The role of RNA metabolism in neurological diseases
Identifieur interne : 002126 ( Ncbi/Merge ); précédent : 002125; suivant : 002127The role of RNA metabolism in neurological diseases
Auteurs : Am Alaqeel [Canada, Arabie saoudite] ; H. Abou Al-Shaar [Arabie saoudite] ; Rk Shariff [Arabie saoudite] ; A. Albakr [Arabie saoudite]Source :
- Balkan Journal of Medical Genetics : BJMG [ 1311-0160 ] ; 2016.
Abstract
Neurodegenerative disorders are commonly encountered in medical practices. Such diseases can lead to major morbidity and mortality among the affected individuals. The molecular pathogenesis of these disorders is not yet clear. Recent literature has revealed that mutations in RNA-binding proteins are a key cause of several human neuronal-based diseases. This review discusses the role of RNA metabolism in neurological diseases with specific emphasis on roles of RNA translation and microRNAs in neurodegeneration, RNA-mediated toxicity, repeat expansion diseases and RNA metabolism, molecular pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia, and neurobiology of survival motor neuron (SMN) and spinal muscular atrophy.
Url:
DOI: 10.1515/bjmg-2015-0080
PubMed: 27785391
PubMed Central: 5026263
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Abou Al-Shaar</name><affiliation wicri:level="1"><nlm:aff id="aff3">College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Shariff, Rk" sort="Shariff, Rk" uniqKey="Shariff R" first="Rk" last="Shariff">Rk Shariff</name><affiliation wicri:level="1"><nlm:aff id="aff3">College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>College of Medicine, Alfaisal University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Albakr, A" sort="Albakr, A" uniqKey="Albakr A" first="A" last="Albakr">A. Albakr</name><affiliation wicri:level="1"><nlm:aff id="aff2">Division of Neurosurgery, Department of Surgery, King Saud University, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Division of Neurosurgery, Department of Surgery, King Saud University, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author></analytic><series><title level="j">Balkan Journal of Medical Genetics : BJMG</title><idno type="ISSN">1311-0160</idno><idno type="eISSN">2199-5761</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><p>Neurodegenerative disorders are commonly encountered in medical practices. Such diseases can lead to major morbidity and mortality among the affected individuals. The molecular pathogenesis of these disorders is not yet clear. Recent literature has revealed that mutations in RNA-binding proteins are a key cause of several human neuronal-based diseases. This review discusses the role of RNA metabolism in neurological diseases with specific emphasis on roles of RNA translation and microRNAs in neurodegeneration, RNA-mediated toxicity, repeat expansion diseases and RNA metabolism, molecular pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia, and neurobiology of survival motor neuron (SMN) and spinal muscular atrophy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Crosiers, D" uniqKey="Crosiers D">D Crosiers</name></author><author><name sortKey="Theuns, J" uniqKey="Theuns J">J Theuns</name></author><author><name sortKey="Cras, P" uniqKey="Cras P">P Cras</name></author><author><name sortKey="Van Broeckhoven, C" uniqKey="Van Broeckhoven C">C Van Broeckhoven</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ross, Ca" uniqKey="Ross C">CA Ross</name></author><author><name sortKey="Tabrizi, Sj" uniqKey="Tabrizi S">SJ 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Balkan J Med Genet</journal-id><journal-id journal-id-type="publisher-id">bjmg</journal-id><journal-id journal-id-type="pmc">bjmg</journal-id><journal-title-group><journal-title>Balkan Journal of Medical Genetics : BJMG</journal-title></journal-title-group><issn pub-type="ppub">1311-0160</issn><issn pub-type="epub">2199-5761</issn><publisher><publisher-name>De Gruyter</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27785391</article-id><article-id pub-id-type="pmc">5026263</article-id><article-id pub-id-type="publisher-id">bjmg-2015-0080</article-id><article-id pub-id-type="doi">10.1515/bjmg-2015-0080</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>The role of RNA metabolism in neurological diseases</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Alaqeel</surname><given-names>AM</given-names></name><degrees>M.D</degrees><email xlink:href="mailto:ahmedalaqeel@hotmail.com">ahmedalaqeel@hotmail.com</email><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Abou Al-Shaar</surname><given-names>H</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Shariff</surname><given-names>RK</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Albakr</surname><given-names>A</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><aff id="aff1"><sup>1</sup>Department of Neurosurgery, University of Calgary, Calgary, Alberta, Canada</aff><aff id="aff2"><sup>2</sup>Division of Neurosurgery, Department of Surgery, King Saud University, Riyadh, Saudi Arabia</aff><aff id="aff3"><sup>3</sup>College of Medicine, Alfaisal University, Riyadh, Saudi Arabia</aff></contrib-group><author-notes><corresp>Ahmed M. Alaqeel, M.D., Department of Neurosurgery, University of Calgary, 1403 29th Street NW, Calgary, Alberta T2N 2T9, Canada. Tel: +403-970-9117. Fax: +403-270-7878</corresp></author-notes><pub-date pub-type="collection"><day>1</day><month>12</month><year>2015</year></pub-date><pub-date pub-type="epub"><day>9</day><month>7</month><year>2016</year></pub-date><volume>18</volume><issue>2</issue><fpage>5</fpage><lpage>14</lpage><permissions><copyright-statement>© 2016 Walter de Gruyter GmbH, Berlin/Boston</copyright-statement><copyright-year>2016</copyright-year></permissions><abstract><title>Abstract</title><p>Neurodegenerative disorders are commonly encountered in medical practices. Such diseases can lead to major morbidity and mortality among the affected individuals. The molecular pathogenesis of these disorders is not yet clear. Recent literature has revealed that mutations in RNA-binding proteins are a key cause of several human neuronal-based diseases. This review discusses the role of RNA metabolism in neurological diseases with specific emphasis on roles of RNA translation and microRNAs in neurodegeneration, RNA-mediated toxicity, repeat expansion diseases and RNA metabolism, molecular pathogenesis of amyotrophic lateral sclerosis and frontotemporal dementia, and neurobiology of survival motor neuron (SMN) and spinal muscular atrophy.</p></abstract><kwd-group><title>Keywords</title><kwd>Amyotrophic lateral sclerosis</kwd><kwd>Frontotemporal dementia</kwd><kwd>RNA</kwd><kwd>Survival motor neuron (SMN)</kwd><kwd>Spinal muscular atrophy</kwd></kwd-group><counts><page-count count="10"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>Arabie saoudite</li><li>Canada</li></country><region><li>Alberta</li></region><settlement><li>Calgary</li></settlement><orgName><li>Université de Calgary</li></orgName></list><tree><country name="Canada"><region name="Alberta"><name sortKey="Alaqeel, Am" sort="Alaqeel, Am" uniqKey="Alaqeel A" first="Am" last="Alaqeel">Am Alaqeel</name></region></country><country name="Arabie saoudite"><noRegion><name sortKey="Alaqeel, Am" sort="Alaqeel, Am" uniqKey="Alaqeel A" first="Am" last="Alaqeel">Am Alaqeel</name></noRegion><name sortKey="Abou Al Shaar, H" sort="Abou Al Shaar, H" uniqKey="Abou Al Shaar H" first="H" last="Abou Al-Shaar">H. Abou Al-Shaar</name><name sortKey="Albakr, A" sort="Albakr, A" uniqKey="Albakr A" first="A" last="Albakr">A. Albakr</name><name sortKey="Shariff, Rk" sort="Shariff, Rk" uniqKey="Shariff R" first="Rk" last="Shariff">Rk Shariff</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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