ParkinsonCanadaV1, PascalFrancis, Checkpoint, bibRecord, 000647

Human retinal pigment epithelial cell implants ameliorate motor deficits in two rat models of parkinson disease

Identifieur interne : 000647 ( PascalFrancis/Checkpoint ); précédent : 000646; suivant : 000648

Human retinal pigment epithelial cell implants ameliorate motor deficits in two rat models of parkinson disease

Auteurs : Ivan L. Cepeda [Canada] ; Joseph Flores [Canada] ; Michael L. Cornfeldt [États-Unis] ; John R. O'Kusky [Canada] ; Doris J. Doudet [Canada]

Source :

Journal of neuropathology and experimental neurology [ 0022-3069 ] ; 2007.

RBID : Pascal:07-0349205

Descripteurs français

Pascal (Inist)
- Système nerveux pathologie, Parkinson maladie, Parkinsonisme, Homme, Rétine, Cellule pigmentaire, Cellule épithéliale, Implant, Modèle animal, Rat, Noyau gris central, Epithélium pigmentaire, Corps strié, Transplantation.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Animal model, Basal ganglion, Corpus striatum, Epithelial cell, Human, Implant, Nervous system diseases, Parkinson disease, Parkinsonism, Pigment cell, Pigment epithelium, Rat, Retina, Transplantation.

Abstract

Intrastriatal transplantation of gelatin microcarrier-attached human retinal pigment epithelial cells (hRPE-GM) may represent an alternative source for cell therapy in Parkinson disease (PD). The use of human retinal pigment epithelial (hRPE) cells in PD relies on the capacity of these cells to produce L-dopa as an intermediate product in the eumelanin synthesis pathway. We investigated the behavioral effects of hRPE-GM implants on forelimb use asymmetries and hindlimb motor deficits in unilateral and bilateral 6-hydroxydopamine (6-OHDA) rat models of PD. We report that intrastriatal unilateral implantation of hRPE-GM in rats with 6-OHDA nigrostriatal lesions produce an amelioration of the contralateral forelimb disuse and the contralateral hindlimb deficits. These results further support the possibility that implantation of cultured hRPE cells may be a promising therapeutic option for patients with PD.

Affiliations:

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Pascal:07-0349205

Le document en format XML

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<fC07 i1="07" i2="X" l="FRE"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Maladie dégénérative</s0>
<s5>41</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Degenerative disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0>
<s5>41</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Système nerveux central pathologie</s0>
<s5>42</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>42</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>42</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Système nerveux central</s0>
<s5>43</s5>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Central nervous system</s0>
<s5>43</s5>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Sistema nervioso central</s0>
<s5>43</s5>
</fC07>
<fN21><s1>225</s1>
</fN21>
<fN44 i1="01"><s1>OTO</s1>
</fN44>
<fN82><s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>New Jersey</li>
</region>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Cepeda, Ivan L" sort="Cepeda, Ivan L" uniqKey="Cepeda I" first="Ivan L." last="Cepeda">Ivan L. Cepeda</name>
</noRegion>
<name sortKey="Doudet, Doris J" sort="Doudet, Doris J" uniqKey="Doudet D" first="Doris J." last="Doudet">Doris J. Doudet</name>
<name sortKey="Flores, Joseph" sort="Flores, Joseph" uniqKey="Flores J" first="Joseph" last="Flores">Joseph Flores</name>
<name sortKey="O Kusky, John R" sort="O Kusky, John R" uniqKey="O Kusky J" first="John R." last="O'Kusky">John R. O'Kusky</name>
</country>
<country name="États-Unis"><region name="New Jersey"><name sortKey="Cornfeldt, Michael L" sort="Cornfeldt, Michael L" uniqKey="Cornfeldt M" first="Michael L." last="Cornfeldt">Michael L. Cornfeldt</name>
</region>
</country>
</tree>
</affiliations>
</record>

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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

Human retinal pigment epithelial cell implants ameliorate motor deficits in two rat models of parkinson disease

Human retinal pigment epithelial cell implants ameliorate motor deficits in two rat models of parkinson disease

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