ParkinsonCanadaV1, PascalFrancis, Checkpoint, bibRecord, 000656

Dopamine dysregulation syndrome : implications for a dopamine hypothesis of bipolar disorder

Identifieur interne : 000656 ( PascalFrancis/Checkpoint ); précédent : 000655; suivant : 000657

Dopamine dysregulation syndrome : implications for a dopamine hypothesis of bipolar disorder

Auteurs : M. Berk [Australie] ; S. Dodd [Australie] ; M. Kauer-Sant'Anna [Canada] ; G. S. Malhi [Australie] ; M. Bourin [France] ; F. Kapczinski [Brésil] ; T. Norman [Australie]

Source :

Acta psychiatrica scandinavica. Supplementum [ 0065-1591 ] ; 2007.

RBID : Pascal:08-0007460

Descripteurs français

Pascal (Inist)
- Dopamine, Trouble bipolaire, Manie, Etat dépressif, Physiopathologie, Transmission dopaminergique, Psychopharmacologie, Article synthèse, Homme.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Bipolar disorder, Depression, Dopamine, Dopaminergic transmission, Human, Mania, Pathophysiology, Psychopharmacology, Review.

Abstract

Objective: Rational therapeutic development in bipolar is hampered by a lack of pathophysiological model. However, there is a wealth of converging data on the role of dopamine in bipolar disorder. This paper therefore examines the possibility of a dopamine hypothesis for bipolar disorder. Method: A literature search was conducted using standard search engines Embase, PyschLIT, PubMed and MEDLINE. In addition, papers and book chapters known to the authors were retrieved and examined for further relevant articles. Results: Collectively, in excess of 100 articles were reviewed from which approximately 75% were relevant to the focus of this paper. Conclusion: Pharmacological models suggest a role of increased dopaminergic drive in mania and the converse in depression. In Parkinson's disease, administration of high-dose dopamine precursors can produce a 'maniform' picture, which switches into a depressive analogue on withdrawal. It is possible that in bipolar disorder there is a cyclical process, where increased dopaminergic transmission in mania leads to a secondary down regulation of dopaminergic receptor sensitivity over time. This may lead to a period of decreased dopaminergic transmission, corresponding with the depressive phase, and the repetition of the cycle. This model, if verified, may have implications for rational drug development.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Objective: Rational therapeutic development in bipolar is hampered by a lack of pathophysiological model. However, there is a wealth of converging data on the role of dopamine in bipolar disorder. This paper therefore examines the possibility of a dopamine hypothesis for bipolar disorder. Method: A literature search was conducted using standard search engines Embase, PyschLIT, PubMed and MEDLINE. In addition, papers and book chapters known to the authors were retrieved and examined for further relevant articles. Results: Collectively, in excess of 100 articles were reviewed from which approximately 75% were relevant to the focus of this paper. Conclusion: Pharmacological models suggest a role of increased dopaminergic drive in mania and the converse in depression. In Parkinson's disease, administration of high-dose dopamine precursors can produce a 'maniform' picture, which switches into a depressive analogue on withdrawal. It is possible that in bipolar disorder there is a cyclical process, where increased dopaminergic transmission in mania leads to a secondary down regulation of dopaminergic receptor sensitivity over time. This may lead to a period of decreased dopaminergic transmission, corresponding with the depressive phase, and the repetition of the cycle. This model, if verified, may have implications for rational drug development.</div>
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<fC03 i1="04" i2="X" l="ENG"><s0>Depression</s0>
<s5>04</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Estado depresivo</s0>
<s5>04</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Physiopathologie</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Pathophysiology</s0>
<s5>05</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Fisiopatología</s0>
<s5>05</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Transmission dopaminergique</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Dopaminergic transmission</s0>
<s5>06</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Transmisión dopaminérgica</s0>
<s5>06</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Psychopharmacologie</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Psychopharmacology</s0>
<s5>07</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Psicofarmacología</s0>
<s5>07</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Article synthèse</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Review</s0>
<s5>08</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Artículo síntesis</s0>
<s5>08</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Homme</s0>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Human</s0>
<s5>18</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Hombre</s0>
<s5>18</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Catécholamine</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Catecholamine</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Catecolamina</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Neurotransmetteur</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Neurotransmitter</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Neurotransmisor</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE"><s0>Trouble de l'humeur</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG"><s0>Mood disorder</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA"><s0>Trastorno humor</s0>
<s5>39</s5>
</fC07>
<fN21><s1>007</s1>
</fN21>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Australie</li>
<li>Brésil</li>
<li>Canada</li>
<li>France</li>
</country>
<region><li>Pays de la Loire</li>
<li>Rio Grande do Sul</li>
</region>
<settlement><li>Nantes</li>
</settlement>
<orgName><li>Université de Nantes</li>
</orgName>
</list>
<tree><country name="Australie"><noRegion><name sortKey="Berk, M" sort="Berk, M" uniqKey="Berk M" first="M." last="Berk">M. Berk</name>
</noRegion>
<name sortKey="Berk, M" sort="Berk, M" uniqKey="Berk M" first="M." last="Berk">M. Berk</name>
<name sortKey="Berk, M" sort="Berk, M" uniqKey="Berk M" first="M." last="Berk">M. Berk</name>
<name sortKey="Dodd, S" sort="Dodd, S" uniqKey="Dodd S" first="S." last="Dodd">S. Dodd</name>
<name sortKey="Malhi, G S" sort="Malhi, G S" uniqKey="Malhi G" first="G. S." last="Malhi">G. S. Malhi</name>
<name sortKey="Malhi, G S" sort="Malhi, G S" uniqKey="Malhi G" first="G. S." last="Malhi">G. S. Malhi</name>
<name sortKey="Norman, T" sort="Norman, T" uniqKey="Norman T" first="T." last="Norman">T. Norman</name>
</country>
<country name="Canada"><noRegion><name sortKey="Kauer Sant Anna, M" sort="Kauer Sant Anna, M" uniqKey="Kauer Sant Anna M" first="M." last="Kauer-Sant'Anna">M. Kauer-Sant'Anna</name>
</noRegion>
</country>
<country name="France"><region name="Pays de la Loire"><name sortKey="Bourin, M" sort="Bourin, M" uniqKey="Bourin M" first="M." last="Bourin">M. Bourin</name>
</region>
</country>
<country name="Brésil"><region name="Rio Grande do Sul"><name sortKey="Kapczinski, F" sort="Kapczinski, F" uniqKey="Kapczinski F" first="F." last="Kapczinski">F. Kapczinski</name>
</region>
</country>
</tree>
</affiliations>
</record>

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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Dopamine dysregulation syndrome : implications for a dopamine hypothesis of bipolar disorder

Dopamine dysregulation syndrome : implications for a dopamine hypothesis of bipolar disorder

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