Rising to the Challenges of Clinical Trial Improvement in Parkinson's Disease.
Identifieur interne : 001A78 ( Ncbi/Merge ); précédent : 001A77; suivant : 001A79Rising to the Challenges of Clinical Trial Improvement in Parkinson's Disease.
Auteurs : Soania Mathur [Canada] ; Steve Dewitte [Royaume-Uni] ; Israel Robledo [Royaume-Uni] ; Tom Isaacs [Royaume-Uni] ; Jon Stamford [Royaume-Uni]Source :
- Journal of Parkinson's disease [ 1877-718X ] ; 2015.
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Abstract
Despite an urgent need for new medications, clinical trials in Parkinson's have a relatively low rate of success. Although many reasons have been proposed for this, the opinions of patients and scientists, the two principal stakeholders, have not been widely canvassed.
DOI: 10.3233/JPD-150541
PubMed: 25720445
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type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Robledo, Israel" sort="Robledo, Israel" uniqKey="Robledo I" first="Israel" last="Robledo">Israel Robledo</name><affiliation wicri:level="3"><nlm:affiliation>Parkinson's Movement, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Parkinson's Movement, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Isaacs, Tom" sort="Isaacs, Tom" uniqKey="Isaacs T" first="Tom" last="Isaacs">Tom Isaacs</name><affiliation wicri:level="3"><nlm:affiliation>Parkinson's Movement, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Parkinson's Movement, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Stamford, Jon" sort="Stamford, Jon" uniqKey="Stamford J" first="Jon" last="Stamford">Jon Stamford</name><affiliation wicri:level="3"><nlm:affiliation>Parkinson's Movement, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Parkinson's Movement, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:25720445</idno><idno type="pmid">25720445</idno><idno type="doi">10.3233/JPD-150541</idno><idno type="wicri:Area/PubMed/Corpus">000606</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" 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S" first="Steve" last="Dewitte">Steve Dewitte</name><affiliation wicri:level="3"><nlm:affiliation>Parkinson's Movement, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Parkinson's Movement, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Robledo, Israel" sort="Robledo, Israel" uniqKey="Robledo I" first="Israel" last="Robledo">Israel Robledo</name><affiliation wicri:level="3"><nlm:affiliation>Parkinson's Movement, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Parkinson's Movement, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Isaacs, Tom" sort="Isaacs, Tom" uniqKey="Isaacs T" first="Tom" last="Isaacs">Tom Isaacs</name><affiliation wicri:level="3"><nlm:affiliation>Parkinson's Movement, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Parkinson's Movement, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Stamford, Jon" sort="Stamford, Jon" uniqKey="Stamford J" first="Jon" last="Stamford">Jon Stamford</name><affiliation wicri:level="3"><nlm:affiliation>Parkinson's Movement, London, UK.</nlm:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Parkinson's Movement, London</wicri:regionArea><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author></analytic><series><title level="j">Journal of Parkinson's disease</title><idno type="eISSN">1877-718X</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Clinical Trials as Topic</term><term>Drug Discovery</term><term>Health Knowledge, Attitudes, Practice</term><term>Humans</term><term>Parkinson Disease (therapy)</term><term>Surveys and Questionnaires</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Clinical Trials as Topic</term><term>Drug Discovery</term><term>Health Knowledge, Attitudes, Practice</term><term>Humans</term><term>Surveys and Questionnaires</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Despite an urgent need for new medications, clinical trials in Parkinson's have a relatively low rate of success. Although many reasons have been proposed for this, the opinions of patients and scientists, the two principal stakeholders, have not been widely canvassed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">25720445</PMID><DateCreated><Year>2015</Year><Month>09</Month><Day>26</Day></DateCreated><DateCompleted><Year>2016</Year><Month>06</Month><Day>22</Day></DateCompleted><DateRevised><Year>2015</Year><Month>09</Month><Day>26</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1877-718X</ISSN><JournalIssue CitedMedium="Internet"><Volume>5</Volume><Issue>2</Issue><PubDate><Year>2015</Year></PubDate></JournalIssue><Title>Journal of Parkinson's disease</Title><ISOAbbreviation>J Parkinsons Dis</ISOAbbreviation></Journal><ArticleTitle>Rising to the Challenges of Clinical Trial Improvement in Parkinson's Disease.</ArticleTitle><Pagination><MedlinePgn>263-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.3233/JPD-150541</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Despite an urgent need for new medications, clinical trials in Parkinson's have a relatively low rate of success. Although many reasons have been proposed for this, the opinions of patients and scientists, the two principal stakeholders, have not been widely canvassed.</AbstractText><AbstractText Label="OBJECTIVE" NlmCategory="OBJECTIVE">The objective of the present study was to establish the main barriers to clinical trials success in Parkinson's, as perceived by people with Parkinson's and those engaged in conducting clinical trials in Parkinson's.</AbstractText><AbstractText Label="METHOD" NlmCategory="METHODS">Three hundred and three people (303) with a connection to Parkinson's completed an online four-item questionnaire, directed towards discovering the barriers that interfere with the establishment of effective clinical trials.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">87% of respondents were patients and their care partners and 11% were medical professionals involved with clinical research. In the survey, those involved in conducting research cited insufficient financial and administrative support as the biggest obstacles to carrying out effective clinical trials. For responders with Parkinson's, the principal barrier to their participation in medical research was fear of potential adverse consequences and misconceptions regarding the clinical trial system as a whole, issues rooted in a perceived lack of communication of relevant information between the research and patient communities.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Areas for future improvement as highlighted by this survey and debated at the Rallying to the Challenge meeting of people with Parkinson's (PwP) at the Van Andel Research Institute that followed included recommendations in the areas of communication, education, funding, recruitment and compliance.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Mathur</LastName><ForeName>Soania</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Designing a Cure Inc, Toronto, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Parkinson's Movement, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>DeWitte</LastName><ForeName>Steve</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Parkinson's Movement, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Parkinson's Action Network, Washington, DC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Robledo</LastName><ForeName>Israel</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Parkinson's Movement, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Parkinson's Action Network, Washington, DC, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Isaacs</LastName><ForeName>Tom</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Parkinson's Movement, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Cure Parkinson's Trust, London, UK.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Stamford</LastName><ForeName>Jon</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Parkinson's Movement, London, UK.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>The Cure Parkinson's Trust, London, UK.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Parkinsons Dis</MedlineTA><NlmUniqueID>101567362</NlmUniqueID><ISSNLinking>1877-7171</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D002986" MajorTopicYN="Y">Clinical Trials as Topic</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055808" MajorTopicYN="N">Drug Discovery</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007722" MajorTopicYN="N">Health Knowledge, Attitudes, Practice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000628" MajorTopicYN="Y">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011795" MajorTopicYN="N">Surveys and Questionnaires</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Clinical trial</Keyword><Keyword MajorTopicYN="N">barriers</Keyword><Keyword MajorTopicYN="N">management</Keyword><Keyword MajorTopicYN="N">patient engagement</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2015</Year><Month>2</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2015</Year><Month>2</Month><Day>28</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>6</Month><Day>23</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">25720445</ArticleId><ArticleId IdType="pii">Y3686445R37TW72V</ArticleId><ArticleId IdType="doi">10.3233/JPD-150541</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Canada"><noRegion><name sortKey="Mathur, Soania" sort="Mathur, Soania" uniqKey="Mathur S" first="Soania" last="Mathur">Soania Mathur</name></noRegion></country><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Dewitte, Steve" sort="Dewitte, Steve" uniqKey="Dewitte S" first="Steve" last="Dewitte">Steve Dewitte</name></region><name sortKey="Isaacs, Tom" sort="Isaacs, Tom" uniqKey="Isaacs T" first="Tom" last="Isaacs">Tom Isaacs</name><name sortKey="Robledo, Israel" sort="Robledo, Israel" uniqKey="Robledo I" first="Israel" last="Robledo">Israel Robledo</name><name sortKey="Stamford, Jon" sort="Stamford, Jon" uniqKey="Stamford J" first="Jon" last="Stamford">Jon Stamford</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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