Sevoflurane has no effect on sinoatrial node function or on normal atrioventricular and accessory pathway conduction in Wolff-Parkinson-White syndrome during alfentanil/midazolam anesthesia.
Identifieur interne : 002679 ( Ncbi/Merge ); précédent : 002678; suivant : 002680Sevoflurane has no effect on sinoatrial node function or on normal atrioventricular and accessory pathway conduction in Wolff-Parkinson-White syndrome during alfentanil/midazolam anesthesia.
Auteurs : M D Sharpe [Canada] ; D J Cuillerier ; J K Lee ; M. Basta ; A D Krahn ; G J Klein ; R. YeeSource :
- Anesthesiology [ 0003-3022 ] ; 1999.
English descriptors
- KwdEn :
- Adult, Alfentanil, Anesthetics, Inhalation (adverse effects), Anesthetics, Intravenous, Atrioventricular Node (drug effects), Catheter Ablation, Electrophysiology, Female, Heart Rate (drug effects), Humans, Male, Methyl Ethers (adverse effects), Midazolam, Neural Pathways (drug effects), Neural Pathways (physiology), Refractory Period, Electrophysiological (drug effects), Sinoatrial Node (drug effects), Wolff-Parkinson-White Syndrome (physiopathology), Wolff-Parkinson-White Syndrome (surgery).
- MESH :
- chemical , adverse effects : Anesthetics, Inhalation, Methyl Ethers.
- chemical : Alfentanil, Anesthetics, Intravenous, Midazolam.
- drug effects : Atrioventricular Node, Heart Rate, Neural Pathways, Refractory Period, Electrophysiological, Sinoatrial Node.
- physiology : Neural Pathways.
- physiopathology : Wolff-Parkinson-White Syndrome.
- surgery : Wolff-Parkinson-White Syndrome.
- Adult, Catheter Ablation, Electrophysiology, Female, Humans, Male.
Abstract
The effects of sevoflurane on the electrophysiologic properties of the human heart are unknown. This study evaluated the effects of sevoflurane on the electrophysiologic properties of the normal atrioventricular conduction system, and on the accessory pathways in patients with Wolff-Parkinson-White syndrome, to determine its suitability as an anesthetic agent for patients undergoing ablative procedures.
PubMed: 9915313
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pubmed:9915313Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sevoflurane has no effect on sinoatrial node function or on normal atrioventricular and accessory pathway conduction in Wolff-Parkinson-White syndrome during alfentanil/midazolam anesthesia.</title><author><name sortKey="Sharpe, M D" sort="Sharpe, M D" uniqKey="Sharpe M" first="M D" last="Sharpe">M D Sharpe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anaesthesia, London Health Sciences Centre, University Campus, University of Western Ontario, Canada. michael.sharpe@lhsc.on.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anaesthesia, London Health Sciences Centre, University Campus, University of Western Ontario</wicri:regionArea><wicri:noRegion>University of Western Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Cuillerier, D J" sort="Cuillerier, D J" uniqKey="Cuillerier D" first="D J" last="Cuillerier">D J Cuillerier</name></author><author><name sortKey="Lee, J K" sort="Lee, J K" uniqKey="Lee J" first="J K" last="Lee">J K Lee</name></author><author><name sortKey="Basta, M" sort="Basta, M" uniqKey="Basta M" first="M" last="Basta">M. Basta</name></author><author><name sortKey="Krahn, A D" sort="Krahn, A D" uniqKey="Krahn A" first="A D" last="Krahn">A D Krahn</name></author><author><name sortKey="Klein, G J" sort="Klein, G J" uniqKey="Klein G" first="G J" last="Klein">G J Klein</name></author><author><name sortKey="Yee, R" sort="Yee, R" uniqKey="Yee R" first="R" last="Yee">R. Yee</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1999">1999</date><idno type="RBID">pubmed:9915313</idno><idno type="pmid">9915313</idno><idno type="wicri:Area/PubMed/Corpus">001730</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001730</idno><idno type="wicri:Area/PubMed/Curation">001730</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001730</idno><idno type="wicri:Area/PubMed/Checkpoint">001730</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001730</idno><idno type="wicri:Area/Ncbi/Merge">002679</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Sevoflurane has no effect on sinoatrial node function or on normal atrioventricular and accessory pathway conduction in Wolff-Parkinson-White syndrome during alfentanil/midazolam anesthesia.</title><author><name sortKey="Sharpe, M D" sort="Sharpe, M D" uniqKey="Sharpe M" first="M D" last="Sharpe">M D Sharpe</name><affiliation wicri:level="1"><nlm:affiliation>Department of Anaesthesia, London Health Sciences Centre, University Campus, University of Western Ontario, Canada. michael.sharpe@lhsc.on.ca</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Anaesthesia, London Health Sciences Centre, University Campus, University of Western Ontario</wicri:regionArea><wicri:noRegion>University of Western Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Cuillerier, D J" sort="Cuillerier, D J" uniqKey="Cuillerier D" first="D J" last="Cuillerier">D J Cuillerier</name></author><author><name sortKey="Lee, J K" sort="Lee, J K" uniqKey="Lee J" first="J K" last="Lee">J K Lee</name></author><author><name sortKey="Basta, M" sort="Basta, M" uniqKey="Basta M" first="M" last="Basta">M. Basta</name></author><author><name sortKey="Krahn, A D" sort="Krahn, A D" uniqKey="Krahn A" first="A D" last="Krahn">A D Krahn</name></author><author><name sortKey="Klein, G J" sort="Klein, G J" uniqKey="Klein G" first="G J" last="Klein">G J Klein</name></author><author><name sortKey="Yee, R" sort="Yee, R" uniqKey="Yee R" first="R" last="Yee">R. Yee</name></author></analytic><series><title level="j">Anesthesiology</title><idno type="ISSN">0003-3022</idno><imprint><date when="1999" type="published">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Alfentanil</term><term>Anesthetics, Inhalation (adverse effects)</term><term>Anesthetics, Intravenous</term><term>Atrioventricular Node (drug effects)</term><term>Catheter Ablation</term><term>Electrophysiology</term><term>Female</term><term>Heart Rate (drug effects)</term><term>Humans</term><term>Male</term><term>Methyl Ethers (adverse effects)</term><term>Midazolam</term><term>Neural Pathways (drug effects)</term><term>Neural Pathways (physiology)</term><term>Refractory Period, Electrophysiological (drug effects)</term><term>Sinoatrial Node (drug effects)</term><term>Wolff-Parkinson-White Syndrome (physiopathology)</term><term>Wolff-Parkinson-White Syndrome (surgery)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Anesthetics, Inhalation</term><term>Methyl Ethers</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Alfentanil</term><term>Anesthetics, Intravenous</term><term>Midazolam</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Atrioventricular Node</term><term>Heart Rate</term><term>Neural Pathways</term><term>Refractory Period, Electrophysiological</term><term>Sinoatrial Node</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Neural Pathways</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Wolff-Parkinson-White Syndrome</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Wolff-Parkinson-White Syndrome</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Catheter Ablation</term><term>Electrophysiology</term><term>Female</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The effects of sevoflurane on the electrophysiologic properties of the human heart are unknown. This study evaluated the effects of sevoflurane on the electrophysiologic properties of the normal atrioventricular conduction system, and on the accessory pathways in patients with Wolff-Parkinson-White syndrome, to determine its suitability as an anesthetic agent for patients undergoing ablative procedures.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">9915313</PMID><DateCreated><Year>1999</Year><Month>02</Month><Day>04</Day></DateCreated><DateCompleted><Year>1999</Year><Month>02</Month><Day>04</Day></DateCompleted><DateRevised><Year>2014</Year><Month>11</Month><Day>20</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0003-3022</ISSN><JournalIssue CitedMedium="Print"><Volume>90</Volume><Issue>1</Issue><PubDate><Year>1999</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Anesthesiology</Title><ISOAbbreviation>Anesthesiology</ISOAbbreviation></Journal><ArticleTitle>Sevoflurane has no effect on sinoatrial node function or on normal atrioventricular and accessory pathway conduction in Wolff-Parkinson-White syndrome during alfentanil/midazolam anesthesia.</ArticleTitle><Pagination><MedlinePgn>60-5</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">The effects of sevoflurane on the electrophysiologic properties of the human heart are unknown. This study evaluated the effects of sevoflurane on the electrophysiologic properties of the normal atrioventricular conduction system, and on the accessory pathways in patients with Wolff-Parkinson-White syndrome, to determine its suitability as an anesthetic agent for patients undergoing ablative procedures.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Fifteen patients with Wolff-Parkinson-White syndrome undergoing elective radiofrequency catheter ablation were studied. Anesthesia was induced with alfentanil (20-50 microg/kg) and midazolam (0.15 mg/kg), and vecuronium (20 mg) and maintained with alfentanil (0.5 to 2 microg x kg(-1) x min(-1)) and midazolam (1 or 2 mg every 10-15 min, as required). An electrophysiologic study measured the effective refractory period of the right atrium, atrioventricular node, and accessory pathway; the shortest conducted cycle length of the atrioventricular node and accessory pathway during atrial pacing; the effective refractory period of the right ventricle and accessory pathway; and the shortest retrograde conducted cycle length of the accessory pathway during ventricular pacing. Parameters of sinoatrial node function included sinus node recovery time, corrected sinus node recovery time, and sinoatrial conduction time. Intraatrial conduction time and the atrial-His interval were also measured. Characteristics of induced reciprocating tachycardia, including cycle length, atrial-His, His-ventricular, and ventriculoatrial intervals, also were measured. Sevoflurane was administered to achieve an end-tidal concentration of 2% (1 minimum alveolar concentration), and the study measurements were repeated.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Sevoflurane had no effect on the electrophysiologic parameters of conduction in the normal atrioventricular conduction system or accessory pathway, or during reciprocating tachycardia. However, sevoflurane caused a statistically significant reduction in the sinoatrial conduction time and atrial-His interval but these changes were not clinically important. All accessory pathways were successfully identified and ablated.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Sevoflurane had no effect on the electrophysiologic nature of the normal atrioventricular or accessory pathway and no clinically important effect on sinoatrial node activity. It is therefore a suitable anesthetic agent for patients undergoing ablative procedures.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Sharpe</LastName><ForeName>M D</ForeName><Initials>MD</Initials><AffiliationInfo><Affiliation>Department of Anaesthesia, London Health Sciences Centre, University Campus, University of Western Ontario, Canada. michael.sharpe@lhsc.on.ca</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cuillerier</LastName><ForeName>D J</ForeName><Initials>DJ</Initials></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>J K</ForeName><Initials>JK</Initials></Author><Author ValidYN="Y"><LastName>Basta</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Krahn</LastName><ForeName>A D</ForeName><Initials>AD</Initials></Author><Author ValidYN="Y"><LastName>Klein</LastName><ForeName>G J</ForeName><Initials>GJ</Initials></Author><Author ValidYN="Y"><LastName>Yee</LastName><ForeName>R</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016430">Clinical Trial</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Anesthesiology</MedlineTA><NlmUniqueID>1300217</NlmUniqueID><ISSNLinking>0003-3022</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018685">Anesthetics, Inhalation</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D018686">Anesthetics, Intravenous</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008738">Methyl Ethers</NameOfSubstance></Chemical><Chemical><RegistryNumber>1N74HM2BS7</RegistryNumber><NameOfSubstance UI="D015760">Alfentanil</NameOfSubstance></Chemical><Chemical><RegistryNumber>38LVP0K73A</RegistryNumber><NameOfSubstance UI="C009250">sevoflurane</NameOfSubstance></Chemical><Chemical><RegistryNumber>R60L0SM5BC</RegistryNumber><NameOfSubstance UI="D008874">Midazolam</NameOfSubstance></Chemical></ChemicalList><CitationSubset>AIM</CitationSubset><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015760" MajorTopicYN="Y">Alfentanil</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018685" MajorTopicYN="Y">Anesthetics, Inhalation</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018686" MajorTopicYN="Y">Anesthetics, Intravenous</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001283" MajorTopicYN="N">Atrioventricular Node</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D017115" MajorTopicYN="N">Catheter Ablation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004594" MajorTopicYN="N">Electrophysiology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006339" MajorTopicYN="N">Heart Rate</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008738" MajorTopicYN="Y">Methyl Ethers</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="N">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008874" MajorTopicYN="Y">Midazolam</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009434" MajorTopicYN="N">Neural Pathways</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012032" MajorTopicYN="N">Refractory Period, Electrophysiological</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012849" MajorTopicYN="N">Sinoatrial Node</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014927" MajorTopicYN="N">Wolff-Parkinson-White Syndrome</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000601" MajorTopicYN="N">surgery</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1999</Year><Month>1</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1999</Year><Month>1</Month><Day>23</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1999</Year><Month>1</Month><Day>23</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">9915313</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Basta, M" sort="Basta, M" uniqKey="Basta M" first="M" last="Basta">M. Basta</name><name sortKey="Cuillerier, D J" sort="Cuillerier, D J" uniqKey="Cuillerier D" first="D J" last="Cuillerier">D J Cuillerier</name><name sortKey="Klein, G J" sort="Klein, G J" uniqKey="Klein G" first="G J" last="Klein">G J Klein</name><name sortKey="Krahn, A D" sort="Krahn, A D" uniqKey="Krahn A" first="A D" last="Krahn">A D Krahn</name><name sortKey="Lee, J K" sort="Lee, J K" uniqKey="Lee J" first="J K" last="Lee">J K Lee</name><name sortKey="Yee, R" sort="Yee, R" uniqKey="Yee R" first="R" last="Yee">R. Yee</name></noCountry><country name="Canada"><noRegion><name sortKey="Sharpe, M D" sort="Sharpe, M D" uniqKey="Sharpe M" first="M D" last="Sharpe">M D Sharpe</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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