Color Discrimination Deficits in Parkinson's Disease are Related to Cognitive Impairment and White-Matter Alterations
Identifieur interne : 000186 ( PascalFrancis/Checkpoint ); précédent : 000185; suivant : 000187Color Discrimination Deficits in Parkinson's Disease are Related to Cognitive Impairment and White-Matter Alterations
Auteurs : Josie-Anne Bertrand [Canada] ; Christophe Bedetti [Canada] ; Ronald B. Postuma [Canada] ; Oury Monchi [Canada] ; Daphne Génier Marchand [Canada] ; Thomas Jubault [Canada] ; Jean-François Gagnon [Canada]Source :
- Movement disorders [ 0885-3185 ] ; 2012.
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Abstract
Color discrimination deficit is a common nonmotor manifestation of Parkinson's disease (PD). However, the pathophysiology of this dysfunction remains poorly understood. Although retinal structure changes found in PD have been suggested to cause color discrimination deficits, the impact of cognitive impairment and cortical alterations remains to be determined. We investigated the contribution of cognitive impairment to color discrimination deficits in PD and correlated them with cortical anomalies. Sixty-six PD patients without dementia and 20 healthy controls performed the Farnsworth-Munsell 100 hue test and underwent a comprehensive neuropsychological assessment for mild cognitive impairment diagnosis. In a subgroup of 26 PD patients, we also used high-definition neuroanatomical magnetic resonance imaging for cortical thickness and diffusion tensor analysis. PD patients with mild cognitive impairment performed poorly on the Farnsworth-Munsell 100 hue test compared with PD patients without mild cognitive impairment and controls. In PD patients, performance on the Farnsworth-Munsell 100 hue test was correlated with measures of visuospatial abilities and executive functions. Neuroimaging analysis revealed higher mean and radial diffusivity values in right posterior white-matter structures that correlated with poor performance on the Farnsworth-Munsell 100 hue test. No cortical thickness correlation reached significance. This study showed that cognitive impairment makes a major contribution to the color discrimination deficits reported in PD. Thus, performance on the Farnsworth-Munsell 100 hue test may reflect cognitive impairment more than color discrimination deficits in PD. Poor performance on the Farnsworth-Munsell 100 hue test was also associated with white-matter alterations in right posterior brain regions.
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Université de Montreal</s1><s2>Montreal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Québec</wicri:noRegion></affiliation></author><author><name sortKey="Bedetti, Christophe" sort="Bedetti, Christophe" uniqKey="Bedetti C" first="Christophe" last="Bedetti">Christophe Bedetti</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Advanced Research in Sleep Medicine, Sacré-Coeur Hospital</s1><s2>Montreal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Unité de Neuroimagerie Fonctionelle, Institut universitaire de gériatrie de Montreal</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Advanced Research in Sleep Medicine, Sacré-Coeur Hospital</s1><s2>Montreal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Québec</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Montreal General Hospital</s1><s2>Montreal, Québec</s2><s3>CAN</s3><sZ>3 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Québec</wicri:noRegion></affiliation></author><author><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Unité de Neuroimagerie Fonctionelle, Institut universitaire de gériatrie de Montreal</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Quebec</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Radiology, Université de Montreal</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Marchand, Daphne Genier" sort="Marchand, Daphne Genier" uniqKey="Marchand D" first="Daphne Génier" last="Marchand">Daphne Génier Marchand</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Advanced Research in Sleep Medicine, Sacré-Coeur Hospital</s1><s2>Montreal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Québec</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Psychology, Université du Quebec à Montreal</s1><s2>Montreal, Québec</s2><s3>CAN</s3><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université du Québec à Montréal</orgName></affiliation></author><author><name sortKey="Jubault, Thomas" sort="Jubault, Thomas" uniqKey="Jubault T" first="Thomas" last="Jubault">Thomas Jubault</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Unité de Neuroimagerie Fonctionelle, Institut universitaire de gériatrie de Montreal</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Quebec</wicri:noRegion></affiliation></author><author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Advanced Research in Sleep Medicine, Sacré-Coeur Hospital</s1><s2>Montreal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Montreal, Québec</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="06"><s1>Department of Psychology, Université du Quebec à Montreal</s1><s2>Montreal, Québec</s2><s3>CAN</s3><sZ>5 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université du Québec à Montréal</orgName></affiliation></author></analytic><series><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Movement disorders</title><title level="j" type="abbreviated">Mov. disord.</title><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cognitive disorder</term><term>Color</term><term>Diffusion tensor imaging</term><term>Discrimination</term><term>Nervous system diseases</term><term>Parkinson disease</term><term>White matter</term><term>mild cognitive impairment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Trouble cognitif</term><term>Déficit cognitif léger</term><term>Pathologie du système nerveux</term><term>Couleur</term><term>Discrimination</term><term>Substance blanche</term><term>Imagerie du tenseur de diffusion</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Color discrimination deficit is a common nonmotor manifestation of Parkinson's disease (PD). However, the pathophysiology of this dysfunction remains poorly understood. Although retinal structure changes found in PD have been suggested to cause color discrimination deficits, the impact of cognitive impairment and cortical alterations remains to be determined. We investigated the contribution of cognitive impairment to color discrimination deficits in PD and correlated them with cortical anomalies. Sixty-six PD patients without dementia and 20 healthy controls performed the Farnsworth-Munsell 100 hue test and underwent a comprehensive neuropsychological assessment for mild cognitive impairment diagnosis. In a subgroup of 26 PD patients, we also used high-definition neuroanatomical magnetic resonance imaging for cortical thickness and diffusion tensor analysis. PD patients with mild cognitive impairment performed poorly on the Farnsworth-Munsell 100 hue test compared with PD patients without mild cognitive impairment and controls. In PD patients, performance on the Farnsworth-Munsell 100 hue test was correlated with measures of visuospatial abilities and executive functions. Neuroimaging analysis revealed higher mean and radial diffusivity values in right posterior white-matter structures that correlated with poor performance on the Farnsworth-Munsell 100 hue test. No cortical thickness correlation reached significance. This study showed that cognitive impairment makes a major contribution to the color discrimination deficits reported in PD. Thus, performance on the Farnsworth-Munsell 100 hue test may reflect cognitive impairment more than color discrimination deficits in PD. Poor performance on the Farnsworth-Munsell 100 hue test was also associated with white-matter alterations in right posterior brain regions.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0885-3185</s0></fA01><fA03 i2="1"><s0>Mov. disord.</s0></fA03><fA05><s2>27</s2></fA05><fA06><s2>14</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Color Discrimination Deficits in Parkinson's Disease are Related to Cognitive Impairment and White-Matter Alterations</s1></fA08><fA11 i1="01" i2="1"><s1>BERTRAND (Josie-Anne)</s1></fA11><fA11 i1="02" i2="1"><s1>BEDETTI (Christophe)</s1></fA11><fA11 i1="03" i2="1"><s1>POSTUMA (Ronald B.)</s1></fA11><fA11 i1="04" i2="1"><s1>MONCHI (Oury)</s1></fA11><fA11 i1="05" i2="1"><s1>MARCHAND (Daphne Génier)</s1></fA11><fA11 i1="06" i2="1"><s1>JUBAULT (Thomas)</s1></fA11><fA11 i1="07" i2="1"><s1>GAGNON (Jean-François)</s1></fA11><fA14 i1="01"><s1>Center for Advanced Research in Sleep Medicine, Sacré-Coeur Hospital</s1><s2>Montreal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Psychology, Université de Montreal</s1><s2>Montreal, Québec</s2><s3>CAN</s3><sZ>1 aut.</sZ></fA14><fA14 i1="03"><s1>Unité de Neuroimagerie Fonctionelle, Institut universitaire de gériatrie de Montreal</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Neurology, Montreal General Hospital</s1><s2>Montreal, Québec</s2><s3>CAN</s3><sZ>3 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Radiology, Université de Montreal</s1><s2>Montreal, Quebec</s2><s3>CAN</s3><sZ>4 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Psychology, Université du Quebec à Montreal</s1><s2>Montreal, Québec</s2><s3>CAN</s3><sZ>5 aut.</sZ><sZ>7 aut.</sZ></fA14><fA20><s1>1781-1788</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>20953</s2><s5>354000503000040160</s5></fA43><fA44><s0>0000</s0><s1>© 2013 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>45 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>13-0063591</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Movement disorders</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Color discrimination deficit is a common nonmotor manifestation of Parkinson's disease (PD). However, the pathophysiology of this dysfunction remains poorly understood. Although retinal structure changes found in PD have been suggested to cause color discrimination deficits, the impact of cognitive impairment and cortical alterations remains to be determined. We investigated the contribution of cognitive impairment to color discrimination deficits in PD and correlated them with cortical anomalies. Sixty-six PD patients without dementia and 20 healthy controls performed the Farnsworth-Munsell 100 hue test and underwent a comprehensive neuropsychological assessment for mild cognitive impairment diagnosis. In a subgroup of 26 PD patients, we also used high-definition neuroanatomical magnetic resonance imaging for cortical thickness and diffusion tensor analysis. PD patients with mild cognitive impairment performed poorly on the Farnsworth-Munsell 100 hue test compared with PD patients without mild cognitive impairment and controls. In PD patients, performance on the Farnsworth-Munsell 100 hue test was correlated with measures of visuospatial abilities and executive functions. Neuroimaging analysis revealed higher mean and radial diffusivity values in right posterior white-matter structures that correlated with poor performance on the Farnsworth-Munsell 100 hue test. No cortical thickness correlation reached significance. This study showed that cognitive impairment makes a major contribution to the color discrimination deficits reported in PD. Thus, performance on the Farnsworth-Munsell 100 hue test may reflect cognitive impairment more than color discrimination deficits in PD. Poor performance on the Farnsworth-Munsell 100 hue test was also associated with white-matter alterations in right posterior brain regions.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Parkinson disease</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Parkinson enfermedad</s0><s2>NM</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Trouble cognitif</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Cognitive disorder</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Trastorno cognitivo</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Déficit cognitif léger</s0><s2>NM</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>mild cognitive impairment</s0><s2>NM</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Disturbio cognitivo ligero</s0><s2>NM</s2><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Couleur</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Color</s0><s5>09</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Color</s0><s5>09</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Discrimination</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Discrimination</s0><s5>10</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Discriminación</s0><s5>10</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Substance blanche</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>White matter</s0><s5>11</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Substancia blanca</s0><s5>11</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Imagerie du tenseur de diffusion</s0><s5>12</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Diffusion tensor imaging</s0><s5>12</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Imágen de tensor de difusión</s0><s5>12</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>40</s5></fC07><fN21><s1>042</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université du Québec à Montréal</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Bertrand, Josie Anne" sort="Bertrand, Josie Anne" uniqKey="Bertrand J" first="Josie-Anne" last="Bertrand">Josie-Anne Bertrand</name></noRegion><name sortKey="Bedetti, Christophe" sort="Bedetti, Christophe" uniqKey="Bedetti C" first="Christophe" last="Bedetti">Christophe Bedetti</name><name sortKey="Bedetti, Christophe" sort="Bedetti, Christophe" uniqKey="Bedetti C" first="Christophe" last="Bedetti">Christophe Bedetti</name><name sortKey="Bertrand, Josie Anne" sort="Bertrand, Josie Anne" uniqKey="Bertrand J" first="Josie-Anne" last="Bertrand">Josie-Anne Bertrand</name><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><name sortKey="Jubault, Thomas" sort="Jubault, Thomas" uniqKey="Jubault T" first="Thomas" last="Jubault">Thomas Jubault</name><name sortKey="Marchand, Daphne Genier" sort="Marchand, Daphne Genier" uniqKey="Marchand D" first="Daphne Génier" last="Marchand">Daphne Génier Marchand</name><name sortKey="Marchand, Daphne Genier" sort="Marchand, Daphne Genier" uniqKey="Marchand D" first="Daphne Génier" last="Marchand">Daphne Génier Marchand</name><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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