La maladie de Parkinson au Canada (serveur d'exploration)

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A. E. Lang And NotElectrodiagnostic

List of bibliographic references

Number of relevant bibliographic references: 82.
Ident.Authors (with country if any)Title
000156 R. B. Postuma [Canada] ; A. E. Lang [Canada] ; J. F. Gagnon [Canada] ; A. Pelletier [Canada] ; J. Y. Montplaisir [Canada]How does parkinsonism start? Prodromal parkinsonism motor changes in idiopathic REM sleep behaviour disorder
000195 Tiago A. Mestre [Canada, Portugal] ; A. E. Lang [Canada] ; Joaquim J. Ferreira [Portugal] ; Vânia Almeida [Portugal] ; Mamede De Carvalho [Portugal] ; Janis Miyasaki [Canada] ; Robert Chen [Canada] ; Susan Fox [Canada]Associated movement disorders in orthostatic tremor
000239 C. Marras [Canada] ; B. Schuele [États-Unis] ; R. P. Munhoz [Brésil] ; E. Rogaeva [Canada] ; J. W. Langston [États-Unis] ; M. Kasten [Allemagne] ; C. Meaney [Canada] ; C. Klein [Allemagne] ; P. M. Wadia [Canada] ; S.-Y. Lim [Canada] ; R. S.-I. Chuang [Canada] ; C. Zadikof [Canada] ; T. Steeves [Canada] ; K. M. Prakash [Canada] ; R. M. A. De Bie [Canada] ; G. Adeli [Canada] ; T. Thomsen [Canada] ; K. K. Johansen [Norvège] ; H. A. Teive [Brésil] ; A. Asante [Canada] ; W. Reginold [Canada] ; A. E. Lang [Canada]Phenotype in parkinsonian and nonparkinsonian LRRK2 G2019S mutation carriers
000318 S. W. Hung [Canada, États-Unis] ; G. M. Adeli [Canada] ; T. Arenovich [Canada] ; S. H. Fox [Canada] ; A. E. Lang [Canada]Patient perception of dyskinesia in Parkinson's disease
000365 T. Van Eimeren [Canada] ; G. Pellecchia [Canada] ; R. Cilia [Canada] ; B. Ballanger [Canada] ; T. D. L. Steeves [Canada] ; S. Houle [Canada] ; J. M. Miyasaki [Canada] ; M. Zurowski [Canada] ; A. E. Lang [Canada] ; A. P. Strafella [Canada]Drug-induced deactivation of inhibitory networks predicts pathological gambling in PD
000454 T. D. L. Steeves [Canada] ; J. Miyasaki [Canada] ; M. Zurowski [Canada] ; A. E. Lang [Canada] ; G. Pellecchia [Canada] ; T. Van Eimeren [Canada] ; P. Rusjan [Canada] ; S. Houle [Canada] ; A. P. Strafella [Canada]Increased striatal dopamine release in Parkinsonian patients with pathological gambling : a [11C] raclopride PET study
000457 J. Chu [Canada] ; A. Wagle-Shukla [Canada] ; C. Gunraj [Canada] ; A. E. Lang [Canada] ; R. Chen [Canada]Impaired presynaptic inhibition in the motor cortex in Parkinson disease
000565 E. Moro [Canada] ; J. Volkmann [Allemagne] ; I. R. Konig [Allemagne] ; S. Winkler [Allemagne] ; A. Hiller [Allemagne] ; S. Hassin-Baer [Israël] ; J. Herzog [Allemagne] ; A. Schnitzler [Allemagne] ; K. Lohmann [Allemagne] ; M. O. Pinsker [Allemagne] ; J. Voges [Allemagne] ; A. Djarmatic [Allemagne] ; P. Seibler [Allemagne] ; A. M. Lozano [Canada] ; E. Rogaeva [Canada] ; A. E. Lang [Canada] ; G. Deuschl [Allemagne] ; C. Klein [Canada, Allemagne]Bilateral subthalamic stimulation in Parkin and PINK1 parkinsonism
000597 A. Sailer [Canada, Suède] ; D. I. Cunic [Canada] ; G. O. Paradiso [Canada] ; C. A. Gunraj [Canada] ; A. Wagle-Shukla [Canada] ; E. Moro [Canada] ; A. M. Lozano [Canada] ; A. E. Lang [Canada] ; R. Chen [Canada]Subthalamic nucleus stimulation modulates afferent inhibition in Parkinson disease
000665 R. M. A. De Bie [Canada, Pays-Bas] ; J. Miyasaki [Canada] ; A. E. Lang [Canada] ; S. H. Fox [Canada]Clinical practice regarding dopamine-agonist use and driving in Parkinson's disease
000679 R. B. Postuma [Canada] ; A. J. Espay [Canada] ; C. Zadikoff [Canada] ; O. Suchowersky [Canada] ; W. R. W. Martin [Canada] ; A.-L. Lafontaine [Canada] ; R. Ranawaya [Canada] ; R. Camicioli [Canada] ; A. E. Lang [Canada]Vitamins and entacapone in levodopa-induced hyperhomocysteinemia : A randomized controlled study
000700 V. Voon [États-Unis, Canada] ; K. Hassan [Canada] ; M. Zurowski [Canada] ; S. Duff-Canning [Canada] ; M. De Souza [Canada] ; S. Fox [Canada] ; A. E. Lang [Canada] ; J. Miyasaki [Canada]Prospective prevalence of pathologic gambling and medication association in Parkinson disease
000702 V. Voon [États-Unis, Canada] ; K. Hassan [Canada] ; M. Zurowski [Canada] ; M. De Souza [Canada] ; T. Thomsen [Canada] ; S. Fox [Canada] ; A. E. Lang [Canada] ; J. Miyasaki [Canada]Prevalence of repetitive and reward-seeking behaviors in Parkinson disease
000765 C. Marras [Canada] ; M. P. Mcdermott [États-Unis] ; P. A. Rochon [Canada] ; C. M. Tanner [États-Unis] ; G. Naglie [Canada] ; A. Rudolph [États-Unis] ; A. E. Lang [Canada]Survival in Parkinson disease: Thirteen-year follow-up of the DATATOP cohort
000783 S. F. Farmer [Royaume-Uni] ; A. J. Espay [Canada] ; J.-Y. Li [Canada] ; L. Johnston [Canada] ; R. Chen [Canada] ; A. E. Lang [Canada]Mirror movements in parkinsonism : evaluation of a new clinical sign. Commentary
000787 C. Paisan-Ruiz [États-Unis, Espagne] ; A. E. Lang [Canada] ; T. Kawarai [Canada] ; C. Sato [Canada] ; S. Salehi-Rad [Canada] ; G. K. Fisman [Canada] ; T. Al-Khairallah [Canada] ; P. St George-Hyslop [Canada] ; A. Singleton [États-Unis] ; E. Rogaeva [Canada]LRRK2 gene in parkinson disease : Mutation analysis and case control association study
000818 Hans-Joachim Freund [Allemagne] ; M. C. Rodriguez-Oroz [Espagne] ; J. A. Obeso [Espagne] ; A. E. Lang [Canada] ; J.-L. Houeto [France] ; P. Pollak [France] ; S. Rehncrona [France] ; J. Kulisevsky [Espagne] ; A. Albanese [Italie] ; J. Volkmann [Allemagne] ; M. I. Hariz [Royaume-Uni] ; N. P. Quinn [Royaume-Uni] ; J. D. Speelman [Pays-Bas] ; J. Guridi [Espagne] ; I. Zamarbide [Espagne] ; A. Gironell [Espagne] ; J. Molet [Espagne] ; B. Pascual-Sedano [Espagne] ; B. Pidoux [France] ; A. M. Bonnet [France] ; Yves Agid [France] ; J. Xie [France] ; A.-L. Benabid [France] ; A. M. Lozano [Canada] ; J. Saint-Cyr [Canada] ; L. Romito [Italie] ; M. F. Contarino [Italie] ; M. Scerrati [Italie] ; V. Fraix [France] ; N. Van Blercom [France]Bilateral deep brain stimulation in Parkinson's disease : a multicentre study with 4 years follow-up. Commentary
000880 R. P. Munhoz [Canada] ; J.-Y. Li [Canada] ; M. Kurtinecz [Canada] ; P. Piboolnurak [États-Unis] ; A. Constantino [États-Unis] ; S. Fahn [États-Unis] ; A. E. Lang [Canada]Evaluation of the pull test technique in assessing postural instability in Parkinson's disease
000882 S. Kedia [États-Unis] ; E. Moro [Canada] ; M. Tagliati [États-Unis] ; A. E. Lang [Canada] ; R. Kumar [États-Unis]Emergence of restless legs syndrome during subthalamic stimulation for Parkinson disease
000891 K. Hedrich [Allemagne] ; A. Djarmati [Allemagne, Serbie] ; N. Sch Fer [Allemagne] ; R. Hering [Allemagne] ; C. Wellenbrock [Allemagne] ; P. H. Weiss [Allemagne] ; R. Hilker [Allemagne] ; P. Vieregge [Allemagne] ; L. J. Ozelius [États-Unis] ; P. Heutink [Pays-Bas] ; V. Bonifati [Pays-Bas, Italie] ; E. Schwinger [Allemagne] ; A. E. Lang [Canada] ; J. Noth [Allemagne] ; S. B. Bressman [États-Unis] ; P. P. Pramstaller [Italie] ; O. Riess [Allemagne] ; C. Klein [Allemagne]DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease
000922 J. G. Nutt [États-Unis] ; K. J. Burchiel [États-Unis] ; C. L. Comella [États-Unis] ; Joseph Jankovic [États-Unis] ; A. E. Lang [Canada] ; E. R. Jr Laws [États-Unis] ; A. M. Lozano [Canada] ; R. D. Penn [États-Unis] ; R. K. Jr Simpson [États-Unis] ; M. Stacy [États-Unis] ; G. F. Wooten [États-Unis]Randomized, double-blind trial of glial cell line-derived neurotrophic factor (GDNF) in PD
000948 G. Paradiso [Canada] ; J. A. Saint-Cyr [Canada] ; A. M. Lozano [Canada] ; A. E. Lang [Canada] ; R. Chen [Canada]Involvement of the human subthalamic nucleus in movement preparation
000990 R. Levy [Canada] ; A. E. Lang [Canada] ; W. D. Hutchison [Canada] ; A. M. Lozano [Canada] ; J. O. Dostrovsky [Canada]Simultaneous repetitive movements following pallidotomy or subthalamic deep brain stimulation in patients with Parkinson's disease
000A24 D. Cunic [Canada] ; L. Roshan [Canada] ; F. I. Khan [Canada] ; A. M. Lozano [Canada] ; A. E. Lang [Canada] ; R. Chen [Canada]Effects of subthalamic nucleus stimulation on motor cortex excitability in Parkinson's disease
000A76 M. Fukuda [États-Unis] ; M. J. Mentis [États-Unis] ; Y. Ma [États-Unis] ; V. Dhawan [États-Unis] ; A. Antonini [États-Unis] ; A. E. Lang [Canada] ; A. M. Lozano [Canada] ; J. Hammerstad [États-Unis] ; K. Lyons [États-Unis] ; W. C. Koller [États-Unis] ; J. R. Moeller [États-Unis] ; D. Eidelberg [États-Unis]Networks mediating the clinical effects of pallidal brain stimulation for Parkinson's disease: A pet study of resting-state glucose metabolism
000B43 R. Kumar [Canada] ; A. E. Lang [Canada] ; M. C. Rodriguez-Oroz [Espagne] ; A. M. Lozano [Canada] ; P. Limousin [France] ; P. Pollak [France] ; A. L. Benabid [France] ; J. Guridi [Espagne] ; E. Ramos [Espagne] ; C. Van Der Linden [Belgique] ; A. Vandewalle [Belgique] ; J. Caemaert [Belgique] ; E. Lannoo [Belgique] ; D. Van Den Abbeele [Belgique] ; G. Vingerhoets [Belgique] ; M. Wolters [Belgique] ; J. A. Obeso [Espagne]eep brain stimulation of the globus pallidus pars interna in advanced Parkinson's disease
000B54 A. E. Lang [Canada] ; LANGSTON ; RASCOL ; BROTCHIE ; BENABID ; MELAMED ; BONUCELLI ; OLANOW ; OBESO ; GIMENEZ-ROLDAN ; RAJPUT ; FAHN ; NUTT ; BROOKS ; CHASESurgery for levodopa-induced dyskinesias. Discussion
000B55 A. E. Lang [Canada]Surgery for Parkinson disease : A critical evaluation of the state of the art
000B59 W. J. Lombardi [États-Unis, Canada] ; R. E. Gross [États-Unis, Canada] ; L. L. Trepanier [Canada] ; A. E. Lang [Canada] ; A. M. Lozano [Canada] ; J. A. Saint-Cyr [Canada]Relationship of lesion location to cognitive outcome following microelectrode-guided pallidotomy for Parkinson's disease: Support for the existence of cognitive circuits in the human pallidum
000B73 L. L. Trepanier [Canada] ; R. Kumar [Canada] ; A. M. Lozano [Canada] ; A. E. Lang [Canada] ; J. A. Saint-Cyr [Canada]Neuropsychological outcome of GPI pallidotomy and GPI or STN deep brain stimulation in Parkinson's disease
000B74 Jean A. Saint-Cyr [Canada] ; Lisa L. Trepanier [Canada] ; Rajeev Kumar [États-Unis] ; Andres M. Lozano [Canada] ; A. E. Lang [Canada]Neuropsychological consequences of chronic bilateral stimulation of the subthalamic nucleus in Parkinson's disease
000B83 J. Fine [Canada] ; J. Duff [Canada] ; R. Chen [Canada] ; W. Hutchison [Canada] ; A. M. Lozano [Canada] ; A. E. Lang [Canada]Long-term follow-up of unilateral pallidotomy in advanced Parkinson's disease
000C12 O. Rascol [France] ; D. J. Brooks [Royaume-Uni] ; A. D. Korczyn [Israël] ; P. P. De Deyn [Belgique] ; C. E. Clarke [Royaume-Uni] ; A. E. Lang [Canada]A five-year study of the incidence of dyskinesia in patients with early parkinson's disease who were treated with ropinirole or levodopa
000C16 R. E. Gross [Canada] ; W. J. Lombardi ; W. D. Hutchison ; S. Narula ; J. A. Saint-Cyr ; J. O. Dostrovsky ; R. R. Tasker ; A. E. Lang ; A. M. LozanoVariability in lesion location after microelectrode-guided pallidotomy for Parkinson's disease : anatomical, physiological, and technical factors that determine lesion distribution
000C19 D. A. Grimes [Canada] ; A. E. LangTreatment of early Parkinson's disease
000C27 M. Ichise [Canada] ; Y. J. Kim [Canada] ; J. R. Ballinger [Canada] ; D. Vines [Canada] ; S. S. Erami [Canada] ; F. Tanaka [Canada] ; A. E. Lang [Canada]SPECT imaging of pre- and postsynaptic dopaminergic alterations in L-dopa-untreated PD
000C29 R. E. Gross [Canada] ; W. J. Lombardi [Canada] ; A. E. Lang [Canada] ; J. Duff [Canada] ; W. D. Hutchison [Canada] ; J. A. Saint-Cyr [Canada] ; R. R. Tasker [Canada] ; A. M. Lozano [Canada]Relationship of lesion location to clinical outcome following microelectrode-guided pallidotomy for Parkinson's disease
000C36 A. E. Lang [Canada] ; J. Duff [Canada] ; J. A. Saint-Cyr [Canada] ; L. Trepanier [Canada] ; R. E. Gross [Canada] ; W. Lombardi [Canada] ; E. Montgomery [États-Unis] ; W. Hutchinson [Canada] ; A. M. Lozano [Canada]Posteroventral medial pallidotomy in Parkinson's disease
000C44 P. Ashby [Canada] ; Y. J. Kim [Canada] ; R. Kumar [Canada] ; A. E. Lang [Canada] ; A. M. Lozano [Canada]Neurophysiological effects of stimulation through electrodes in the human subthalamic nucleus
000C54 M. Ichise [Canada] ; Y. J. Kim ; S. S. Erami ; J. R. Ballinger ; D. Vines ; F. Tanaka ; A. E. LangFunctional morphometry of the striatum in Parkinson's disease on three-dimensional surface display of 123I-β-CIT SPECT data
000C67 R. Kumar [Canada] ; A. M. Lozano [Canada] ; E. Sime [Canada] ; E. Halket [Canada] ; A. E. Lang [Canada]Comparative effects of unilateral and bilateral subthalamic nucleus deep brain stimulation
000C68 I. Litvan [États-Unis] ; D. A. Grimes [Canada] ; A. E. Lang [Canada] ; Joseph Jankovic [États-Unis] ; A. Mckee [États-Unis] ; M. Verny [France] ; K. Jellinger [Autriche] ; K. R. Chaudhuri [Royaume-Uni] ; R. K. B. Pearce [Royaume-Uni]Clinical features differentiating patients with postmortem confirmed progressive supranuclear palsy and corticobasal degeneration
000C91 A. E. Lang [Canada] ; A. M. Lozano [Canada]Parkinson's disease: First of two parts
000C92 A. E. Lang [Canada] ; A. M. Lozano [Canada]Parkinson's disease : Second of two parts
000C93 A. M. Lozano [Canada] ; A. E. Lang [Canada] ; W. D. Hutchison [Canada]Pallidotomy for tremor
000C94 R. Kumar [Canada] ; A. M. Lozano [Canada] ; E. Montgomery [États-Unis] ; A. E. Lang [Canada]Pallidotomy and deep brain stimulation of the pallidum and subthalamic nucleus in advanced Parkinson's disease
000C95 N. Galvez-Jimenez [Canada] ; A. Lozano [Canada] ; R. Tasker [Canada] ; J. Duff [Canada] ; W. Hutchison [Canada] ; A. E. Lang [Canada]Pallidal stimulation in Parkinson's disease patients with a prior unilateral pallidotomy
000C96 L. L. Trepanier [Canada] ; J. A. Saint-Cyr [Canada] ; A. M. Lozano [Canada] ; A. E. Lang [Canada]Neuropsychological consequences of posteroventral pallidotomy for the treatment of Parkinson's disease
000C97 W. D. Hutchison [Canada] ; R. J. Allan [Canada] ; H. Opitz [Canada] ; R. Levy [Canada] ; J. O. Dostrovsky [Canada] ; A. E. Lang [Canada] ; A. M. Lozano [Canada]Neurophysiological identification of the subthalamic nucleus in surgery for Parkinson's disease
000D00 A. M. Lozano [Canada] ; W. D. Hutchison [Canada] ; R. R. Tasker [Canada] ; A. E. Lang [Canada] ; F. Junn [Canada] ; J. O. Dostrovsky [Canada]Microelectrode recordings define the ventral posteromedial pallidotomy target
000D08 P. Ashby [Canada] ; A. Strafella [Canada] ; J. O. Dostrovsky [Canada] ; A. Lozano [Canada] ; A. E. Lang [Canada]Immediate motor effects of stimulation through electrodes implanted in the human globus pallidus
000D19 R. Kumar [Canada] ; A. M. Lozano [Canada] ; Y. J. Kim [Canada] ; W. D. Hutchison [Canada] ; E. Sime [Canada] ; E. Halket [Canada] ; A. E. Lang [Canada]Double-blind evaluation of subthalamic nucleus deep brain stimulation in advanced Parkinson disease
000D63 A. E. Lang [Canada] ; A. M. Lozano [Canada] ; E. Montgomery [États-Unis] ; J. Duff [Canada] ; R. Tasker [Canada] ; W. Hutchinson [Canada]Posteroventral medial pallidotomy in advanced Parkinson's disease
000D65 A. Strafella [Canada] ; P. Ashby ; A. Lozano ; A. E. LangPallidotomy increases cortical inhibition in Parkinson's disease
000D66 R. R. Tasker [Canada] ; A. E. Lang [Canada] ; A. M. Lozano [Canada]Pallidal and thalamic surgery for Parkinson's disease
000D70 K. Markopoulou [États-Unis] ; K. W. Larsen [États-Unis] ; E. K. Wszolek [États-Unis] ; M. A. Denson [États-Unis] ; A. E. Lang [Canada] ; R. F. Pfeiffer [États-Unis] ; Z. K. Wszolek [États-Unis]Olfactory dysfunction in familial parkinsonism
000D74 A. M. Lozano [Canada] ; A. E. Lang [Canada] ; W. D. Hutchison [Canada] ; J. O. Dostrovsky [Canada]Microelectrode recording-guided posteroventral pallidotomy in patients with Parkinson's disease
000D75 A. E. Lang [Canada] ; A. Lozano [Canada] ; J. Duff [Canada] ; R. Tasker [Canada] ; J. Miyasaki ; N. Galvez-Jimenez ; W. Hutchison ; J. DostrovskyMedial pallidotomy in late-stage Parkinson's disease and striatonigral degeneration
000D80 W. D. Hutchison [Canada] ; A. M. Lozano [Canada] ; R. R. Tasker [Canada] ; A. E. Lang [Canada] ; J. O. Dostrovsky [Canada]Identification and characterization of neurons with tremor-frequency activity in human globus pallidus
000D96 R. Kumar [Canada] ; A. E. Lang [Canada]Coexistence of tics and parkinsonism : Evidence for non-dopaminergic mechanisms in tic pathogenesis
000E13 P. Sandor [Canada] ; A. E. Lang [Canada] ; S. Singal [Canada] ; C. Augus [Canada]Remoxipride in the treatment of levodopa-induced psychosis
000E14 N. Galvez-Jimenez [Canada] ; A. E. Lang [Canada]Perioperative problems in Parkinson's disease and their management : Apomorphine with rectal domperidone
000E20 C. L. Barclay [Canada] ; J. Duff ; P. Sandor ; A. E. LangLimited usefulness of electroconvulsive therapy in progressive supranuclear palsy
000E21 SANJAY KALRA [Canada] ; C. Bergeron [Canada] ; A. E. Lang [Canada]Lewy body disease and dementia : A review
000E50 A. E. Lang [Canada] ; P. Sandor ; J. Duff [Canada]Remoxipride in Parkinson's disease : differential response in patients with dyskinesias fluctuations versus psychosis
000E62 A. E. Lang [Canada]Hemiatrophy, juvenile-onset exertional alternating leg paresis, hypotonia, and hemidystonia and adult-onset hemiparkinsonism : the spectrum of hemiparkinsonism-hemiatrophy syndrome
000E68 A. M. Lozano [Canada] ; A. E. Lang ; N. Galvez-Jimenez ; J. Miyasaki ; J. Duff ; W. D. Hutchinson ; J. O. DostrovskyEffect of GPi pallidotomy on motor function in Parkinson's disease
000F13 W. D. Hutchison [Canada] ; A. M. Lozano ; K. D. Davis [Canada] ; J. A. Saint-Cyr ; A. E. Lang ; J. O. DostrovskyDifferential neuronal activity in segments of globus pallidus in Parkinson's disease patients
000F32 J. A. Saint-Cyr [Canada] ; A. E. Taylor [Canada] ; A. E. LangNeuropsychological and psychiatric side effects in the treatment of Parkinson's disease
001002 S. G. Adams [Canada] ; A. E. LangCan the Lombard effect be used to improve low voice intensity in Parkinson's disease?
001056 A. E. Taylor ; J. A. Saint-Cyr ; A. E. LangMemory and learning in early Parkinson's disease : evidence for a frontal lobe syndrome
001075 A. E. Lang ; D. E. Riley ; L. Vachon ; X. LatasteCQA 206-291 in Parkinson's disease : an acute single escalating dosage study
001094 D. Riley ; A. E. Lang ; R. D. G. Blair ; A. Birnbaum ; B. ReidFrozen shoulder and other shoulder disturbances in Parkinson's disease
001115 J. A. Saint-Cyr ; A. E. Taylor ; A. E. LangProcedural learning and neostriatal dysfunction in man
001117 D. Riley ; A. E. LangPractical application of a low-protein diet for Parkinson's disease
001122 A. E. Taylor ; J. A. Saint-Cyr ; A. E. LangIdiopathic Parkinson's disease: revised concepts of cognitive and affective status
001138 J. A. Sharpe ; W. A. Fletcher ; A. E. Lang ; D. H. ZackonSmooth pursuit during dose-related on-off fluctuations in Parkinson's disease
001142 A. E. LangRestless legs syndrome and Parkinson's disease: insights into pathophysiology
001144 A. E. Taylor ; J. A. Saint-Cyr ; A. E. LangParkinson's disease: cognitive changes in relation to treatment response
001146 A. E. LangManipulating the dopaminergic system in Parkinson's disease
001158 A. E. Lang ; K. JohnsonAkathisia in idiopathic Parkinson's disease
001174 A. E. Taylor ; J. A. Saint-Cyr ; A. E. LangFrontal lobe dysfunction in Parkinson's disease

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