Mediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort
Identifieur interne : 002179 ( Ncbi/Merge ); précédent : 002178; suivant : 002180Mediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort
Auteurs : Michelle Luciano ; Janie Corley ; Simon R. Cox ; Maria C. Valdés Hernández ; Leone C. A. Craig ; David Alexander Dickie ; Sherif Karama ; Geraldine M. Mcneill ; Mark E. Bastin ; Joanna M. Wardlaw ; Ian J. DearySource :
- Neurology [ 0028-3878 ] ; 2017.
Abstract
To assess the association between Mediterranean-type diet (MeDi) and change in brain MRI volumetric measures and mean cortical thickness across a 3-year period in older age (73–76 years).
We focused on 2 longitudinal brain volumes (total and gray matter; n = 401 and 398, respectively) plus a longitudinal measurement of cortical thickness (n = 323), for which the previous cross-sectional evidence of an association with the MeDi was strongest. Adherence to the MeDi was calculated from data gathered from a food frequency questionnaire at age 70, 3 years prior to the baseline imaging data collection.
In regression models adjusting for relevant demographic and physical health indicators, we found that lower adherence to the MeDi was associated with greater 3-year reduction in total brain volume (explaining 0.5% of variance,
Lower adherence to the MeDi in an older Scottish cohort is predictive of total brain atrophy over a 3-year interval. Fish and meat consumption does not drive this change, suggesting that other components of the MeDi or, possibly, all of its components in combination are responsible for the association.
Url:
DOI: 10.1212/WNL.0000000000003559
PubMed: 28053008
PubMed Central: 5278943
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort</title><author><name sortKey="Luciano, Michelle" sort="Luciano, Michelle" uniqKey="Luciano M" first="Michelle" last="Luciano">Michelle Luciano</name></author><author><name sortKey="Corley, Janie" sort="Corley, Janie" uniqKey="Corley J" first="Janie" last="Corley">Janie Corley</name></author><author><name sortKey="Cox, Simon R" sort="Cox, Simon R" uniqKey="Cox S" first="Simon R." last="Cox">Simon R. Cox</name></author><author><name sortKey="Valdes Hernandez, Maria C" sort="Valdes Hernandez, Maria C" uniqKey="Valdes Hernandez M" first="Maria C." last="Valdés Hernández">Maria C. Valdés Hernández</name></author><author><name sortKey="Craig, Leone C A" sort="Craig, Leone C A" uniqKey="Craig L" first="Leone C. A." last="Craig">Leone C. A. Craig</name></author><author><name sortKey="Dickie, David Alexander" sort="Dickie, David Alexander" uniqKey="Dickie D" first="David Alexander" last="Dickie">David Alexander Dickie</name></author><author><name sortKey="Karama, Sherif" sort="Karama, Sherif" uniqKey="Karama S" first="Sherif" last="Karama">Sherif Karama</name></author><author><name sortKey="Mcneill, Geraldine M" sort="Mcneill, Geraldine M" uniqKey="Mcneill G" first="Geraldine M." last="Mcneill">Geraldine M. Mcneill</name></author><author><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E." last="Bastin">Mark E. Bastin</name></author><author><name sortKey="Wardlaw, Joanna M" sort="Wardlaw, Joanna M" uniqKey="Wardlaw J" first="Joanna M." last="Wardlaw">Joanna M. Wardlaw</name></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28053008</idno><idno type="pmc">5278943</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5278943</idno><idno type="RBID">PMC:5278943</idno><idno type="doi">10.1212/WNL.0000000000003559</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000A51</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000A51</idno><idno type="wicri:Area/Pmc/Curation">000A51</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000A51</idno><idno type="wicri:Area/Pmc/Checkpoint">000013</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000013</idno><idno type="wicri:Area/Ncbi/Merge">002179</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort</title><author><name sortKey="Luciano, Michelle" sort="Luciano, Michelle" uniqKey="Luciano M" first="Michelle" last="Luciano">Michelle Luciano</name></author><author><name sortKey="Corley, Janie" sort="Corley, Janie" uniqKey="Corley J" first="Janie" last="Corley">Janie Corley</name></author><author><name sortKey="Cox, Simon R" sort="Cox, Simon R" uniqKey="Cox S" first="Simon R." last="Cox">Simon R. Cox</name></author><author><name sortKey="Valdes Hernandez, Maria C" sort="Valdes Hernandez, Maria C" uniqKey="Valdes Hernandez M" first="Maria C." last="Valdés Hernández">Maria C. Valdés Hernández</name></author><author><name sortKey="Craig, Leone C A" sort="Craig, Leone C A" uniqKey="Craig L" first="Leone C. A." last="Craig">Leone C. A. Craig</name></author><author><name sortKey="Dickie, David Alexander" sort="Dickie, David Alexander" uniqKey="Dickie D" first="David Alexander" last="Dickie">David Alexander Dickie</name></author><author><name sortKey="Karama, Sherif" sort="Karama, Sherif" uniqKey="Karama S" first="Sherif" last="Karama">Sherif Karama</name></author><author><name sortKey="Mcneill, Geraldine M" sort="Mcneill, Geraldine M" uniqKey="Mcneill G" first="Geraldine M." last="Mcneill">Geraldine M. Mcneill</name></author><author><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E." last="Bastin">Mark E. Bastin</name></author><author><name sortKey="Wardlaw, Joanna M" sort="Wardlaw, Joanna M" uniqKey="Wardlaw J" first="Joanna M." last="Wardlaw">Joanna M. Wardlaw</name></author><author><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name></author></analytic><series><title level="j">Neurology</title><idno type="ISSN">0028-3878</idno><idno type="eISSN">1526-632X</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Objective:</title><p>To assess the association between Mediterranean-type diet (MeDi) and change in brain MRI volumetric measures and mean cortical thickness across a 3-year period in older age (73–76 years).</p></sec><sec><title>Methods:</title><p>We focused on 2 longitudinal brain volumes (total and gray matter; n = 401 and 398, respectively) plus a longitudinal measurement of cortical thickness (n = 323), for which the previous cross-sectional evidence of an association with the MeDi was strongest. Adherence to the MeDi was calculated from data gathered from a food frequency questionnaire at age 70, 3 years prior to the baseline imaging data collection.</p></sec><sec><title>Results:</title><p>In regression models adjusting for relevant demographic and physical health indicators, we found that lower adherence to the MeDi was associated with greater 3-year reduction in total brain volume (explaining 0.5% of variance, <italic>p</italic> < 0.05). This effect was half the size of the largest covariate effect (i.e., age). Cross-sectional associations between MeDi and baseline MRI measures in 562 participants were not significant. Targeted analyses of meat and fish consumption did not replicate previous associations with total brain volume or total gray matter volume.</p></sec><sec><title>Conclusions:</title><p>Lower adherence to the MeDi in an older Scottish cohort is predictive of total brain atrophy over a 3-year interval. Fish and meat consumption does not drive this change, suggesting that other components of the MeDi or, possibly, all of its components in combination are responsible for the association.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Sofi, F" uniqKey="Sofi F">F Sofi</name></author><author><name sortKey="Macchi, C" uniqKey="Macchi C">C Macchi</name></author><author><name sortKey="Abbate, R" uniqKey="Abbate R">R Abbate</name></author><author><name sortKey="Gensini, Gf" uniqKey="Gensini G">GF Gensini</name></author><author><name sortKey="Casini, A" uniqKey="Casini A">A Casini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Galland, L" uniqKey="Galland L">L Galland</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Luciano, M" uniqKey="Luciano M">M Luciano</name></author><author><name sortKey="Mottus, R" uniqKey="Mottus R">R 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Neurology</journal-id><journal-id journal-id-type="iso-abbrev">Neurology</journal-id><journal-id journal-id-type="hwp">neurology</journal-id><journal-id journal-id-type="publisher-id">neur</journal-id><journal-id journal-id-type="pmc">neurology</journal-id><journal-id journal-id-type="publisher-id">NEUROLOGY</journal-id><journal-title-group><journal-title>Neurology</journal-title></journal-title-group><issn pub-type="ppub">0028-3878</issn><issn pub-type="epub">1526-632X</issn><publisher><publisher-name>Lippincott Williams & Wilkins</publisher-name><publisher-loc>Hagerstown, MD</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28053008</article-id><article-id pub-id-type="pmc">5278943</article-id><article-id pub-id-type="publisher-id">NEUROLOGY2016738898</article-id><article-id pub-id-type="doi">10.1212/WNL.0000000000003559</article-id><article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>54</subject><subject>59</subject><subject>120</subject></subj-group><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Mediterranean-type diet and brain structural change from 73 to 76 years in a Scottish cohort</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Luciano</surname><given-names>Michelle</given-names></name><degrees>PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Corley</surname><given-names>Janie</given-names></name><degrees>PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Cox</surname><given-names>Simon R.</given-names></name><degrees>PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Valdés Hernández</surname><given-names>Maria C.</given-names></name><degrees>PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>I am a member of the World Journal of Radiology Editorial Board (ID:02666832) from 01.01.2014 until 31.12.2017</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>Row Fogo Charitable Trust</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Craig</surname><given-names>Leone C.A.</given-names></name><degrees>PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>Scottish Government Rural and Environment Science and Analytical Services Division (RESAS) 2011-present.Funding for PhD student: Seafish Industry Authority/Interface food and drink network 2012-2016.</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Dickie</surname><given-names>David Alexander</given-names></name><degrees>PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>DD Analytics Cubed Limited, Director, 1.5 years</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>Royal Society Edinburgh, Exchange Travel Award.</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Karama</surname><given-names>Sherif</given-names></name><degrees>MD, PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for travel or speaker honoraria:</title><list-item><p>Fonds de Recherche Sant? Qu?bec</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>Intelligence</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>McNeill</surname><given-names>Geraldine M.</given-names></name><degrees>PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>My husband Paul Haggarty serves on the UK Scientific Advisory Council on Nutrition, a not-or-profit body.</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>My husband Paul Haggarty works asc a researcher in an institute funded largely by the Scottish Government</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>My husband Paul Haggarty has received funding for research from the UK Economic and Social Research Council</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Bastin</surname><given-names>Mark E.</given-names></name><degrees>PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Wardlaw</surname><given-names>Joanna M.</given-names></name><degrees>MD, FRCP, FRCR</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>IXICO consultancy fee</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>GSK consultancy fee (</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>Medical Research Council. ?Centre in Cognitive Ageing and Cognitive Epidemiology?, ?3,413,977 FEC over five years from August 2008. Renewed Sept 2013 ? Aug 2018. I Deary (Centre head), R Logie, J Seckl, J McCulloch, D Porteous, J Wardlaw (Imaging lead). Medical Research Council. ?Brain white matter imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II.? ?764,304, 1st April 2011-31st Mar 2015. Prof IJ Deary (PI), Prof JM Wardlaw, Dr M Bastin, Prof J Starr. EU Joint Programme - Neurodegenerative Disease Research. ?Realising the potential of cohort studies to determine the vascular contribution to neurodegeneration?, ?47,416, 1st Oct 2014 to 31st Mar 2015. J Wardlaw, Medical Research Council. ?Brain white matter imaging and cognitive ageing in the Lothian Birth Cohort of 1936:III? ?1,300,000 (FEC), 31st Mar 2015 to 28th Feb 2019. IJ Deary (PI), JM Wardlaw, J Starr, M Bastin. Technology Strategy Board. ?Quantification of vascular disease burden to stratify dementia for diagnosis and care management?, ?1,048,661 (?306,946 to Edinburgh), 1st Apr 2015 to 31st Mar 2017. R Wolz (Ixico Technologies Ltd.), D Rueckert, J Wardlaw. EU H2020 SVDs@Target ?6million multicollaborator project</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>Scottish Funding Council SPIRIT Scheme. ?Novel and collaborative approaches to knowledge exchange in translational imaging?, ?1,124,928 - 1st Apr 2010-31st Dec 2014. Professor J Wardlaw, Dr J DeWilde, Dr A Murray, Dr R Lerski, Dr J Owen. Ref No. HR09021. SFC: SINAPSE-2 Continued development of the SINAPSE Network?, ?325,000, 31st Oct 2014 to 30th Sep 2019. D Wyer, J Wardlaw, A Murray, D Lerski, K Muir, D Donaldson, A O?Connor. EPSRC. ?Multi-modal retinal biomarkers for vascular dementia: developing enabling image analysis tools.? ?1,100,000, 1st Apr 2015 to 31st Mar 2018. E Trucco, J Wardlaw, T MacGillivray, F Doubal, I Deary, A Doney.</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>The Row Fogo Trust. ?Research studies in stroke and other common brain diseases?, ?400,000, 1st Apr 2001 to 31st Jul 2009. ?316,000 extension until 2014. Renewed to 2018 ?380,000. Dr JM Wardlaw, Dr I Marshall, Dr M Bastin and the Stroke Research Group. Ref No: AD.ROW4.35, R35865. Age UK. ?The Disconnected Mind?, ?2,500,000 over 5 years from 1st April 2011. Deary, I.J., & Starr, J.M., & Wardlaw, J.M.</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><contrib contrib-type="author"><name><surname>Deary</surname><given-names>Ian J.</given-names></name><degrees>PhD</degrees><author-comment content-type="disclosure"><p><list list-type="order"><title>Scientific Advisory Boards:</title><list-item><p>Member, Executive Committee and Steering Committee of the Medical Research Council Dementia Platform, 2013 to 2016. Member, Medical Research Council Cross-Board Advisory Group, 2011 to 2014. Member, Medical Research Council Population Health Sciences Group, 2011 to 2014. Member, Medical Research Council Neurosciences and Mental Health Board, 2011 to 2014.</p></list-item></list></p><p><list list-type="order"><title>Gifts:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Funding for Travel or Speaker Honoraria:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Editorial Boards:</title><list-item><p>Book Review Editor and Member, Editorial Board, Intelligence 1999 to 2015. Member, Editorial Board, European Journal of Personality 1996 to date. Member, Editorial Board, Personality and Individual Differences 1997 to date. Member, Editorial Advisory Board, Journal of Psychosomatic Research 1998 to date. Member, Board of Consulting Editors, Spanish Journal of Psychology 2002 to date. Member, Editorial Board, European Journal of Psychological Assessment 2005 to date. Member, Editorial Board, Psychological Science 2010 to date. Member, Editorial Board, Longitudinal and Life Course Studies, 2010 to date.</p></list-item></list></p><p><list list-type="order"><title>Patents:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Publishing Royalties:</title><list-item><p>Deary, I. J., Whalley, L. J., & Starr, J. M. (2009). A lifetime of intelligence: follow-up studies of the Scottish Mental Surveys of 1932 and 1947. Washington, DC: American Psychological Association. Matthews, G., Deary, I. J. & Whiteman, M. C. (2009). Personality traits (third edition). Cambridge: Cambridge University Press. (Translated into Romanian [2005].) Deary, I. J. (2001). Intelligence: A very short introduction. Oxford: Oxford University Press. (Translated into Arabic [2005], German [2013], Hebrew [2006], Hungarian [2003], Japanese [2004], Korean [2005], Polish [2012], Portuguese [2006] Romanian [2008], and Spanish [2004].)</p></list-item></list></p><p><list list-type="order"><title>Employment, Commercial Entity:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Consultancies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Speakers' Bureaus:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Other Activities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Clinical Procedures or Imaging Studies:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Commercial Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Government Entities:</title><list-item><p>Deary, I. J., Bastin, M., Starr, J. M., Wardlaw, J. M., & Penke, L. Brain white matter imaging and cognitive ageing in the Lothian Birth Cohort 1936: II. Medical Research Council. ?808,224. April 2011-March 2014. (G1001245.) Deary, I. J. Grant to establish Medical Research Council Centre for Cognitive Ageing and Cognitive Epidemiology (Director I. J. Deary). Medical Research Council. ?3,400,000 approx. August 2008-July 2013 (G0700704/84698.) Deary, I. J. Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Medical Research Council and Biotechnology and Biological Sciences Research Council. ?4,258,772. September 2013-August 2018. (MR/K026992/1). Deary, I. J., Luciano, M., Prendergast, J., Wardlaw, J. M., Bastin, M., &Starr, J. M. JPND: Brain Imaging, cognition, Dementia and next generation Genomics. Medical Research Council. ?592,325. May 2016-April 2019. (MR/N027558/1.)</p></list-item></list></p><p><list list-type="order"><title>Research Support, Academic Entities:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Research Support, Foundations and Societies:</title><list-item><p>Deary, I. J., & Starr, J. M., & Wardlaw, J. M. The Disconnected Mind, Phase 2. Age UK. ?2,500,000. April 2011-March 2016. Deary, I. J., Starr, J. M., Wardlaw, J. M, & Bastin, M. E. The Disconnected Mind, Phase 3. Age UK. ?1,317,193. April 2016-March 2019.</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options/Board of Directors Compensation:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>License Fee Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Royalty Payments, Technology or Inventions:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Research Sponsor:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Stock/Stock Options, Medical Equipment & Materials:</title><list-item><p>NONE</p></list-item></list></p><p><list list-type="order"><title>Legal Proceedings:</title><list-item><p>NONE</p></list-item></list></p></author-comment></contrib><aff>From the Centre for Cognitive Ageing and Cognitive Epidemiology (M.L., J.C., S.R.C., I.J.D.), Department of Psychology (M.L., J.C., S.R.C., I.J.D.), Brain Research Imaging Centre (M.C.V.H., D.A.D., M.E.B., J.M.W.), Centre for Clinical Brain Sciences (M.C.V.H., D.A.D., M.E.B., J.M.W.), and Scottish Imaging Network, A Platform for Scientific Excellence (SINAPSE) Collaboration, Department of Neuroimaging Sciences (S.R.C., M.C.V.H., D.A.D., M.E.B., J.M.W.), University of Edinburgh; Rowett Institute of Nutrition and Health (L.C.A.C.) and The Institute of Applied Health Sciences (G.M.M.), University of Aberdeen, UK; and Montreal Neurological Institute and Hospital and Douglas Mental Health University Institute (S.K.), McGill University, Canada.</aff></contrib-group><author-notes><corresp>Correspondence to Dr. Luciano: <email>michelle.luciano@ed.ac.uk</email></corresp><fn fn-type="financial-disclosure"><p>Go to <ext-link ext-link-type="uri" xlink:href="http://neurology.org/lookup/doi/10.1212/WNL.0000000000003559">Neurology.org</ext-link> for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article. The Article Processing Charge was paid by the RCUK UK Open Access Fund.</p></fn></author-notes><pub-date pub-type="ppub"><day>31</day><month>1</month><year>2017</year></pub-date><pub-date pub-type="pmc-release"><day>31</day><month>1</month><year>2017</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>88</volume><issue>5</issue><fpage>449</fpage><lpage>455</lpage><history><date date-type="received"><day>15</day><month>4</month><year>2016</year></date><date date-type="accepted"><day>27</day><month>10</month><year>2016</year></date></history><permissions><copyright-statement>© 2017 American Academy of Neurology</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>American Academy of Neurology</copyright-holder><license license-type="open-access"><license-p>This is an open access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution Licence 4.0 (CC BY)</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><self-uri xlink:title="pdf" xlink:href="NEUROLOGY2016738898.pdf"></self-uri><abstract><sec><title>Objective:</title><p>To assess the association between Mediterranean-type diet (MeDi) and change in brain MRI volumetric measures and mean cortical thickness across a 3-year period in older age (73–76 years).</p></sec><sec><title>Methods:</title><p>We focused on 2 longitudinal brain volumes (total and gray matter; n = 401 and 398, respectively) plus a longitudinal measurement of cortical thickness (n = 323), for which the previous cross-sectional evidence of an association with the MeDi was strongest. Adherence to the MeDi was calculated from data gathered from a food frequency questionnaire at age 70, 3 years prior to the baseline imaging data collection.</p></sec><sec><title>Results:</title><p>In regression models adjusting for relevant demographic and physical health indicators, we found that lower adherence to the MeDi was associated with greater 3-year reduction in total brain volume (explaining 0.5% of variance, <italic>p</italic> < 0.05). This effect was half the size of the largest covariate effect (i.e., age). Cross-sectional associations between MeDi and baseline MRI measures in 562 participants were not significant. Targeted analyses of meat and fish consumption did not replicate previous associations with total brain volume or total gray matter volume.</p></sec><sec><title>Conclusions:</title><p>Lower adherence to the MeDi in an older Scottish cohort is predictive of total brain atrophy over a 3-year interval. Fish and meat consumption does not drive this change, suggesting that other components of the MeDi or, possibly, all of its components in combination are responsible for the association.</p></sec></abstract><custom-meta-group><custom-meta><meta-name>OPEN-ACCESS</meta-name><meta-value>TRUE</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Bastin, Mark E" sort="Bastin, Mark E" uniqKey="Bastin M" first="Mark E." last="Bastin">Mark E. Bastin</name><name sortKey="Corley, Janie" sort="Corley, Janie" uniqKey="Corley J" first="Janie" last="Corley">Janie Corley</name><name sortKey="Cox, Simon R" sort="Cox, Simon R" uniqKey="Cox S" first="Simon R." last="Cox">Simon R. Cox</name><name sortKey="Craig, Leone C A" sort="Craig, Leone C A" uniqKey="Craig L" first="Leone C. A." last="Craig">Leone C. A. Craig</name><name sortKey="Deary, Ian J" sort="Deary, Ian J" uniqKey="Deary I" first="Ian J." last="Deary">Ian J. Deary</name><name sortKey="Dickie, David Alexander" sort="Dickie, David Alexander" uniqKey="Dickie D" first="David Alexander" last="Dickie">David Alexander Dickie</name><name sortKey="Karama, Sherif" sort="Karama, Sherif" uniqKey="Karama S" first="Sherif" last="Karama">Sherif Karama</name><name sortKey="Luciano, Michelle" sort="Luciano, Michelle" uniqKey="Luciano M" first="Michelle" last="Luciano">Michelle Luciano</name><name sortKey="Mcneill, Geraldine M" sort="Mcneill, Geraldine M" uniqKey="Mcneill G" first="Geraldine M." last="Mcneill">Geraldine M. Mcneill</name><name sortKey="Valdes Hernandez, Maria C" sort="Valdes Hernandez, Maria C" uniqKey="Valdes Hernandez M" first="Maria C." last="Valdés Hernández">Maria C. Valdés Hernández</name><name sortKey="Wardlaw, Joanna M" sort="Wardlaw, Joanna M" uniqKey="Wardlaw J" first="Joanna M." last="Wardlaw">Joanna M. Wardlaw</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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