ParkinsonCanadaV1, PascalFrancis, Checkpoint, bibRecord, 000431

NSAID Use and the Risk of Parkinson's Disease: Systematic Review and Meta-Analysis of Observational Studies

Identifieur interne : 000431 ( PascalFrancis/Checkpoint ); précédent : 000430; suivant : 000432

NSAID Use and the Risk of Parkinson's Disease: Systematic Review and Meta-Analysis of Observational Studies

Auteurs : Ali Samii [États-Unis] ; Mahyar Etminan [Canada] ; Matthew O. Wiens [Canada] ; Siavash Jafari [Canada]

Source :

Drugs & aging [ 1170-229X ] ; 2009.

RBID : Pascal:09-0427296

Descripteurs français

Pascal (Inist)
- Antiinflammatoire non stéroïde, Facteur risque, Maladie de Parkinson, Revue systématique, Article synthèse, Métaanalyse, Personne âgée, Ibuprofène, Acide acétylsalicylique, Analgésique, Antipyrétique, Inhibiteur thromboagrégation, Risque relatif.
Wicri :
- topic : Personne âgée.

English descriptors

KwdEn :
- Acetylsalicylic acid, Analgesic, Antiplatelet agent, Antipyretic, Elderly, Ibuprofen, Metaanalysis, Non steroidal antiinflammatory agent, Parkinson disease, Relative risk, Review, Risk factor, Systematic review.

Abstract

Background: Several studies have suggested that NSAID use may modify the risk of developing Parkinson's disease (PD). Objective: Our aim was to conduct a meta-analysis of observational studies evaluating NSAID use and the risk of PD. Methods: We systematically searched MEDLINE (1966-November 2008), EMBASE (1980-November 2008) and other databases. Data from 11 studies were included in the meta-analysis. We used the random effects model to calculate risk ratios (relative risks) and their corresponding 95% confidence intervals (CIs). Results: The pooled risk ratio of PD with NSAID use was 0.95 (95% CI 0.80, 1.12). The pooled risk ratio of PD with high-dose or long-duration NSAID use was 0.91 (95% CI 0.78, 1.05). The pooled risk ratio of PD for aspirin (acetylsalicylic acid) users was 1.08 (95% CI 0.93, 1.26). The pooled risk ratio of PD among ibuprofen users was 0.76 (95% CI 0.65, 0.89). The pooled risk ratio of PD in men using NSAIDs was 0.79 (95% CI 0.69, 0.92), and in women using NSAIDs, it was 0.72 (95% CI 0.45, 1.15). Conclusions: NSAIDs as a class do not seem to modify the risk of PD. However, ibuprofen may have a slight protective effect in lowering the risk of PD. Although the risk ratios of PD in male and female NSAID users were similar, the 95% CI for men was suggestive of a slight risk reduction.

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Background: Several studies have suggested that NSAID use may modify the risk of developing Parkinson's disease (PD). Objective: Our aim was to conduct a meta-analysis of observational studies evaluating NSAID use and the risk of PD. Methods: We systematically searched MEDLINE (1966-November 2008), EMBASE (1980-November 2008) and other databases. Data from 11 studies were included in the meta-analysis. We used the random effects model to calculate risk ratios (relative risks) and their corresponding 95% confidence intervals (CIs). Results: The pooled risk ratio of PD with NSAID use was 0.95 (95% CI 0.80, 1.12). The pooled risk ratio of PD with high-dose or long-duration NSAID use was 0.91 (95% CI 0.78, 1.05). The pooled risk ratio of PD for aspirin (acetylsalicylic acid) users was 1.08 (95% CI 0.93, 1.26). The pooled risk ratio of PD among ibuprofen users was 0.76 (95% CI 0.65, 0.89). The pooled risk ratio of PD in men using NSAIDs was 0.79 (95% CI 0.69, 0.92), and in women using NSAIDs, it was 0.72 (95% CI 0.45, 1.15). Conclusions: NSAIDs as a class do not seem to modify the risk of PD. However, ibuprofen may have a slight protective effect in lowering the risk of PD. Although the risk ratios of PD in male and female NSAID users were similar, the 95% CI for men was suggestive of a slight risk reduction.</div>
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<s5>39</s5>
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<fC07 i1="04" i2="X" l="SPA"><s0>Encéfalo patología</s0>
<s5>39</s5>
</fC07>
<fC07 i1="05" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="05" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0>
<s5>40</s5>
</fC07>
<fC07 i1="06" i2="X" l="FRE"><s0>Pathologie du   système nerveux central</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="ENG"><s0>Central nervous system disease</s0>
<s5>41</s5>
</fC07>
<fC07 i1="06" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0>
<s5>41</s5>
</fC07>
<fC07 i1="07" i2="X" l="FRE"><s0>Dérivé de l'acide arylpropionique</s0>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="ENG"><s0>Arylpropionic acid derivatives</s0>
<s5>42</s5>
</fC07>
<fC07 i1="07" i2="X" l="SPA"><s0>Arilpropionico ácido derivado</s0>
<s5>42</s5>
</fC07>
<fC07 i1="08" i2="X" l="FRE"><s0>Inhibiteur enzyme</s0>
<s5>43</s5>
</fC07>
<fC07 i1="08" i2="X" l="ENG"><s0>Enzyme inhibitor</s0>
<s5>43</s5>
</fC07>
<fC07 i1="08" i2="X" l="SPA"><s0>Inhibidor enzima</s0>
<s5>43</s5>
</fC07>
<fC07 i1="09" i2="X" l="FRE"><s0>Prostaglandin-endoperoxide synthase</s0>
<s2>FE</s2>
<s5>44</s5>
</fC07>
<fC07 i1="09" i2="X" l="ENG"><s0>Prostaglandin-endoperoxide synthase</s0>
<s2>FE</s2>
<s5>44</s5>
</fC07>
<fC07 i1="09" i2="X" l="SPA"><s0>Prostaglandin-endoperoxide synthase</s0>
<s2>FE</s2>
<s5>44</s5>
</fC07>
<fC07 i1="10" i2="X" l="FRE"><s0>Oxidoreductases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="10" i2="X" l="ENG"><s0>Oxidoreductases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="10" i2="X" l="SPA"><s0>Oxidoreductases</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="11" i2="X" l="FRE"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="11" i2="X" l="ENG"><s0>Enzyme</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="11" i2="X" l="SPA"><s0>Enzima</s0>
<s2>FE</s2>
</fC07>
<fC07 i1="12" i2="X" l="FRE"><s0>Salicylés</s0>
<s5>45</s5>
</fC07>
<fC07 i1="12" i2="X" l="ENG"><s0>Salicylates</s0>
<s5>45</s5>
</fC07>
<fC07 i1="12" i2="X" l="SPA"><s0>Salicilatos</s0>
<s5>45</s5>
</fC07>
<fN21><s1>306</s1>
</fN21>
</pA>
</standard>
</inist>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Washington (État)</li>
</region>
<settlement><li>Seattle</li>
</settlement>
<orgName><li>Université de Washington</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Washington (État)"><name sortKey="Samii, Ali" sort="Samii, Ali" uniqKey="Samii A" first="Ali" last="Samii">Ali Samii</name>
</region>
</country>
<country name="Canada"><noRegion><name sortKey="Etminan, Mahyar" sort="Etminan, Mahyar" uniqKey="Etminan M" first="Mahyar" last="Etminan">Mahyar Etminan</name>
</noRegion>
<name sortKey="Jafari, Siavash" sort="Jafari, Siavash" uniqKey="Jafari S" first="Siavash" last="Jafari">Siavash Jafari</name>
<name sortKey="Wiens, Matthew O" sort="Wiens, Matthew O" uniqKey="Wiens M" first="Matthew O." last="Wiens">Matthew O. Wiens</name>
<name sortKey="Wiens, Matthew O" sort="Wiens, Matthew O" uniqKey="Wiens M" first="Matthew O." last="Wiens">Matthew O. Wiens</name>
</country>
</tree>
</affiliations>
</record>

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   |texte=   NSAID Use and the Risk of Parkinson's Disease: Systematic Review and Meta-Analysis of Observational Studies
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This area was generated with Dilib version V0.6.29.
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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

NSAID Use and the Risk of Parkinson's Disease: Systematic Review and Meta-Analysis of Observational Studies

NSAID Use and the Risk of Parkinson's Disease: Systematic Review and Meta-Analysis of Observational Studies

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