Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder
Identifieur interne : 000157 ( PascalFrancis/Checkpoint ); précédent : 000156; suivant : 000158Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder
Auteurs : Thien Thanh Dang-Vu [Canada, Belgique] ; Jean-François Gagnon [Canada] ; Mélanie Vendette [Canada] ; Jean-Paul Soucy [Canada] ; Ronald B. Postuma [Canada] ; Jacques Montplaisir [Canada]Source :
- Neurology [ 0028-3878 ] ; 2012.
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- Pascal (Inist)
English descriptors
Abstract
Objectives: Patients with idiopathic REM sleep behavior disorder (IRBD) are at risk for developing Parkinson disease (PD) and dementia with Lewy bodies (DLB). We aimed to identify functional brain imaging patterns predicting the emergence of PD and DLB in patients with IRBD, using SPECT with 99mTc-ethylene cysteinate dimer (ECD). Methods: Twenty patients with IRBD were scanned at baseline during wakefulness using 99mTc-ECD SPECT. After a follow-up of 3 years on average, patients were divided into 2 groups according to whether or not they developed defined neurodegenerative disease (PD, DLB). SPECT data analysis comparing regional cerebral blood flow (rCBF) between groups assessed whether specific brain perfusion patterns were associated with subsequent clinical evolution. Regression analysis between rCBF and clinical markers of neurodegeneration (motor, color vision, olfaction) looked for neural structures involved in this process. Results: Of the 20 patients with IRBD recruited for this study, 10 converted to PD or DLB during the follow-up. rCBF at baseline was increased in the hippocampus of patients who would later convert compared with those who would not (p < 0.05 corrected). Hippocampal perfusion was correlated with motor and color vision scores across all IRBD patients. Conclusions: 99mTc-ECD SPECT identifies patients with IRBD at risk for conversion to other neurodegenerative disorders such as PD or DLB; disease progression in IRBD is predicted by abnormal perfusion in the hippocampus at baseline. Perfusion within this structure is correlated with clinical markers of neurodegeneration, further suggesting its involvement in the development of presumed synucleinopathies.
Affiliations:
- Belgique, Canada
- Province de Liège, Québec, Région wallonne
- Liège, Montréal
- Université de Liège, Université du Québec à Montréal
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wicri:step="Checkpoint">000157</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder</title><author><name sortKey="Thanh Dang Vu, Thien" sort="Thanh Dang Vu, Thien" uniqKey="Thanh Dang Vu T" first="Thien" last="Thanh Dang-Vu">Thien Thanh Dang-Vu</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</wicri:noRegion></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Exercise Science and Center for Studies in Behavioral Neurobiology, Concordia University</s1><s2>Montreal</s2><s3>CAN</s3><sZ>1 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><inist:fA14 i1="03"><s1>Cyclotron Research Centre, University of Liege</s1><s3>BEL</s3><sZ>1 aut.</sZ></inist:fA14><country>Belgique</country><placeName><settlement type="city">Liège</settlement><region type="region" nuts="1">Région wallonne</region><region type="province" nuts="1">Province de Liège</region></placeName><orgName type="university">Université de Liège</orgName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Neurology, Centre Hospitalier Universitaire de Liege</s1><s3>BEL</s3><sZ>1 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>Department of Neurology, Centre Hospitalier Universitaire de Liege</wicri:noRegion></affiliation></author><author><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Department of Psychology, Université du Quebec à Montreal</s1><s3>CAN</s3><sZ>2 aut.</sZ></inist:fA14><country>Canada</country><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName><orgName type="university">Université du Québec à Montréal</orgName></affiliation></author><author><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</wicri:noRegion></affiliation></author><author><name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Nuclear Medicine, Centre Hospitalier de l'Université de Montreal</s1><s3>CAN</s3><sZ>4 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Nuclear Medicine, Centre Hospitalier de l'Université de Montreal</wicri:noRegion></affiliation></author><author><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Department of Neurology, Montreal General Hospita</s1><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Neurology, Montreal General Hospita</wicri:noRegion></affiliation></author><author><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Department of Psychiatry, University of Montreal</s1><s3>CAN</s3><sZ>6 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Department of Psychiatry, University of Montreal</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Behavior</term><term>Hippocampus</term><term>Nervous system diseases</term><term>Rapid eye movement sleep</term><term>Sleep disorder</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Trouble du sommeil</term><term>Pathologie du système nerveux</term><term>Hippocampe</term><term>Sommeil paradoxal</term><term>Comportement</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objectives: Patients with idiopathic REM sleep behavior disorder (IRBD) are at risk for developing Parkinson disease (PD) and dementia with Lewy bodies (DLB). We aimed to identify functional brain imaging patterns predicting the emergence of PD and DLB in patients with IRBD, using SPECT with <sup>99m</sup>Tc-ethylene cysteinate dimer (ECD). Methods: Twenty patients with IRBD were scanned at baseline during wakefulness using <sup>99m</sup>Tc-ECD SPECT. After a follow-up of 3 years on average, patients were divided into 2 groups according to whether or not they developed defined neurodegenerative disease (PD, DLB). SPECT data analysis comparing regional cerebral blood flow (rCBF) between groups assessed whether specific brain perfusion patterns were associated with subsequent clinical evolution. Regression analysis between rCBF and clinical markers of neurodegeneration (motor, color vision, olfaction) looked for neural structures involved in this process. Results: Of the 20 patients with IRBD recruited for this study, 10 converted to PD or DLB during the follow-up. rCBF at baseline was increased in the hippocampus of patients who would later convert compared with those who would not (p < 0.05 corrected). Hippocampal perfusion was correlated with motor and color vision scores across all IRBD patients. Conclusions: <sup>99m</sup>Tc-ECD SPECT identifies patients with IRBD at risk for conversion to other neurodegenerative disorders such as PD or DLB; disease progression in IRBD is predicted by abnormal perfusion in the hippocampus at baseline. Perfusion within this structure is correlated with clinical markers of neurodegeneration, further suggesting its involvement in the development of presumed synucleinopathies.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0028-3878</s0></fA01><fA02 i1="01"><s0>NEURAI</s0></fA02><fA03 i2="1"><s0>Neurology</s0></fA03><fA05><s2>79</s2></fA05><fA06><s2>24</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Hippocampal perfusion predicts impending neurodegeneration in REM sleep behavior disorder</s1></fA08><fA11 i1="01" i2="1"><s1>THANH DANG-VU (Thien)</s1></fA11><fA11 i1="02" i2="1"><s1>GAGNON (Jean-François)</s1></fA11><fA11 i1="03" i2="1"><s1>VENDETTE (Mélanie)</s1></fA11><fA11 i1="04" i2="1"><s1>SOUCY (Jean-Paul)</s1></fA11><fA11 i1="05" i2="1"><s1>POSTUMA (Ronald B.)</s1></fA11><fA11 i1="06" i2="1"><s1>MONTPLAISIR (Jacques)</s1></fA11><fA14 i1="01"><s1>Center for Advanced Research in Sleep Medicine, Hopital du Sacté-Cœut de Montreal</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ></fA14><fA14 i1="02"><s1>Department of Exercise Science and Center for Studies in Behavioral Neurobiology, Concordia University</s1><s2>Montreal</s2><s3>CAN</s3><sZ>1 aut.</sZ></fA14><fA14 i1="03"><s1>Cyclotron Research Centre, University of Liege</s1><s3>BEL</s3><sZ>1 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Neurology, Centre Hospitalier Universitaire de Liege</s1><s3>BEL</s3><sZ>1 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Psychology, Université du Quebec à Montreal</s1><s3>CAN</s3><sZ>2 aut.</sZ></fA14><fA14 i1="06"><s1>Department of Nuclear Medicine, Centre Hospitalier de l'Université de Montreal</s1><s3>CAN</s3><sZ>4 aut.</sZ></fA14><fA14 i1="07"><s1>Department of Neurology, Montreal General Hospita</s1><s3>CAN</s3><sZ>5 aut.</sZ></fA14><fA14 i1="08"><s1>Department of Psychiatry, University of Montreal</s1><s3>CAN</s3><sZ>6 aut.</sZ></fA14><fA20><s1>2302-2306</s1></fA20><fA21><s1>2012</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>6345</s2><s5>354000506304910030</s5></fA43><fA44><s0>0000</s0><s1>© 2013 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>10 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>13-0043228</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Neurology</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>Objectives: Patients with idiopathic REM sleep behavior disorder (IRBD) are at risk for developing Parkinson disease (PD) and dementia with Lewy bodies (DLB). We aimed to identify functional brain imaging patterns predicting the emergence of PD and DLB in patients with IRBD, using SPECT with <sup>99m</sup>Tc-ethylene cysteinate dimer (ECD). Methods: Twenty patients with IRBD were scanned at baseline during wakefulness using <sup>99m</sup>Tc-ECD SPECT. After a follow-up of 3 years on average, patients were divided into 2 groups according to whether or not they developed defined neurodegenerative disease (PD, DLB). SPECT data analysis comparing regional cerebral blood flow (rCBF) between groups assessed whether specific brain perfusion patterns were associated with subsequent clinical evolution. Regression analysis between rCBF and clinical markers of neurodegeneration (motor, color vision, olfaction) looked for neural structures involved in this process. Results: Of the 20 patients with IRBD recruited for this study, 10 converted to PD or DLB during the follow-up. rCBF at baseline was increased in the hippocampus of patients who would later convert compared with those who would not (p < 0.05 corrected). Hippocampal perfusion was correlated with motor and color vision scores across all IRBD patients. Conclusions: <sup>99m</sup>Tc-ECD SPECT identifies patients with IRBD at risk for conversion to other neurodegenerative disorders such as PD or DLB; disease progression in IRBD is predicted by abnormal perfusion in the hippocampus at baseline. Perfusion within this structure is correlated with clinical markers of neurodegeneration, further suggesting its involvement in the development of presumed synucleinopathies.</s0></fC01><fC02 i1="01" i2="X"><s0>002B17</s0></fC02><fC02 i1="02" i2="X"><s0>002B17A02</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Trouble du sommeil</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Sleep disorder</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Trastorno sueño</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Hippocampe</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Hippocampus</s0><s5>09</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Hipocampo</s0><s5>09</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Sommeil paradoxal</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Rapid eye movement sleep</s0><s5>10</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Sueño paradojal</s0><s5>10</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Comportement</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Behavior</s0><s5>11</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Conducta</s0><s5>11</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Encéphale</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Encephalon</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Encéfalo</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Système nerveux central</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Central nervous system</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Sistema nervioso central</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Cycle veille sommeil</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Sleep wake cycle</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Ciclo sueño vigilia</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Trouble neurologique</s0><s5>41</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Neurological disorder</s0><s5>41</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Trastorno neurológico</s0><s5>41</s5></fC07><fN21><s1>028</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist><affiliations><list><country><li>Belgique</li><li>Canada</li></country><region><li>Province de Liège</li><li>Québec</li><li>Région wallonne</li></region><settlement><li>Liège</li><li>Montréal</li></settlement><orgName><li>Université de Liège</li><li>Université du Québec à Montréal</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Thanh Dang Vu, Thien" sort="Thanh Dang Vu, Thien" uniqKey="Thanh Dang Vu T" first="Thien" last="Thanh Dang-Vu">Thien Thanh Dang-Vu</name></noRegion><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><name sortKey="Gagnon, Jean Francois" sort="Gagnon, Jean Francois" uniqKey="Gagnon J" first="Jean-François" last="Gagnon">Jean-François Gagnon</name><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><name sortKey="Montplaisir, Jacques" sort="Montplaisir, Jacques" uniqKey="Montplaisir J" first="Jacques" last="Montplaisir">Jacques Montplaisir</name><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name><name sortKey="Postuma, Ronald B" sort="Postuma, Ronald B" uniqKey="Postuma R" first="Ronald B." last="Postuma">Ronald B. Postuma</name><name sortKey="Soucy, Jean Paul" sort="Soucy, Jean Paul" uniqKey="Soucy J" first="Jean-Paul" last="Soucy">Jean-Paul Soucy</name><name sortKey="Thanh Dang Vu, Thien" sort="Thanh Dang Vu, Thien" uniqKey="Thanh Dang Vu T" first="Thien" last="Thanh Dang-Vu">Thien Thanh Dang-Vu</name><name sortKey="Vendette, Melanie" sort="Vendette, Melanie" uniqKey="Vendette M" first="Mélanie" last="Vendette">Mélanie Vendette</name></country><country name="Belgique"><region name="Région wallonne"><name sortKey="Thanh Dang Vu, Thien" sort="Thanh Dang Vu, Thien" uniqKey="Thanh Dang Vu T" first="Thien" last="Thanh Dang-Vu">Thien Thanh Dang-Vu</name></region><name sortKey="Thanh Dang Vu, Thien" sort="Thanh Dang Vu, Thien" uniqKey="Thanh Dang Vu T" first="Thien" last="Thanh Dang-Vu">Thien Thanh Dang-Vu</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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