Sensorimotor adaptation of speech in Parkinson’s disease
Identifieur interne : 001507 ( Ncbi/Merge ); précédent : 001506; suivant : 001508Sensorimotor adaptation of speech in Parkinson’s disease
Auteurs : Fatemeh Mollaei [Canada] ; Douglas M. Shiller [Canada] ; Vincent L. Gracco [Canada, États-Unis]Source :
- Movement disorders : official journal of the Movement Disorder Society [ 0885-3185 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- physiology : Adaptation, Physiological, Feedback, Sensory, Learning, Psychomotor Performance, Speech.
- physiopathology : Parkinson Disease.
- Aged, Female, Humans, Male, Middle Aged, Severity of Illness Index, Speech Acoustics.
Abstract
The basal ganglia (BG) are involved in establishing motor plans for a wide range of behaviors. Parkinson’s disease (PD) is a manifestation of basal ganglia dysfunction associated with a deficit in sensorimotor integration and difficulty in acquiring new motor sequences, thereby affecting motor learning. Previous studies of sensorimotor integration and sensorimotor adaptation (SA) in PD have focused on limb movements using visual and force-field alterations.
Here we report the results from a SA experiment investigating the ability of PD patients to make speech motor adjustments to a constant and predictable auditory feedback manipulation. Participants produced speech while their auditory feedback was altered and maintained in a manner consistent with a change in tongue position. The degree of adaptation was associated with the severity of motor symptoms.
The PD patients exhibited adaptation to the induced sensory error, however the degree of adaptation was reduced compared to healthy age-matched control participants.
The reduced capacity to adapt to a change in auditory feedback is consistent with reduced gain in the sensorimotor system for speech and with previous studies demonstrating limitations in the adaptation of limb movements following changes in visual feedback in PD patients.
Url:
DOI: 10.1002/mds.25588
PubMed: 23861349
PubMed Central: 3812368
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Gracco</name><affiliation wicri:level="3"><nlm:aff id="A1">Centre for Research on Brain, Language and Music, Montréal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Research on Brain, Language and Music, Montréal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">School of Communication Sciences and Disorders, McGill University, Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>School of Communication Sciences and Disorders, McGill University, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Haskins Laboratories, New Haven, CT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Haskins Laboratories, New Haven, CT</wicri:regionArea><wicri:noRegion>CT</wicri:noRegion></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological (physiology)</term><term>Aged</term><term>Feedback, Sensory (physiology)</term><term>Female</term><term>Humans</term><term>Learning (physiology)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (physiopathology)</term><term>Psychomotor Performance (physiology)</term><term>Severity of Illness Index</term><term>Speech (physiology)</term><term>Speech Acoustics</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Adaptation, Physiological</term><term>Feedback, Sensory</term><term>Learning</term><term>Psychomotor Performance</term><term>Speech</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Speech Acoustics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">The basal ganglia (BG) are involved in establishing motor plans for a wide range of behaviors. Parkinson’s disease (PD) is a manifestation of basal ganglia dysfunction associated with a deficit in sensorimotor integration and difficulty in acquiring new motor sequences, thereby affecting motor learning. Previous studies of sensorimotor integration and sensorimotor adaptation (SA) in PD have focused on limb movements using visual and force-field alterations.<sup><xref rid="R1" ref-type="bibr">1</xref>–<xref rid="R4" ref-type="bibr">4</xref></sup></p></sec><sec id="S2"><title>Methods</title><p id="P2">Here we report the results from a SA experiment investigating the ability of PD patients to make speech motor adjustments to a constant and predictable auditory feedback manipulation. Participants produced speech while their auditory feedback was altered and maintained in a manner consistent with a change in tongue position. The degree of adaptation was associated with the severity of motor symptoms.</p></sec><sec id="S3"><title>Results</title><p id="P3">The PD patients exhibited adaptation to the induced sensory error, however the degree of adaptation was reduced compared to healthy age-matched control participants.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The reduced capacity to adapt to a change in auditory feedback is consistent with reduced gain in the sensorimotor system for speech and with previous studies demonstrating limitations in the adaptation of limb movements following changes in visual feedback in PD patients.</p></sec></div></front></TEI><double pmid="23861349"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sensorimotor adaptation of speech in Parkinson’s disease</title><author><name sortKey="Mollaei, Fatemeh" sort="Mollaei, Fatemeh" uniqKey="Mollaei F" first="Fatemeh" last="Mollaei">Fatemeh Mollaei</name><affiliation wicri:level="3"><nlm:aff id="A1">Centre for Research on Brain, Language and Music, Montréal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Research on Brain, Language and Music, Montréal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">School of Communication Sciences and Disorders, McGill University, Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>School of Communication Sciences and Disorders, McGill University, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Shiller, Douglas M" sort="Shiller, Douglas M" uniqKey="Shiller D" first="Douglas M." last="Shiller">Douglas M. Shiller</name><affiliation wicri:level="3"><nlm:aff id="A1">Centre for Research on Brain, Language and Music, Montréal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Research on Brain, Language and Music, Montréal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A3">Centre de recherche CHU Sainte Justine, Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de recherche CHU Sainte Justine, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">École d’orthophonie et d’audiologie, Université de Montréal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>École d’orthophonie et d’audiologie, Université de Montréal</wicri:regionArea><wicri:noRegion>Université de Montréal</wicri:noRegion></affiliation></author><author><name sortKey="Gracco, Vincent L" sort="Gracco, Vincent L" uniqKey="Gracco V" first="Vincent L." last="Gracco">Vincent L. Gracco</name><affiliation wicri:level="3"><nlm:aff id="A1">Centre for Research on Brain, Language and Music, Montréal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Research on Brain, Language and Music, Montréal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">School of Communication Sciences and Disorders, McGill University, Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>School of Communication Sciences and Disorders, McGill University, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Haskins Laboratories, New Haven, CT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Haskins Laboratories, New Haven, CT</wicri:regionArea><wicri:noRegion>CT</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23861349</idno><idno type="pmc">3812368</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3812368</idno><idno type="RBID">PMC:3812368</idno><idno type="doi">10.1002/mds.25588</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000837</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000837</idno><idno type="wicri:Area/Pmc/Curation">000837</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000837</idno><idno type="wicri:Area/Pmc/Checkpoint">000583</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000583</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Sensorimotor adaptation of speech in Parkinson’s disease</title><author><name sortKey="Mollaei, Fatemeh" sort="Mollaei, Fatemeh" uniqKey="Mollaei F" first="Fatemeh" last="Mollaei">Fatemeh Mollaei</name><affiliation wicri:level="3"><nlm:aff id="A1">Centre for Research on Brain, Language and Music, Montréal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Research on Brain, Language and Music, Montréal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">School of Communication Sciences and Disorders, McGill University, Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>School of Communication Sciences and Disorders, McGill University, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation></author><author><name sortKey="Shiller, Douglas M" sort="Shiller, Douglas M" uniqKey="Shiller D" first="Douglas M." last="Shiller">Douglas M. Shiller</name><affiliation wicri:level="3"><nlm:aff id="A1">Centre for Research on Brain, Language and Music, Montréal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Research on Brain, Language and Music, Montréal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="3"><nlm:aff id="A3">Centre de recherche CHU Sainte Justine, Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de recherche CHU Sainte Justine, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="1"><nlm:aff id="A4">École d’orthophonie et d’audiologie, Université de Montréal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>École d’orthophonie et d’audiologie, Université de Montréal</wicri:regionArea><wicri:noRegion>Université de Montréal</wicri:noRegion></affiliation></author><author><name sortKey="Gracco, Vincent L" sort="Gracco, Vincent L" uniqKey="Gracco V" first="Vincent L." last="Gracco">Vincent L. Gracco</name><affiliation wicri:level="3"><nlm:aff id="A1">Centre for Research on Brain, Language and Music, Montréal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Research on Brain, Language and Music, Montréal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation><affiliation wicri:level="4"><nlm:aff id="A2">School of Communication Sciences and Disorders, McGill University, Montreal, Canada</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>School of Communication Sciences and Disorders, McGill University, Montreal</wicri:regionArea><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region><settlement type="city">Montréal</settlement></placeName><orgName type="university">Université McGill</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="A5">Haskins Laboratories, New Haven, CT, USA</nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Haskins Laboratories, New Haven, CT</wicri:regionArea><wicri:noRegion>CT</wicri:noRegion></affiliation></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec id="S1"><title>Background</title><p id="P1">The basal ganglia (BG) are involved in establishing motor plans for a wide range of behaviors. Parkinson’s disease (PD) is a manifestation of basal ganglia dysfunction associated with a deficit in sensorimotor integration and difficulty in acquiring new motor sequences, thereby affecting motor learning. Previous studies of sensorimotor integration and sensorimotor adaptation (SA) in PD have focused on limb movements using visual and force-field alterations.<sup><xref rid="R1" ref-type="bibr">1</xref>–<xref rid="R4" ref-type="bibr">4</xref></sup></p></sec><sec id="S2"><title>Methods</title><p id="P2">Here we report the results from a SA experiment investigating the ability of PD patients to make speech motor adjustments to a constant and predictable auditory feedback manipulation. Participants produced speech while their auditory feedback was altered and maintained in a manner consistent with a change in tongue position. The degree of adaptation was associated with the severity of motor symptoms.</p></sec><sec id="S3"><title>Results</title><p id="P3">The PD patients exhibited adaptation to the induced sensory error, however the degree of adaptation was reduced compared to healthy age-matched control participants.</p></sec><sec id="S4"><title>Conclusions</title><p id="P4">The reduced capacity to adapt to a change in auditory feedback is consistent with reduced gain in the sensorimotor system for speech and with previous studies demonstrating limitations in the adaptation of limb movements following changes in visual feedback in PD patients.</p></sec></div></front></TEI></pmc><pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Sensorimotor adaptation of speech in Parkinson's disease.</title><author><name sortKey="Mollaei, Fatemeh" sort="Mollaei, Fatemeh" uniqKey="Mollaei F" first="Fatemeh" last="Mollaei">Fatemeh Mollaei</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada; School of Communication Sciences and Disorders, McGill University, Montreal, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada; School of Communication Sciences and Disorders, McGill University, Montreal, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Shiller, Douglas M" sort="Shiller, Douglas M" uniqKey="Shiller D" first="Douglas M" last="Shiller">Douglas M. Shiller</name></author><author><name sortKey="Gracco, Vincent L" sort="Gracco, Vincent L" uniqKey="Gracco V" first="Vincent L" last="Gracco">Vincent L. Gracco</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23861349</idno><idno type="pmid">23861349</idno><idno type="doi">10.1002/mds.25588</idno><idno type="wicri:Area/PubMed/Corpus">000858</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000858</idno><idno type="wicri:Area/PubMed/Curation">000858</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000858</idno><idno type="wicri:Area/PubMed/Checkpoint">000858</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000858</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Sensorimotor adaptation of speech in Parkinson's disease.</title><author><name sortKey="Mollaei, Fatemeh" sort="Mollaei, Fatemeh" uniqKey="Mollaei F" first="Fatemeh" last="Mollaei">Fatemeh Mollaei</name><affiliation wicri:level="4"><nlm:affiliation>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada; School of Communication Sciences and Disorders, McGill University, Montreal, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Centre for Research on Brain, Language and Music, Montreal, Quebec, Canada; School of Communication Sciences and Disorders, McGill University, Montreal, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Shiller, Douglas M" sort="Shiller, Douglas M" uniqKey="Shiller D" first="Douglas M" last="Shiller">Douglas M. Shiller</name></author><author><name sortKey="Gracco, Vincent L" sort="Gracco, Vincent L" uniqKey="Gracco V" first="Vincent L" last="Gracco">Vincent L. Gracco</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Physiological (physiology)</term><term>Aged</term><term>Feedback, Sensory (physiology)</term><term>Female</term><term>Humans</term><term>Learning (physiology)</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (physiopathology)</term><term>Psychomotor Performance (physiology)</term><term>Severity of Illness Index</term><term>Speech (physiology)</term><term>Speech Acoustics</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Adaptation, Physiological</term><term>Feedback, Sensory</term><term>Learning</term><term>Psychomotor Performance</term><term>Speech</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Speech Acoustics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The basal ganglia are involved in establishing motor plans for a wide range of behaviors. Parkinson's disease (PD) is a manifestation of basal ganglia dysfunction associated with a deficit in sensorimotor integration and difficulty in acquiring new motor sequences, thereby affecting motor learning. Previous studies of sensorimotor integration and sensorimotor adaptation in PD have focused on limb movements using visual and force-field alterations. Here, we report the results from a sensorimotor adaptation experiment investigating the ability of PD patients to make speech motor adjustments to a constant and predictable auditory feedback manipulation. Participants produced speech while their auditory feedback was altered and maintained in a manner consistent with a change in tongue position. The degree of adaptation was associated with the severity of motor symptoms. The patients with PD exhibited adaptation to the induced sensory error; however, the degree of adaptation was reduced compared with healthy, age-matched control participants. The reduced capacity to adapt to a change in auditory feedback is consistent with reduced gain in the sensorimotor system for speech and with previous studies demonstrating limitations in the adaptation of limb movements after changes in visual feedback among patients with PD.</div></front></TEI></pubmed></double></record>Pour manipuler ce document sous Unix (Dilib)
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