ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000100

DOES INCREASED GAMMA ACTIVITY IN PATIENTS SUFFERING FROM PARKINSON'S DISEASE COUNTERACT THE MOVEMENT INHIBITING BETA ACTIVITY?

Identifieur interne : 000100 ( PascalFrancis/Corpus ); précédent : 000099; suivant : 000101

DOES INCREASED GAMMA ACTIVITY IN PATIENTS SUFFERING FROM PARKINSON'S DISEASE COUNTERACT THE MOVEMENT INHIBITING BETA ACTIVITY?

Auteurs : E. Florin ; R. Erasmi ; C. Reck ; M. Maarouf ; A. Schnitzler ; G. R. Fink ; L. Timmermann

Source :

Neuroscience [ 0306-4522 ] ; 2013.

RBID : Pascal:13-0177455

Descripteurs français

Pascal (Inist)
- Potentiel champ, Maladie de Parkinson, Homme, Stimulation cérébrale profonde.

English descriptors

KwdEn :
- Deep brain stimulation, Field potential, Human, Parkinson disease.

Abstract

Akinesia and rigidity are cardinal symptoms of Parkinson's disease (PD). Previous studies analysing event-related desynchronization during movement onset associated both symptoms with pathologically increased oscillations in the beta frequency range. By focusing on the movement onset only, these studies cannot, however, shed light onto the question how oscillatory activity is changed during continuous movements. To investigate this issue, we compared the power of the local field potentials (LFP) within and above the subthalamic nucleus (STN) during rest, an isometric hold condition of the forearm, and a fist flexion and extension task in 13 patients with idiopathic PD during implantation of deep brain stimulation (DBS) electrodes. During fist flexion and extension (relative to rest), significantly increased activity in the low beta (12-18 Hz) and gamma (30-48 Hz) frequency ranges was observed within the STN, while during hold (compared to rest) no significant difference was found. For the regions above the STN the power during fist movements (compared to rest) was significantly higher, i.e. in the range of 18-30 Hz, with no significant changes in the gamma frequency range. Beta activity is claimed to inhibit movement and thereby could render fist movements more exhausting. Therefore, the observed increase in beta activity in the STN during fist movements might result in bradykinesia as experienced by many patients. We hypothesise that in order to enable repetitive fist movement despite increased beta activity, "prokinetic" gamma activity may be increased as a compensatory mechanism.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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C01	`01`		`ENG`	@0 Akinesia and rigidity are cardinal symptoms of Parkinson's disease (PD). Previous studies analysing event-related desynchronization during movement onset associated both symptoms with pathologically increased oscillations in the beta frequency range. By focusing on the movement onset only, these studies cannot, however, shed light onto the question how oscillatory activity is changed during continuous movements. To investigate this issue, we compared the power of the local field potentials (LFP) within and above the subthalamic nucleus (STN) during rest, an isometric hold condition of the forearm, and a fist flexion and extension task in 13 patients with idiopathic PD during implantation of deep brain stimulation (DBS) electrodes. During fist flexion and extension (relative to rest), significantly increased activity in the low beta (12-18 Hz) and gamma (30-48 Hz) frequency ranges was observed within the STN, while during hold (compared to rest) no significant difference was found. For the regions above the STN the power during fist movements (compared to rest) was significantly higher, i.e. in the range of 18-30 Hz, with no significant changes in the gamma frequency range. Beta activity is claimed to inhibit movement and thereby could render fist movements more exhausting. Therefore, the observed increase in beta activity in the STN during fist movements might result in bradykinesia as experienced by many patients. We hypothesise that in order to enable repetitive fist movement despite increased beta activity, "prokinetic" gamma activity may be increased as a compensatory mechanism.
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C07	`02`	`X`	`FRE`	`@0 Pathologie du système nerveux @5 21`
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Format Inist (serveur)

NO :	PASCAL 13-0177455 INIST
ET :	DOES INCREASED GAMMA ACTIVITY IN PATIENTS SUFFERING FROM PARKINSON'S DISEASE COUNTERACT THE MOVEMENT INHIBITING BETA ACTIVITY?
AU :	FLORIN (E.); ERASMI (R.); RECK (C.); MAAROUF (M.); SCHNITZLER (A.); FINK (G. R.); TIMMERMANN (L.)
AF :	Department of Neurology, University Hospital Cologne, Kerpener Strasse 62/50937 Köln/Allemagne (1 aut., 2 aut., 3 aut., 6 aut., 7 aut.); Institute of Neuroscience and Medicine (INM-3), Cognitive Neurology Section, Research Center Jülich, Leo-Brandt-Strasse 5/52425 Jülich/Allemagne (1 aut., 6 aut.); McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, 3801 University St/Montreal, QC H3A 2B4/Canada (1 aut.); Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Kerpener Strasse 62/50937 Köln/Allemagne (4 aut.); Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine-University, Moorenstr. 5/40225 Düsseldorf/Allemagne (5 aut.); Department of Neurology, Heinrich-Heine-University, Moorenstr. 5/40225 Düsseldorf/Allemagne (5 aut.)
DT :	Publication en série; Niveau analytique
SO :	Neuroscience; ISSN 0306-4522; Coden NRSCDN; Pays-Bas; Da. 2013; Vol. 237; Pp. 42-50; Bibl. 1 p.
LA :	Anglais
EA :	Akinesia and rigidity are cardinal symptoms of Parkinson's disease (PD). Previous studies analysing event-related desynchronization during movement onset associated both symptoms with pathologically increased oscillations in the beta frequency range. By focusing on the movement onset only, these studies cannot, however, shed light onto the question how oscillatory activity is changed during continuous movements. To investigate this issue, we compared the power of the local field potentials (LFP) within and above the subthalamic nucleus (STN) during rest, an isometric hold condition of the forearm, and a fist flexion and extension task in 13 patients with idiopathic PD during implantation of deep brain stimulation (DBS) electrodes. During fist flexion and extension (relative to rest), significantly increased activity in the low beta (12-18 Hz) and gamma (30-48 Hz) frequency ranges was observed within the STN, while during hold (compared to rest) no significant difference was found. For the regions above the STN the power during fist movements (compared to rest) was significantly higher, i.e. in the range of 18-30 Hz, with no significant changes in the gamma frequency range. Beta activity is claimed to inhibit movement and thereby could render fist movements more exhausting. Therefore, the observed increase in beta activity in the STN during fist movements might result in bradykinesia as experienced by many patients. We hypothesise that in order to enable repetitive fist movement despite increased beta activity, "prokinetic" gamma activity may be increased as a compensatory mechanism.
CC :	002B17G; 002B17A01
FD :	Potentiel champ; Maladie de Parkinson; Homme; Stimulation cérébrale profonde
FG :	Maladie dégénérative; Pathologie du système nerveux; Pathologie de l'encéphale; Syndrome extrapyramidal; Pathologie du système nerveux central; Electrophysiologie
ED :	Field potential; Parkinson disease; Human; Deep brain stimulation
EG :	Degenerative disease; Nervous system diseases; Cerebral disorder; Extrapyramidal syndrome; Central nervous system disease; Electrophysiology
SD :	Potencial campo; Parkinson enfermedad; Hombre
LO :	INIST-17194.354000173322490050
ID :	13-0177455

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Pascal:13-0177455

Le document en format XML

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<front><div type="abstract" xml:lang="en">Akinesia and rigidity are cardinal symptoms of Parkinson's disease (PD). Previous studies analysing event-related desynchronization during movement onset associated both symptoms with pathologically increased oscillations in the beta frequency range. By focusing on the movement onset only, these studies cannot, however, shed light onto the question how oscillatory activity is changed during continuous movements. To investigate this issue, we compared the power of the local field potentials (LFP) within and above the subthalamic nucleus (STN) during rest, an isometric hold condition of the forearm, and a fist flexion and extension task in 13 patients with idiopathic PD during implantation of deep brain stimulation (DBS) electrodes. During fist flexion and extension (relative to rest), significantly increased activity in the low beta (12-18 Hz) and gamma (30-48 Hz) frequency ranges was observed within the STN, while during hold (compared to rest) no significant difference was found. For the regions above the STN the power during fist movements (compared to rest) was significantly higher, i.e. in the range of 18-30 Hz, with no significant changes in the gamma frequency range. Beta activity is claimed to inhibit movement and thereby could render fist movements more exhausting. Therefore, the observed increase in beta activity in the STN during fist movements might result in bradykinesia as experienced by many patients. We hypothesise that in order to enable repetitive fist movement despite increased beta activity, "prokinetic" gamma activity may be increased as a compensatory mechanism.</div>
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<fA08 i1="01" i2="1" l="ENG"><s1>DOES INCREASED GAMMA ACTIVITY IN PATIENTS SUFFERING FROM PARKINSON'S DISEASE COUNTERACT THE MOVEMENT INHIBITING BETA ACTIVITY?</s1>
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<ET>DOES INCREASED GAMMA ACTIVITY IN PATIENTS SUFFERING FROM PARKINSON'S DISEASE COUNTERACT THE MOVEMENT INHIBITING BETA ACTIVITY?</ET>
<AU>FLORIN (E.); ERASMI (R.); RECK (C.); MAAROUF (M.); SCHNITZLER (A.); FINK (G. R.); TIMMERMANN (L.)</AU>
<AF>Department of Neurology, University Hospital Cologne, Kerpener Strasse 62/50937 Köln/Allemagne (1 aut., 2 aut., 3 aut., 6 aut., 7 aut.); Institute of Neuroscience and Medicine (INM-3), Cognitive Neurology Section, Research Center Jülich, Leo-Brandt-Strasse 5/52425 Jülich/Allemagne (1 aut., 6 aut.); McConnell Brain Imaging Center, Montreal Neurological Institute, McGill University, 3801 University St/Montreal, QC H3A 2B4/Canada (1 aut.); Department of Stereotaxy and Functional Neurosurgery, University Hospital Cologne, Kerpener Strasse 62/50937 Köln/Allemagne (4 aut.); Institute of Clinical Neuroscience and Medical Psychology, Heinrich-Heine-University, Moorenstr. 5/40225 Düsseldorf/Allemagne (5 aut.); Department of Neurology, Heinrich-Heine-University, Moorenstr. 5/40225 Düsseldorf/Allemagne (5 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Neuroscience; ISSN 0306-4522; Coden NRSCDN; Pays-Bas; Da. 2013; Vol. 237; Pp. 42-50; Bibl. 1 p.</SO>
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<EA>Akinesia and rigidity are cardinal symptoms of Parkinson's disease (PD). Previous studies analysing event-related desynchronization during movement onset associated both symptoms with pathologically increased oscillations in the beta frequency range. By focusing on the movement onset only, these studies cannot, however, shed light onto the question how oscillatory activity is changed during continuous movements. To investigate this issue, we compared the power of the local field potentials (LFP) within and above the subthalamic nucleus (STN) during rest, an isometric hold condition of the forearm, and a fist flexion and extension task in 13 patients with idiopathic PD during implantation of deep brain stimulation (DBS) electrodes. During fist flexion and extension (relative to rest), significantly increased activity in the low beta (12-18 Hz) and gamma (30-48 Hz) frequency ranges was observed within the STN, while during hold (compared to rest) no significant difference was found. For the regions above the STN the power during fist movements (compared to rest) was significantly higher, i.e. in the range of 18-30 Hz, with no significant changes in the gamma frequency range. Beta activity is claimed to inhibit movement and thereby could render fist movements more exhausting. Therefore, the observed increase in beta activity in the STN during fist movements might result in bradykinesia as experienced by many patients. We hypothesise that in order to enable repetitive fist movement despite increased beta activity, "prokinetic" gamma activity may be increased as a compensatory mechanism.</EA>
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	La maladie de Parkinson au Canada (serveur d'exploration)
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La maladie de Parkinson au Canada (serveur d'exploration)

DOES INCREASED GAMMA ACTIVITY IN PATIENTS SUFFERING FROM PARKINSON'S DISEASE COUNTERACT THE MOVEMENT INHIBITING BETA ACTIVITY?

DOES INCREASED GAMMA ACTIVITY IN PATIENTS SUFFERING FROM PARKINSON'S DISEASE COUNTERACT THE MOVEMENT INHIBITING BETA ACTIVITY?

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