Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease
Identifieur interne : 000A04 ( PascalFrancis/Checkpoint ); précédent : 000A03; suivant : 000A05Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease
Auteurs : Aviva Abosch [Canada] ; William D. Hutchison ; Jean A. Saint-Cyr ; Jonathan O. Dostrovsky ; Andres M. LozanoSource :
- Journal of neurosurgery [ 0022-3085 ] ; 2002.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Object. The subthalamic nucleus (STN) is a target in the surgical treatment of Parkinson disease (PD). Little is known about the neurons within the human STN that modulate movement. The authors' goal was to examine the distribution of movement-related neurons within the STN of humans by using microelectrode recording to identify neuronal receptive fields. Methods. Data were retrospectively collected from microelectrode recordings that had been obtained in 38 patients with PD during surgery for placement of STN deep brain stimulation electrodes. The recordings had been obtained in awake, nonsedated patients. Antiparkinsonian medications were withheld the night before surgery. Neuronal discharges were amplified, filtered, and displayed on an oscilloscope and fed to an audio monitor. The receptive fields were identified by the presence of reproducible, audible changes in the firing rate that were time-locked to the movement of specific joint(s). The median number of electrode tracks per patient was six (range two-nine). The receptive fields were identified in 278 (55%) of 510 STN neurons studied. One hundred one tracks yielded receptive field data. Fourteen percent of 64 cells tested positive for face receptive fields, 32% of 687 cells tested positive for upper-extremity receptive fields, and 21% of 242 cells tested positive for lower-extremity receptive fields. Sixty-eight cells (24%) demonstrated multiple-joint receptive fields. Ninety-three cells (65%) with movement-related receptive fields were located in the dorsal half of the STN, and 96.8% of these were located in the rostral two thirds of the STN. Analysis of receptive field locations from pooled data and along individual electrode tracks failed to reveal a consistent somatotopic organization. Conclusions. Data from this study demonstrate a regional compartmentalization of neurons with movement-related receptive fields within the STN, supporting the existence of specific motor territories within the STN in patients suffering from PD.
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
Pascal:03-0064789Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease</title><author><name sortKey="Abosch, Aviva" sort="Abosch, Aviva" uniqKey="Abosch A" first="Aviva" last="Abosch">Aviva Abosch</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgery, Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute</s1><s2>Ontario</s2><s3>CAN</s3></inist:fA14><country>Canada</country><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Physiology, University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D." last="Hutchison">William D. Hutchison</name></author><author><name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A." last="Saint-Cyr">Jean A. Saint-Cyr</name></author><author><name sortKey="Dostrovsky, Jonathan O" sort="Dostrovsky, Jonathan O" uniqKey="Dostrovsky J" first="Jonathan O." last="Dostrovsky">Jonathan O. Dostrovsky</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">03-0064789</idno><date when="2002">2002</date><idno type="stanalyst">PASCAL 03-0064789 INIST</idno><idno type="RBID">Pascal:03-0064789</idno><idno type="wicri:Area/PascalFrancis/Corpus">000B40</idno><idno type="wicri:Area/PascalFrancis/Curation">000183</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000A04</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000A04</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease</title><author><name sortKey="Abosch, Aviva" sort="Abosch, Aviva" uniqKey="Abosch A" first="Aviva" last="Abosch">Aviva Abosch</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Surgery, Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute</s1><s2>Ontario</s2><s3>CAN</s3></inist:fA14><country>Canada</country><wicri:noRegion>Ontario</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Physiology, University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3></inist:fA14><country>Canada</country><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName><orgName type="university">Université de Toronto</orgName></affiliation></author><author><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D." last="Hutchison">William D. Hutchison</name></author><author><name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A." last="Saint-Cyr">Jean A. Saint-Cyr</name></author><author><name sortKey="Dostrovsky, Jonathan O" sort="Dostrovsky, Jonathan O" uniqKey="Dostrovsky J" first="Jonathan O." last="Dostrovsky">Jonathan O. Dostrovsky</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name></author></analytic><series><title level="j" type="main">Journal of neurosurgery</title><title level="j" type="abbreviated">J. neurosurg.</title><idno type="ISSN">0022-3085</idno><imprint><date when="2002">2002</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of neurosurgery</title><title level="j" type="abbreviated">J. neurosurg.</title><idno type="ISSN">0022-3085</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Exploration</term><term>Human</term><term>Microelectrode</term><term>Neuron</term><term>Parkinson disease</term><term>Receptive field</term><term>Subthalamic nucleus</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Noyau sousthalamique</term><term>Champ récepteur</term><term>Neurone</term><term>Microélectrode</term><term>Exploration</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Object. The subthalamic nucleus (STN) is a target in the surgical treatment of Parkinson disease (PD). Little is known about the neurons within the human STN that modulate movement. The authors' goal was to examine the distribution of movement-related neurons within the STN of humans by using microelectrode recording to identify neuronal receptive fields. Methods. Data were retrospectively collected from microelectrode recordings that had been obtained in 38 patients with PD during surgery for placement of STN deep brain stimulation electrodes. The recordings had been obtained in awake, nonsedated patients. Antiparkinsonian medications were withheld the night before surgery. Neuronal discharges were amplified, filtered, and displayed on an oscilloscope and fed to an audio monitor. The receptive fields were identified by the presence of reproducible, audible changes in the firing rate that were time-locked to the movement of specific joint(s). The median number of electrode tracks per patient was six (range two-nine). The receptive fields were identified in 278 (55%) of 510 STN neurons studied. One hundred one tracks yielded receptive field data. Fourteen percent of 64 cells tested positive for face receptive fields, 32% of 687 cells tested positive for upper-extremity receptive fields, and 21% of 242 cells tested positive for lower-extremity receptive fields. Sixty-eight cells (24%) demonstrated multiple-joint receptive fields. Ninety-three cells (65%) with movement-related receptive fields were located in the dorsal half of the STN, and 96.8% of these were located in the rostral two thirds of the STN. Analysis of receptive field locations from pooled data and along individual electrode tracks failed to reveal a consistent somatotopic organization. Conclusions. Data from this study demonstrate a regional compartmentalization of neurons with movement-related receptive fields within the STN, supporting the existence of specific motor territories within the STN in patients suffering from PD.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-3085</s0></fA01><fA02 i1="01"><s0>JONSAC</s0></fA02><fA03 i2="1"><s0>J. neurosurg.</s0></fA03><fA05><s2>97</s2></fA05><fA06><s2>5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease</s1></fA08><fA11 i1="01" i2="1"><s1>ABOSCH (Aviva)</s1></fA11><fA11 i1="02" i2="1"><s1>HUTCHISON (William D.)</s1></fA11><fA11 i1="03" i2="1"><s1>SAINT-CYR (Jean A.)</s1></fA11><fA11 i1="04" i2="1"><s1>DOSTROVSKY (Jonathan O.)</s1></fA11><fA11 i1="05" i2="1"><s1>LOZANO (Andres M.)</s1></fA11><fA14 i1="01"><s1>Department of Surgery, Division of Neurosurgery, Toronto Western Hospital, Toronto Western Research Institute</s1><s2>Ontario</s2><s3>CAN</s3></fA14><fA14 i1="02"><s1>Department of Physiology, University of Toronto</s1><s2>Ontario</s2><s3>CAN</s3></fA14><fA20><s1>1167-1172</s1></fA20><fA21><s1>2002</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>6023</s2><s5>354000105190400230</s5></fA43><fA44><s0>0000</s0><s1>© 2003 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>26 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>03-0064789</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Journal of neurosurgery</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Object. The subthalamic nucleus (STN) is a target in the surgical treatment of Parkinson disease (PD). Little is known about the neurons within the human STN that modulate movement. The authors' goal was to examine the distribution of movement-related neurons within the STN of humans by using microelectrode recording to identify neuronal receptive fields. Methods. Data were retrospectively collected from microelectrode recordings that had been obtained in 38 patients with PD during surgery for placement of STN deep brain stimulation electrodes. The recordings had been obtained in awake, nonsedated patients. Antiparkinsonian medications were withheld the night before surgery. Neuronal discharges were amplified, filtered, and displayed on an oscilloscope and fed to an audio monitor. The receptive fields were identified by the presence of reproducible, audible changes in the firing rate that were time-locked to the movement of specific joint(s). The median number of electrode tracks per patient was six (range two-nine). The receptive fields were identified in 278 (55%) of 510 STN neurons studied. One hundred one tracks yielded receptive field data. Fourteen percent of 64 cells tested positive for face receptive fields, 32% of 687 cells tested positive for upper-extremity receptive fields, and 21% of 242 cells tested positive for lower-extremity receptive fields. Sixty-eight cells (24%) demonstrated multiple-joint receptive fields. Ninety-three cells (65%) with movement-related receptive fields were located in the dorsal half of the STN, and 96.8% of these were located in the rostral two thirds of the STN. Analysis of receptive field locations from pooled data and along individual electrode tracks failed to reveal a consistent somatotopic organization. Conclusions. Data from this study demonstrate a regional compartmentalization of neurons with movement-related receptive fields within the STN, supporting the existence of specific motor territories within the STN in patients suffering from PD.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Parkinson maladie</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Noyau sousthalamique</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Subthalamic nucleus</s0><s5>04</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Núcleo subtalámico</s0><s5>04</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Champ récepteur</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Receptive field</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Campo receptor</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Neurone</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Neuron</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Neurona</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Microélectrode</s0><s5>13</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Microelectrode</s0><s5>13</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Microeléctrodo</s0><s5>13</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Exploration</s0><s5>17</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Exploration</s0><s5>17</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Exploración</s0><s5>17</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Homme</s0><s5>20</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Human</s0><s5>20</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Hombre</s0><s5>20</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Système nerveux pathologie</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Encéphale pathologie</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Encéphale</s0><s5>45</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Brain (vertebrata)</s0><s5>45</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Encéfalo</s0><s5>45</s5></fC07><fN21><s1>034</s1></fN21><fN82><s1>PSI</s1></fN82></pA></standard></inist><affiliations><list><country><li>Canada</li></country><region><li>Ontario</li></region><settlement><li>Toronto</li></settlement><orgName><li>Université de Toronto</li></orgName></list><tree><noCountry><name sortKey="Dostrovsky, Jonathan O" sort="Dostrovsky, Jonathan O" uniqKey="Dostrovsky J" first="Jonathan O." last="Dostrovsky">Jonathan O. Dostrovsky</name><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D." last="Hutchison">William D. Hutchison</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M." last="Lozano">Andres M. Lozano</name><name sortKey="Saint Cyr, Jean A" sort="Saint Cyr, Jean A" uniqKey="Saint Cyr J" first="Jean A." last="Saint-Cyr">Jean A. Saint-Cyr</name></noCountry><country name="Canada"><noRegion><name sortKey="Abosch, Aviva" sort="Abosch, Aviva" uniqKey="Abosch A" first="Aviva" last="Abosch">Aviva Abosch</name></noRegion><name sortKey="Abosch, Aviva" sort="Abosch, Aviva" uniqKey="Abosch A" first="Aviva" last="Abosch">Aviva Abosch</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/PascalFrancis/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000A04 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 000A04 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= PascalFrancis
|étape= Checkpoint
|type= RBID
|clé= Pascal:03-0064789
|texte= Movement-related neurons of the subthalamic nucleus in patients with Parkinson disease
}}
| This area was generated with Dilib version V0.6.29. |  |