ParkinsonCanadaV1, PascalFrancis, Corpus, bibRecord, 000079

Glucocorticoid Excess Induces Accumulation of Cardiac Glycogen and Triglyceride: Suggested Role for AMPK : Metabolic Syndrome and Cardiovascular Health: A Look Beyond the Horizon

Identifieur interne : 000079 ( PascalFrancis/Corpus ); précédent : 000078; suivant : 000080

Glucocorticoid Excess Induces Accumulation of Cardiac Glycogen and Triglyceride: Suggested Role for AMPK : Metabolic Syndrome and Cardiovascular Health: A Look Beyond the Horizon

Auteurs : Prasanth Puthanveetil ; Brian Rodrigues

Source :

Current pharmaceutical design : (Print) [ 1381-6128 ] ; 2013.

RBID : Pascal:13-0258530

Descripteurs français

Pascal (Inist)
- Glucocorticoïde, Accumulation biologique, Coeur, Glycogène, Triglycéride, cAMP-dependent protein kinase, Métabolisme, Insuffisance cardiaque, Article synthèse.

English descriptors

KwdEn :
- Biological accumulation, Glucocorticoid, Glycogen, Heart, Heart failure, Metabolism, Review, Triglyceride, cAMP-dependent protein kinase.

Abstract

Glucocorticoids include steroid hormones released from the adrenal cortex or synthetic analogues developed for various inflammatory and immune disorders. GCs are known to play an important role in maintaining the body's metabolic balance, but their irregular activity has been associated with complications like Cushing's syndrome, insulin resistance, and heart disease. Conventional GC action is through their nuclear receptor activation, but specific and non-specific membrane bound receptor mediated non-genomic actions have also been reported. GCs increase AMPK phosphorylation at Thr172, in addition to augmenting AMPK protein and gene expressions. AMPK is insulin mimetic in many of its actions like glucose uptake and inhibition of lipolysis, and these properties of AMPK are made used in conditions like insulin resistance and diabetes. Nevertheless, if AMPK is activated by GC in the absence of diabetes or decreased insulin signaling, accumulation of substrates in the form of glycogen and triglycerides could precipitate cardiac abnormalities. Glycogen storage can lead to many disorders like hypertrophy, conduction system disease and Wolff Parkinson White syndrome. TG accumulation is associated with generation of free radicals, ceramide formation, mitochondrial dysfunction and cardiac cell death. In this review, we outline the cardiometabolic changes associated with GC, especially related to augmentation in AMPK, and link these changes to cardiac dysfunction.

Notice en format standard (ISO 2709)

Pour connaître la documentation sur le format Inist Standard.

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A11	`01`	`1`		`@1 PUTHANVEETIL (Prasanth)`
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C01	`01`		`ENG`	@0 Glucocorticoids include steroid hormones released from the adrenal cortex or synthetic analogues developed for various inflammatory and immune disorders. GCs are known to play an important role in maintaining the body's metabolic balance, but their irregular activity has been associated with complications like Cushing's syndrome, insulin resistance, and heart disease. Conventional GC action is through their nuclear receptor activation, but specific and non-specific membrane bound receptor mediated non-genomic actions have also been reported. GCs increase AMPK phosphorylation at Thr172, in addition to augmenting AMPK protein and gene expressions. AMPK is insulin mimetic in many of its actions like glucose uptake and inhibition of lipolysis, and these properties of AMPK are made used in conditions like insulin resistance and diabetes. Nevertheless, if AMPK is activated by GC in the absence of diabetes or decreased insulin signaling, accumulation of substrates in the form of glycogen and triglycerides could precipitate cardiac abnormalities. Glycogen storage can lead to many disorders like hypertrophy, conduction system disease and Wolff Parkinson White syndrome. TG accumulation is associated with generation of free radicals, ceramide formation, mitochondrial dysfunction and cardiac cell death. In this review, we outline the cardiometabolic changes associated with GC, especially related to augmentation in AMPK, and link these changes to cardiac dysfunction.
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C03	`04`	`X`	`ENG`	`@0 Glycogen @5 04`
C03	`04`	`X`	`SPA`	`@0 Glicógeno @5 04`
C03	`05`	`X`	`FRE`	`@0 Triglycéride @5 05`
C03	`05`	`X`	`ENG`	`@0 Triglyceride @5 05`
C03	`05`	`X`	`SPA`	`@0 Triglicérido @5 05`
C03	`06`	`X`	`FRE`	`@0 cAMP-dependent protein kinase @2 FE @5 06`
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C03	`08`	`X`	`ENG`	`@0 Heart failure @5 08`
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C07	`01`	`X`	`ENG`	`@0 Lipids @5 38`
C07	`01`	`X`	`SPA`	`@0 Lípido @5 38`
C07	`02`	`X`	`FRE`	`@0 Pathologie de l'appareil circulatoire @5 40`
C07	`02`	`X`	`ENG`	`@0 Cardiovascular disease @5 40`
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N21				`@1 245`

Format Inist (serveur)

NO :	PASCAL 13-0258530 INIST
ET :	Glucocorticoid Excess Induces Accumulation of Cardiac Glycogen and Triglyceride: Suggested Role for AMPK : Metabolic Syndrome and Cardiovascular Health: A Look Beyond the Horizon
AU :	PUTHANVEETIL (Prasanth); RODRIGUES (Brian)
AF :	Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall/Vancouver, BC V6T 1Z3/Canada (1 aut., 2 aut.)
DT :	Publication en série; Niveau analytique
SO :	Current pharmaceutical design : (Print); ISSN 1381-6128; Emirats Arabes Unis; Da. 2013; Vol. 19; No. 27; Pp. 4818-4830; Bibl. 205 ref.
LA :	Anglais
EA :	Glucocorticoids include steroid hormones released from the adrenal cortex or synthetic analogues developed for various inflammatory and immune disorders. GCs are known to play an important role in maintaining the body's metabolic balance, but their irregular activity has been associated with complications like Cushing's syndrome, insulin resistance, and heart disease. Conventional GC action is through their nuclear receptor activation, but specific and non-specific membrane bound receptor mediated non-genomic actions have also been reported. GCs increase AMPK phosphorylation at Thr172, in addition to augmenting AMPK protein and gene expressions. AMPK is insulin mimetic in many of its actions like glucose uptake and inhibition of lipolysis, and these properties of AMPK are made used in conditions like insulin resistance and diabetes. Nevertheless, if AMPK is activated by GC in the absence of diabetes or decreased insulin signaling, accumulation of substrates in the form of glycogen and triglycerides could precipitate cardiac abnormalities. Glycogen storage can lead to many disorders like hypertrophy, conduction system disease and Wolff Parkinson White syndrome. TG accumulation is associated with generation of free radicals, ceramide formation, mitochondrial dysfunction and cardiac cell death. In this review, we outline the cardiometabolic changes associated with GC, especially related to augmentation in AMPK, and link these changes to cardiac dysfunction.
CC :	002B12A01
FD :	Glucocorticoïde; Accumulation biologique; Coeur; Glycogène; Triglycéride; cAMP-dependent protein kinase; Métabolisme; Insuffisance cardiaque; Article synthèse
FG :	Lipide; Pathologie de l'appareil circulatoire; Cardiopathie
ED :	Glucocorticoid; Biological accumulation; Heart; Glycogen; Triglyceride; cAMP-dependent protein kinase; Metabolism; Heart failure; Review
EG :	Lipids; Cardiovascular disease; Heart disease
SD :	Glucocorticoide; Acumulación biológica; Corazón; Glicógeno; Triglicérido; cAMP-dependent protein kinase; Metabolismo; Insuficiencia cardíaca; Artículo síntesis
LO :	INIST-26320.354000506523700030
ID :	13-0258530

Links to Exploration step

Pascal:13-0258530

Le document en format XML

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<front><div type="abstract" xml:lang="en">Glucocorticoids include steroid hormones released from the adrenal cortex or synthetic analogues developed for various inflammatory and immune disorders. GCs are known to play an important role in maintaining the body's metabolic balance, but their irregular activity has been associated with complications like Cushing's syndrome, insulin resistance, and heart disease. Conventional GC action is through their nuclear receptor activation, but specific and non-specific membrane bound receptor mediated non-genomic actions have also been reported. GCs increase AMPK phosphorylation at Thr172, in addition to augmenting AMPK protein and gene expressions. AMPK is insulin mimetic in many of its actions like glucose uptake and inhibition of lipolysis, and these properties of AMPK are made used in conditions like insulin resistance and diabetes. Nevertheless, if AMPK is activated by GC in the absence of diabetes or decreased insulin signaling, accumulation of substrates in the form of glycogen and triglycerides could precipitate cardiac abnormalities. Glycogen storage can lead to many disorders like hypertrophy, conduction system disease and Wolff Parkinson White syndrome. TG accumulation is associated with generation of free radicals, ceramide formation, mitochondrial dysfunction and cardiac cell death. In this review, we outline the cardiometabolic changes associated with GC, especially related to augmentation in AMPK, and link these changes to cardiac dysfunction.</div>
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<ET>Glucocorticoid Excess Induces Accumulation of Cardiac Glycogen and Triglyceride: Suggested Role for AMPK : Metabolic Syndrome and Cardiovascular Health: A Look Beyond the Horizon</ET>
<AU>PUTHANVEETIL (Prasanth); RODRIGUES (Brian)</AU>
<AF>Faculty of Pharmaceutical Sciences, The University of British Columbia, 2146 East Mall/Vancouver, BC V6T 1Z3/Canada (1 aut., 2 aut.)</AF>
<DT>Publication en série; Niveau analytique</DT>
<SO>Current pharmaceutical design : (Print); ISSN 1381-6128; Emirats Arabes Unis; Da. 2013; Vol. 19; No. 27; Pp. 4818-4830; Bibl. 205 ref.</SO>
<LA>Anglais</LA>
<EA>Glucocorticoids include steroid hormones released from the adrenal cortex or synthetic analogues developed for various inflammatory and immune disorders. GCs are known to play an important role in maintaining the body's metabolic balance, but their irregular activity has been associated with complications like Cushing's syndrome, insulin resistance, and heart disease. Conventional GC action is through their nuclear receptor activation, but specific and non-specific membrane bound receptor mediated non-genomic actions have also been reported. GCs increase AMPK phosphorylation at Thr172, in addition to augmenting AMPK protein and gene expressions. AMPK is insulin mimetic in many of its actions like glucose uptake and inhibition of lipolysis, and these properties of AMPK are made used in conditions like insulin resistance and diabetes. Nevertheless, if AMPK is activated by GC in the absence of diabetes or decreased insulin signaling, accumulation of substrates in the form of glycogen and triglycerides could precipitate cardiac abnormalities. Glycogen storage can lead to many disorders like hypertrophy, conduction system disease and Wolff Parkinson White syndrome. TG accumulation is associated with generation of free radicals, ceramide formation, mitochondrial dysfunction and cardiac cell death. In this review, we outline the cardiometabolic changes associated with GC, especially related to augmentation in AMPK, and link these changes to cardiac dysfunction.</EA>
<CC>002B12A01</CC>
<FD>Glucocorticoïde; Accumulation biologique; Coeur; Glycogène; Triglycéride; cAMP-dependent protein kinase; Métabolisme; Insuffisance cardiaque; Article synthèse</FD>
<FG>Lipide; Pathologie de l'appareil circulatoire; Cardiopathie</FG>
<ED>Glucocorticoid; Biological accumulation; Heart; Glycogen; Triglyceride; cAMP-dependent protein kinase; Metabolism; Heart failure; Review</ED>
<EG>Lipids; Cardiovascular disease; Heart disease</EG>
<SD>Glucocorticoide; Acumulación biológica; Corazón; Glicógeno; Triglicérido; cAMP-dependent protein kinase; Metabolismo; Insuficiencia cardíaca; Artículo síntesis</SD>
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<ID>13-0258530</ID>
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La maladie de Parkinson au Canada (serveur d'exploration)

Glucocorticoid Excess Induces Accumulation of Cardiac Glycogen and Triglyceride: Suggested Role for AMPK : Metabolic Syndrome and Cardiovascular Health: A Look Beyond the Horizon

Glucocorticoid Excess Induces Accumulation of Cardiac Glycogen and Triglyceride: Suggested Role for AMPK : Metabolic Syndrome and Cardiovascular Health: A Look Beyond the Horizon

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