Buccal mucosal irritation studies of sublingual apomorphine film (APL-130277) in Syrian golden hamsters.
Identifieur interne : 002046 ( Ncbi/Merge ); précédent : 002045; suivant : 002047Buccal mucosal irritation studies of sublingual apomorphine film (APL-130277) in Syrian golden hamsters.
Auteurs : Thierry Bilbault [Canada] ; Simon Taylor [Canada] ; Robin Walker [Canada] ; Starr L. Grundy [États-Unis] ; Eric J. Pappert [Canada] ; Albert Agro [Canada]Source :
- Therapeutic delivery [ 2041-6008 ] ; 2016.
Abstract
Determine the potential for cheek pouch buccal mucosa irritation in hamsters following administration of apomorphine hydrochloride film (APL-130277).
DOI: 10.4155/tde-2016-0043
PubMed: 27506115
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Buccal mucosal irritation studies of sublingual apomorphine film (APL-130277) in Syrian golden hamsters.</title><author><name sortKey="Bilbault, Thierry" sort="Bilbault, Thierry" uniqKey="Bilbault T" first="Thierry" last="Bilbault">Thierry Bilbault</name><affiliation wicri:level="1"><nlm:affiliation>Cynapsus Therapeutics, Inc., Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Cynapsus Therapeutics, Inc., Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Taylor, Simon" sort="Taylor, Simon" uniqKey="Taylor S" first="Simon" last="Taylor">Simon Taylor</name><affiliation wicri:level="1"><nlm:affiliation>Nucro-technics, Scarborough, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Nucro-technics, Scarborough, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Walker, Robin" sort="Walker, Robin" uniqKey="Walker R" first="Robin" last="Walker">Robin Walker</name><affiliation wicri:level="1"><nlm:affiliation>Mississauga, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Mississauga, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Grundy, Starr L" sort="Grundy, Starr L" uniqKey="Grundy S" first="Starr L" last="Grundy">Starr L. Grundy</name><affiliation wicri:level="2"><nlm:affiliation>SD Scientific, Inc., San Diego, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>SD Scientific, Inc., San Diego, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Pappert, Eric J" sort="Pappert, Eric J" uniqKey="Pappert E" first="Eric J" last="Pappert">Eric J. Pappert</name><affiliation wicri:level="1"><nlm:affiliation>Cynapsus Therapeutics, Inc., Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Cynapsus Therapeutics, Inc., Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Agro, Albert" sort="Agro, Albert" uniqKey="Agro A" first="Albert" last="Agro">Albert Agro</name><affiliation wicri:level="1"><nlm:affiliation>Cynapsus Therapeutics, Inc., Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Cynapsus Therapeutics, Inc., Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27506115</idno><idno type="pmid">27506115</idno><idno type="doi">10.4155/tde-2016-0043</idno><idno type="wicri:Area/PubMed/Corpus">000178</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000178</idno><idno type="wicri:Area/PubMed/Curation">000178</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000178</idno><idno type="wicri:Area/PubMed/Checkpoint">000178</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000178</idno><idno type="wicri:Area/Ncbi/Merge">002046</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Buccal mucosal irritation studies of sublingual apomorphine film (APL-130277) in Syrian golden hamsters.</title><author><name sortKey="Bilbault, Thierry" sort="Bilbault, Thierry" uniqKey="Bilbault T" first="Thierry" last="Bilbault">Thierry Bilbault</name><affiliation wicri:level="1"><nlm:affiliation>Cynapsus Therapeutics, Inc., Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Cynapsus Therapeutics, Inc., Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Taylor, Simon" sort="Taylor, Simon" uniqKey="Taylor S" first="Simon" last="Taylor">Simon Taylor</name><affiliation wicri:level="1"><nlm:affiliation>Nucro-technics, Scarborough, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Nucro-technics, Scarborough, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Walker, Robin" sort="Walker, Robin" uniqKey="Walker R" first="Robin" last="Walker">Robin Walker</name><affiliation wicri:level="1"><nlm:affiliation>Mississauga, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Mississauga, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Grundy, Starr L" sort="Grundy, Starr L" uniqKey="Grundy S" first="Starr L" last="Grundy">Starr L. Grundy</name><affiliation wicri:level="2"><nlm:affiliation>SD Scientific, Inc., San Diego, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>SD Scientific, Inc., San Diego, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Pappert, Eric J" sort="Pappert, Eric J" uniqKey="Pappert E" first="Eric J" last="Pappert">Eric J. Pappert</name><affiliation wicri:level="1"><nlm:affiliation>Cynapsus Therapeutics, Inc., Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Cynapsus Therapeutics, Inc., Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Agro, Albert" sort="Agro, Albert" uniqKey="Agro A" first="Albert" last="Agro">Albert Agro</name><affiliation wicri:level="1"><nlm:affiliation>Cynapsus Therapeutics, Inc., Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Cynapsus Therapeutics, Inc., Toronto, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author></analytic><series><title level="j">Therapeutic delivery</title><idno type="eISSN">2041-6008</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Determine the potential for cheek pouch buccal mucosa irritation in hamsters following administration of apomorphine hydrochloride film (APL-130277).</div></front></TEI><pubmed><MedlineCitation Status="In-Process" Owner="NLM"><PMID Version="1">27506115</PMID><DateCreated><Year>2016</Year><Month>09</Month><Day>01</Day></DateCreated><DateRevised><Year>2016</Year><Month>09</Month><Day>01</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">2041-6008</ISSN><JournalIssue CitedMedium="Internet"><Volume>7</Volume><Issue>9</Issue><PubDate><Year>2016</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Therapeutic delivery</Title><ISOAbbreviation>Ther Deliv</ISOAbbreviation></Journal><ArticleTitle>Buccal mucosal irritation studies of sublingual apomorphine film (APL-130277) in Syrian golden hamsters.</ArticleTitle><Pagination><MedlinePgn>611-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.4155/tde-2016-0043</ELocationID><Abstract><AbstractText Label="AIM" NlmCategory="OBJECTIVE">Determine the potential for cheek pouch buccal mucosa irritation in hamsters following administration of apomorphine hydrochloride film (APL-130277).</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Three studies were conducted with Syrian golden hamsters. (First study, four hamsters received APL-130277 three times a day [TID] for 7 days. Second study, four hamsters received APL-130277 once a day [QD] for days 1-3, twice a day [BID] for days 4-7 and TID for days 8-21. Third study, 32 hamsters received either a placebo strip or APL-130277-dosed TID for 28 days). For all the studies, the macroscopic appearance of the buccal cavities was evaluated throughout the study. In the third study, all animals were necropsied on day 29, and macroscopic and histopathological examinations were performed.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">In the first and second studies, the buccal mucosa of the cheek pouch did not show any signs of irritation. In the third study, administration of APL-130277-dosed TID for 28 consecutive days did not result in observable local irritation of the buccal mucosa.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">In all the studies, APL-130277 produced no irritation of the cheek pouch buccal mucosa.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Bilbault</LastName><ForeName>Thierry</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Cynapsus Therapeutics, Inc., Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Taylor</LastName><ForeName>Simon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Nucro-technics, Scarborough, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Walker</LastName><ForeName>Robin</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Mississauga, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Grundy</LastName><ForeName>Starr L</ForeName><Initials>SL</Initials><AffiliationInfo><Affiliation>SD Scientific, Inc., San Diego, CA, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pappert</LastName><ForeName>Eric J</ForeName><Initials>EJ</Initials><AffiliationInfo><Affiliation>Cynapsus Therapeutics, Inc., Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Agro</LastName><ForeName>Albert</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Cynapsus Therapeutics, Inc., Toronto, Ontario, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>08</Month><Day>10</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Ther Deliv</MedlineTA><NlmUniqueID>101538870</NlmUniqueID><ISSNLinking>2041-5990</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">APL-130277</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">apomorphine</Keyword><Keyword MajorTopicYN="N">buccal mucosal</Keyword><Keyword MajorTopicYN="N">irritation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>8</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27506115</ArticleId><ArticleId IdType="doi">10.4155/tde-2016-0043</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li><li>États-Unis</li></country><region><li>Californie</li></region></list><tree><country name="Canada"><noRegion><name sortKey="Bilbault, Thierry" sort="Bilbault, Thierry" uniqKey="Bilbault T" first="Thierry" last="Bilbault">Thierry Bilbault</name></noRegion><name sortKey="Agro, Albert" sort="Agro, Albert" uniqKey="Agro A" first="Albert" last="Agro">Albert Agro</name><name sortKey="Pappert, Eric J" sort="Pappert, Eric J" uniqKey="Pappert E" first="Eric J" last="Pappert">Eric J. Pappert</name><name sortKey="Taylor, Simon" sort="Taylor, Simon" uniqKey="Taylor S" first="Simon" last="Taylor">Simon Taylor</name><name sortKey="Walker, Robin" sort="Walker, Robin" uniqKey="Walker R" first="Robin" last="Walker">Robin Walker</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Grundy, Starr L" sort="Grundy, Starr L" uniqKey="Grundy S" first="Starr L" last="Grundy">Starr L. Grundy</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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