Distribution of vesicular glutamate transporters in the human brain
Identifieur interne : 001B08 ( Ncbi/Merge ); précédent : 001B07; suivant : 001B09Distribution of vesicular glutamate transporters in the human brain
Auteurs : Érika Vigneault [Canada] ; Odile Poirel [France] ; Mustapha Riad [Canada] ; Josée Prud'Homme [Canada] ; Sylvie Dumas [France] ; Gustavo Turecki [Canada] ; Caroline Fasano [Canada] ; Naguib Mechawar [Canada] ; Salah El Mestikawy [Canada, France]Source :
- Frontiers in Neuroanatomy [ 1662-5129 ] ; 2015.
Abstract
Glutamate is the major excitatory transmitter in the brain. Vesicular glutamate transporters (VGLUT1-3) are responsible for uploading glutamate into synaptic vesicles. VGLUT1 and VGLUT2 are considered as specific markers of canonical glutamatergic neurons, while VGLUT3 is found in neurons previously shown to use other neurotransmitters than glutamate. Although there exists a rich literature on the localization of these glutamatergic markers in the rodent brain, little is currently known about the distribution of VGLUT1-3 in the human brain. In the present study, using subtype specific probes and antisera, we examined the localization of the three vesicular glutamate transporters in the human brain by
Url:
DOI: 10.3389/fnana.2015.00023
PubMed: 25798091
PubMed Central: 4350397
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<front><div type="abstract" xml:lang="en"><p>Glutamate is the major excitatory transmitter in the brain. Vesicular glutamate transporters (VGLUT1-3) are responsible for uploading glutamate into synaptic vesicles. VGLUT1 and VGLUT2 are considered as specific markers of canonical glutamatergic neurons, while VGLUT3 is found in neurons previously shown to use other neurotransmitters than glutamate. Although there exists a rich literature on the localization of these glutamatergic markers in the rodent brain, little is currently known about the distribution of VGLUT1-3 in the human brain. In the present study, using subtype specific probes and antisera, we examined the localization of the three vesicular glutamate transporters in the human brain by <italic>in situ</italic>
hybridization, immunoautoradiography and immunohistochemistry. We found that the VGLUT1 transcript was highly expressed in the cerebral cortex, hippocampus and cerebellum, whereas VGLUT2 mRNA was mainly found in the thalamus and brainstem. VGLUT3 mRNA was localized in scarce neurons within the cerebral cortex, hippocampus, striatum and raphe nuclei. Following immunoautoradiographic labeling, intense VGLUT1- and VGLUT2-immunoreactivities were observed in all regions investigated (cerebral cortex, hippocampus, caudate-putamen, cerebellum, thalamus, amygdala, substantia nigra, raphe) while VGLUT3 was absent from the thalamus and cerebellum. This extensive mapping of VGLUT1-3 in human brain reveals distributions that correspond for the most part to those previously described in rodent brains.</p>
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<journal-id journal-id-type="iso-abbrev">Front Neuroanat</journal-id>
<journal-id journal-id-type="publisher-id">Front. Neuroanat.</journal-id>
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<publisher><publisher-name>Frontiers Media S.A.</publisher-name>
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<article-meta><article-id pub-id-type="pmid">25798091</article-id>
<article-id pub-id-type="pmc">4350397</article-id>
<article-id pub-id-type="doi">10.3389/fnana.2015.00023</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Neuroscience</subject>
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<contrib contrib-type="author"><name><surname>Turecki</surname>
<given-names>Gustavo</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/48489"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Fasano</surname>
<given-names>Caroline</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/206145"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Mechawar</surname>
<given-names>Naguib</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="author-notes" rid="fn001"><sup>*</sup>
</xref>
<xref ref-type="author-notes" rid="fn003"><sup>†</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/14282"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>El Mestikawy</surname>
<given-names>Salah</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<xref ref-type="aff" rid="aff4"><sup>4</sup>
</xref>
<xref ref-type="author-notes" rid="fn001"><sup>*</sup>
</xref>
<xref ref-type="author-notes" rid="fn003"><sup>†</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://community.frontiersin.org/people/u/8597"></uri>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup>
<institution>Department of Psychiatry, Douglas Mental Health University Institute, McGill University</institution>
<country>Montreal, QC, Canada</country>
</aff>
<aff id="aff2"><sup>2</sup>
<institution>Institut National de la Santé et de la Recherche Médicale, UMR-S 1130, Neuroscience Paris Seine</institution>
<country>Paris, France</country>
</aff>
<aff id="aff3"><sup>3</sup>
<institution>Centre National de la Recherche Scientifique UMR 8246, Neuroscience Paris Seine</institution>
<country>Paris, France</country>
</aff>
<aff id="aff4"><sup>4</sup>
<institution>Sorbonne University, Université Pierre et Marie Curie Paris 06, UM119, Neuroscience Paris Seine</institution>
<country>Paris, France</country>
</aff>
<aff id="aff5"><sup>5</sup>
<institution>Oramacell</institution>
<country>Paris, France</country>
</aff>
<author-notes><fn fn-type="edited-by"><p>Edited by: Kathleen S. Rockland, Boston University School Medicine, USA</p>
</fn>
<fn fn-type="edited-by"><p>Reviewed by: Ricardo Insausti, University of Castilla -la Mancha, Spain; Gudrun Ahnert-Hilger, Institute for Integrative Neuroanatomy Charite, Germany</p>
</fn>
<corresp id="fn001">*Correspondence: Naguib Mechawar and Salah El Mestikawy, Department of Psychiatry, Douglas Mental Health University Institute, McGill University, 6875 Lasalle blvd, Montréal, QC H4H 1R3, Canada e-mail: <email xlink:type="simple">naguib.mechawar@mcgill.ca</email>
; <email xlink:type="simple">salah.elmestikawy@mcgill.ca</email>
</corresp>
<fn fn-type="other" id="fn002"><p>This article was submitted to the journal Frontiers in Neuroanatomy.</p>
</fn>
<fn fn-type="present-address" id="fn003"><p>†These authors have contributed equally to this work.</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>05</day>
<month>3</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="collection"><year>2015</year>
</pub-date>
<volume>9</volume>
<elocation-id>23</elocation-id>
<history><date date-type="received"><day>17</day>
<month>12</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>12</day>
<month>2</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2015 Vigneault, Poirel, Riad, Prud'homme, Dumas, Turecki, Fasano, Mechawar and El Mestikawy.</copyright-statement>
<copyright-year>2015</copyright-year>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract><p>Glutamate is the major excitatory transmitter in the brain. Vesicular glutamate transporters (VGLUT1-3) are responsible for uploading glutamate into synaptic vesicles. VGLUT1 and VGLUT2 are considered as specific markers of canonical glutamatergic neurons, while VGLUT3 is found in neurons previously shown to use other neurotransmitters than glutamate. Although there exists a rich literature on the localization of these glutamatergic markers in the rodent brain, little is currently known about the distribution of VGLUT1-3 in the human brain. In the present study, using subtype specific probes and antisera, we examined the localization of the three vesicular glutamate transporters in the human brain by <italic>in situ</italic>
hybridization, immunoautoradiography and immunohistochemistry. We found that the VGLUT1 transcript was highly expressed in the cerebral cortex, hippocampus and cerebellum, whereas VGLUT2 mRNA was mainly found in the thalamus and brainstem. VGLUT3 mRNA was localized in scarce neurons within the cerebral cortex, hippocampus, striatum and raphe nuclei. Following immunoautoradiographic labeling, intense VGLUT1- and VGLUT2-immunoreactivities were observed in all regions investigated (cerebral cortex, hippocampus, caudate-putamen, cerebellum, thalamus, amygdala, substantia nigra, raphe) while VGLUT3 was absent from the thalamus and cerebellum. This extensive mapping of VGLUT1-3 in human brain reveals distributions that correspond for the most part to those previously described in rodent brains.</p>
</abstract>
<kwd-group><kwd><italic>Homo sapiens</italic>
</kwd>
<kwd>brain</kwd>
<kwd>neurotransmission</kwd>
<kwd>glutamate</kwd>
<kwd>VGLUTs</kwd>
<kwd>anatomy</kwd>
</kwd-group>
<counts><fig-count count="10"></fig-count>
<table-count count="3"></table-count>
<equation-count count="0"></equation-count>
<ref-count count="52"></ref-count>
<page-count count="13"></page-count>
<word-count count="7409"></word-count>
</counts>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Canada</li>
<li>France</li>
</country>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Vigneault, Erika" sort="Vigneault, Erika" uniqKey="Vigneault E" first="Érika" last="Vigneault">Érika Vigneault</name>
</noRegion>
<name sortKey="El Mestikawy, Salah" sort="El Mestikawy, Salah" uniqKey="El Mestikawy S" first="Salah" last="El Mestikawy">Salah El Mestikawy</name>
<name sortKey="Fasano, Caroline" sort="Fasano, Caroline" uniqKey="Fasano C" first="Caroline" last="Fasano">Caroline Fasano</name>
<name sortKey="Mechawar, Naguib" sort="Mechawar, Naguib" uniqKey="Mechawar N" first="Naguib" last="Mechawar">Naguib Mechawar</name>
<name sortKey="Prud Homme, Josee" sort="Prud Homme, Josee" uniqKey="Prud Homme J" first="Josée" last="Prud'Homme">Josée Prud'Homme</name>
<name sortKey="Riad, Mustapha" sort="Riad, Mustapha" uniqKey="Riad M" first="Mustapha" last="Riad">Mustapha Riad</name>
<name sortKey="Turecki, Gustavo" sort="Turecki, Gustavo" uniqKey="Turecki G" first="Gustavo" last="Turecki">Gustavo Turecki</name>
</country>
<country name="France"><noRegion><name sortKey="Poirel, Odile" sort="Poirel, Odile" uniqKey="Poirel O" first="Odile" last="Poirel">Odile Poirel</name>
</noRegion>
<name sortKey="Dumas, Sylvie" sort="Dumas, Sylvie" uniqKey="Dumas S" first="Sylvie" last="Dumas">Sylvie Dumas</name>
<name sortKey="El Mestikawy, Salah" sort="El Mestikawy, Salah" uniqKey="El Mestikawy S" first="Salah" last="El Mestikawy">Salah El Mestikawy</name>
<name sortKey="El Mestikawy, Salah" sort="El Mestikawy, Salah" uniqKey="El Mestikawy S" first="Salah" last="El Mestikawy">Salah El Mestikawy</name>
<name sortKey="El Mestikawy, Salah" sort="El Mestikawy, Salah" uniqKey="El Mestikawy S" first="Salah" last="El Mestikawy">Salah El Mestikawy</name>
<name sortKey="Poirel, Odile" sort="Poirel, Odile" uniqKey="Poirel O" first="Odile" last="Poirel">Odile Poirel</name>
<name sortKey="Poirel, Odile" sort="Poirel, Odile" uniqKey="Poirel O" first="Odile" last="Poirel">Odile Poirel</name>
</country>
</tree>
</affiliations>
</record>
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