Bradykinesia is not a "systematic" feature of adult-onset Huntington's disease; implications for basal ganglia pathophysiology
Identifieur interne : 000564 ( PascalFrancis/Checkpoint ); précédent : 000563; suivant : 000565Bradykinesia is not a "systematic" feature of adult-onset Huntington's disease; implications for basal ganglia pathophysiology
Auteurs : Alison Fenney [Canada] ; Mandar S. Jog [Canada] ; Christian Duval [Canada]Source :
- Brain research [ 0006-8993 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Adulte.
English descriptors
- KwdEn :
Abstract
Our goal was to determine whether bradykinesia is present in choreic adult-onset Huntington's disease (HD) patients, and determine the impact of chorea on their voluntary movements. We recorded whole-body involuntary movements (WBIM) and voluntary motor acts simultaneously, using a magnetic tracker system, in 15 choreic HD patients and 15 healthy age- and gender-matched control subjects. Participants were asked to perform two distinct tasks; a manual-tracking (MT) task yielding a measure of chorea intrusion during accurate movements, and a rapid alternating movement (RAM) task, yielding measures of bradykinesia. Results show that patients with HD presented with deviations from the target that hindered their ability to match the target velocity during the MT task. Furthermore, error in performance was correlated with the amplitude of whole-body chorea (Rho=0.67), illustrating the deleterious effect of chorea during accurate movements. However, patients with choreic HD presented with significantly higher RAM range and velocity than matched controls, therefore ruling out the idea that bradykinesia is a systematic feature of HD even when chorea is predominant. The present results imply that patients may have benefited from an intact direct pathway ("select ON" pathway in the focused attention model of basal ganglia function) that allowed them to supersede any dysfunctions associated with the progressive alteration of the "control function" (striatal-globus pallidus-subthalamic) pathway responsible for generating the chorea. Finally, the present results suggest that patients with adult-onset HD having chorea would greatly benefit from improved treatments aiming at reducing their involuntary movements while maintaining proper motor function.
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000663
- to stream PascalFrancis, to step Corpus: 000694
- to stream PascalFrancis, to step Curation: 000647
Links to Exploration step
Pascal:08-0158112Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Bradykinesia is not a "systematic" feature of adult-onset Huntington's disease; implications for basal ganglia pathophysiology</title><author><name sortKey="Fenney, Alison" sort="Fenney, Alison" uniqKey="Fenney A" first="Alison" last="Fenney">Alison Fenney</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Département de kinanthropologie, Université du Québec à Montréal</s1><s2>Montréal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université du Québec à Montréal</orgName></affiliation></author><author><name sortKey="Jog, Mandar S" sort="Jog, Mandar S" uniqKey="Jog M" first="Mandar S." last="Jog">Mandar S. Jog</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinical Neurological Sciences, University of Western Ontario Health Centre-University Hospital</s1><s2>London, Ontario</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>London, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Duval, Christian" sort="Duval, Christian" uniqKey="Duval C" first="Christian" last="Duval">Christian Duval</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Département de kinanthropologie, Université du Québec à Montréal</s1><s2>Montréal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université du Québec à Montréal</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0158112</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0158112 INIST</idno><idno type="RBID">Pascal:08-0158112</idno><idno type="wicri:Area/PascalFrancis/Corpus">000663</idno><idno type="stanalyst">FRANCIS 08-0158112 INIST</idno><idno type="wicri:Area/PascalFrancis/Corpus">000694</idno><idno type="wicri:Area/PascalFrancis/Curation">000647</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000564</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000564</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Bradykinesia is not a "systematic" feature of adult-onset Huntington's disease; implications for basal ganglia pathophysiology</title><author><name sortKey="Fenney, Alison" sort="Fenney, Alison" uniqKey="Fenney A" first="Alison" last="Fenney">Alison Fenney</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Département de kinanthropologie, Université du Québec à Montréal</s1><s2>Montréal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université du Québec à Montréal</orgName></affiliation></author><author><name sortKey="Jog, Mandar S" sort="Jog, Mandar S" uniqKey="Jog M" first="Mandar S." last="Jog">Mandar S. Jog</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Clinical Neurological Sciences, University of Western Ontario Health Centre-University Hospital</s1><s2>London, Ontario</s2><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>London, Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Duval, Christian" sort="Duval, Christian" uniqKey="Duval C" first="Christian" last="Duval">Christian Duval</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Département de kinanthropologie, Université du Québec à Montréal</s1><s2>Montréal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université du Québec à Montréal</orgName></affiliation></author></analytic><series><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain res.</title><idno type="ISSN">0006-8993</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Brain research</title><title level="j" type="abbreviated">Brain res.</title><idno type="ISSN">0006-8993</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Basal ganglion</term><term>Body movement</term><term>Dyskinesia</term><term>Huntington disease</term><term>Motor control</term><term>Parkinson disease</term><term>Pathophysiology</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Noyau gris central</term><term>Physiopathologie</term><term>Mouvement corporel</term><term>Dyskinésie</term><term>Chorée de Huntington</term><term>Maladie de Parkinson</term><term>Adulte</term><term>Contrôle moteur</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Adulte</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Our goal was to determine whether bradykinesia is present in choreic adult-onset Huntington's disease (HD) patients, and determine the impact of chorea on their voluntary movements. We recorded whole-body involuntary movements (WBIM) and voluntary motor acts simultaneously, using a magnetic tracker system, in 15 choreic HD patients and 15 healthy age- and gender-matched control subjects. Participants were asked to perform two distinct tasks; a manual-tracking (MT) task yielding a measure of chorea intrusion during accurate movements, and a rapid alternating movement (RAM) task, yielding measures of bradykinesia. Results show that patients with HD presented with deviations from the target that hindered their ability to match the target velocity during the MT task. Furthermore, error in performance was correlated with the amplitude of whole-body chorea (Rho=0.67), illustrating the deleterious effect of chorea during accurate movements. However, patients with choreic HD presented with significantly higher RAM range and velocity than matched controls, therefore ruling out the idea that bradykinesia is a systematic feature of HD even when chorea is predominant. The present results imply that patients may have benefited from an intact direct pathway ("select ON" pathway in the focused attention model of basal ganglia function) that allowed them to supersede any dysfunctions associated with the progressive alteration of the "control function" (striatal-globus pallidus-subthalamic) pathway responsible for generating the chorea. Finally, the present results suggest that patients with adult-onset HD having chorea would greatly benefit from improved treatments aiming at reducing their involuntary movements while maintaining proper motor function.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0006-8993</s0></fA01><fA02 i1="01"><s0>BRREAP</s0></fA02><fA03 i2="1"><s0>Brain res.</s0></fA03><fA05><s2>1193</s2></fA05><fA08 i1="01" i2="1" l="ENG"><s1>Bradykinesia is not a "systematic" feature of adult-onset Huntington's disease; implications for basal ganglia pathophysiology</s1></fA08><fA11 i1="01" i2="1"><s1>FENNEY (Alison)</s1></fA11><fA11 i1="02" i2="1"><s1>JOG (Mandar S.)</s1></fA11><fA11 i1="03" i2="1"><s1>DUVAL (Christian)</s1></fA11><fA14 i1="01"><s1>Département de kinanthropologie, Université du Québec à Montréal</s1><s2>Montréal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>3 aut.</sZ></fA14><fA14 i1="02"><s1>Clinical Neurological Sciences, University of Western Ontario Health Centre-University Hospital</s1><s2>London, Ontario</s2><s3>CAN</s3><sZ>2 aut.</sZ></fA14><fA20><s1>67-75</s1></fA20><fA21><s1>2008</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>12895</s2><s5>354000183573360080</s5></fA43><fA44><s0>0000</s0><s1>© 2008 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>1 p.1/4</s0></fA45><fA47 i1="01" i2="1"><s0>08-0158112</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Brain research</s0></fA64><fA66 i1="01"><s0>NLD</s0></fA66><fC01 i1="01" l="ENG"><s0>Our goal was to determine whether bradykinesia is present in choreic adult-onset Huntington's disease (HD) patients, and determine the impact of chorea on their voluntary movements. We recorded whole-body involuntary movements (WBIM) and voluntary motor acts simultaneously, using a magnetic tracker system, in 15 choreic HD patients and 15 healthy age- and gender-matched control subjects. Participants were asked to perform two distinct tasks; a manual-tracking (MT) task yielding a measure of chorea intrusion during accurate movements, and a rapid alternating movement (RAM) task, yielding measures of bradykinesia. Results show that patients with HD presented with deviations from the target that hindered their ability to match the target velocity during the MT task. Furthermore, error in performance was correlated with the amplitude of whole-body chorea (Rho=0.67), illustrating the deleterious effect of chorea during accurate movements. However, patients with choreic HD presented with significantly higher RAM range and velocity than matched controls, therefore ruling out the idea that bradykinesia is a systematic feature of HD even when chorea is predominant. The present results imply that patients may have benefited from an intact direct pathway ("select ON" pathway in the focused attention model of basal ganglia function) that allowed them to supersede any dysfunctions associated with the progressive alteration of the "control function" (striatal-globus pallidus-subthalamic) pathway responsible for generating the chorea. Finally, the present results suggest that patients with adult-onset HD having chorea would greatly benefit from improved treatments aiming at reducing their involuntary movements while maintaining proper motor function.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17G</s0></fC02><fC02 i1="02" i2="X"><s0>002B18C13</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Noyau gris central</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Basal ganglion</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Núcleo basal</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Physiopathologie</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Pathophysiology</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Fisiopatología</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Mouvement corporel</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Body movement</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Movimiento corporal</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Dyskinésie</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Dyskinesia</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Disquinesia</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Chorée de Huntington</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Huntington disease</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Corea Huntington</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>12</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>12</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>12</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Adulte</s0><s5>54</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Adult</s0><s5>54</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Adulto</s0><s5>54</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Contrôle moteur</s0><s5>69</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Motor control</s0><s5>69</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Control motor</s0><s5>69</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>20</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>20</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>20</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Maladie héréditaire</s0><s5>21</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Genetic disease</s0><s5>21</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Enfermedad hereditaria</s0><s5>21</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>22</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>22</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>22</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>23</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>23</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>23</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>24</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>24</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>24</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>25</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>25</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>25</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Encéphale</s0><s5>26</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Encephalon</s0><s5>26</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Encéfalo</s0><s5>26</s5></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>27</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Central nervous system</s0><s5>27</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>27</s5></fC07><fC07 i1="09" i2="X" l="FRE"><s0>Motricité</s0><s5>28</s5></fC07><fC07 i1="09" i2="X" l="ENG"><s0>Motricity</s0><s5>28</s5></fC07><fC07 i1="09" i2="X" l="SPA"><s0>Motricidad</s0><s5>28</s5></fC07><fC07 i1="10" i2="X" l="FRE"><s0>Mouvement involontaire</s0><s5>29</s5></fC07><fC07 i1="10" i2="X" l="ENG"><s0>Involuntary movement</s0><s5>29</s5></fC07><fC07 i1="10" i2="X" l="SPA"><s0>Movimiento involuntario</s0><s5>29</s5></fC07><fC07 i1="11" i2="X" l="FRE"><s0>Trouble neurologique</s0><s5>30</s5></fC07><fC07 i1="11" i2="X" l="ENG"><s0>Neurological disorder</s0><s5>30</s5></fC07><fC07 i1="11" i2="X" l="SPA"><s0>Trastorno neurológico</s0><s5>30</s5></fC07><fC07 i1="12" i2="X" l="FRE"><s0>Homme</s0></fC07><fC07 i1="12" i2="X" l="ENG"><s0>Human</s0></fC07><fC07 i1="12" i2="X" l="SPA"><s0>Hombre</s0></fC07><fN21><s1>098</s1></fN21></pA></standard></inist><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université du Québec à Montréal</li></orgName></list><tree><country name="Canada"><region name="Québec"><name sortKey="Fenney, Alison" sort="Fenney, Alison" uniqKey="Fenney A" first="Alison" last="Fenney">Alison Fenney</name></region><name sortKey="Duval, Christian" sort="Duval, Christian" uniqKey="Duval C" first="Christian" last="Duval">Christian Duval</name><name sortKey="Jog, Mandar S" sort="Jog, Mandar S" uniqKey="Jog M" first="Mandar S." last="Jog">Mandar S. Jog</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/PascalFrancis/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000564 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PascalFrancis/Checkpoint/biblio.hfd -nk 000564 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= PascalFrancis
|étape= Checkpoint
|type= RBID
|clé= Pascal:08-0158112
|texte= Bradykinesia is not a "systematic" feature of adult-onset Huntington's disease; implications for basal ganglia pathophysiology
}}
| This area was generated with Dilib version V0.6.29. |  |