Proteomics of human embryonic stem cells
Identifieur interne : 000233 ( PascalFrancis/Checkpoint ); précédent : 000232; suivant : 000234Proteomics of human embryonic stem cells
Auteurs : Chris S. Hughes [Canada] ; Amelia A. Nuhn [Canada] ; Lynne M. Postovit [Canada] ; Gilles A. Lajoie [Canada]Source :
- Proteomics : (Weinheim. Print) [ 1615-9853 ] ; 2011.
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- Pascal (Inist)
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- topic : Homme, Cellule souche.
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Abstract
Human embryonic stem cells (hESCs) offer exciting potential in regenerative medicine for the treatment of a host of diseases including cancer, Alzheimer's and Parkinson's disease. R They also provide insight into human development and disease and can be used as models for drug discovery and toxicity analyses. The key properties of hESCs that make them so promising for medical use are that they have the ability to self-renew indefinitely in culture and they are pluripotent, which means that they can differentiate into any of more than 200 human cell types. Since proteins are the effectors of cellular processes, it is important to investigate hESC expression at the protein level as well as at the transcript level. In addition, post-translational modifications, such as phosphorylation, may influence the activity of pivotal proteins in hESCs, and this information can only be determined by studying the proteome. In this review, we summarize the results obtained from several proteomics analyses of hESCs that have been reported in the last few years.
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Lajoie</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Don Rix Protein Identification Facility, Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario</s1><s2>London, ON</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>London, ON</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0473730</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0473730 INIST</idno><idno type="RBID">Pascal:11-0473730</idno><idno type="wicri:Area/PascalFrancis/Corpus">000270</idno><idno type="wicri:Area/PascalFrancis/Curation">000993</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000233</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000233</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Proteomics of human embryonic stem cells</title><author><name sortKey="Hughes, Chris S" sort="Hughes, Chris S" uniqKey="Hughes C" first="Chris S." last="Hughes">Chris S. 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Lajoie</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Don Rix Protein Identification Facility, Department of Biochemistry, Schulich School of Medicine and Dentistry, University of Western Ontario</s1><s2>London, ON</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>London, ON</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Proteomics : (Weinheim. Print)</title><title level="j" type="abbreviated">Proteomics : (Weinh., Print)</title><idno type="ISSN">1615-9853</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Proteomics : (Weinheim. Print)</title><title level="j" type="abbreviated">Proteomics : (Weinh., Print)</title><idno type="ISSN">1615-9853</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Human</term><term>Proteomics</term><term>Stem cell</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Homme</term><term>Protéomique</term><term>Cellule souche</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term><term>Cellule souche</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Human embryonic stem cells (hESCs) offer exciting potential in regenerative medicine for the treatment of a host of diseases including cancer, Alzheimer's and Parkinson's disease. <sup>R</sup> They also provide insight into human development and disease and can be used as models for drug discovery and toxicity analyses. 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Since proteins are the effectors of cellular processes, it is important to investigate hESC expression at the protein level as well as at the transcript level. In addition, post-translational modifications, such as phosphorylation, may influence the activity of pivotal proteins in hESCs, and this information can only be determined by studying the proteome. 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Hughes</name></noRegion><name sortKey="Lajoie, Gilles A" sort="Lajoie, Gilles A" uniqKey="Lajoie G" first="Gilles A." last="Lajoie">Gilles A. Lajoie</name><name sortKey="Nuhn, Amelia A" sort="Nuhn, Amelia A" uniqKey="Nuhn A" first="Amelia A." last="Nuhn">Amelia A. Nuhn</name><name sortKey="Postovit, Lynne M" sort="Postovit, Lynne M" uniqKey="Postovit L" first="Lynne M." last="Postovit">Lynne M. Postovit</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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