DOPA-sparing strategy in the treatment of young onset Parkinson's disease
Identifieur interne : 001E83 ( Ncbi/Merge ); précédent : 001E82; suivant : 001E84DOPA-sparing strategy in the treatment of young onset Parkinson's disease
Auteurs : Abdul Qayyum Rana ; Mohamad Saleh ; Muhammad Saad Yousuf ; Wasim Mansoor ; Syed Hussaini ; Maniza Rahman ; Zohair IqbalSource :
- Journal of Neurosciences in Rural Practice [ 0976-3147 ] ; 2016.
Abstract
Late onset Parkinson's disease (LOPD) is a neurodegenerative disorder afflicting individuals of ages 60 and older. However, 5–10% of cases can begin earlier between the ages 20 to 40, and are classified as young onset Parkinson disease (YOPD).
In turn, this study aims to observe the trend in the choice of drug administered to patients with both YOPD and LOPD, with particular emphasis on this trend in its relation to the practice background of the neurologist.
A cross-sectional study was conducted in a community based Parkinson's disease and movement disorder clinic.
Using a retrospective chart review data was obtained and analysed.
The results showed that 83% of general neurologists prescribed levodopa to their patients with YOPD, whereas movement-disorder specialists took a different approach altogether. They opted not to use levodopa and, in its stead, prescribed a mixture of alternate drugs.
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DOI: 10.4103/0976-3147.172155
PubMed: 26933347
PubMed Central: 4750343
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id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Saleh, Mohamad" sort="Saleh, Mohamad" uniqKey="Saleh M" first="Mohamad" last="Saleh">Mohamad Saleh</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Yousuf, Muhammad Saad" sort="Yousuf, Muhammad Saad" uniqKey="Yousuf M" first="Muhammad Saad" last="Yousuf">Muhammad Saad Yousuf</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><italic>Centre for Neuroscience, University of Alberta, Edmonton, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Mansoor, Wasim" sort="Mansoor, Wasim" uniqKey="Mansoor W" first="Wasim" last="Mansoor">Wasim Mansoor</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Hussaini, Syed" sort="Hussaini, Syed" uniqKey="Hussaini S" first="Syed" last="Hussaini">Syed Hussaini</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Rahman, Maniza" sort="Rahman, Maniza" uniqKey="Rahman M" first="Maniza" last="Rahman">Maniza Rahman</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Iqbal, Zohair" sort="Iqbal, Zohair" uniqKey="Iqbal Z" first="Zohair" last="Iqbal">Zohair Iqbal</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Neurosciences in Rural Practice</title><idno type="ISSN">0976-3147</idno><idno type="eISSN">0976-3155</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Context:</title><p>Late onset Parkinson's disease (LOPD) is a neurodegenerative disorder afflicting individuals of ages 60 and older. However, 5–10% of cases can begin earlier between the ages 20 to 40, and are classified as young onset Parkinson disease (YOPD).</p></sec><sec id="st2"><title>Aim:</title><p>In turn, this study aims to observe the trend in the choice of drug administered to patients with both YOPD and LOPD, with particular emphasis on this trend in its relation to the practice background of the neurologist.</p></sec><sec id="st3"><title>Settings and Design:</title><p>A cross-sectional study was conducted in a community based Parkinson's disease and movement disorder clinic.</p></sec><sec id="st4"><title>Statistical Analysis Used:</title><p>Using a retrospective chart review data was obtained and analysed.</p></sec><sec id="st5"><title>Results:</title><p>The results showed that 83% of general neurologists prescribed levodopa to their patients with YOPD, whereas movement-disorder specialists took a different approach altogether. They opted not to use levodopa and, in its stead, prescribed a mixture of alternate drugs.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Rana, Aq" uniqKey="Rana A">AQ Rana</name></author><author><name sortKey="Siddiqui, I" uniqKey="Siddiqui I">I Siddiqui</name></author><author><name sortKey="Yousuf, Ms" uniqKey="Yousuf M">MS Yousuf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halkias, Ia" uniqKey="Halkias I">IA Halkias</name></author><author><name sortKey="Haq, I" uniqKey="Haq I">I Haq</name></author><author><name sortKey="Huang, Z" uniqKey="Huang Z">Z Huang</name></author><author><name sortKey="Fernandez, Hh" uniqKey="Fernandez H">HH Fernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Yh" uniqKey="Zhang Y">YH Zhang</name></author><author><name sortKey="Tang, Bs" uniqKey="Tang B">BS Tang</name></author><author><name sortKey="Song, Cy" uniqKey="Song C">CY Song</name></author><author><name sortKey="Xu, Q" uniqKey="Xu Q">Q Xu</name></author><author><name sortKey="Lou, Mx" uniqKey="Lou M">MX Lou</name></author><author><name sortKey="Liu, Zh" uniqKey="Liu Z">ZH Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giroux, Ml" uniqKey="Giroux M">ML Giroux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sujith, Ok" uniqKey="Sujith O">OK Sujith</name></author><author><name sortKey="Lane, C" uniqKey="Lane C">C Lane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoehn, Mm" uniqKey="Hoehn M">MM Hoehn</name></author><author><name sortKey="Yahr, Md" uniqKey="Yahr M">MD Yahr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonuccelli, U" uniqKey="Bonuccelli U">U Bonuccelli</name></author><author><name sortKey="Del Dotto, P" uniqKey="Del Dotto P">P Del Dotto</name></author><author><name sortKey="Rascol, O" uniqKey="Rascol O">O Rascol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bostwick, Jm" uniqKey="Bostwick J">JM Bostwick</name></author><author><name sortKey="Hecksel, Ka" uniqKey="Hecksel K">KA Hecksel</name></author><author><name sortKey="Stevens, Sr" uniqKey="Stevens S">SR Stevens</name></author><author><name sortKey="Bower, Jh" uniqKey="Bower J">JH Bower</name></author><author><name sortKey="Ahlskog, Je" uniqKey="Ahlskog J">JE Ahlskog</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kostic, Vs" uniqKey="Kostic V">VS Kostic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clarke, Ce" uniqKey="Clarke C">CE Clarke</name></author><author><name sortKey="Worth, P" uniqKey="Worth P">P Worth</name></author><author><name sortKey="Grosset, D" uniqKey="Grosset D">D Grosset</name></author><author><name sortKey="Stewart, D" uniqKey="Stewart D">D Stewart</name></author></analytic></biblStruct></listBibl></div1></back></TEI><double pmid="26933347"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">DOPA-sparing strategy in the treatment of young onset Parkinson's disease</title><author><name sortKey="Rana, Abdul Qayyum" sort="Rana, Abdul Qayyum" uniqKey="Rana A" first="Abdul Qayyum" last="Rana">Abdul Qayyum Rana</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Saleh, Mohamad" sort="Saleh, Mohamad" uniqKey="Saleh M" first="Mohamad" last="Saleh">Mohamad Saleh</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Yousuf, Muhammad Saad" sort="Yousuf, Muhammad Saad" uniqKey="Yousuf M" first="Muhammad Saad" last="Yousuf">Muhammad Saad Yousuf</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><italic>Centre for Neuroscience, University of Alberta, Edmonton, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Mansoor, Wasim" sort="Mansoor, Wasim" uniqKey="Mansoor W" first="Wasim" last="Mansoor">Wasim Mansoor</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Hussaini, Syed" sort="Hussaini, Syed" uniqKey="Hussaini S" first="Syed" last="Hussaini">Syed Hussaini</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Rahman, Maniza" sort="Rahman, Maniza" uniqKey="Rahman M" first="Maniza" last="Rahman">Maniza Rahman</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Iqbal, Zohair" sort="Iqbal, Zohair" uniqKey="Iqbal Z" first="Zohair" last="Iqbal">Zohair Iqbal</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26933347</idno><idno type="pmc">4750343</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4750343</idno><idno type="RBID">PMC:4750343</idno><idno type="doi">10.4103/0976-3147.172155</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000143</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000143</idno><idno type="wicri:Area/Pmc/Curation">000143</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000143</idno><idno type="wicri:Area/Pmc/Checkpoint">000143</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000143</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">DOPA-sparing strategy in the treatment of young onset Parkinson's disease</title><author><name sortKey="Rana, Abdul Qayyum" sort="Rana, Abdul Qayyum" uniqKey="Rana A" first="Abdul Qayyum" last="Rana">Abdul Qayyum Rana</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Saleh, Mohamad" sort="Saleh, Mohamad" uniqKey="Saleh M" first="Mohamad" last="Saleh">Mohamad Saleh</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Yousuf, Muhammad Saad" sort="Yousuf, Muhammad Saad" uniqKey="Yousuf M" first="Muhammad Saad" last="Yousuf">Muhammad Saad Yousuf</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation><affiliation><nlm:aff id="aff2"><italic>Centre for Neuroscience, University of Alberta, Edmonton, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Mansoor, Wasim" sort="Mansoor, Wasim" uniqKey="Mansoor W" first="Wasim" last="Mansoor">Wasim Mansoor</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Hussaini, Syed" sort="Hussaini, Syed" uniqKey="Hussaini S" first="Syed" last="Hussaini">Syed Hussaini</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Rahman, Maniza" sort="Rahman, Maniza" uniqKey="Rahman M" first="Maniza" last="Rahman">Maniza Rahman</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author><author><name sortKey="Iqbal, Zohair" sort="Iqbal, Zohair" uniqKey="Iqbal Z" first="Zohair" last="Iqbal">Zohair Iqbal</name><affiliation><nlm:aff id="aff1"><italic>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada</italic></nlm:aff></affiliation></author></analytic><series><title level="j">Journal of Neurosciences in Rural Practice</title><idno type="ISSN">0976-3147</idno><idno type="eISSN">0976-3155</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="st1"><title>Context:</title><p>Late onset Parkinson's disease (LOPD) is a neurodegenerative disorder afflicting individuals of ages 60 and older. However, 5–10% of cases can begin earlier between the ages 20 to 40, and are classified as young onset Parkinson disease (YOPD).</p></sec><sec id="st2"><title>Aim:</title><p>In turn, this study aims to observe the trend in the choice of drug administered to patients with both YOPD and LOPD, with particular emphasis on this trend in its relation to the practice background of the neurologist.</p></sec><sec id="st3"><title>Settings and Design:</title><p>A cross-sectional study was conducted in a community based Parkinson's disease and movement disorder clinic.</p></sec><sec id="st4"><title>Statistical Analysis Used:</title><p>Using a retrospective chart review data was obtained and analysed.</p></sec><sec id="st5"><title>Results:</title><p>The results showed that 83% of general neurologists prescribed levodopa to their patients with YOPD, whereas movement-disorder specialists took a different approach altogether. They opted not to use levodopa and, in its stead, prescribed a mixture of alternate drugs.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Rana, Aq" uniqKey="Rana A">AQ Rana</name></author><author><name sortKey="Siddiqui, I" uniqKey="Siddiqui I">I Siddiqui</name></author><author><name sortKey="Yousuf, Ms" uniqKey="Yousuf M">MS Yousuf</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Halkias, Ia" uniqKey="Halkias I">IA Halkias</name></author><author><name sortKey="Haq, I" uniqKey="Haq I">I Haq</name></author><author><name sortKey="Huang, Z" uniqKey="Huang Z">Z Huang</name></author><author><name sortKey="Fernandez, Hh" uniqKey="Fernandez H">HH Fernandez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhang, Yh" uniqKey="Zhang Y">YH Zhang</name></author><author><name sortKey="Tang, Bs" uniqKey="Tang B">BS Tang</name></author><author><name sortKey="Song, Cy" uniqKey="Song C">CY Song</name></author><author><name sortKey="Xu, Q" uniqKey="Xu Q">Q Xu</name></author><author><name sortKey="Lou, Mx" uniqKey="Lou M">MX Lou</name></author><author><name sortKey="Liu, Zh" uniqKey="Liu Z">ZH Liu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Giroux, Ml" uniqKey="Giroux M">ML Giroux</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sujith, Ok" uniqKey="Sujith O">OK Sujith</name></author><author><name sortKey="Lane, C" uniqKey="Lane C">C Lane</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hoehn, Mm" uniqKey="Hoehn M">MM Hoehn</name></author><author><name sortKey="Yahr, Md" uniqKey="Yahr M">MD Yahr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bonuccelli, U" uniqKey="Bonuccelli U">U Bonuccelli</name></author><author><name sortKey="Del Dotto, P" uniqKey="Del Dotto P">P Del Dotto</name></author><author><name sortKey="Rascol, O" uniqKey="Rascol O">O Rascol</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bostwick, Jm" uniqKey="Bostwick J">JM Bostwick</name></author><author><name sortKey="Hecksel, Ka" uniqKey="Hecksel K">KA Hecksel</name></author><author><name sortKey="Stevens, Sr" uniqKey="Stevens S">SR Stevens</name></author><author><name sortKey="Bower, Jh" uniqKey="Bower J">JH Bower</name></author><author><name sortKey="Ahlskog, Je" uniqKey="Ahlskog J">JE Ahlskog</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kostic, Vs" uniqKey="Kostic V">VS Kostic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clarke, Ce" uniqKey="Clarke C">CE Clarke</name></author><author><name sortKey="Worth, P" uniqKey="Worth P">P Worth</name></author><author><name sortKey="Grosset, D" uniqKey="Grosset D">D Grosset</name></author><author><name sortKey="Stewart, D" uniqKey="Stewart D">D Stewart</name></author></analytic></biblStruct></listBibl></div1></back></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">DOPA-sparing strategy in the treatment of young onset Parkinson's disease.</title><author><name sortKey="Rana, Abdul Qayyum" sort="Rana, Abdul Qayyum" uniqKey="Rana A" first="Abdul Qayyum" last="Rana">Abdul Qayyum Rana</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Saleh, Mohamad" sort="Saleh, Mohamad" uniqKey="Saleh M" first="Mohamad" last="Saleh">Mohamad Saleh</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Yousuf, Muhammad Saad" sort="Yousuf, Muhammad Saad" uniqKey="Yousuf M" first="Muhammad Saad" last="Yousuf">Muhammad Saad Yousuf</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada; Centre for Neuroscience, University of Alberta, Edmonton, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada; Centre for Neuroscience, University of Alberta, Edmonton</wicri:regionArea><wicri:noRegion>Edmonton</wicri:noRegion></affiliation></author><author><name sortKey="Mansoor, Wasim" sort="Mansoor, Wasim" uniqKey="Mansoor W" first="Wasim" last="Mansoor">Wasim Mansoor</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Hussaini, Syed" sort="Hussaini, Syed" uniqKey="Hussaini S" first="Syed" last="Hussaini">Syed Hussaini</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Rahman, Maniza" sort="Rahman, Maniza" uniqKey="Rahman M" first="Maniza" last="Rahman">Maniza Rahman</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Iqbal, Zohair" sort="Iqbal, Zohair" uniqKey="Iqbal Z" first="Zohair" last="Iqbal">Zohair Iqbal</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2016 Jan-Mar</MedlineDate></PubDate></date><idno type="RBID">pubmed:26933347</idno><idno type="pmid">26933347</idno><idno type="doi">10.4103/0976-3147.172155</idno><idno type="wicri:Area/PubMed/Corpus">000332</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000332</idno><idno type="wicri:Area/PubMed/Curation">000332</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000332</idno><idno type="wicri:Area/PubMed/Checkpoint">000332</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000332</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">DOPA-sparing strategy in the treatment of young onset Parkinson's disease.</title><author><name sortKey="Rana, Abdul Qayyum" sort="Rana, Abdul Qayyum" uniqKey="Rana A" first="Abdul Qayyum" last="Rana">Abdul Qayyum Rana</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Saleh, Mohamad" sort="Saleh, Mohamad" uniqKey="Saleh M" first="Mohamad" last="Saleh">Mohamad Saleh</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Yousuf, Muhammad Saad" sort="Yousuf, Muhammad Saad" uniqKey="Yousuf M" first="Muhammad Saad" last="Yousuf">Muhammad Saad Yousuf</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada; Centre for Neuroscience, University of Alberta, Edmonton, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada; Centre for Neuroscience, University of Alberta, Edmonton</wicri:regionArea><wicri:noRegion>Edmonton</wicri:noRegion></affiliation></author><author><name sortKey="Mansoor, Wasim" sort="Mansoor, Wasim" uniqKey="Mansoor W" first="Wasim" last="Mansoor">Wasim Mansoor</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Hussaini, Syed" sort="Hussaini, Syed" uniqKey="Hussaini S" first="Syed" last="Hussaini">Syed Hussaini</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Rahman, Maniza" sort="Rahman, Maniza" uniqKey="Rahman M" first="Maniza" last="Rahman">Maniza Rahman</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author><author><name sortKey="Iqbal, Zohair" sort="Iqbal, Zohair" uniqKey="Iqbal Z" first="Zohair" last="Iqbal">Zohair Iqbal</name><affiliation wicri:level="1"><nlm:affiliation>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Parkinson's Clinic of Eastern Toronto and Movement Disorders Center, Toronto</wicri:regionArea><wicri:noRegion>Toronto</wicri:noRegion></affiliation></author></analytic><series><title level="j">Journal of neurosciences in rural practice</title><idno type="ISSN">0976-3147</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Late onset Parkinson's disease (LOPD) is a neurodegenerative disorder afflicting individuals of ages 60 and older. However, 5-10% of cases can begin earlier between the ages 20 to 40, and are classified as young onset Parkinson disease (YOPD).</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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