The effects of dopaminergic medication on dynamic decision making in Parkinson's disease
Identifieur interne : 000002 ( PascalFrancis/Checkpoint ); précédent : 000001; suivant : 000003The effects of dopaminergic medication on dynamic decision making in Parkinson's disease
Auteurs : Magda Osman [Royaume-Uni] ; Agata Rytersk [Royaume-Uni] ; Kash Karimi [Royaume-Uni] ; LINGLING TU [République populaire de Chine] ; Ignacio Obeso [Canada] ; Maarten Speekenbrink [Royaume-Uni] ; Marjan Jahanshahi [Royaume-Uni]Source :
- Neuropsychologia [ 0028-3932 ] ; 2014.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Prise de décision, Homme.
English descriptors
- KwdEn :
Abstract
In the present study we address the following questions: (1) How is performance affected when patients with Parkinson's Disease (PD) perform a dynamic decision making task? (2) Does dopaminergic medication differentially affect dynamic decision making? To address these questions participants were trained with different goals during learning: either they made intervention-based decisions or prediction-based decisions during learning. The findings show that overall there is an advantage for those trained to intervene over those trained to predict. In addition, the results are the first demonstration that PD patients 'ON' (N=20) compared to 'OFF' L-Dopa (N=15) medication and also relative to healthy age matched controls (N=16) showed lower levels of relative improvement in the accuracy of their decisions in a dynamic decision making task, and tended to use sub-optimal strategies. These findings provide support for the 'Dopamine Overdose' hypothesis using a novel decision making task, and suggest that executive functions such as decision making can be adversely affected by dopaminergic medication in PD.
Affiliations:
- Canada, Royaume-Uni, République populaire de Chine
- Angleterre, Grand Londres, Ontario
- Londres, Toronto
- University College de Londres, Université de Londres, Université de Toronto
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Way</s1><s2>London WC1H 0AP</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>London WC1H 0AP</wicri:noRegion><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, 33 Queen Square</s1><s2>London WC1N 3 BG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>London WC1N 3 BG</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">14-0055586</idno><date when="2014">2014</date><idno type="stanalyst">PASCAL 14-0055586 INIST</idno><idno type="RBID">Pascal:14-0055586</idno><idno type="wicri:Area/PascalFrancis/Corpus">000040</idno><idno type="stanalyst">FRANCIS 14-0055586 INIST</idno><idno type="wicri:Area/PascalFrancis/Corpus">000056</idno><idno type="wicri:Area/PascalFrancis/Curation">000B78</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000002</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000002</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">The effects of dopaminergic medication on dynamic decision making in Parkinson's disease</title><author><name sortKey="Osman, Magda" sort="Osman, Magda" uniqKey="Osman M" first="Magda" last="Osman">Magda Osman</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Biological and Experimental Psychology, School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road</s1><s2>London E1 4NS</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>London E1 4NS</wicri:noRegion><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, 33 Queen Square</s1><s2>London WC1N 3 BG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>London WC1N 3 BG</wicri:noRegion></affiliation><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Cognitive, Perceptual and Brain Sciences, University College London, 26 Bedford Way</s1><s2>London WC1H 0AP</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>London WC1H 0AP</wicri:noRegion><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Rytersk, Agata" sort="Rytersk, Agata" uniqKey="Rytersk A" first="Agata" last="Rytersk">Agata Rytersk</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Biological and Experimental Psychology, School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road</s1><s2>London E1 4NS</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>London E1 4NS</wicri:noRegion><orgName type="university">Université de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, 33 Queen Square</s1><s2>London WC1N 3 BG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>London WC1N 3 BG</wicri:noRegion></affiliation></author><author><name sortKey="Karimi, Kash" sort="Karimi, Kash" uniqKey="Karimi K" first="Kash" last="Karimi">Kash Karimi</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, 33 Queen Square</s1><s2>London WC1N 3 BG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>London WC1N 3 BG</wicri:noRegion></affiliation></author><author><name sortKey="Lingling Tu" sort="Lingling Tu" uniqKey="Lingling Tu" last="Lingling Tu">LINGLING TU</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychiatry, Sir Run Run Shaw Hospital, 3 East Qingchun Road</s1><s2>310016 Hangzhou, Zhejiang</s2><s3>CHN</s3><sZ>4 aut.</sZ></inist:fA14><country>République populaire de Chine</country><wicri:noRegion>310016 Hangzhou, Zhejiang</wicri:noRegion></affiliation></author><author><name sortKey="Obeso, Ignacio" sort="Obeso, Ignacio" uniqKey="Obeso I" first="Ignacio" last="Obeso">Ignacio Obeso</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Psychology Department at the St. George Campus, University of Toronto, 100 St. George Street, 4th Floor, Sidney Smith Hall</s1><s2>Toronto, Ontario, M5S 3G3</s2><s3>CAN</s3><sZ>5 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Toronto, Ontario, M5S 3G3</wicri:noRegion><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Speekenbrink, Maarten" sort="Speekenbrink, Maarten" uniqKey="Speekenbrink M" first="Maarten" last="Speekenbrink">Maarten Speekenbrink</name><affiliation wicri:level="4"><inist:fA14 i1="05"><s1>Cognitive, Perceptual and Brain Sciences, University College London, 26 Bedford Way</s1><s2>London WC1H 0AP</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>London WC1H 0AP</wicri:noRegion><orgName type="university">University College de Londres</orgName><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, 33 Queen Square</s1><s2>London WC1N 3 BG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>London WC1N 3 BG</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neuropsychologia</title><title level="j" type="abbreviated">Neuropsychologia</title><idno type="ISSN">0028-3932</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neuropsychologia</title><title level="j" type="abbreviated">Neuropsychologia</title><idno type="ISSN">0028-3932</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiparkinson agent</term><term>Decision making</term><term>Dopamine</term><term>Human</term><term>Learning</term><term>Overdosing</term><term>Parkinson disease</term><term>Prediction</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Dopamine</term><term>Prise de décision</term><term>Maladie de Parkinson</term><term>Prédiction</term><term>Surdosage</term><term>Apprentissage</term><term>Antiparkinsonien</term><term>Homme</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Prise de décision</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the present study we address the following questions: (1) How is performance affected when patients with Parkinson's Disease (PD) perform a dynamic decision making task? (2) Does dopaminergic medication differentially affect dynamic decision making? To address these questions participants were trained with different goals during learning: either they made intervention-based decisions or prediction-based decisions during learning. The findings show that overall there is an advantage for those trained to intervene over those trained to predict. In addition, the results are the first demonstration that PD patients 'ON' (N=20) compared to 'OFF' L-Dopa (N=15) medication and also relative to healthy age matched controls (N=16) showed lower levels of relative improvement in the accuracy of their decisions in a dynamic decision making task, and tended to use sub-optimal strategies. These findings provide support for the 'Dopamine Overdose' hypothesis using a novel decision making task, and suggest that executive functions such as decision making can be adversely affected by dopaminergic medication in PD.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0028-3932</s0></fA01><fA02 i1="01"><s0>NUPSA6</s0></fA02><fA03 i2="1"><s0>Neuropsychologia</s0></fA03><fA05><s2>53</s2></fA05><fA08 i1="01" i2="1" l="ENG"><s1>The effects of dopaminergic medication on dynamic decision making in Parkinson's disease</s1></fA08><fA11 i1="01" i2="1"><s1>OSMAN (Magda)</s1></fA11><fA11 i1="02" i2="1"><s1>RYTERSK (Agata)</s1></fA11><fA11 i1="03" i2="1"><s1>KARIMI (Kash)</s1></fA11><fA11 i1="04" i2="1"><s1>LINGLING TU</s1></fA11><fA11 i1="05" i2="1"><s1>OBESO (Ignacio)</s1></fA11><fA11 i1="06" i2="1"><s1>SPEEKENBRINK (Maarten)</s1></fA11><fA11 i1="07" i2="1"><s1>JAHANSHAHI (Marjan)</s1></fA11><fA14 i1="01"><s1>Biological and Experimental Psychology, School of Biological and Chemical Sciences, Queen Mary University of London, Mile End Road</s1><s2>London E1 4NS</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ></fA14><fA14 i1="02"><s1>Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, UCL Institute of Neurology, 33 Queen Square</s1><s2>London WC1N 3 BG</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Psychiatry, Sir Run Run Shaw Hospital, 3 East Qingchun Road</s1><s2>310016 Hangzhou, Zhejiang</s2><s3>CHN</s3><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>Psychology Department at the St. George Campus, University of Toronto, 100 St. George Street, 4th Floor, Sidney Smith Hall</s1><s2>Toronto, Ontario, M5S 3G3</s2><s3>CAN</s3><sZ>5 aut.</sZ></fA14><fA14 i1="05"><s1>Cognitive, Perceptual and Brain Sciences, University College London, 26 Bedford Way</s1><s2>London WC1H 0AP</s2><s3>GBR</s3><sZ>1 aut.</sZ><sZ>6 aut.</sZ></fA14><fA20><s1>157-164</s1></fA20><fA21><s1>2014</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>11143</s2><s5>354000505714970160</s5></fA43><fA44><s0>0000</s0><s1>© 2014 INIST-CNRS. 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In addition, the results are the first demonstration that PD patients 'ON' (N=20) compared to 'OFF' L-Dopa (N=15) medication and also relative to healthy age matched controls (N=16) showed lower levels of relative improvement in the accuracy of their decisions in a dynamic decision making task, and tended to use sub-optimal strategies. These findings provide support for the 'Dopamine Overdose' hypothesis using a novel decision making task, and suggest that executive functions such as decision making can be adversely affected by dopaminergic medication in PD.</s0></fC01><fC02 i1="01" i2="X"><s0>002B18C13</s0></fC02><fC02 i1="02" i2="X"><s0>002B17G</s0></fC02><fC02 i1="03" i2="X"><s0>002B17A01</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Dopamine</s0><s2>NK</s2><s2>FR</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Dopamine</s0><s2>NK</s2><s2>FR</s2><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Dopamina</s0><s2>NK</s2><s2>FR</s2><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Prise de décision</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Decision making</s0><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Toma decision</s0><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Maladie de Parkinson</s0><s2>NM</s2><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Parkinson 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l="FRE"><s0>Homme</s0><s5>18</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Human</s0><s5>18</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Hombre</s0><s5>18</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Catécholamine</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Catecholamine</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Catecolamina</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Neurotransmetteur</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Neurotransmitter</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Neurotransmisor</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Cognition</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Cognition</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Cognición</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Pathologie de l'encéphale</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Cerebral disorder</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Encéfalo patología</s0><s5>40</s5></fC07><fC07 i1="05" i2="X" l="FRE"><s0>Syndrome extrapyramidal</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="ENG"><s0>Extrapyramidal syndrome</s0><s5>41</s5></fC07><fC07 i1="05" i2="X" l="SPA"><s0>Extrapiramidal síndrome</s0><s5>41</s5></fC07><fC07 i1="06" i2="X" l="FRE"><s0>Maladie dégénérative</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="ENG"><s0>Degenerative disease</s0><s5>42</s5></fC07><fC07 i1="06" i2="X" l="SPA"><s0>Enfermedad degenerativa</s0><s5>42</s5></fC07><fC07 i1="07" i2="X" l="FRE"><s0>Pathologie du système nerveux central</s0><s5>43</s5></fC07><fC07 i1="07" i2="X" l="ENG"><s0>Central nervous system disease</s0><s5>43</s5></fC07><fC07 i1="07" i2="X" l="SPA"><s0>Sistema nervosio central patología</s0><s5>43</s5></fC07><fC07 i1="08" i2="X" l="FRE"><s0>Pathologie du système nerveux</s0><s5>44</s5></fC07><fC07 i1="08" i2="X" l="ENG"><s0>Nervous system diseases</s0><s5>44</s5></fC07><fC07 i1="08" i2="X" l="SPA"><s0>Sistema nervioso patología</s0><s5>44</s5></fC07><fC07 i1="09" i2="X" l="FRE"><s0>Processus acquisition</s0><s5>45</s5></fC07><fC07 i1="09" i2="X" l="ENG"><s0>Acquisition process</s0><s5>45</s5></fC07><fC07 i1="09" i2="X" l="SPA"><s0>Proceso adquisición</s0><s5>45</s5></fC07><fN21><s1>069</s1></fN21></pA></standard></inist><affiliations><list><country><li>Canada</li><li>Royaume-Uni</li><li>République populaire de Chine</li></country><region><li>Angleterre</li><li>Grand Londres</li><li>Ontario</li></region><settlement><li>Londres</li><li>Toronto</li></settlement><orgName><li>University College de Londres</li><li>Université de Londres</li><li>Université de Toronto</li></orgName></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Osman, Magda" sort="Osman, Magda" uniqKey="Osman M" first="Magda" last="Osman">Magda Osman</name></region><name sortKey="Jahanshahi, Marjan" sort="Jahanshahi, Marjan" uniqKey="Jahanshahi M" first="Marjan" last="Jahanshahi">Marjan Jahanshahi</name><name sortKey="Karimi, Kash" sort="Karimi, Kash" uniqKey="Karimi K" first="Kash" last="Karimi">Kash Karimi</name><name sortKey="Osman, Magda" sort="Osman, Magda" uniqKey="Osman M" first="Magda" last="Osman">Magda Osman</name><name sortKey="Osman, Magda" sort="Osman, Magda" uniqKey="Osman M" first="Magda" last="Osman">Magda Osman</name><name sortKey="Rytersk, Agata" sort="Rytersk, Agata" uniqKey="Rytersk A" first="Agata" last="Rytersk">Agata Rytersk</name><name sortKey="Rytersk, Agata" sort="Rytersk, Agata" uniqKey="Rytersk A" first="Agata" last="Rytersk">Agata Rytersk</name><name sortKey="Speekenbrink, Maarten" sort="Speekenbrink, Maarten" uniqKey="Speekenbrink M" first="Maarten" last="Speekenbrink">Maarten Speekenbrink</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Lingling Tu" sort="Lingling Tu" uniqKey="Lingling Tu" last="Lingling Tu">LINGLING TU</name></noRegion></country><country name="Canada"><region name="Ontario"><name sortKey="Obeso, Ignacio" sort="Obeso, Ignacio" uniqKey="Obeso I" first="Ignacio" last="Obeso">Ignacio Obeso</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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|texte= The effects of dopaminergic medication on dynamic decision making in Parkinson's disease
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