Pathophysiology of rigidity and akinesia in Parkinson's disease.
Identifieur interne : 001D64 ( Ncbi/Merge ); précédent : 001D63; suivant : 001D65Pathophysiology of rigidity and akinesia in Parkinson's disease.
Auteurs : R G Lee [Canada]Source :
- European neurology [ 0014-3022 ] ; 1989.
English descriptors
- KwdEn :
- MESH :
- complications : Parkinson Disease.
- etiology : Muscle Rigidity.
- physiopathology : Muscle Rigidity, Parkinson Disease.
- Humans.
Abstract
Although rigidity and akinesia are two of the cardinal features of Parkinson's disease, their exact pathophysiology remains uncertain. Mechanisms which may contribute to rigidity include accentuation of the long-latency component of the stretch reflex and enhanced fusimotor drive causing increased sensitivity of muscle spindles. Current evidence concerning the role of these factors in rigidity is reviewed. The relationship between akinesia, prolonged reaction times, and delay in initiation of internally generated movements in parkinsonian patients is discussed.
PubMed: 2653833
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 001C36
- to stream PubMed, to step Curation: 001C36
- to stream PubMed, to step Checkpoint: 001C36
Links to Exploration step
pubmed:2653833Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pathophysiology of rigidity and akinesia in Parkinson's disease.</title>
<author><name sortKey="Lee, R G" sort="Lee, R G" uniqKey="Lee R" first="R G" last="Lee">R G Lee</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Neurosciences, University of Calgary, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Clinical Neurosciences, University of Calgary</wicri:regionArea>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
<orgName type="university">Université de Calgary</orgName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1989">1989</date>
<idno type="RBID">pubmed:2653833</idno>
<idno type="pmid">2653833</idno>
<idno type="wicri:Area/PubMed/Corpus">001C36</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001C36</idno>
<idno type="wicri:Area/PubMed/Curation">001C36</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001C36</idno>
<idno type="wicri:Area/PubMed/Checkpoint">001C36</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001C36</idno>
<idno type="wicri:Area/Ncbi/Merge">001D64</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Pathophysiology of rigidity and akinesia in Parkinson's disease.</title>
<author><name sortKey="Lee, R G" sort="Lee, R G" uniqKey="Lee R" first="R G" last="Lee">R G Lee</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Clinical Neurosciences, University of Calgary, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Clinical Neurosciences, University of Calgary</wicri:regionArea>
<placeName><settlement type="city">Calgary</settlement>
<region type="state">Alberta</region>
</placeName>
<orgName type="university">Université de Calgary</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j">European neurology</title>
<idno type="ISSN">0014-3022</idno>
<imprint><date when="1989" type="published">1989</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Humans</term>
<term>Muscle Rigidity (etiology)</term>
<term>Muscle Rigidity (physiopathology)</term>
<term>Parkinson Disease (complications)</term>
<term>Parkinson Disease (physiopathology)</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Muscle Rigidity</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Muscle Rigidity</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Humans</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Although rigidity and akinesia are two of the cardinal features of Parkinson's disease, their exact pathophysiology remains uncertain. Mechanisms which may contribute to rigidity include accentuation of the long-latency component of the stretch reflex and enhanced fusimotor drive causing increased sensitivity of muscle spindles. Current evidence concerning the role of these factors in rigidity is reviewed. The relationship between akinesia, prolonged reaction times, and delay in initiation of internally generated movements in parkinsonian patients is discussed.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2653833</PMID>
<DateCreated><Year>1989</Year>
<Month>06</Month>
<Day>13</Day>
</DateCreated>
<DateCompleted><Year>1989</Year>
<Month>06</Month>
<Day>13</Day>
</DateCompleted>
<DateRevised><Year>2005</Year>
<Month>11</Month>
<Day>16</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0014-3022</ISSN>
<JournalIssue CitedMedium="Print"><Volume>29 Suppl 1</Volume>
<PubDate><Year>1989</Year>
</PubDate>
</JournalIssue>
<Title>European neurology</Title>
<ISOAbbreviation>Eur. Neurol.</ISOAbbreviation>
</Journal>
<ArticleTitle>Pathophysiology of rigidity and akinesia in Parkinson's disease.</ArticleTitle>
<Pagination><MedlinePgn>13-8</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Although rigidity and akinesia are two of the cardinal features of Parkinson's disease, their exact pathophysiology remains uncertain. Mechanisms which may contribute to rigidity include accentuation of the long-latency component of the stretch reflex and enhanced fusimotor drive causing increased sensitivity of muscle spindles. Current evidence concerning the role of these factors in rigidity is reviewed. The relationship between akinesia, prolonged reaction times, and delay in initiation of internally generated movements in parkinsonian patients is discussed.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Lee</LastName>
<ForeName>R G</ForeName>
<Initials>RG</Initials>
<AffiliationInfo><Affiliation>Department of Clinical Neurosciences, University of Calgary, Canada.</Affiliation>
</AffiliationInfo>
</Author>
</AuthorList>
<Language>eng</Language>
<PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType>
<PublicationType UI="D016454">Review</PublicationType>
</PublicationTypeList>
</Article>
<MedlineJournalInfo><Country>Switzerland</Country>
<MedlineTA>Eur Neurol</MedlineTA>
<NlmUniqueID>0150760</NlmUniqueID>
<ISSNLinking>0014-3022</ISSNLinking>
</MedlineJournalInfo>
<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009127" MajorTopicYN="N">Muscle Rigidity</DescriptorName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="N">complications</QualifierName>
<QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName>
</MeshHeading>
</MeshHeadingList>
<NumberOfReferences>23</NumberOfReferences>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1989</Year>
<Month>1</Month>
<Day>1</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>1989</Year>
<Month>1</Month>
<Day>1</Day>
<Hour>0</Hour>
<Minute>1</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>1989</Year>
<Month>1</Month>
<Day>1</Day>
<Hour>0</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">2653833</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list><country><li>Canada</li>
</country>
<region><li>Alberta</li>
</region>
<settlement><li>Calgary</li>
</settlement>
<orgName><li>Université de Calgary</li>
</orgName>
</list>
<tree><country name="Canada"><region name="Alberta"><name sortKey="Lee, R G" sort="Lee, R G" uniqKey="Lee R" first="R G" last="Lee">R G Lee</name>
</region>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001D64 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 001D64 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Canada |area= ParkinsonCanadaV1 |flux= Ncbi |étape= Merge |type= RBID |clé= pubmed:2653833 |texte= Pathophysiology of rigidity and akinesia in Parkinson's disease. }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:2653833" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a ParkinsonCanadaV1
![]() | This area was generated with Dilib version V0.6.29. | ![]() |