ParkinsonCanadaV1, PascalFrancis, Checkpoint, bibRecord, 000B68

Ovarian steroids and raloxifene prevent MPTP-induced dopamine depletion in mice

Identifieur interne : 000B68 ( PascalFrancis/Checkpoint ); précédent : 000B67; suivant : 000B69

Ovarian steroids and raloxifene prevent MPTP-induced dopamine depletion in mice

Auteurs : M. Grandbois [Canada] ; M. Morissette [Canada] ; S. Callier [Canada, France] ; T. Di Paolo [Canada]

Source :

Neuroreport : (Oxford) [ 0959-4965 ] ; 2000.

RBID : Pascal:00-0365236

Descripteurs français

Pascal (Inist)
- Modèle animal, Parkinson maladie, Voie dopaminergique, Mâle, Estradiol, Encéphale, Animal, Souris, Souris C57BL/6.

English descriptors

KwdEn :
- Animal, Animal model, Brain (vertebrata), Dopaminergic pathway, Estradiol, Male, Mouse, Parkinson disease.

Abstract

The activity of steroids was studied in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned retired breeder C57BL/6 male mice as a model of Parkinson's disease. Steroids were injected daily for 5 days before MPTP (4 injections, 15 mg/kg i.p;, at 2 h intervals) and hormonal treatment continued for 5 more days. Mice that received 17β-estradiol or progesterone or raloxifene (a selective estrogen receptor modulator) and MPTP had striatal concentrations of dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) similar to those in control animals, whereas mice that received MPTP alone or with 17α-estradiol (the isomer with weak estrogenic activity) has an extensive decrease of DA and its metabolites. These results suggest stereospecific prevention of MPTP-induced dopamine loss by 17β-estradiol, which is also observed with progesterone and raloxifene.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">The activity of steroids was studied in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) lesioned retired breeder C57BL/6 male mice as a model of Parkinson's disease. Steroids were injected daily for 5 days before MPTP (4 injections, 15 mg/kg i.p;, at 2 h intervals) and hormonal treatment continued for 5 more days. Mice that received 17β-estradiol or progesterone or raloxifene (a selective estrogen receptor modulator) and MPTP had striatal concentrations of dopamine (DA) and its metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) similar to those in control animals, whereas mice that received MPTP alone or with 17α-estradiol (the isomer with weak estrogenic activity) has an extensive decrease of DA and its metabolites. These results suggest stereospecific prevention of MPTP-induced dopamine loss by 17β-estradiol, which is also observed with progesterone and raloxifene.</div>
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<s5>35</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>35</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>35</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Rodentia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="FRE"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="ENG"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="04" i2="X" l="SPA"><s0>Mammalia</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Vertebrata</s0>
<s2>NS</s2>
</fC07>
<fN21><s1>248</s1>
</fN21>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Canada</li>
<li>France</li>
</country>
<region><li>Île-de-France</li>
</region>
<settlement><li>Paris</li>
</settlement>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Grandbois, M" sort="Grandbois, M" uniqKey="Grandbois M" first="M." last="Grandbois">M. Grandbois</name>
</noRegion>
<name sortKey="Callier, S" sort="Callier, S" uniqKey="Callier S" first="S." last="Callier">S. Callier</name>
<name sortKey="Callier, S" sort="Callier, S" uniqKey="Callier S" first="S." last="Callier">S. Callier</name>
<name sortKey="Di Paolo, T" sort="Di Paolo, T" uniqKey="Di Paolo T" first="T." last="Di Paolo">T. Di Paolo</name>
<name sortKey="Di Paolo, T" sort="Di Paolo, T" uniqKey="Di Paolo T" first="T." last="Di Paolo">T. Di Paolo</name>
<name sortKey="Grandbois, M" sort="Grandbois, M" uniqKey="Grandbois M" first="M." last="Grandbois">M. Grandbois</name>
<name sortKey="Morissette, M" sort="Morissette, M" uniqKey="Morissette M" first="M." last="Morissette">M. Morissette</name>
<name sortKey="Morissette, M" sort="Morissette, M" uniqKey="Morissette M" first="M." last="Morissette">M. Morissette</name>
</country>
<country name="France"><region name="Île-de-France"><name sortKey="Callier, S" sort="Callier, S" uniqKey="Callier S" first="S." last="Callier">S. Callier</name>
</region>
</country>
</tree>
</affiliations>
</record>

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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Ovarian steroids and raloxifene prevent MPTP-induced dopamine depletion in mice

Ovarian steroids and raloxifene prevent MPTP-induced dopamine depletion in mice

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