Regulation of the VHL/HIF-1 pathway by DJ-1.
Identifieur interne : 001784 ( Ncbi/Merge ); précédent : 001783; suivant : 001785Regulation of the VHL/HIF-1 pathway by DJ-1.
Auteurs : Mohammad Parsanejad ; Yi Zhang ; Dianbo Qu ; Isabella Irrcher [Canada] ; Maxime W C. Rousseaux ; Hossein Aleyasin ; Fatemeh Kamkar ; Steve Callaghan ; Ruth S. Slack ; Tak W. Mak ; Stephen Lee ; Daniel Figeys [Canada] ; David S. Park [Canada]Source :
- The Journal of neuroscience : the official journal of the Society for Neuroscience [ 1529-2401 ] ; 2014.
English descriptors
- KwdEn :
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (pharmacology), Animals, Cells, Cultured, Embryo, Mammalian, Female, Gene Expression Regulation (drug effects), Gene Expression Regulation (genetics), Humans, Hypoxia-Inducible Factor 1, alpha Subunit (genetics), Hypoxia-Inducible Factor 1, alpha Subunit (metabolism), Male, Mice, Mice, Knockout, Neuroblastoma (pathology), Neurons (drug effects), Neurons (metabolism), Neurotoxins (pharmacology), Oncogene Proteins (deficiency), Oncogene Proteins (metabolism), Oxidative Stress (drug effects), Oxidative Stress (genetics), Parkinson Disease (pathology), Peroxiredoxins, Protein Deglycase DJ-1, Signal Transduction (drug effects), Signal Transduction (physiology), Time Factors, Von Hippel-Lindau Tumor Suppressor Protein (genetics), Von Hippel-Lindau Tumor Suppressor Protein (metabolism).
- MESH :
- chemical , deficiency : Oncogene Proteins.
- chemical , genetics : Hypoxia-Inducible Factor 1, alpha Subunit, Von Hippel-Lindau Tumor Suppressor Protein.
- chemical , metabolism : Hypoxia-Inducible Factor 1, alpha Subunit, Oncogene Proteins, Von Hippel-Lindau Tumor Suppressor Protein.
- chemical , pharmacology : 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Neurotoxins.
- drug effects : Gene Expression Regulation, Neurons, Oxidative Stress, Signal Transduction.
- genetics : Gene Expression Regulation, Oxidative Stress.
- metabolism : Neurons.
- pathology : Neuroblastoma, Parkinson Disease.
- physiology : Signal Transduction.
- Animals, Cells, Cultured, Embryo, Mammalian, Female, Humans, Male, Mice, Mice, Knockout, Peroxiredoxins, Protein Deglycase DJ-1, Time Factors.
Abstract
DJ-1 (PARK7) is a gene linked to autosomal recessive Parkinson disease (PD). We showed previously that DJ-1 loss sensitizes neurons in models of PD and stroke. However, the biochemical mechanisms underlying this protective role are not completely clear. Here, we identify Von Hippel Lindau (VHL) protein as a critical DJ-1-interacting protein. We provide evidence that DJ-1 negatively regulates VHL ubiquitination activity of the α-subunit of hypoxia-inducible factor-1 (HIF-1α) by inhibiting HIF-VHL interaction. Consistent with this observation, DJ-1 deficiency leads to lowered HIF-1α levels in models of both hypoxia and oxidative stress, two stresses known to stabilize HIF-1α. We also demonstrate that HIF-1α accumulation rescues DJ-1-deficient neurons against 1-methyl-4-phenylpyridinium-induced toxicity. Interestingly, lymphoblast cells extracted from DJ-1-related PD patients show impaired HIF-1α stabilization when compared with normal individuals, indicating that the DJ-1-VHL link may also be relevant to a human context. Together, our findings delineate a model by which DJ-1 mediates neuronal survival by regulation of the VHL-HIF-1α pathway.
DOI: 10.1523/JNEUROSCI.1244-13.2014
PubMed: 24899725
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Rousseaux</name><affiliation><nlm:affiliation>Department of Cellular and Molecular Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Department of Cellular and Molecular Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Aleyasin, Hossein" sort="Aleyasin, Hossein" uniqKey="Aleyasin H" first="Hossein" last="Aleyasin">Hossein Aleyasin</name><affiliation><nlm:affiliation>Department of Cellular and Molecular Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Department of Cellular and Molecular Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Kamkar, Fatemeh" sort="Kamkar, Fatemeh" uniqKey="Kamkar F" first="Fatemeh" last="Kamkar">Fatemeh Kamkar</name><affiliation><nlm:affiliation>Department of Cellular and Molecular Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Department of Cellular and Molecular Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Callaghan, Steve" sort="Callaghan, Steve" uniqKey="Callaghan S" first="Steve" last="Callaghan">Steve Callaghan</name><affiliation><nlm:affiliation>Department of Cellular and Molecular Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Department of Cellular and Molecular Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Slack, Ruth S" sort="Slack, Ruth S" uniqKey="Slack R" first="Ruth S" last="Slack">Ruth S. Slack</name><affiliation><nlm:affiliation>Department of Cellular and Molecular Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Department of Cellular and Molecular Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Mak, Tak W" sort="Mak, Tak W" uniqKey="Mak T" first="Tak W" last="Mak">Tak W. Mak</name><affiliation><nlm:affiliation>The Campbell Family Institute for Breast Cancer Research, Toronto, Ontario M5G 2C1, Canada, and.</nlm:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Lee, Stephen" sort="Lee, Stephen" uniqKey="Lee S" first="Stephen" last="Lee">Stephen Lee</name><affiliation><nlm:affiliation>Department of Cellular and Molecular Medicine.</nlm:affiliation><wicri:noCountry code="no comma">Department of Cellular and Molecular Medicine.</wicri:noCountry></affiliation></author><author><name sortKey="Figeys, Daniel" sort="Figeys, Daniel" uniqKey="Figeys D" first="Daniel" last="Figeys">Daniel Figeys</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Systems Biology, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Institute of Systems Biology, University of Ottawa, Ottawa, Ontario K1H 8M5</wicri:regionArea><wicri:noRegion>Ontario K1H 8M5</wicri:noRegion></affiliation></author><author><name sortKey="Park, David S" sort="Park, David S" uniqKey="Park D" first="David S" last="Park">David S. Park</name><affiliation wicri:level="1"><nlm:affiliation>Department of Cellular and Molecular Medicine, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Korea dpark@uottawa.ca.</nlm:affiliation><country wicri:rule="url">Canada</country><wicri:regionArea>Department of Cellular and Molecular Medicine, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735</wicri:regionArea><wicri:noRegion>Busan 609-735</wicri:noRegion></affiliation></author></analytic><series><title level="j">The Journal of neuroscience : the official journal of the Society for Neuroscience</title><idno type="eISSN">1529-2401</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (pharmacology)</term><term>Animals</term><term>Cells, Cultured</term><term>Embryo, Mammalian</term><term>Female</term><term>Gene Expression Regulation (drug effects)</term><term>Gene Expression Regulation (genetics)</term><term>Humans</term><term>Hypoxia-Inducible Factor 1, alpha Subunit (genetics)</term><term>Hypoxia-Inducible Factor 1, alpha Subunit (metabolism)</term><term>Male</term><term>Mice</term><term>Mice, Knockout</term><term>Neuroblastoma (pathology)</term><term>Neurons (drug effects)</term><term>Neurons (metabolism)</term><term>Neurotoxins (pharmacology)</term><term>Oncogene Proteins (deficiency)</term><term>Oncogene Proteins (metabolism)</term><term>Oxidative Stress (drug effects)</term><term>Oxidative Stress (genetics)</term><term>Parkinson Disease (pathology)</term><term>Peroxiredoxins</term><term>Protein Deglycase DJ-1</term><term>Signal Transduction (drug effects)</term><term>Signal Transduction (physiology)</term><term>Time Factors</term><term>Von Hippel-Lindau Tumor Suppressor Protein (genetics)</term><term>Von Hippel-Lindau Tumor Suppressor Protein (metabolism)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Oncogene Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Hypoxia-Inducible Factor 1, alpha Subunit</term><term>Von Hippel-Lindau Tumor Suppressor Protein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hypoxia-Inducible Factor 1, alpha Subunit</term><term>Oncogene Proteins</term><term>Von Hippel-Lindau Tumor Suppressor Protein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</term><term>Neurotoxins</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Gene Expression Regulation</term><term>Neurons</term><term>Oxidative Stress</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Gene Expression Regulation</term><term>Oxidative Stress</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Neurons</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Neuroblastoma</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Cells, Cultured</term><term>Embryo, Mammalian</term><term>Female</term><term>Humans</term><term>Male</term><term>Mice</term><term>Mice, Knockout</term><term>Peroxiredoxins</term><term>Protein Deglycase DJ-1</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">DJ-1 (PARK7) is a gene linked to autosomal recessive Parkinson disease (PD). We showed previously that DJ-1 loss sensitizes neurons in models of PD and stroke. However, the biochemical mechanisms underlying this protective role are not completely clear. Here, we identify Von Hippel Lindau (VHL) protein as a critical DJ-1-interacting protein. We provide evidence that DJ-1 negatively regulates VHL ubiquitination activity of the α-subunit of hypoxia-inducible factor-1 (HIF-1α) by inhibiting HIF-VHL interaction. Consistent with this observation, DJ-1 deficiency leads to lowered HIF-1α levels in models of both hypoxia and oxidative stress, two stresses known to stabilize HIF-1α. We also demonstrate that HIF-1α accumulation rescues DJ-1-deficient neurons against 1-methyl-4-phenylpyridinium-induced toxicity. Interestingly, lymphoblast cells extracted from DJ-1-related PD patients show impaired HIF-1α stabilization when compared with normal individuals, indicating that the DJ-1-VHL link may also be relevant to a human context. Together, our findings delineate a model by which DJ-1 mediates neuronal survival by regulation of the VHL-HIF-1α pathway.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">24899725</PMID><DateCreated><Year>2014</Year><Month>06</Month><Day>06</Day></DateCreated><DateCompleted><Year>2014</Year><Month>07</Month><Day>25</Day></DateCompleted><DateRevised><Year>2016</Year><Month>11</Month><Day>25</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1529-2401</ISSN><JournalIssue CitedMedium="Internet"><Volume>34</Volume><Issue>23</Issue><PubDate><Year>2014</Year><Month>Jun</Month><Day>04</Day></PubDate></JournalIssue><Title>The Journal of neuroscience : the official journal of the Society for Neuroscience</Title><ISOAbbreviation>J. Neurosci.</ISOAbbreviation></Journal><ArticleTitle>Regulation of the VHL/HIF-1 pathway by DJ-1.</ArticleTitle><Pagination><MedlinePgn>8043-50</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1523/JNEUROSCI.1244-13.2014</ELocationID><Abstract><AbstractText>DJ-1 (PARK7) is a gene linked to autosomal recessive Parkinson disease (PD). We showed previously that DJ-1 loss sensitizes neurons in models of PD and stroke. However, the biochemical mechanisms underlying this protective role are not completely clear. Here, we identify Von Hippel Lindau (VHL) protein as a critical DJ-1-interacting protein. We provide evidence that DJ-1 negatively regulates VHL ubiquitination activity of the α-subunit of hypoxia-inducible factor-1 (HIF-1α) by inhibiting HIF-VHL interaction. Consistent with this observation, DJ-1 deficiency leads to lowered HIF-1α levels in models of both hypoxia and oxidative stress, two stresses known to stabilize HIF-1α. We also demonstrate that HIF-1α accumulation rescues DJ-1-deficient neurons against 1-methyl-4-phenylpyridinium-induced toxicity. Interestingly, lymphoblast cells extracted from DJ-1-related PD patients show impaired HIF-1α stabilization when compared with normal individuals, indicating that the DJ-1-VHL link may also be relevant to a human context. Together, our findings delineate a model by which DJ-1 mediates neuronal survival by regulation of the VHL-HIF-1α pathway.</AbstractText><CopyrightInformation>Copyright © 2014 the authors 0270-6474/14/338043-08$15.00/0.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Parsanejad</LastName><ForeName>Mohammad</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Cellular and Molecular Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhang</LastName><ForeName>Yi</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Cellular and Molecular Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Qu</LastName><ForeName>Dianbo</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Cellular and Molecular Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Irrcher</LastName><ForeName>Isabella</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Cellular and Molecular Medicine, Department of Ophthalmology, Queen's University, Kingston, Ontario K7L 5G2, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Rousseaux</LastName><ForeName>Maxime W C</ForeName><Initials>MW</Initials><AffiliationInfo><Affiliation>Department of Cellular and Molecular Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Aleyasin</LastName><ForeName>Hossein</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Cellular and Molecular Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kamkar</LastName><ForeName>Fatemeh</ForeName><Initials>F</Initials><AffiliationInfo><Affiliation>Department of Cellular and Molecular Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Callaghan</LastName><ForeName>Steve</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Cellular and Molecular Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Slack</LastName><ForeName>Ruth S</ForeName><Initials>RS</Initials><AffiliationInfo><Affiliation>Department of Cellular and Molecular Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mak</LastName><ForeName>Tak W</ForeName><Initials>TW</Initials><AffiliationInfo><Affiliation>The Campbell Family Institute for Breast Cancer Research, Toronto, Ontario M5G 2C1, Canada, and.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lee</LastName><ForeName>Stephen</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Cellular and Molecular Medicine.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Figeys</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><Identifier Source="ORCID">http://orcid.org/0000-0002-5373-7546</Identifier><AffiliationInfo><Affiliation>Institute of Systems Biology, University of Ottawa, Ottawa, Ontario K1H 8M5, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Park</LastName><ForeName>David S</ForeName><Initials>DS</Initials><AffiliationInfo><Affiliation>Department of Cellular and Molecular Medicine, Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 609-735, Korea dpark@uottawa.ca.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>J Neurosci</MedlineTA><NlmUniqueID>8102140</NlmUniqueID><ISSNLinking>0270-6474</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="C497443">Hif1a protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D051795">Hypoxia-Inducible Factor 1, alpha Subunit</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D009498">Neurotoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015513">Oncogene Proteins</NameOfSubstance></Chemical><Chemical><RegistryNumber>9P21XSP91P</RegistryNumber><NameOfSubstance UI="D015632">1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.11.1.15</RegistryNumber><NameOfSubstance UI="D054464">Peroxiredoxins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 2.3.2.27</RegistryNumber><NameOfSubstance UI="D051794">Von Hippel-Lindau Tumor Suppressor Protein</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.2.-</RegistryNumber><NameOfSubstance UI="C503466">PARK7 protein, mouse</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 3.1.2.-</RegistryNumber><NameOfSubstance UI="D000071617">Protein Deglycase DJ-1</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D015632" MajorTopicYN="N">1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002478" MajorTopicYN="N">Cells, Cultured</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004622" MajorTopicYN="N">Embryo, Mammalian</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005786" MajorTopicYN="N">Gene Expression Regulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051795" MajorTopicYN="N">Hypoxia-Inducible Factor 1, alpha Subunit</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051379" MajorTopicYN="N">Mice</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D018345" MajorTopicYN="N">Mice, Knockout</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009447" MajorTopicYN="N">Neuroblastoma</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009474" MajorTopicYN="N">Neurons</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009498" MajorTopicYN="N">Neurotoxins</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="N">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015513" MajorTopicYN="N">Oncogene Proteins</DescriptorName><QualifierName UI="Q000172" MajorTopicYN="N">deficiency</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018384" MajorTopicYN="N">Oxidative Stress</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054464" MajorTopicYN="N">Peroxiredoxins</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000071617" MajorTopicYN="N">Protein Deglycase DJ-1</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D051794" MajorTopicYN="N">Von Hippel-Lindau Tumor Suppressor Protein</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">DJ-1</Keyword><Keyword MajorTopicYN="N">Parkinson's disease</Keyword><Keyword MajorTopicYN="N">oxidative stress</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2014</Year><Month>6</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2014</Year><Month>6</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>7</Month><Day>26</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">24899725</ArticleId><ArticleId IdType="pii">34/23/8043</ArticleId><ArticleId IdType="doi">10.1523/JNEUROSCI.1244-13.2014</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Aleyasin, Hossein" sort="Aleyasin, Hossein" uniqKey="Aleyasin H" first="Hossein" last="Aleyasin">Hossein Aleyasin</name><name sortKey="Callaghan, Steve" sort="Callaghan, Steve" uniqKey="Callaghan S" first="Steve" last="Callaghan">Steve Callaghan</name><name sortKey="Kamkar, Fatemeh" sort="Kamkar, Fatemeh" uniqKey="Kamkar F" first="Fatemeh" last="Kamkar">Fatemeh Kamkar</name><name sortKey="Lee, Stephen" sort="Lee, Stephen" uniqKey="Lee S" first="Stephen" last="Lee">Stephen Lee</name><name sortKey="Mak, Tak W" sort="Mak, Tak W" uniqKey="Mak T" first="Tak W" last="Mak">Tak W. Mak</name><name sortKey="Parsanejad, Mohammad" sort="Parsanejad, Mohammad" uniqKey="Parsanejad M" first="Mohammad" last="Parsanejad">Mohammad Parsanejad</name><name sortKey="Qu, Dianbo" sort="Qu, Dianbo" uniqKey="Qu D" first="Dianbo" last="Qu">Dianbo Qu</name><name sortKey="Rousseaux, Maxime W C" sort="Rousseaux, Maxime W C" uniqKey="Rousseaux M" first="Maxime W C" last="Rousseaux">Maxime W C. Rousseaux</name><name sortKey="Slack, Ruth S" sort="Slack, Ruth S" uniqKey="Slack R" first="Ruth S" last="Slack">Ruth S. Slack</name><name sortKey="Zhang, Yi" sort="Zhang, Yi" uniqKey="Zhang Y" first="Yi" last="Zhang">Yi Zhang</name></noCountry><country name="Canada"><noRegion><name sortKey="Irrcher, Isabella" sort="Irrcher, Isabella" uniqKey="Irrcher I" first="Isabella" last="Irrcher">Isabella Irrcher</name></noRegion><name sortKey="Figeys, Daniel" sort="Figeys, Daniel" uniqKey="Figeys D" first="Daniel" last="Figeys">Daniel Figeys</name><name sortKey="Park, David S" sort="Park, David S" uniqKey="Park D" first="David S" last="Park">David S. Park</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Ncbi/Merge
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Ou
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{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Ncbi
|étape= Merge
|type= RBID
|clé= pubmed:24899725
|texte= Regulation of the VHL/HIF-1 pathway by DJ-1.
}}
Pour générer des pages wiki
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| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
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