Mild cognitive impairment is linked with faster rate of cortical thinning in patients with Parkinson's disease longitudinally
Identifieur interne : 000054 ( PascalFrancis/Corpus ); précédent : 000053; suivant : 000055Mild cognitive impairment is linked with faster rate of cortical thinning in patients with Parkinson's disease longitudinally
Auteurs : Alexandru Hanganu ; Christophe Bedetti ; Clotilde Degroot ; Beatriz Mejia-Constain ; Anne-Louise Lafontaine ; Valerie Soland ; Sylvain Chouinard ; Marie-Andrée Bruneau ; Samira Mellah ; Sylvie Belleville ; Oury MonchiSource :
- Brain [ 0006-8950 ] ; 2014.
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- Pascal (Inist)
English descriptors
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Abstract
Previous studies have shown greater atrophy in grey and white matter of various brain regions in patients with Parkinson's disease with mild cognitive impairment than in those without. These anatomical differences likely account for the distinct clinical profiles observed between those groups, but do not account for the evolution of regional brain degradation observed as the disease evolves. Although we have shown recently that cortical thinning correlates significantly more with disease duration in Parkinson's patients with mild cognitive impairment than in those without, to the best of our knowledge no study to date has explored this longitudinally. The present study investigated the longitudinal changes of the cortical and subcortical grey matter in patients with Parkinson's disease with and without mild cognitive impairment. Additionally, these two groups were compared with healthy controls. We found a higher rate of cortical thinning in the temporal, occipital, parietal and supplementary motor area, in patients with Parkinson's disease with mild cognitive impairment compared with both cognitively stable patients and healthy controls. On the other hand cognitively stable patients had only one lateral occipital and one fusiform cluster with increased rate of thinning compared with healthy individuals. Correlating the rate of change of cortical thickness with the results of Montreal Cognitive Assessment scores revealed significant thinning associated with cognitive decline in the group of all patients, in similar regions including temporal and medial occipital lobe. Finally, a significant decrease in the volume of the amygdala and nucleus accumbens was observed specifically in patients with Parkinson's disease with mild cognitive impairment. These results indicate that the early presence of mild cognitive impairment in patients with Parkinson's disease is associated with a faster rate of grey matter thinning in various cortical regions as well as a significant diminishment of limbic subcortical structures. This specific pattern of brain degradation associated with the early presence of mild cognitive impairment might serve as a marker of development toward dementia.
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Format Inist (serveur)
| NO : | FRANCIS 14-0080049 INIST |
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| ET : | Mild cognitive impairment is linked with faster rate of cortical thinning in patients with Parkinson's disease longitudinally |
| AU : | HANGANU (Alexandru); BEDETTI (Christophe); DEGROOT (Clotilde); MEJIA-CONSTAIN (Beatriz); LAFONTAINE (Anne-Louise); SOLAND (Valerie); CHOUINARD (Sylvain); BRUNEAU (Marie-Andrée); MELLAH (Samira); BELLEVILLE (Sylvie); MONCHI (Oury) |
| AF : | Centre de Recherche, Institut Universitaire de Gériatrie de Montreal/QC/Canada (1 aut., 2 aut., 3 aut., 4 aut., 8 aut., 9 aut., 10 aut., 11 aut.); Centre d'Études Avancées en Medicine du Sommeil, Hôpital du Sacré-Cœur de Montréal/QC/Canada (2 aut.); Department of Radiology, Faculty of Medicine, University of Montreal/QC/Canada (3 aut., 11 aut.); Movement Disorders Unit, McGill University Health Centre/Montréal, QC/Canada (5 aut.); Unité des Troubles du Mouvement André Barbeau, Centre Hospitalier de l'Université de Montréal/QC/Canada (6 aut., 7 aut.); Department of Psychology, Université du Québec à Montréal/Montreal, QC/Canada (10 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Brain; ISSN 0006-8950; Royaume-Uni; Da. 2014; Vol. 137; No. p. 4; Pp. 1120-1129; Bibl. 2 p. |
| LA : | Anglais |
| EA : | Previous studies have shown greater atrophy in grey and white matter of various brain regions in patients with Parkinson's disease with mild cognitive impairment than in those without. These anatomical differences likely account for the distinct clinical profiles observed between those groups, but do not account for the evolution of regional brain degradation observed as the disease evolves. Although we have shown recently that cortical thinning correlates significantly more with disease duration in Parkinson's patients with mild cognitive impairment than in those without, to the best of our knowledge no study to date has explored this longitudinally. The present study investigated the longitudinal changes of the cortical and subcortical grey matter in patients with Parkinson's disease with and without mild cognitive impairment. Additionally, these two groups were compared with healthy controls. We found a higher rate of cortical thinning in the temporal, occipital, parietal and supplementary motor area, in patients with Parkinson's disease with mild cognitive impairment compared with both cognitively stable patients and healthy controls. On the other hand cognitively stable patients had only one lateral occipital and one fusiform cluster with increased rate of thinning compared with healthy individuals. Correlating the rate of change of cortical thickness with the results of Montreal Cognitive Assessment scores revealed significant thinning associated with cognitive decline in the group of all patients, in similar regions including temporal and medial occipital lobe. Finally, a significant decrease in the volume of the amygdala and nucleus accumbens was observed specifically in patients with Parkinson's disease with mild cognitive impairment. These results indicate that the early presence of mild cognitive impairment in patients with Parkinson's disease is associated with a faster rate of grey matter thinning in various cortical regions as well as a significant diminishment of limbic subcortical structures. This specific pattern of brain degradation associated with the early presence of mild cognitive impairment might serve as a marker of development toward dementia. |
| CC : | 770D05 |
| FD : | Déficit cognitif léger; Trouble cognitif; Maladie de Parkinson; Pathologie du système nerveux; Homme; Imagerie RMN |
| FG : | Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Imagerie médicale |
| ED : | mild cognitive impairment; Cognitive disorder; Parkinson disease; Nervous system diseases; Human; Nuclear magnetic resonance imaging |
| EG : | Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Medical imagery |
| SD : | Disturbio cognitivo ligero; Trastorno cognitivo; Parkinson enfermedad; Sistema nervioso patología; Hombre; Imaginería RMN |
| LO : | INIST-998.354000506128200160 |
| ID : | 14-0080049 |
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sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name><affiliation><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Department of Radiology, Faculty of Medicine, University of Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0080049</idno><date when="2014">2014</date><idno type="stanalyst">FRANCIS 14-0080049 INIST</idno><idno type="RBID">Francis:14-0080049</idno><idno type="wicri:Area/PascalFrancis/Corpus">000054</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Mild cognitive impairment is linked with faster rate of cortical thinning in patients with Parkinson's disease longitudinally</title><author><name sortKey="Hanganu, Alexandru" sort="Hanganu, Alexandru" uniqKey="Hanganu A" first="Alexandru" last="Hanganu">Alexandru Hanganu</name><affiliation><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bedetti, Christophe" sort="Bedetti, Christophe" uniqKey="Bedetti C" first="Christophe" last="Bedetti">Christophe Bedetti</name><affiliation><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>Centre d'Études Avancées en Medicine du Sommeil, Hôpital du Sacré-Cœur de Montréal</s1><s2>QC</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Degroot, Clotilde" sort="Degroot, Clotilde" uniqKey="Degroot C" first="Clotilde" last="Degroot">Clotilde Degroot</name><affiliation><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Department of Radiology, Faculty of Medicine, University of Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mejia Constain, Beatriz" sort="Mejia Constain, Beatriz" uniqKey="Mejia Constain B" first="Beatriz" last="Mejia-Constain">Beatriz Mejia-Constain</name><affiliation><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lafontaine, Anne Louise" sort="Lafontaine, Anne Louise" uniqKey="Lafontaine A" first="Anne-Louise" last="Lafontaine">Anne-Louise Lafontaine</name><affiliation><inist:fA14 i1="04"><s1>Movement Disorders Unit, McGill University Health Centre</s1><s2>Montréal, QC</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Soland, Valerie" sort="Soland, Valerie" uniqKey="Soland V" first="Valerie" last="Soland">Valerie Soland</name><affiliation><inist:fA14 i1="05"><s1>Unité des Troubles du Mouvement André Barbeau, Centre Hospitalier de l'Université de Montréal</s1><s2>QC</s2><s3>CAN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Chouinard, Sylvain" sort="Chouinard, Sylvain" uniqKey="Chouinard S" first="Sylvain" last="Chouinard">Sylvain Chouinard</name><affiliation><inist:fA14 i1="05"><s1>Unité des Troubles du Mouvement André Barbeau, Centre Hospitalier de l'Université de Montréal</s1><s2>QC</s2><s3>CAN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Bruneau, Marie Andree" sort="Bruneau, Marie Andree" uniqKey="Bruneau M" first="Marie-Andrée" last="Bruneau">Marie-Andrée Bruneau</name><affiliation><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mellah, Samira" sort="Mellah, Samira" uniqKey="Mellah S" first="Samira" last="Mellah">Samira Mellah</name><affiliation><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Belleville, Sylvie" sort="Belleville, Sylvie" uniqKey="Belleville S" first="Sylvie" last="Belleville">Sylvie Belleville</name><affiliation><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="06"><s1>Department of Psychology, Université du Québec à Montréal</s1><s2>Montreal, QC</s2><s3>CAN</s3><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name><affiliation><inist:fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="03"><s1>Department of Radiology, Faculty of Medicine, University of Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Brain</title><title level="j" type="abbreviated">Brain</title><idno type="ISSN">0006-8950</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain</title><title level="j" type="abbreviated">Brain</title><idno type="ISSN">0006-8950</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognitive disorder</term><term>Human</term><term>Nervous system diseases</term><term>Nuclear magnetic resonance imaging</term><term>Parkinson disease</term><term>mild cognitive impairment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Déficit cognitif léger</term><term>Trouble cognitif</term><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Homme</term><term>Imagerie RMN</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Previous studies have shown greater atrophy in grey and white matter of various brain regions in patients with Parkinson's disease with mild cognitive impairment than in those without. These anatomical differences likely account for the distinct clinical profiles observed between those groups, but do not account for the evolution of regional brain degradation observed as the disease evolves. Although we have shown recently that cortical thinning correlates significantly more with disease duration in Parkinson's patients with mild cognitive impairment than in those without, to the best of our knowledge no study to date has explored this longitudinally. The present study investigated the longitudinal changes of the cortical and subcortical grey matter in patients with Parkinson's disease with and without mild cognitive impairment. Additionally, these two groups were compared with healthy controls. We found a higher rate of cortical thinning in the temporal, occipital, parietal and supplementary motor area, in patients with Parkinson's disease with mild cognitive impairment compared with both cognitively stable patients and healthy controls. On the other hand cognitively stable patients had only one lateral occipital and one fusiform cluster with increased rate of thinning compared with healthy individuals. Correlating the rate of change of cortical thickness with the results of Montreal Cognitive Assessment scores revealed significant thinning associated with cognitive decline in the group of all patients, in similar regions including temporal and medial occipital lobe. Finally, a significant decrease in the volume of the amygdala and nucleus accumbens was observed specifically in patients with Parkinson's disease with mild cognitive impairment. These results indicate that the early presence of mild cognitive impairment in patients with Parkinson's disease is associated with a faster rate of grey matter thinning in various cortical regions as well as a significant diminishment of limbic subcortical structures. This specific pattern of brain degradation associated with the early presence of mild cognitive impairment might serve as a marker of development toward dementia.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0006-8950</s0></fA01><fA03 i2="1"><s0>Brain</s0></fA03><fA05><s2>137</s2></fA05><fA06><s3>p. 4</s3></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Mild cognitive impairment is linked with faster rate of cortical thinning in patients with Parkinson's disease longitudinally</s1></fA08><fA11 i1="01" i2="1"><s1>HANGANU (Alexandru)</s1></fA11><fA11 i1="02" i2="1"><s1>BEDETTI (Christophe)</s1></fA11><fA11 i1="03" i2="1"><s1>DEGROOT (Clotilde)</s1></fA11><fA11 i1="04" i2="1"><s1>MEJIA-CONSTAIN (Beatriz)</s1></fA11><fA11 i1="05" i2="1"><s1>LAFONTAINE (Anne-Louise)</s1></fA11><fA11 i1="06" i2="1"><s1>SOLAND (Valerie)</s1></fA11><fA11 i1="07" i2="1"><s1>CHOUINARD (Sylvain)</s1></fA11><fA11 i1="08" i2="1"><s1>BRUNEAU (Marie-Andrée)</s1></fA11><fA11 i1="09" i2="1"><s1>MELLAH (Samira)</s1></fA11><fA11 i1="10" i2="1"><s1>BELLEVILLE (Sylvie)</s1></fA11><fA11 i1="11" i2="1"><s1>MONCHI (Oury)</s1></fA11><fA14 i1="01"><s1>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>8 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="02"><s1>Centre d'Études Avancées en Medicine du Sommeil, Hôpital du Sacré-Cœur de Montréal</s1><s2>QC</s2><s3>CAN</s3><sZ>2 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Radiology, Faculty of Medicine, University of Montreal</s1><s2>QC</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="04"><s1>Movement Disorders Unit, McGill University Health Centre</s1><s2>Montréal, QC</s2><s3>CAN</s3><sZ>5 aut.</sZ></fA14><fA14 i1="05"><s1>Unité des Troubles du Mouvement André Barbeau, Centre Hospitalier de l'Université de Montréal</s1><s2>QC</s2><s3>CAN</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Psychology, Université du Québec à Montréal</s1><s2>Montreal, QC</s2><s3>CAN</s3><sZ>10 aut.</sZ></fA14><fA20><s1>1120-1129</s1></fA20><fA21><s1>2014</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>998</s2><s5>354000506128200160</s5></fA43><fA44><s0>0000</s0><s1>© 2014 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>2 p.</s0></fA45><fA47 i1="01" i2="1"><s0>14-0080049</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Brain</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>Previous studies have shown greater atrophy in grey and white matter of various brain regions in patients with Parkinson's disease with mild cognitive impairment than in those without. These anatomical differences likely account for the distinct clinical profiles observed between those groups, but do not account for the evolution of regional brain degradation observed as the disease evolves. Although we have shown recently that cortical thinning correlates significantly more with disease duration in Parkinson's patients with mild cognitive impairment than in those without, to the best of our knowledge no study to date has explored this longitudinally. The present study investigated the longitudinal changes of the cortical and subcortical grey matter in patients with Parkinson's disease with and without mild cognitive impairment. Additionally, these two groups were compared with healthy controls. We found a higher rate of cortical thinning in the temporal, occipital, parietal and supplementary motor area, in patients with Parkinson's disease with mild cognitive impairment compared with both cognitively stable patients and healthy controls. On the other hand cognitively stable patients had only one lateral occipital and one fusiform cluster with increased rate of thinning compared with healthy individuals. Correlating the rate of change of cortical thickness with the results of Montreal Cognitive Assessment scores revealed significant thinning associated with cognitive decline in the group of all patients, in similar regions including temporal and medial occipital lobe. Finally, a significant decrease in the volume of the amygdala and nucleus accumbens was observed specifically in patients with Parkinson's disease with mild cognitive impairment. These results indicate that the early presence of mild cognitive impairment in patients with Parkinson's disease is associated with a faster rate of grey matter thinning in various cortical regions as well as a significant diminishment of limbic subcortical structures. This specific pattern of brain degradation associated with the early presence of mild cognitive impairment might serve as a marker of development toward dementia.</s0></fC01><fC02 i1="01" i2="X"><s0>770D05</s0><s1>IV</s1></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Déficit cognitif léger</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>mild cognitive impairment</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Disturbio cognitivo ligero</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Trouble cognitif</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Cognitive disorder</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Trastorno cognitivo</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Homme</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Human</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Hombre</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Imagerie RMN</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Nuclear magnetic resonance imaging</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Imaginería RMN</s0><s5>10</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Imagerie médicale</s0><s5>42</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Medical imagery</s0><s5>42</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Imaginería médica</s0><s5>42</s5></fC07><fN21><s1>111</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>FRANCIS 14-0080049 INIST</NO><ET>Mild cognitive impairment is linked with faster rate of cortical thinning in patients with Parkinson's disease longitudinally</ET><AU>HANGANU (Alexandru); BEDETTI (Christophe); DEGROOT (Clotilde); MEJIA-CONSTAIN (Beatriz); LAFONTAINE (Anne-Louise); SOLAND (Valerie); CHOUINARD (Sylvain); BRUNEAU (Marie-Andrée); MELLAH (Samira); BELLEVILLE (Sylvie); MONCHI (Oury)</AU><AF>Centre de Recherche, Institut Universitaire de Gériatrie de Montreal/QC/Canada (1 aut., 2 aut., 3 aut., 4 aut., 8 aut., 9 aut., 10 aut., 11 aut.); Centre d'Études Avancées en Medicine du Sommeil, Hôpital du Sacré-Cœur de Montréal/QC/Canada (2 aut.); Department of Radiology, Faculty of Medicine, University of Montreal/QC/Canada (3 aut., 11 aut.); Movement Disorders Unit, McGill University Health Centre/Montréal, QC/Canada (5 aut.); Unité des Troubles du Mouvement André Barbeau, Centre Hospitalier de l'Université de Montréal/QC/Canada (6 aut., 7 aut.); Department of Psychology, Université du Québec à Montréal/Montreal, QC/Canada (10 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Brain; ISSN 0006-8950; Royaume-Uni; Da. 2014; Vol. 137; No. p. 4; Pp. 1120-1129; Bibl. 2 p.</SO><LA>Anglais</LA><EA>Previous studies have shown greater atrophy in grey and white matter of various brain regions in patients with Parkinson's disease with mild cognitive impairment than in those without. These anatomical differences likely account for the distinct clinical profiles observed between those groups, but do not account for the evolution of regional brain degradation observed as the disease evolves. Although we have shown recently that cortical thinning correlates significantly more with disease duration in Parkinson's patients with mild cognitive impairment than in those without, to the best of our knowledge no study to date has explored this longitudinally. The present study investigated the longitudinal changes of the cortical and subcortical grey matter in patients with Parkinson's disease with and without mild cognitive impairment. Additionally, these two groups were compared with healthy controls. We found a higher rate of cortical thinning in the temporal, occipital, parietal and supplementary motor area, in patients with Parkinson's disease with mild cognitive impairment compared with both cognitively stable patients and healthy controls. On the other hand cognitively stable patients had only one lateral occipital and one fusiform cluster with increased rate of thinning compared with healthy individuals. Correlating the rate of change of cortical thickness with the results of Montreal Cognitive Assessment scores revealed significant thinning associated with cognitive decline in the group of all patients, in similar regions including temporal and medial occipital lobe. Finally, a significant decrease in the volume of the amygdala and nucleus accumbens was observed specifically in patients with Parkinson's disease with mild cognitive impairment. These results indicate that the early presence of mild cognitive impairment in patients with Parkinson's disease is associated with a faster rate of grey matter thinning in various cortical regions as well as a significant diminishment of limbic subcortical structures. This specific pattern of brain degradation associated with the early presence of mild cognitive impairment might serve as a marker of development toward dementia.</EA><CC>770D05</CC><FD>Déficit cognitif léger; Trouble cognitif; Maladie de Parkinson; Pathologie du système nerveux; Homme; Imagerie RMN</FD><FG>Pathologie de l'encéphale; Syndrome extrapyramidal; Maladie dégénérative; Pathologie du système nerveux central; Imagerie médicale</FG><ED>mild cognitive impairment; Cognitive disorder; Parkinson disease; Nervous system diseases; Human; Nuclear magnetic resonance imaging</ED><EG>Cerebral disorder; Extrapyramidal syndrome; Degenerative disease; Central nervous system disease; Medical imagery</EG><SD>Disturbio cognitivo ligero; Trastorno cognitivo; Parkinson enfermedad; Sistema nervioso patología; Hombre; Imaginería RMN</SD><LO>INIST-998.354000506128200160</LO><ID>14-0080049</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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