Using a startling acoustic stimulus to investigate underlying mechanisms of bradykinesia in Parkinson's disease
Identifieur interne : 000113 ( PascalFrancis/Corpus ); précédent : 000112; suivant : 000114Using a startling acoustic stimulus to investigate underlying mechanisms of bradykinesia in Parkinson's disease
Auteurs : Anthony N. Carlsen ; Quincy J. Almeida ; Ian M. FranksSource :
- Neuropsychologia [ 0028-3932 ] ; 2013.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Delays in the initiation of a movement response and slowness during movement are among the hallmark motor symptoms in patients with Parkinson's disease (PD). These impairments may result from deficits in neural structures related to perception, response programming, response initiation, or a combination of all three. However, the relative impact of each process on movement control in PD is still unclear. The present study investigated which processes might be responsible for the observed slowness. Patients performed a simple reaction time (RT) task involving arm extension where the normal 82 dB acoustic "go" signal was unexpectedly replaced with a 124 dB startling acoustic stimulus (SAS) on selected trials. The SAS was used as a probe of motor preparatory state since it has been shown to act as a subcortically-mediated involuntarily trigger for actions that are sufficiently prepared and waiting to be initiated by normal cortical processes. It was expected that release of the voluntary response by startle would not occur in PD patients if bradykinetic symptoms were attributable primarily to motor programming deficits. In contrast, results clearly showed that when a SAS was presented, the prepared response was elicited at a significantly shorter latency. In addition, the amplitude and timing pattern of EMG output appeared to be improved compared to control, resulting in a faster, more normalized movement. These results suggest that in PD patients motor programming processes are relatively intact, while the dysfunctional basal ganglia likely assert an inhibitory effect on the thalamo-cortical connections responsible for the initiation of motor acts.
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Format Inist (serveur)
NO : | PASCAL 13-0107113 INIST |
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ET : | Using a startling acoustic stimulus to investigate underlying mechanisms of bradykinesia in Parkinson's disease |
AU : | CARLSEN (Anthony N.); ALMEIDA (Quincy J.); FRANKS (Ian M.) |
AF : | School of Human Kinetics, University Ottawa, 352-125 University Private/Ottawa, ON K1N 6N5/Canada (1 aut.); Sun Life Financial Movement Disorders Research and Rehabilitation Centre, Wilfrid Laurier University/Waterloo, ON/Canada (2 aut.); School of Kinesiology, University British Columbia/Vancouver, BC/Canada (3 aut.) |
DT : | Publication en série; Niveau analytique |
SO : | Neuropsychologia; ISSN 0028-3932; Coden NUPSA6; Royaume-Uni; Da. 2013; Vol. 51; No. 3; Pp. 392-399; Bibl. 1 p.1/4 |
LA : | Anglais |
EA : | Delays in the initiation of a movement response and slowness during movement are among the hallmark motor symptoms in patients with Parkinson's disease (PD). These impairments may result from deficits in neural structures related to perception, response programming, response initiation, or a combination of all three. However, the relative impact of each process on movement control in PD is still unclear. The present study investigated which processes might be responsible for the observed slowness. Patients performed a simple reaction time (RT) task involving arm extension where the normal 82 dB acoustic "go" signal was unexpectedly replaced with a 124 dB startling acoustic stimulus (SAS) on selected trials. The SAS was used as a probe of motor preparatory state since it has been shown to act as a subcortically-mediated involuntarily trigger for actions that are sufficiently prepared and waiting to be initiated by normal cortical processes. It was expected that release of the voluntary response by startle would not occur in PD patients if bradykinetic symptoms were attributable primarily to motor programming deficits. In contrast, results clearly showed that when a SAS was presented, the prepared response was elicited at a significantly shorter latency. In addition, the amplitude and timing pattern of EMG output appeared to be improved compared to control, resulting in a faster, more normalized movement. These results suggest that in PD patients motor programming processes are relatively intact, while the dysfunctional basal ganglia likely assert an inhibitory effect on the thalamo-cortical connections responsible for the initiation of motor acts. |
CC : | 002B18C13; 002B17A01; 002B17G |
FD : | Stimulus acoustique; Trouble moteur; Maladie de Parkinson; Noyau gris central; Réflexe sursaut; Temps réaction; Electromyographie; Homme; Bradykinésie |
FG : | Pathologie du système nerveux; Trouble neurologique; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Encéphale; Système nerveux central; Electrophysiologie |
ED : | Acoustic stimulus; Motor system disorder; Parkinson disease; Basal ganglion; Startle reflex; Reaction time; Electromyography; Human |
EG : | Nervous system diseases; Neurological disorder; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Encephalon; Central nervous system; Electrophysiology |
SD : | Estímulo acústico; Trastorno motor; Parkinson enfermedad; Núcleo basal; Reflejo sobresalto; Tiempo reacción; Electromiografía; Hombre |
LO : | INIST-11143.354000503701300020 |
ID : | 13-0107113 |
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Pascal:13-0107113Le document en format XML
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<front><div type="abstract" xml:lang="en">Delays in the initiation of a movement response and slowness during movement are among the hallmark motor symptoms in patients with Parkinson's disease (PD). These impairments may result from deficits in neural structures related to perception, response programming, response initiation, or a combination of all three. However, the relative impact of each process on movement control in PD is still unclear. The present study investigated which processes might be responsible for the observed slowness. Patients performed a simple reaction time (RT) task involving arm extension where the normal 82 dB acoustic "go" signal was unexpectedly replaced with a 124 dB startling acoustic stimulus (SAS) on selected trials. The SAS was used as a probe of motor preparatory state since it has been shown to act as a subcortically-mediated involuntarily trigger for actions that are sufficiently prepared and waiting to be initiated by normal cortical processes. It was expected that release of the voluntary response by startle would not occur in PD patients if bradykinetic symptoms were attributable primarily to motor programming deficits. In contrast, results clearly showed that when a SAS was presented, the prepared response was elicited at a significantly shorter latency. In addition, the amplitude and timing pattern of EMG output appeared to be improved compared to control, resulting in a faster, more normalized movement. These results suggest that in PD patients motor programming processes are relatively intact, while the dysfunctional basal ganglia likely assert an inhibitory effect on the thalamo-cortical connections responsible for the initiation of motor acts.</div>
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<ET>Using a startling acoustic stimulus to investigate underlying mechanisms of bradykinesia in Parkinson's disease</ET>
<AU>CARLSEN (Anthony N.); ALMEIDA (Quincy J.); FRANKS (Ian M.)</AU>
<AF>School of Human Kinetics, University Ottawa, 352-125 University Private/Ottawa, ON K1N 6N5/Canada (1 aut.); Sun Life Financial Movement Disorders Research and Rehabilitation Centre, Wilfrid Laurier University/Waterloo, ON/Canada (2 aut.); School of Kinesiology, University British Columbia/Vancouver, BC/Canada (3 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neuropsychologia; ISSN 0028-3932; Coden NUPSA6; Royaume-Uni; Da. 2013; Vol. 51; No. 3; Pp. 392-399; Bibl. 1 p.1/4</SO>
<LA>Anglais</LA>
<EA>Delays in the initiation of a movement response and slowness during movement are among the hallmark motor symptoms in patients with Parkinson's disease (PD). These impairments may result from deficits in neural structures related to perception, response programming, response initiation, or a combination of all three. However, the relative impact of each process on movement control in PD is still unclear. The present study investigated which processes might be responsible for the observed slowness. Patients performed a simple reaction time (RT) task involving arm extension where the normal 82 dB acoustic "go" signal was unexpectedly replaced with a 124 dB startling acoustic stimulus (SAS) on selected trials. The SAS was used as a probe of motor preparatory state since it has been shown to act as a subcortically-mediated involuntarily trigger for actions that are sufficiently prepared and waiting to be initiated by normal cortical processes. It was expected that release of the voluntary response by startle would not occur in PD patients if bradykinetic symptoms were attributable primarily to motor programming deficits. In contrast, results clearly showed that when a SAS was presented, the prepared response was elicited at a significantly shorter latency. In addition, the amplitude and timing pattern of EMG output appeared to be improved compared to control, resulting in a faster, more normalized movement. These results suggest that in PD patients motor programming processes are relatively intact, while the dysfunctional basal ganglia likely assert an inhibitory effect on the thalamo-cortical connections responsible for the initiation of motor acts.</EA>
<CC>002B18C13; 002B17A01; 002B17G</CC>
<FD>Stimulus acoustique; Trouble moteur; Maladie de Parkinson; Noyau gris central; Réflexe sursaut; Temps réaction; Electromyographie; Homme; Bradykinésie</FD>
<FG>Pathologie du système nerveux; Trouble neurologique; Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Encéphale; Système nerveux central; Electrophysiologie</FG>
<ED>Acoustic stimulus; Motor system disorder; Parkinson disease; Basal ganglion; Startle reflex; Reaction time; Electromyography; Human</ED>
<EG>Nervous system diseases; Neurological disorder; Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Encephalon; Central nervous system; Electrophysiology</EG>
<SD>Estímulo acústico; Trastorno motor; Parkinson enfermedad; Núcleo basal; Reflejo sobresalto; Tiempo reacción; Electromiografía; Hombre</SD>
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<ID>13-0107113</ID>
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