Human positron emission tomographic [18F]fluorodopa studies correlate with dopamine cell counts and levels
Identifieur interne : 000F39 ( PascalFrancis/Checkpoint ); précédent : 000F38; suivant : 000F40Human positron emission tomographic [18F]fluorodopa studies correlate with dopamine cell counts and levels
Auteurs : B. J. Snow [Canada] ; I. Tooyama ; E. G. Mcgeer [Canada] ; T. Yamada ; D. B. Calne [Canada] ; H. Takahashi [Canada] ; H. KimuraSource :
- Annals of neurology [ 0364-5134 ] ; 1993.
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- topic : Homme.
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Abstract
Postmortem counts of dopaminergic cell densities in the substantia nigra (5 subjects) and striatal levels of dopamine (DA) and its metabolites (6 subjects) were determined on 1 parkinsonian (PD), 3 progressive supranuclear palsy (PSP), 1 amyotrophic lateral sclerosis, and 1 Alzheimer's case who had been positron emission tomography scanned with 6-{18F}fluorodopa during life. {18F}Fluorodopa uptake rate constants, which presumably depend on the number of functioning striatal DA terminals, were strictly proportional to cell densities (significant correlation with zero intercept) and also correlated significantly with striatal DA levels but with an intercept indicating greater losses of DA than of terminals in PSP and PD
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British Columbia, neurodegenerative disorders cent.</s1><s2>Vancouver BC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver BC</wicri:noRegion></affiliation></author><author><name sortKey="Yamada, T" sort="Yamada, T" uniqKey="Yamada T" first="T." last="Yamada">T. Yamada</name></author><author><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D. B." last="Calne">D. B. Calne</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. British Columbia, neurodegenerative disorders cent.</s1><s2>Vancouver BC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver BC</wicri:noRegion></affiliation></author><author><name sortKey="Takahashi, H" sort="Takahashi, H" uniqKey="Takahashi H" first="H." last="Takahashi">H. Takahashi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. British Columbia, neurodegenerative disorders cent.</s1><s2>Vancouver BC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver BC</wicri:noRegion></affiliation></author><author><name sortKey="Kimura, H" sort="Kimura, H" uniqKey="Kimura H" first="H." last="Kimura">H. Kimura</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">94-0185932</idno><date when="1993">1993</date><idno type="stanalyst">PASCAL 94-0185932 INIST</idno><idno type="RBID">Pascal:94-0185932</idno><idno type="wicri:Area/PascalFrancis/Corpus">001029</idno><idno type="wicri:Area/PascalFrancis/Curation">000E96</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000F39</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000F39</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Human positron emission tomographic [<sup>18</sup>F]fluorodopa studies correlate with dopamine cell counts and levels</title><author><name sortKey="Snow, B J" sort="Snow, B J" uniqKey="Snow B" first="B. J." last="Snow">B. J. Snow</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. British Columbia, neurodegenerative disorders cent.</s1><s2>Vancouver BC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver BC</wicri:noRegion></affiliation></author><author><name sortKey="Tooyama, I" sort="Tooyama, I" uniqKey="Tooyama I" first="I." last="Tooyama">I. Tooyama</name></author><author><name sortKey="Mcgeer, E G" sort="Mcgeer, E G" uniqKey="Mcgeer E" first="E. G." last="Mcgeer">E. G. Mcgeer</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. British Columbia, neurodegenerative disorders cent.</s1><s2>Vancouver BC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver BC</wicri:noRegion></affiliation></author><author><name sortKey="Yamada, T" sort="Yamada, T" uniqKey="Yamada T" first="T." last="Yamada">T. Yamada</name></author><author><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D. B." last="Calne">D. B. Calne</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. British Columbia, neurodegenerative disorders cent.</s1><s2>Vancouver BC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver BC</wicri:noRegion></affiliation></author><author><name sortKey="Takahashi, H" sort="Takahashi, H" uniqKey="Takahashi H" first="H." last="Takahashi">H. Takahashi</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Univ. British Columbia, neurodegenerative disorders cent.</s1><s2>Vancouver BC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Vancouver BC</wicri:noRegion></affiliation></author><author><name sortKey="Kimura, H" sort="Kimura, H" uniqKey="Kimura H" first="H." last="Kimura">H. Kimura</name></author></analytic><series><title level="j" type="main">Annals of neurology</title><title level="j" type="abbreviated">Ann. neurol.</title><idno type="ISSN">0364-5134</idno><imprint><date when="1993">1993</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Annals of neurology</title><title level="j" type="abbreviated">Ann. neurol.</title><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alzheimer disease</term><term>Amyotrophic lateral sclerosis</term><term>Brain (vertebrata)</term><term>Cell density</term><term>Dopamine</term><term>Dopaminergic neuron</term><term>Human</term><term>Metabolite</term><term>Parkinson disease</term><term>Positron</term><term>Positron emission tomography</term><term>Postmortem</term><term>Progressive</term><term>Radionuclide study</term><term>Supranuclear paralysis</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Paralysie susnucléaire</term><term>Sclérose latérale amyotrophique</term><term>Densité cellulaire</term><term>Neurone dopaminergique</term><term>Tomoscintigraphie</term><term>Homme</term><term>Postmortem</term><term>Dopamine</term><term>Métabolite</term><term>Exploration radioisotopique</term><term>Progressif</term><term>Démence Alzheimer</term><term>Positon</term><term>Encéphale</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Postmortem counts of dopaminergic cell densities in the substantia nigra (5 subjects) and striatal levels of dopamine (DA) and its metabolites (6 subjects) were determined on 1 parkinsonian (PD), 3 progressive supranuclear palsy (PSP), 1 amyotrophic lateral sclerosis, and 1 Alzheimer's case who had been positron emission tomography scanned with 6-{<sup>18</sup>F}fluorodopa during life. {<sup>18</sup>F}Fluorodopa uptake rate constants, which presumably depend on the number of functioning striatal DA terminals, were strictly proportional to cell densities (significant correlation with zero intercept) and also correlated significantly with striatal DA levels but with an intercept indicating greater losses of DA than of terminals in PSP and PD</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0364-5134</s0></fA01><fA02 i1="01"><s0>ANNED3</s0></fA02><fA03 i2="1"><s0>Ann. neurol.</s0></fA03><fA05><s2>34</s2></fA05><fA06><s2>3</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Human positron emission tomographic [<sup>18</sup>F]fluorodopa studies correlate with dopamine cell counts and levels</s1></fA08><fA11 i1="01" i2="1"><s1>SNOW (B. J.)</s1></fA11><fA11 i1="02" i2="1"><s1>TOOYAMA (I.)</s1></fA11><fA11 i1="03" i2="1"><s1>MCGEER (E. G.)</s1></fA11><fA11 i1="04" i2="1"><s1>YAMADA (T.)</s1></fA11><fA11 i1="05" i2="1"><s1>CALNE (D. B.)</s1></fA11><fA11 i1="06" i2="1"><s1>TAKAHASHI (H.)</s1></fA11><fA11 i1="07" i2="1"><s1>KIMURA (H.)</s1></fA11><fA14 i1="01"><s1>Univ. British Columbia, neurodegenerative disorders cent.</s1><s2>Vancouver BC</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA20><s1>324-330</s1></fA20><fA21><s1>1993</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>16555</s2><s5>354000024155200030</s5></fA43><fA44><s0>0000</s0></fA44><fA45><s0>27 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>94-0185932</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Annals of neurology</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Postmortem counts of dopaminergic cell densities in the substantia nigra (5 subjects) and striatal levels of dopamine (DA) and its metabolites (6 subjects) were determined on 1 parkinsonian (PD), 3 progressive supranuclear palsy (PSP), 1 amyotrophic lateral sclerosis, and 1 Alzheimer's case who had been positron emission tomography scanned with 6-{<sup>18</sup>F}fluorodopa during life. {<sup>18</sup>F}Fluorodopa uptake rate constants, which presumably depend on the number of functioning striatal DA terminals, were strictly proportional to cell densities (significant correlation with zero intercept) and also correlated significantly with striatal DA levels but with an intercept indicating greater losses of DA than of terminals in PSP and PD</s0></fC01><fC02 i1="01" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Paralysie susnucléaire</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Supranuclear paralysis</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Parálisis supranuclear</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Sclérose latérale amyotrophique</s0><s2>NM</s2><s5>04</s5></fC03><fC03 i1="03" i2="X" 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i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Moelle épinière pathologie</s0><s5>47</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Spinal cord disease</s0><s5>47</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Médula espinal patología</s0><s5>47</s5></fC07><fN21><s1>090</s1></fN21></pA></standard></inist><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Kimura, H" sort="Kimura, H" uniqKey="Kimura H" first="H." last="Kimura">H. Kimura</name><name sortKey="Tooyama, I" sort="Tooyama, I" uniqKey="Tooyama I" first="I." last="Tooyama">I. Tooyama</name><name sortKey="Yamada, T" sort="Yamada, T" uniqKey="Yamada T" first="T." last="Yamada">T. Yamada</name></noCountry><country name="Canada"><noRegion><name sortKey="Snow, B J" sort="Snow, B J" uniqKey="Snow B" first="B. J." last="Snow">B. J. Snow</name></noRegion><name sortKey="Calne, D B" sort="Calne, D B" uniqKey="Calne D" first="D. B." last="Calne">D. B. Calne</name><name sortKey="Mcgeer, E G" sort="Mcgeer, E G" uniqKey="Mcgeer E" first="E. G." last="Mcgeer">E. G. Mcgeer</name><name sortKey="Takahashi, H" sort="Takahashi, H" uniqKey="Takahashi H" first="H." last="Takahashi">H. Takahashi</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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