La maladie de Parkinson au Canada (serveur d'exploration)

Attention, ce site est en cours de développement !
Attention, site généré par des moyens informatiques à partir de corpus bruts.
Les informations ne sont donc pas validées.

Statistical determination of the optimal subthalamic nucleus stimulation site in patients with Parkinson disease

Identifieur interne : 000601 ( PascalFrancis/Checkpoint ); précédent : 000600; suivant : 000602

Statistical determination of the optimal subthalamic nucleus stimulation site in patients with Parkinson disease

Auteurs : Dominique Guehl [France] ; Roderick Edwards [Canada] ; Emmanuel Cuny [France] ; Pierre Burbaud [France] ; Alain Rougier [France] ; Julien Modolo [France] ; Anne Beuter [France]

Source :

RBID : Pascal:07-0153227

Descripteurs français

English descriptors

Abstract

Object. The subthalamic nucleus (STN) is currently recognized as the preferred target for deep brain stimulation (DBS) in patients with Parkinson disease (PD). If there is agreement in the literature that DBS improves motor symptoms significantly, the situation is less clear with respect to the side effects of this procedure. The goal of this study was to correlate the coordinate values of active electrode contacts with the amplitude of residual clinical symptoms and side effects using a mathematical approach. Methods. In this study the investigators examined a cohort of 41 patients with PD who received clinical benefits from DBS after stimulating electrodes had been implanted bilaterally into the STN. The combined scores of residual clinical symptoms plus side effects, including speech disturbance, postural instability, and weight gain, were fitted by using either inverted ellipsoidal exponentials or smooth splines. These analyses showed evidence of lower combined scores for stimulating contacts at an x coordinate approximately 12.0 to 12.3 mm lateral to the anterior commissure-posterior commissure (AC-PC) line and at a z coordinate approximately 3.1 to 3.3 mm under the AC-PC line. There was insufficient evidence for a preferred y coordinate location. Conclusions. The authors propose a "best" therapeutic ellipse area that is centered at an x, z location of 12.5 mm, -3.3 mm and characterized by an extension of 1.85 mm in the x direction and 2.22 mm in the z direction. Therapeutic electrode contacts located within this area are well correlated with the lowest occurrence of residual symptoms and the lowest occurrence of side effects independent of STN anatomical considerations. The lack of a significant result in the y direction remains to be explored further.


Affiliations:


Links toward previous steps (curation, corpus...)


Links to Exploration step

Pascal:07-0153227

Le document en format XML

<record>
<TEI>
<teiHeader>
<fileDesc>
<titleStmt>
<title xml:lang="en" level="a">Statistical determination of the optimal subthalamic nucleus stimulation site in patients with Parkinson disease</title>
<author>
<name sortKey="Guehl, Dominique" sort="Guehl, Dominique" uniqKey="Guehl D" first="Dominique" last="Guehl">Dominique Guehl</name>
<affiliation wicri:level="4">
<inist:fA14 i1="01">
<s1>Service de Neurophysiologie Clinique, Hôpital Pellegrin, Université de Bordeaux</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Université de Bordeaux</wicri:noRegion>
<placeName>
<settlement type="city">Bordeaux</settlement>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
<author>
<name sortKey="Edwards, Roderick" sort="Edwards, Roderick" uniqKey="Edwards R" first="Roderick" last="Edwards">Roderick Edwards</name>
<affiliation wicri:level="1">
<inist:fA14 i1="02">
<s1>Department of Mathematics and Statistics, University of Victoria</s1>
<s2>British Columbia</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Cuny, Emmanuel" sort="Cuny, Emmanuel" uniqKey="Cuny E" first="Emmanuel" last="Cuny">Emmanuel Cuny</name>
<affiliation wicri:level="4">
<inist:fA14 i1="03">
<s1>Service de Neurochirurgie, et Service de Neurologie, Hôpital Pellegrin, Université de Bordeaux</s1>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Université de Bordeaux</wicri:noRegion>
<placeName>
<settlement type="city">Bordeaux</settlement>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
<author>
<name sortKey="Burbaud, Pierre" sort="Burbaud, Pierre" uniqKey="Burbaud P" first="Pierre" last="Burbaud">Pierre Burbaud</name>
<affiliation wicri:level="4">
<inist:fA14 i1="01">
<s1>Service de Neurophysiologie Clinique, Hôpital Pellegrin, Université de Bordeaux</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Université de Bordeaux</wicri:noRegion>
<placeName>
<settlement type="city">Bordeaux</settlement>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
<author>
<name sortKey="Rougier, Alain" sort="Rougier, Alain" uniqKey="Rougier A" first="Alain" last="Rougier">Alain Rougier</name>
<affiliation wicri:level="4">
<inist:fA14 i1="03">
<s1>Service de Neurochirurgie, et Service de Neurologie, Hôpital Pellegrin, Université de Bordeaux</s1>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Université de Bordeaux</wicri:noRegion>
<placeName>
<settlement type="city">Bordeaux</settlement>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
<author>
<name sortKey="Modolo, Julien" sort="Modolo, Julien" uniqKey="Modolo J" first="Julien" last="Modolo">Julien Modolo</name>
<affiliation wicri:level="3">
<inist:fA14 i1="04">
<s1>Institut de Cognitique, Université Victor Segalen Bordeaux</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName>
<region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Beuter, Anne" sort="Beuter, Anne" uniqKey="Beuter A" first="Anne" last="Beuter">Anne Beuter</name>
<affiliation wicri:level="3">
<inist:fA14 i1="04">
<s1>Institut de Cognitique, Université Victor Segalen Bordeaux</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName>
<region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt>
<idno type="wicri:source">INIST</idno>
<idno type="inist">07-0153227</idno>
<date when="2007">2007</date>
<idno type="stanalyst">PASCAL 07-0153227 INIST</idno>
<idno type="RBID">Pascal:07-0153227</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000765</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000555</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000601</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000601</idno>
</publicationStmt>
<sourceDesc>
<biblStruct>
<analytic>
<title xml:lang="en" level="a">Statistical determination of the optimal subthalamic nucleus stimulation site in patients with Parkinson disease</title>
<author>
<name sortKey="Guehl, Dominique" sort="Guehl, Dominique" uniqKey="Guehl D" first="Dominique" last="Guehl">Dominique Guehl</name>
<affiliation wicri:level="4">
<inist:fA14 i1="01">
<s1>Service de Neurophysiologie Clinique, Hôpital Pellegrin, Université de Bordeaux</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Université de Bordeaux</wicri:noRegion>
<placeName>
<settlement type="city">Bordeaux</settlement>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
<author>
<name sortKey="Edwards, Roderick" sort="Edwards, Roderick" uniqKey="Edwards R" first="Roderick" last="Edwards">Roderick Edwards</name>
<affiliation wicri:level="1">
<inist:fA14 i1="02">
<s1>Department of Mathematics and Statistics, University of Victoria</s1>
<s2>British Columbia</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia</wicri:noRegion>
</affiliation>
</author>
<author>
<name sortKey="Cuny, Emmanuel" sort="Cuny, Emmanuel" uniqKey="Cuny E" first="Emmanuel" last="Cuny">Emmanuel Cuny</name>
<affiliation wicri:level="4">
<inist:fA14 i1="03">
<s1>Service de Neurochirurgie, et Service de Neurologie, Hôpital Pellegrin, Université de Bordeaux</s1>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Université de Bordeaux</wicri:noRegion>
<placeName>
<settlement type="city">Bordeaux</settlement>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
<author>
<name sortKey="Burbaud, Pierre" sort="Burbaud, Pierre" uniqKey="Burbaud P" first="Pierre" last="Burbaud">Pierre Burbaud</name>
<affiliation wicri:level="4">
<inist:fA14 i1="01">
<s1>Service de Neurophysiologie Clinique, Hôpital Pellegrin, Université de Bordeaux</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Université de Bordeaux</wicri:noRegion>
<placeName>
<settlement type="city">Bordeaux</settlement>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
<author>
<name sortKey="Rougier, Alain" sort="Rougier, Alain" uniqKey="Rougier A" first="Alain" last="Rougier">Alain Rougier</name>
<affiliation wicri:level="4">
<inist:fA14 i1="03">
<s1>Service de Neurochirurgie, et Service de Neurologie, Hôpital Pellegrin, Université de Bordeaux</s1>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>France</country>
<wicri:noRegion>Université de Bordeaux</wicri:noRegion>
<placeName>
<settlement type="city">Bordeaux</settlement>
<region type="region" nuts="2">Nouvelle-Aquitaine</region>
<region type="old region" nuts="2">Aquitaine</region>
</placeName>
<orgName type="university">Université de Bordeaux</orgName>
</affiliation>
</author>
<author>
<name sortKey="Modolo, Julien" sort="Modolo, Julien" uniqKey="Modolo J" first="Julien" last="Modolo">Julien Modolo</name>
<affiliation wicri:level="3">
<inist:fA14 i1="04">
<s1>Institut de Cognitique, Université Victor Segalen Bordeaux</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName>
<region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
<author>
<name sortKey="Beuter, Anne" sort="Beuter, Anne" uniqKey="Beuter A" first="Anne" last="Beuter">Anne Beuter</name>
<affiliation wicri:level="3">
<inist:fA14 i1="04">
<s1>Institut de Cognitique, Université Victor Segalen Bordeaux</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>France</country>
<placeName>
<region type="region">Nouvelle-Aquitaine</region>
<region type="old region">Aquitaine</region>
<settlement type="city">Bordeaux</settlement>
</placeName>
</affiliation>
</author>
</analytic>
<series>
<title level="j" type="main">Journal of neurosurgery</title>
<title level="j" type="abbreviated">J. neurosurg.</title>
<idno type="ISSN">0022-3085</idno>
<imprint>
<date when="2007">2007</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt>
<title level="j" type="main">Journal of neurosurgery</title>
<title level="j" type="abbreviated">J. neurosurg.</title>
<idno type="ISSN">0022-3085</idno>
</seriesStmt>
</fileDesc>
<profileDesc>
<textClass>
<keywords scheme="KwdEn" xml:lang="en">
<term>Human</term>
<term>Parkinson disease</term>
<term>Subthalamic nucleus</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr">
<term>Parkinson maladie</term>
<term>Noyau sousthalamique</term>
<term>Homme</term>
</keywords>
<keywords scheme="Wicri" type="topic" xml:lang="fr">
<term>Homme</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front>
<div type="abstract" xml:lang="en">Object. The subthalamic nucleus (STN) is currently recognized as the preferred target for deep brain stimulation (DBS) in patients with Parkinson disease (PD). If there is agreement in the literature that DBS improves motor symptoms significantly, the situation is less clear with respect to the side effects of this procedure. The goal of this study was to correlate the coordinate values of active electrode contacts with the amplitude of residual clinical symptoms and side effects using a mathematical approach. Methods. In this study the investigators examined a cohort of 41 patients with PD who received clinical benefits from DBS after stimulating electrodes had been implanted bilaterally into the STN. The combined scores of residual clinical symptoms plus side effects, including speech disturbance, postural instability, and weight gain, were fitted by using either inverted ellipsoidal exponentials or smooth splines. These analyses showed evidence of lower combined scores for stimulating contacts at an x coordinate approximately 12.0 to 12.3 mm lateral to the anterior commissure-posterior commissure (AC-PC) line and at a z coordinate approximately 3.1 to 3.3 mm under the AC-PC line. There was insufficient evidence for a preferred y coordinate location. Conclusions. The authors propose a "best" therapeutic ellipse area that is centered at an x, z location of 12.5 mm, -3.3 mm and characterized by an extension of 1.85 mm in the x direction and 2.22 mm in the z direction. Therapeutic electrode contacts located within this area are well correlated with the lowest occurrence of residual symptoms and the lowest occurrence of side effects independent of STN anatomical considerations. The lack of a significant result in the y direction remains to be explored further.</div>
</front>
</TEI>
<inist>
<standard h6="B">
<pA>
<fA01 i1="01" i2="1">
<s0>0022-3085</s0>
</fA01>
<fA02 i1="01">
<s0>JONSAC</s0>
</fA02>
<fA03 i2="1">
<s0>J. neurosurg.</s0>
</fA03>
<fA05>
<s2>106</s2>
</fA05>
<fA06>
<s2>1</s2>
</fA06>
<fA08 i1="01" i2="1" l="ENG">
<s1>Statistical determination of the optimal subthalamic nucleus stimulation site in patients with Parkinson disease</s1>
</fA08>
<fA11 i1="01" i2="1">
<s1>GUEHL (Dominique)</s1>
</fA11>
<fA11 i1="02" i2="1">
<s1>EDWARDS (Roderick)</s1>
</fA11>
<fA11 i1="03" i2="1">
<s1>CUNY (Emmanuel)</s1>
</fA11>
<fA11 i1="04" i2="1">
<s1>BURBAUD (Pierre)</s1>
</fA11>
<fA11 i1="05" i2="1">
<s1>ROUGIER (Alain)</s1>
</fA11>
<fA11 i1="06" i2="1">
<s1>MODOLO (Julien)</s1>
</fA11>
<fA11 i1="07" i2="1">
<s1>BEUTER (Anne)</s1>
</fA11>
<fA14 i1="01">
<s1>Service de Neurophysiologie Clinique, Hôpital Pellegrin, Université de Bordeaux</s1>
<s3>FRA</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="02">
<s1>Department of Mathematics and Statistics, University of Victoria</s1>
<s2>British Columbia</s2>
<s3>CAN</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="03">
<s1>Service de Neurochirurgie, et Service de Neurologie, Hôpital Pellegrin, Université de Bordeaux</s1>
<s3>FRA</s3>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="04">
<s1>Institut de Cognitique, Université Victor Segalen Bordeaux</s1>
<s2>Bordeaux</s2>
<s3>FRA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</fA14>
<fA20>
<s1>101-110</s1>
</fA20>
<fA21>
<s1>2007</s1>
</fA21>
<fA23 i1="01">
<s0>ENG</s0>
</fA23>
<fA43 i1="01">
<s1>INIST</s1>
<s2>6023</s2>
<s5>354000159766090170</s5>
</fA43>
<fA44>
<s0>0000</s0>
<s1>© 2007 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45>
<s0>29 ref.</s0>
</fA45>
<fA47 i1="01" i2="1">
<s0>07-0153227</s0>
</fA47>
<fA60>
<s1>P</s1>
</fA60>
<fA61>
<s0>A</s0>
</fA61>
<fA64 i1="01" i2="1">
<s0>Journal of neurosurgery</s0>
</fA64>
<fA66 i1="01">
<s0>USA</s0>
</fA66>
<fC01 i1="01" l="ENG">
<s0>Object. The subthalamic nucleus (STN) is currently recognized as the preferred target for deep brain stimulation (DBS) in patients with Parkinson disease (PD). If there is agreement in the literature that DBS improves motor symptoms significantly, the situation is less clear with respect to the side effects of this procedure. The goal of this study was to correlate the coordinate values of active electrode contacts with the amplitude of residual clinical symptoms and side effects using a mathematical approach. Methods. In this study the investigators examined a cohort of 41 patients with PD who received clinical benefits from DBS after stimulating electrodes had been implanted bilaterally into the STN. The combined scores of residual clinical symptoms plus side effects, including speech disturbance, postural instability, and weight gain, were fitted by using either inverted ellipsoidal exponentials or smooth splines. These analyses showed evidence of lower combined scores for stimulating contacts at an x coordinate approximately 12.0 to 12.3 mm lateral to the anterior commissure-posterior commissure (AC-PC) line and at a z coordinate approximately 3.1 to 3.3 mm under the AC-PC line. There was insufficient evidence for a preferred y coordinate location. Conclusions. The authors propose a "best" therapeutic ellipse area that is centered at an x, z location of 12.5 mm, -3.3 mm and characterized by an extension of 1.85 mm in the x direction and 2.22 mm in the z direction. Therapeutic electrode contacts located within this area are well correlated with the lowest occurrence of residual symptoms and the lowest occurrence of side effects independent of STN anatomical considerations. The lack of a significant result in the y direction remains to be explored further.</s0>
</fC01>
<fC02 i1="01" i2="X">
<s0>002B25J</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE">
<s0>Parkinson maladie</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG">
<s0>Parkinson disease</s0>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA">
<s0>Parkinson enfermedad</s0>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE">
<s0>Noyau sousthalamique</s0>
<s5>09</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG">
<s0>Subthalamic nucleus</s0>
<s5>09</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA">
<s0>Núcleo subtalámico</s0>
<s5>09</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE">
<s0>Homme</s0>
<s5>10</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG">
<s0>Human</s0>
<s5>10</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA">
<s0>Hombre</s0>
<s5>10</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE">
<s0>Encéphale pathologie</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG">
<s0>Cerebral disorder</s0>
<s5>37</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA">
<s0>Encéfalo patología</s0>
<s5>37</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE">
<s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG">
<s0>Extrapyramidal syndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA">
<s0>Extrapiramidal síndrome</s0>
<s5>38</s5>
</fC07>
<fC07 i1="03" i2="X" l="FRE">
<s0>Maladie dégénérative</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="ENG">
<s0>Degenerative disease</s0>
<s5>39</s5>
</fC07>
<fC07 i1="03" i2="X" l="SPA">
<s0>Enfermedad degenerativa</s0>
<s5>39</s5>
</fC07>
<fC07 i1="04" i2="X" l="FRE">
<s0>Système nerveux central pathologie</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="ENG">
<s0>Central nervous system disease</s0>
<s5>40</s5>
</fC07>
<fC07 i1="04" i2="X" l="SPA">
<s0>Sistema nervosio central patología</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE">
<s0>Système nerveux pathologie</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG">
<s0>Nervous system diseases</s0>
<s5>41</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA">
<s0>Sistema nervioso patología</s0>
<s5>41</s5>
</fC07>
<fN21>
<s1>099</s1>
</fN21>
<fN44 i1="01">
<s1>OTO</s1>
</fN44>
<fN82>
<s1>OTO</s1>
</fN82>
</pA>
</standard>
</inist>
<affiliations>
<list>
<country>
<li>Canada</li>
<li>France</li>
</country>
<region>
<li>Aquitaine</li>
<li>Nouvelle-Aquitaine</li>
</region>
<settlement>
<li>Bordeaux</li>
</settlement>
<orgName>
<li>Université de Bordeaux</li>
</orgName>
</list>
<tree>
<country name="France">
<region name="Nouvelle-Aquitaine">
<name sortKey="Guehl, Dominique" sort="Guehl, Dominique" uniqKey="Guehl D" first="Dominique" last="Guehl">Dominique Guehl</name>
</region>
<name sortKey="Beuter, Anne" sort="Beuter, Anne" uniqKey="Beuter A" first="Anne" last="Beuter">Anne Beuter</name>
<name sortKey="Burbaud, Pierre" sort="Burbaud, Pierre" uniqKey="Burbaud P" first="Pierre" last="Burbaud">Pierre Burbaud</name>
<name sortKey="Cuny, Emmanuel" sort="Cuny, Emmanuel" uniqKey="Cuny E" first="Emmanuel" last="Cuny">Emmanuel Cuny</name>
<name sortKey="Modolo, Julien" sort="Modolo, Julien" uniqKey="Modolo J" first="Julien" last="Modolo">Julien Modolo</name>
<name sortKey="Rougier, Alain" sort="Rougier, Alain" uniqKey="Rougier A" first="Alain" last="Rougier">Alain Rougier</name>
</country>
<country name="Canada">
<noRegion>
<name sortKey="Edwards, Roderick" sort="Edwards, Roderick" uniqKey="Edwards R" first="Roderick" last="Edwards">Roderick Edwards</name>
</noRegion>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/PascalFrancis/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000601 | SxmlIndent | more

Ou

HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 000601 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    PascalFrancis
   |étape=   Checkpoint
   |type=    RBID
   |clé=     Pascal:07-0153227
   |texte=   Statistical determination of the optimal subthalamic nucleus stimulation site in patients with Parkinson disease
}}

Wicri

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022