a startling acoustic stimulus to investigate underlying mechanisms of bradykinesia in Parkinson's disease

Auteurs : Anthony N. Carlsen ; Quincy J. Almeida ; Ian M. Franks

Source :

Neuropsychologia [ 0028-3932 ] ; 2013.

RBID : Francis:13-0107113

Descripteurs français

Pascal (Inist)
- Stimulus acoustique, Trouble moteur, Maladie de Parkinson, Noyau gris central, Réflexe sursaut, Temps réaction, Electromyographie, Homme, Bradykinésie.

English descriptors

KwdEn :
- Acoustic stimulus, Basal ganglion, Electromyography, Human, Motor system disorder, Parkinson disease, Reaction time, Startle reflex.

Abstract

Delays in the initiation of a movement response and slowness during movement are among the hallmark motor symptoms in patients with Parkinson's disease (PD). These impairments may result from deficits in neural structures related to perception, response programming, response initiation, or a combination of all three. However, the relative impact of each process on movement control in PD is still unclear. The present study investigated which processes might be responsible for the observed slowness. Patients performed a simple reaction time (RT) task involving arm extension where the normal 82 dB acoustic "go" signal was unexpectedly replaced with a 124 dB startling acoustic stimulus (SAS) on selected trials. The SAS was used as a probe of motor preparatory state since it has been shown to act as a subcortically-mediated involuntarily trigger for actions that are sufficiently prepared and waiting to be initiated by normal cortical processes. It was expected that release of the voluntary response by startle would not occur in PD patients if bradykinetic symptoms were attributable primarily to motor programming deficits. In contrast, results clearly showed that when a SAS was presented, the prepared response was elicited at a significantly shorter latency. In addition, the amplitude and timing pattern of EMG output appeared to be improved compared to control, resulting in a faster, more normalized movement. These results suggest that in PD patients motor programming processes are relatively intact, while the dysfunctional basal ganglia likely assert an inhibitory effect on the thalamo-cortical connections responsible for the initiation of motor acts.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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Format Inist (serveur)

NO :	FRANCIS 13-0107113 INIST
ET :	Using a startling acoustic stimulus to investigate underlying mechanisms of bradykinesia in Parkinson's disease
AU :	CARLSEN (Anthony N.); ALMEIDA (Quincy J.); FRANKS (Ian M.)
AF :	School of Human Kinetics, University Ottawa, 352-125 University Private/Ottawa, ON K1N 6N5/Canada (1 aut.); Sun Life Financial Movement Disorders Research and Rehabilitation Centre, Wilfrid Laurier University/Waterloo, ON/Canada (2 aut.); School of Kinesiology, University British Columbia/Vancouver, BC/Canada (3 aut.)
DT :	Publication en série; Niveau analytique
SO :	Neuropsychologia; ISSN 0028-3932; Coden NUPSA6; Royaume-Uni; Da. 2013; Vol. 51; No. 3; Pp. 392-399; Bibl. 1 p.1/4
LA :	Anglais
EA :	Delays in the initiation of a movement response and slowness during movement are among the hallmark motor symptoms in patients with Parkinson's disease (PD). These impairments may result from deficits in neural structures related to perception, response programming, response initiation, or a combination of all three. However, the relative impact of each process on movement control in PD is still unclear. The present study investigated which processes might be responsible for the observed slowness. Patients performed a simple reaction time (RT) task involving arm extension where the normal 82 dB acoustic "go" signal was unexpectedly replaced with a 124 dB startling acoustic stimulus (SAS) on selected trials. The SAS was used as a probe of motor preparatory state since it has been shown to act as a subcortically-mediated involuntarily trigger for actions that are sufficiently prepared and waiting to be initiated by normal cortical processes. It was expected that release of the voluntary response by startle would not occur in PD patients if bradykinetic symptoms were attributable primarily to motor programming deficits. In contrast, results clearly showed that when a SAS was presented, the prepared response was elicited at a significantly shorter latency. In addition, the amplitude and timing pattern of EMG output appeared to be improved compared to control, resulting in a faster, more normalized movement. These results suggest that in PD patients motor programming processes are relatively intact, while the dysfunctional basal ganglia likely assert an inhibitory effect on the thalamo-cortical connections responsible for the initiation of motor acts.
CC :	770D03M
FD :	Stimulus acoustique; Trouble moteur; Maladie de Parkinson; Noyau gris central; Réflexe sursaut; Temps réaction; Electromyographie; Homme; Bradykinésie
FG :	Pathologie du système nerveux; Trouble neurologique; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Encéphale; Système nerveux central; Electrophysiologie
ED :	Acoustic stimulus; Motor system disorder; Parkinson disease; Basal ganglion; Startle reflex; Reaction time; Electromyography; Human
EG :	Nervous system diseases; Neurological disorder; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Encephalon; Central nervous system; Electrophysiology
SD :	Estímulo acústico; Trastorno motor; Parkinson enfermedad; Núcleo basal; Reflejo sobresalto; Tiempo reacción; Electromiografía; Hombre
LO :	INIST-11143.354000503701300020
ID :	13-0107113

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Francis:13-0107113

Le document en format XML

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<front><div type="abstract" xml:lang="en">Delays in the initiation of a movement response and slowness during movement are among the hallmark motor symptoms in patients with Parkinson's disease (PD). These impairments may result from deficits in neural structures related to perception, response programming, response initiation, or a combination of all three. However, the relative impact of each process on movement control in PD is still unclear. The present study investigated which processes might be responsible for the observed slowness. Patients performed a simple reaction time (RT) task involving arm extension where the normal 82 dB acoustic "go" signal was unexpectedly replaced with a 124 dB startling acoustic stimulus (SAS) on selected trials. The SAS was used as a probe of motor preparatory state since it has been shown to act as a subcortically-mediated involuntarily trigger for actions that are sufficiently prepared and waiting to be initiated by normal cortical processes. It was expected that release of the voluntary response by startle would not occur in PD patients if bradykinetic symptoms were attributable primarily to motor programming deficits. In contrast, results clearly showed that when a SAS was presented, the prepared response was elicited at a significantly shorter latency. In addition, the amplitude and timing pattern of EMG output appeared to be improved compared to control, resulting in a faster, more normalized movement. These results suggest that in PD patients motor programming processes are relatively intact, while the dysfunctional basal ganglia likely assert an inhibitory effect on the thalamo-cortical connections responsible for the initiation of motor acts.</div>
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<server><NO>FRANCIS 13-0107113 INIST</NO>
<ET>Using a startling acoustic stimulus to investigate underlying mechanisms of bradykinesia in Parkinson's disease</ET>
<AU>CARLSEN (Anthony N.); ALMEIDA (Quincy J.); FRANKS (Ian M.)</AU>
<AF>School of Human Kinetics, University Ottawa, 352-125 University Private/Ottawa, ON K1N 6N5/Canada (1 aut.); Sun Life Financial Movement Disorders Research and Rehabilitation Centre, Wilfrid Laurier University/Waterloo, ON/Canada (2 aut.); School of Kinesiology, University British Columbia/Vancouver, BC/Canada (3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neuropsychologia; ISSN 0028-3932; Coden NUPSA6; Royaume-Uni; Da. 2013; Vol. 51; No. 3; Pp. 392-399; Bibl. 1 p.1/4</SO>
<LA>Anglais</LA>
<EA>Delays in the initiation of a movement response and slowness during movement are among the hallmark motor symptoms in patients with Parkinson's disease (PD). These impairments may result from deficits in neural structures related to perception, response programming, response initiation, or a combination of all three. However, the relative impact of each process on movement control in PD is still unclear. The present study investigated which processes might be responsible for the observed slowness. Patients performed a simple reaction time (RT) task involving arm extension where the normal 82 dB acoustic "go" signal was unexpectedly replaced with a 124 dB startling acoustic stimulus (SAS) on selected trials. The SAS was used as a probe of motor preparatory state since it has been shown to act as a subcortically-mediated involuntarily trigger for actions that are sufficiently prepared and waiting to be initiated by normal cortical processes. It was expected that release of the voluntary response by startle would not occur in PD patients if bradykinetic symptoms were attributable primarily to motor programming deficits. In contrast, results clearly showed that when a SAS was presented, the prepared response was elicited at a significantly shorter latency. In addition, the amplitude and timing pattern of EMG output appeared to be improved compared to control, resulting in a faster, more normalized movement. These results suggest that in PD patients motor programming processes are relatively intact, while the dysfunctional basal ganglia likely assert an inhibitory effect on the thalamo-cortical connections responsible for the initiation of motor acts.</EA>
<CC>770D03M</CC>
<FD>Stimulus acoustique; Trouble moteur; Maladie de Parkinson; Noyau gris central; Réflexe sursaut; Temps réaction; Electromyographie; Homme; Bradykinésie</FD>
<FG>Pathologie du   système nerveux; Trouble neurologique; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du   système nerveux central; Encéphale; Système nerveux central; Electrophysiologie</FG>
<ED>Acoustic stimulus; Motor system disorder; Parkinson disease; Basal ganglion; Startle reflex; Reaction time; Electromyography; Human</ED>
<EG>Nervous system diseases; Neurological disorder; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Encephalon; Central nervous system; Electrophysiology</EG>
<SD>Estímulo acústico; Trastorno motor; Parkinson enfermedad; Núcleo basal; Reflejo sobresalto; Tiempo reacción; Electromiografía; Hombre</SD>
<LO>INIST-11143.354000503701300020</LO>
<ID>13-0107113</ID>
</server>
</inist>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

Using a startling acoustic stimulus to investigate underlying mechanisms of bradykinesia in Parkinson's disease

Using a startling acoustic stimulus to investigate underlying mechanisms of bradykinesia in Parkinson's disease

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