Doxepin and cognitive behavioural therapy for insomnia in patients with Parkinson's disease -- a randomized study.
Identifieur interne : 001425 ( Ncbi/Merge ); précédent : 001424; suivant : 001426Doxepin and cognitive behavioural therapy for insomnia in patients with Parkinson's disease -- a randomized study.
Auteurs : S. Rios Romenets [Canada] ; L. Creti ; C. Fichten ; S. Bailes ; E. Libman ; A. Pelletier ; R B PostumaSource :
- Parkinsonism & related disorders [ 1873-5126 ] ; 2013.
English descriptors
- KwdEn :
- Actigraphy, Adult, Aged, Aged, 80 and over, Antidepressive Agents, Tricyclic (therapeutic use), Cognitive Therapy (methods), Doxepin (therapeutic use), Female, Humans, Male, Middle Aged, Parkinson Disease (complications), Severity of Illness Index, Sleep Initiation and Maintenance Disorders (drug therapy), Sleep Initiation and Maintenance Disorders (etiology), Sleep Initiation and Maintenance Disorders (rehabilitation), Treatment Outcome.
- MESH :
- chemical , therapeutic use : Antidepressive Agents, Tricyclic, Doxepin.
- complications : Parkinson Disease.
- drug therapy : Sleep Initiation and Maintenance Disorders.
- etiology : Sleep Initiation and Maintenance Disorders.
- methods : Cognitive Therapy.
- rehabilitation : Sleep Initiation and Maintenance Disorders.
- Actigraphy, Adult, Aged, Aged, 80 and over, Female, Humans, Male, Middle Aged, Severity of Illness Index, Treatment Outcome.
Abstract
Although a variety of pharmacologic and non-pharmacologic treatments are effective for insomnia in the general population, insomnia in Parkinson's disease differs in important ways and may need different treatments. No studies have conclusively demonstrated effective insomnia treatments in Parkinson's disease.
DOI: 10.1016/j.parkreldis.2013.03.003
PubMed: 23561946
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pubmed:23561946Le document en format XML
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Creti</name></author><author><name sortKey="Fichten, C" sort="Fichten, C" uniqKey="Fichten C" first="C" last="Fichten">C. Fichten</name></author><author><name sortKey="Bailes, S" sort="Bailes, S" uniqKey="Bailes S" first="S" last="Bailes">S. Bailes</name></author><author><name sortKey="Libman, E" sort="Libman, E" uniqKey="Libman E" first="E" last="Libman">E. Libman</name></author><author><name sortKey="Pelletier, A" sort="Pelletier, A" uniqKey="Pelletier A" first="A" last="Pelletier">A. Pelletier</name></author><author><name sortKey="Postuma, R B" sort="Postuma, R B" uniqKey="Postuma R" first="R B" last="Postuma">R B Postuma</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23561946</idno><idno type="pmid">23561946</idno><idno type="doi">10.1016/j.parkreldis.2013.03.003</idno><idno type="wicri:Area/PubMed/Corpus">000900</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000900</idno><idno type="wicri:Area/PubMed/Curation">000900</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000900</idno><idno type="wicri:Area/PubMed/Checkpoint">000900</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000900</idno><idno type="wicri:Area/Ncbi/Merge">001425</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Doxepin and cognitive behavioural therapy for insomnia in patients with Parkinson's disease -- a randomized study.</title><author><name sortKey="Rios Romenets, S" sort="Rios Romenets, S" uniqKey="Rios Romenets S" first="S" last="Rios Romenets">S. Rios Romenets</name><affiliation wicri:level="4"><nlm:affiliation>Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec</wicri:regionArea><orgName type="university">Université McGill</orgName><placeName><settlement type="city">Montréal</settlement><region type="state">Québec</region></placeName></affiliation></author><author><name sortKey="Creti, L" sort="Creti, L" uniqKey="Creti L" first="L" last="Creti">L. Creti</name></author><author><name sortKey="Fichten, C" sort="Fichten, C" uniqKey="Fichten C" first="C" last="Fichten">C. Fichten</name></author><author><name sortKey="Bailes, S" sort="Bailes, S" uniqKey="Bailes S" first="S" last="Bailes">S. Bailes</name></author><author><name sortKey="Libman, E" sort="Libman, E" uniqKey="Libman E" first="E" last="Libman">E. Libman</name></author><author><name sortKey="Pelletier, A" sort="Pelletier, A" uniqKey="Pelletier A" first="A" last="Pelletier">A. Pelletier</name></author><author><name sortKey="Postuma, R B" sort="Postuma, R B" uniqKey="Postuma R" first="R B" last="Postuma">R B Postuma</name></author></analytic><series><title level="j">Parkinsonism & related disorders</title><idno type="eISSN">1873-5126</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Actigraphy</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Antidepressive Agents, Tricyclic (therapeutic use)</term><term>Cognitive Therapy (methods)</term><term>Doxepin (therapeutic use)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Severity of Illness Index</term><term>Sleep Initiation and Maintenance Disorders (drug therapy)</term><term>Sleep Initiation and Maintenance Disorders (etiology)</term><term>Sleep Initiation and Maintenance Disorders (rehabilitation)</term><term>Treatment Outcome</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antidepressive Agents, Tricyclic</term><term>Doxepin</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Sleep Initiation and Maintenance Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Sleep Initiation and Maintenance Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Cognitive Therapy</term></keywords><keywords scheme="MESH" qualifier="rehabilitation" xml:lang="en"><term>Sleep Initiation and Maintenance Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Actigraphy</term><term>Adult</term><term>Aged</term><term>Aged, 80 and over</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Severity of Illness Index</term><term>Treatment Outcome</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Although a variety of pharmacologic and non-pharmacologic treatments are effective for insomnia in the general population, insomnia in Parkinson's disease differs in important ways and may need different treatments. No studies have conclusively demonstrated effective insomnia treatments in Parkinson's disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23561946</PMID><DateCreated><Year>2013</Year><Month>05</Month><Day>28</Day></DateCreated><DateCompleted><Year>2014</Year><Month>01</Month><Day>07</Day></DateCompleted><DateRevised><Year>2013</Year><Month>05</Month><Day>28</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-5126</ISSN><JournalIssue CitedMedium="Internet"><Volume>19</Volume><Issue>7</Issue><PubDate><Year>2013</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Parkinsonism & related disorders</Title><ISOAbbreviation>Parkinsonism Relat. Disord.</ISOAbbreviation></Journal><ArticleTitle>Doxepin and cognitive behavioural therapy for insomnia in patients with Parkinson's disease -- a randomized study.</ArticleTitle><Pagination><MedlinePgn>670-5</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.parkreldis.2013.03.003</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1353-8020(13)00119-3</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">Although a variety of pharmacologic and non-pharmacologic treatments are effective for insomnia in the general population, insomnia in Parkinson's disease differs in important ways and may need different treatments. No studies have conclusively demonstrated effective insomnia treatments in Parkinson's disease.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We conducted a three-arm six-week randomized pilot study assessing non-pharmacologic treatment (cognitive behavioural therapy with bright light therapy) or doxepin (10 mg daily), compared to an inactive placebo in Parkinson's patients with insomnia. Sleep outcomes included insomnia scales, clinical global impression, sleep diaries and actigraphy. Secondary outcomes included motor severity, fatigue, depression and quality of life.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">18 patients were randomized, 6 to each group. Compared to placebo, doxepin improved the Insomnia Severity Index (-9 ± 5.4 vs. -2 ± 3.9, p = 0.03), the SCOPA-night score (-5.2 ± 1.5 vs. -2.3 ± 2.8, p = 0.049), the Pittsburgh Sleep Quality Index-sleep disturbances subscale (-0.5 ± 0.5 vs 0.2 ± 0.4, p = 0.02), and both patient and examiner-rated clinical global impression of change (1.7 ± 0.8 vs. 0.5 ± 0.8, p = 0.03 and 1.4 ± 0.5 vs. 0.3 ± 0.5, p = 0.003). On secondary outcomes doxepin reduced the fatigue severity scale (p = 0.02) and improved scores on the Montreal Cognitive Assessment (p = 0.007). Non-pharmacological treatment reduced the Insomnia Severity Index (-7.8 ± 3.8 vs. -2.0 ± 3.9, p = 0.03), and the examiner-reported clinical global impression of change (p = 0.006), but was associated with decline in Parkinson Disease Questionnaire-39. There were no changes in other primary and secondary outcomes, including actigraphy outcomes. Adverse events were comparable in all groups.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Doxepin and non-pharmacologic treatment substantially improved insomnia in Parkinson's disease. These potential benefits must be replicated in a full confirmatory randomized controlled trial.</AbstractText><CopyrightInformation>Crown Copyright © 2013. Published by Elsevier Ltd. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rios Romenets</LastName><ForeName>S</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Neurology, McGill University, Montreal General Hospital, Montreal, Quebec, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Creti</LastName><ForeName>L</ForeName><Initials>L</Initials></Author><Author ValidYN="Y"><LastName>Fichten</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Bailes</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Libman</LastName><ForeName>E</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Pelletier</LastName><ForeName>A</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Postuma</LastName><ForeName>R B</ForeName><Initials>RB</Initials></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><Agency>Canadian Institutes of Health Research</Agency><Country>Canada</Country></Grant></GrantList><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>04</Month><Day>02</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Parkinsonism Relat Disord</MedlineTA><NlmUniqueID>9513583</NlmUniqueID><ISSNLinking>1353-8020</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000929">Antidepressive Agents, Tricyclic</NameOfSubstance></Chemical><Chemical><RegistryNumber>1668-19-5</RegistryNumber><NameOfSubstance UI="D004316">Doxepin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D056044" MajorTopicYN="N">Actigraphy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000929" MajorTopicYN="N">Antidepressive Agents, Tricyclic</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015928" MajorTopicYN="N">Cognitive Therapy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="Y">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004316" MajorTopicYN="N">Doxepin</DescriptorName><QualifierName UI="Q000627" MajorTopicYN="Y">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012720" MajorTopicYN="N">Severity of Illness Index</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007319" MajorTopicYN="Y">Sleep Initiation and Maintenance Disorders</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000534" MajorTopicYN="N">rehabilitation</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016896" MajorTopicYN="N">Treatment Outcome</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2013</Year><Month>01</Month><Day>16</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>02</Month><Day>24</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>03</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>4</Month><Day>9</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>1</Month><Day>8</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23561946</ArticleId><ArticleId IdType="pii">S1353-8020(13)00119-3</ArticleId><ArticleId IdType="doi">10.1016/j.parkreldis.2013.03.003</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country><region><li>Québec</li></region><settlement><li>Montréal</li></settlement><orgName><li>Université McGill</li></orgName></list><tree><noCountry><name sortKey="Bailes, S" sort="Bailes, S" uniqKey="Bailes S" first="S" last="Bailes">S. Bailes</name><name sortKey="Creti, L" sort="Creti, L" uniqKey="Creti L" first="L" last="Creti">L. Creti</name><name sortKey="Fichten, C" sort="Fichten, C" uniqKey="Fichten C" first="C" last="Fichten">C. Fichten</name><name sortKey="Libman, E" sort="Libman, E" uniqKey="Libman E" first="E" last="Libman">E. Libman</name><name sortKey="Pelletier, A" sort="Pelletier, A" uniqKey="Pelletier A" first="A" last="Pelletier">A. Pelletier</name><name sortKey="Postuma, R B" sort="Postuma, R B" uniqKey="Postuma R" first="R B" last="Postuma">R B Postuma</name></noCountry><country name="Canada"><region name="Québec"><name sortKey="Rios Romenets, S" sort="Rios Romenets, S" uniqKey="Rios Romenets S" first="S" last="Rios Romenets">S. Rios Romenets</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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