ParkinsonCanadaV1, PascalFrancis, Checkpoint, bibRecord, 000055

REACHING TO PROPRIOCEPTIVELY DEFINED TARGETS IN PARKINSON'S DISEASE: EFFECTS OF DEEP BRAIN STIMULATION THERAPY

Identifieur interne : 000055 ( PascalFrancis/Checkpoint ); précédent : 000054; suivant : 000056

REACHING TO PROPRIOCEPTIVELY DEFINED TARGETS IN PARKINSON'S DISEASE: EFFECTS OF DEEP BRAIN STIMULATION THERAPY

Auteurs : D. Lee [États-Unis] ; D. Y. Henriques [Canada] ; J. Snider [États-Unis] ; D. Song [États-Unis] ; H. Poizner [États-Unis]

Source :

Neuroscience [ 0306-4522 ] ; 2013.

RBID : Pascal:13-0270350

Descripteurs français

Pascal (Inist)
- Proprioception, Noyau sousthalamique, Maladie de Parkinson, Homme, Stimulation cérébrale profonde.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Deep brain stimulation, Human, Parkinson disease, Proprioception, Subthalamic nucleus.

Abstract

Deep brain stimulation of the subthalamic nucleus (STN DBS) provides a unique window into human brain function since it can reversibly alter the functioning of specific brain circuits. Basal ganglia-cortical circuits are thought to be excessively noisy in patients with Parkinson's disease (PD), based in part on the lack of specificity of proprioceptive signals in basal ganglia-thalamic-cortical circuits in monkey models of the disease. PD patients are known to have deficits in proprioception, but the effects are often subtle, with paradigms typically restricted to one or two joint movements in a plane. Moreover, the effects of STN DBS on proprioception are virtually unexplored. We tested the following hypotheses: first, that PD patients will show substantial deficits in unconstrained, multi-joint proprioception, and, second, that STN DBS will improve multi-joint proprioception. Twelve PD patients with bilaterally implanted electrodes in the subthalamic nucleus and 12 age-matched healthy subjects were asked to position the left hand at a location that was proprioceptively defined in 3D space with the right hand. In a second condition, subjects were provided visual feedback during the task so that they were not forced to rely on proprioception. Overall, with STN DBS switched off, PD patients showed significantly larger proprioceptive localization errors, and greater variability in endpoint localizations than the control subjects. Visual feedback partially normalized PD performance, and demonstrated that the errors in proprioceptive localization were not simply due to a difficulty in executing the movements or in remembering target locations. Switching STN DBS on significantly reduced localization errors from those of control subjects when patients moved without visual feedback relative to when they moved with visual feedback (when proprioception was not required). However, this reduction in localization errors without vision came at the cost of increased localization variability.

Affiliations:

Canada, États-Unis

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Deep brain stimulation of the subthalamic nucleus (STN DBS) provides a unique window into human brain function since it can reversibly alter the functioning of specific brain circuits. Basal ganglia-cortical circuits are thought to be excessively noisy in patients with Parkinson's disease (PD), based in part on the lack of specificity of proprioceptive signals in basal ganglia-thalamic-cortical circuits in monkey models of the disease. PD patients are known to have deficits in proprioception, but the effects are often subtle, with paradigms typically restricted to one or two joint movements in a plane. Moreover, the effects of STN DBS on proprioception are virtually unexplored. We tested the following hypotheses: first, that PD patients will show substantial deficits in unconstrained, multi-joint proprioception, and, second, that STN DBS will improve multi-joint proprioception. Twelve PD patients with bilaterally implanted electrodes in the subthalamic nucleus and 12 age-matched healthy subjects were asked to position the left hand at a location that was proprioceptively defined in 3D space with the right hand. In a second condition, subjects were provided visual feedback during the task so that they were not forced to rely on proprioception. Overall, with STN DBS switched off, PD patients showed significantly larger proprioceptive localization errors, and greater variability in endpoint localizations than the control subjects. Visual feedback partially normalized PD performance, and demonstrated that the errors in proprioceptive localization were not simply due to a difficulty in executing the movements or in remembering target locations. Switching STN DBS on significantly reduced localization errors from those of control subjects when patients moved without visual feedback relative to when they moved with visual feedback (when proprioception was not required). However, this reduction in localization errors without vision came at the cost of increased localization variability.</div>
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   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    PascalFrancis
   |étape=   Checkpoint
   |type=    RBID
   |clé=     Pascal:13-0270350
   |texte=   REACHING TO PROPRIOCEPTIVELY DEFINED TARGETS IN PARKINSON'S DISEASE: EFFECTS OF DEEP BRAIN STIMULATION THERAPY
}}

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	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

La maladie de Parkinson au Canada (serveur d'exploration)

REACHING TO PROPRIOCEPTIVELY DEFINED TARGETS IN PARKINSON'S DISEASE: EFFECTS OF DEEP BRAIN STIMULATION THERAPY

REACHING TO PROPRIOCEPTIVELY DEFINED TARGETS IN PARKINSON'S DISEASE: EFFECTS OF DEEP BRAIN STIMULATION THERAPY

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