Are Verbal Fluency and Nonliteral Language Comprehension Deficits Related to Depressive Symptoms in Parkinson's Disease?
Identifieur interne : 001121 ( Ncbi/Merge ); précédent : 001120; suivant : 001122Are Verbal Fluency and Nonliteral Language Comprehension Deficits Related to Depressive Symptoms in Parkinson's Disease?
Auteurs : Christina Tremblay [Canada] ; Oury Monchi [Canada] ; Carol Hudon [Canada] ; Joël Macoir [Canada] ; Laura Monetta [Canada]Source :
- Parkinson's Disease [ 2090-8083 ] ; 2012.
Abstract
Depression in Parkinson's disease (PD) is frequently associated with executive deficits, which can influence nonliteral comprehension and lexical access. This study explores whether depressive symptoms in PD modulate verbal fluency and nonliteral language comprehension. Twelve individuals with PD without depressive symptoms, 13 with PD and depressive symptoms (PDDSs), and 13 healthy controls completed a semantic and phonemic verbal fluency task and an indirect speech acts comprehension task. All groups had the same performance in the phonemic fluency task while the PDDS group was impaired in the semantic task. For the indirect speech act comprehension task, no difference was observed between the groups. However, the PDDS group had difficulty answering direct speech act questions. As some language impairments in PD become apparent when depressive symptoms are associated with the disease, it would appear to be important to take the presence of depressive symptoms into account when evaluating language abilities in PD.
Url:
DOI: 10.1155/2012/308501
PubMed: 22496988
PubMed Central: 3306925
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Comprehension Deficits Related to Depressive Symptoms in Parkinson's Disease?</title><author><name sortKey="Tremblay, Christina" sort="Tremblay, Christina" uniqKey="Tremblay C" first="Christina" last="Tremblay">Christina Tremblay</name><affiliation wicri:level="1"><nlm:aff id="I1">Département de Réadaptation, Faculté de Médecine, Université Laval, QC, Canada G1V 0A6</nlm:aff><country>Canada</country><wicri:regionArea>Département de Réadaptation, Faculté de Médecine, Université Laval, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Centre de Recherche Université Laval Robert Giffard, 2601 Rue de la Canardière, Québec, QC, Canada G1J 2G3</nlm:aff><country>Canada</country><wicri:regionArea>Centre de Recherche Université Laval Robert Giffard, 2601 Rue de la Canardière, Québec, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name><affiliation wicri:level="1"><nlm:aff id="I3">Functional Neuroimaging Unit, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada H3W 1W5</nlm:aff><country>Canada</country><wicri:regionArea>Functional Neuroimaging Unit, Institut Universitaire de Gériatrie de Montréal, Montréal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Hudon, Carol" sort="Hudon, Carol" uniqKey="Hudon C" first="Carol" last="Hudon">Carol Hudon</name><affiliation wicri:level="1"><nlm:aff id="I2">Centre de Recherche Université Laval Robert Giffard, 2601 Rue de la Canardière, Québec, QC, Canada G1J 2G3</nlm:aff><country>Canada</country><wicri:regionArea>Centre de Recherche Université Laval Robert Giffard, 2601 Rue de la Canardière, Québec, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I4">École de psychologie, Université 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QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Monetta, Laura" sort="Monetta, Laura" uniqKey="Monetta L" first="Laura" last="Monetta">Laura Monetta</name><affiliation wicri:level="1"><nlm:aff id="I1">Département de Réadaptation, Faculté de Médecine, Université Laval, QC, Canada G1V 0A6</nlm:aff><country>Canada</country><wicri:regionArea>Département de Réadaptation, Faculté de Médecine, Université Laval, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="I2">Centre de Recherche Université Laval Robert Giffard, 2601 Rue de la Canardière, Québec, QC, Canada G1J 2G3</nlm:aff><country>Canada</country><wicri:regionArea>Centre de Recherche Université Laval Robert Giffard, 2601 Rue de la Canardière, Québec, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author></analytic><series><title level="j">Parkinson's Disease</title><idno type="ISSN">2090-8083</idno><idno type="eISSN">2042-0080</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Depression in Parkinson's disease (PD) is frequently associated with executive deficits, which can influence nonliteral comprehension and lexical access. This study explores whether depressive symptoms in PD modulate verbal fluency and nonliteral language comprehension. Twelve individuals with PD without depressive symptoms, 13 with PD and depressive symptoms (PDDSs), and 13 healthy controls completed a semantic and phonemic verbal fluency task and an indirect speech acts comprehension task. All groups had the same performance in the phonemic fluency task while the PDDS group was impaired in the semantic task. For the indirect speech act comprehension task, no difference was observed between the groups. However, the PDDS group had difficulty answering direct speech act questions. As some language impairments in PD become apparent when depressive symptoms are associated with the disease, it would appear to be important to take the presence of depressive symptoms into account when evaluating language abilities in PD.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Oguru, M" uniqKey="Oguru M">M Oguru</name></author><author><name sortKey="Tachibana, H" uniqKey="Tachibana H">H Tachibana</name></author><author><name sortKey="Toda, K" uniqKey="Toda K">K Toda</name></author><author><name sortKey="Okuda, B" uniqKey="Okuda B">B Okuda</name></author><author><name sortKey="Oka, N" uniqKey="Oka N">N Oka</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gagnon, Jf" uniqKey="Gagnon J">JF Gagnon</name></author><author><name sortKey="Bedard, Ma" uniqKey="Bedard M">MA Bédard</name></author><author><name sortKey="Fantini, Ml" uniqKey="Fantini M">ML 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Parkinsons Dis</journal-id><journal-id journal-id-type="iso-abbrev">Parkinsons Dis</journal-id><journal-id journal-id-type="publisher-id">PD</journal-id><journal-title-group><journal-title>Parkinson's Disease</journal-title></journal-title-group><issn pub-type="ppub">2090-8083</issn><issn pub-type="epub">2042-0080</issn><publisher><publisher-name>Hindawi Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22496988</article-id><article-id pub-id-type="pmc">3306925</article-id><article-id pub-id-type="doi">10.1155/2012/308501</article-id><article-categories><subj-group subj-group-type="heading"><subject>Clinical Study</subject></subj-group></article-categories><title-group><article-title>Are Verbal Fluency and Nonliteral Language Comprehension Deficits Related to Depressive Symptoms in Parkinson's Disease?</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Tremblay</surname><given-names>Christina</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref><xref ref-type="aff" rid="I2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Monchi</surname><given-names>Oury</given-names></name><xref ref-type="aff" rid="I3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Hudon</surname><given-names>Carol</given-names></name><xref ref-type="aff" rid="I2"><sup>2</sup></xref><xref ref-type="aff" rid="I4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Macoir</surname><given-names>Joël</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref><xref ref-type="aff" rid="I2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Monetta</surname><given-names>Laura</given-names></name><xref ref-type="aff" rid="I1"><sup>1</sup></xref><xref ref-type="aff" rid="I2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1">*</xref></contrib></contrib-group><aff id="I1"><sup>1</sup>Département de Réadaptation, Faculté de Médecine, Université Laval, QC, Canada G1V 0A6</aff><aff id="I2"><sup>2</sup>Centre de Recherche Université Laval Robert Giffard, 2601 Rue de la Canardière, Québec, QC, Canada G1J 2G3</aff><aff id="I3"><sup>3</sup>Functional Neuroimaging Unit, Institut Universitaire de Gériatrie de Montréal, Montréal, QC, Canada H3W 1W5</aff><aff id="I4"><sup>4</sup>École de psychologie, Université Laval, QC, Canada G1V 0A6</aff><author-notes><corresp id="cor1">*Laura Monetta: <email>laura.monetta@rea.ulaval.ca</email></corresp><fn fn-type="other"><p>Academic Editor: Heinz Reichmann</p></fn></author-notes><pub-date pub-type="ppub"><year>2012</year></pub-date><pub-date pub-type="epub"><day>12</day><month>2</month><year>2012</year></pub-date><volume>2012</volume><elocation-id>308501</elocation-id><history><date date-type="received"><day>23</day><month>9</month><year>2011</year></date><date date-type="rev-recd"><day>17</day><month>11</month><year>2011</year></date><date date-type="accepted"><day>20</day><month>11</month><year>2011</year></date></history><permissions><copyright-statement>Copyright © 2012 Christina Tremblay et al.</copyright-statement><copyright-year>2012</copyright-year><license license-type="open-access"><license-p>This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Depression in Parkinson's disease (PD) is frequently associated with executive deficits, which can influence nonliteral comprehension and lexical access. This study explores whether depressive symptoms in PD modulate verbal fluency and nonliteral language comprehension. Twelve individuals with PD without depressive symptoms, 13 with PD and depressive symptoms (PDDSs), and 13 healthy controls completed a semantic and phonemic verbal fluency task and an indirect speech acts comprehension task. All groups had the same performance in the phonemic fluency task while the PDDS group was impaired in the semantic task. For the indirect speech act comprehension task, no difference was observed between the groups. However, the PDDS group had difficulty answering direct speech act questions. As some language impairments in PD become apparent when depressive symptoms are associated with the disease, it would appear to be important to take the presence of depressive symptoms into account when evaluating language abilities in PD.</p></abstract></article-meta></front><floats-group><fig id="fig1" position="float"><label>Figure 1</label><caption><p>Phonemic and semantic verbal fluency mean results (±SEM) for participants with Parkinson's disease with (white column) and without (grey column) depressive symptoms and healthy controls (black column).</p></caption><graphic xlink:href="PD2012-308501.001"></graphic></fig><fig id="fig2" position="float"><label>Figure 2</label><caption><p>Direct and indirect speech act mean results (±SEM) for participants with Parkinson's disease with (white column) and without (grey column) depressive symptoms and healthy controls (black column).</p></caption><graphic xlink:href="PD2012-308501.002"></graphic></fig><table-wrap id="tab1" position="float"><label>Table 1</label><caption><p>Demographic and clinical characteristics of healthy controls (HCs) and participants with Parkinson's disease with (PDDS) and without (PD) depressive symptoms.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="2" colspan="1"> Features</th><th align="center" colspan="3" rowspan="1">Groups</th><th align="center" rowspan="2" colspan="1">Significant difference with HC</th></tr><tr><th align="center" rowspan="1" colspan="1">HC <break></break>Mean (SD)</th><th align="center" rowspan="1" colspan="1">PD <break></break>Mean (SD)</th><th align="center" rowspan="1" colspan="1">PDDS <break></break>Mean (SD)</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Age (years)</td><td align="center" rowspan="1" colspan="1">61,94 (5,62)</td><td align="center" rowspan="1" colspan="1">61,81 (4,81)</td><td align="center" rowspan="1" colspan="1">64,77 (6,00)</td><td align="center" rowspan="1" colspan="1">NS<sup>a</sup></td></tr><tr><td align="left" rowspan="1" colspan="1">Education (years)</td><td align="center" rowspan="1" colspan="1">14,85 (3,37)</td><td align="center" rowspan="1" colspan="1">13,00 (2,72)</td><td align="center" rowspan="1" colspan="1">14,23 (2,77)</td><td align="center" rowspan="1" colspan="1">NS</td></tr><tr><td align="left" rowspan="1" colspan="1">Gender (% men)</td><td align="center" rowspan="1" colspan="1">30,77</td><td align="center" rowspan="1" colspan="1">50,00</td><td align="center" rowspan="1" colspan="1">76,92</td><td align="center" rowspan="1" colspan="1">PDDS*</td></tr><tr><td align="left" rowspan="1" colspan="1">Disease duration (years)</td><td align="center" rowspan="1" colspan="1">—</td><td align="center" rowspan="1" colspan="1">4,42 (3,00)</td><td align="center" rowspan="1" colspan="1">6,31 (4,25)</td><td align="center" rowspan="1" colspan="1">NS</td></tr><tr><td align="left" rowspan="1" colspan="1">Age at onset (years)</td><td align="center" rowspan="1" colspan="1">—</td><td align="center" rowspan="1" colspan="1">57,39 (6,86)</td><td align="center" rowspan="1" colspan="1">58,46 (6,32)</td><td align="center" rowspan="1" colspan="1">NS</td></tr><tr><td align="left" rowspan="1" colspan="1">Montreal Cognitive Assessment (MoCA)</td><td align="center" rowspan="1" colspan="1">28,38 (1,27)</td><td align="center" rowspan="1" colspan="1">28,08 (1,16)</td><td align="center" rowspan="1" colspan="1">27,15 (1,77)</td><td align="center" rowspan="1" colspan="1">NS</td></tr><tr><td align="left" rowspan="1" colspan="1">UPDRS-III</td><td align="center" rowspan="1" colspan="1">—</td><td align="center" rowspan="1" colspan="1">26,58 (7,88)</td><td align="center" rowspan="1" colspan="1">33,00 (9,24)</td><td align="center" rowspan="1" colspan="1">NS</td></tr><tr><td align="left" rowspan="1" colspan="1">Beck Depression Inventory (BDI)</td><td align="center" rowspan="1" colspan="1">2,92 (2,25)</td><td align="center" rowspan="1" colspan="1">4,17 (2,12)</td><td align="center" rowspan="1" colspan="1">14,54 (5,32)</td><td align="center" rowspan="1" colspan="1">PDDS***</td></tr></tbody></table><table-wrap-foot><fn><p>All tests were performed without dopaminergic medication.</p></fn><fn><p><sup>a</sup>NS (non-significant); *<italic>P</italic> < 0.05; ***<italic>P</italic> < 0.001.</p></fn><fn><p>No results are significantly different between PDDS and PD except for BDI (<italic>P</italic> < 0.001).</p></fn><fn><p>UPDRS: Unified Parkinson's Disease Rating Scale.</p></fn></table-wrap-foot></table-wrap><table-wrap id="tab2" position="float"><label>Table 2</label><caption><p>Neuropsychological performance of healthy controls (HCs) and participants with Parkinson's disease with (PDDS) and without (PD) depressive symptoms.</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="2" colspan="1"> Tests of executive resources</th><th align="center" colspan="3" rowspan="1">Groups</th><th align="center" rowspan="2" colspan="1">Significant difference with HC</th></tr><tr><th align="center" rowspan="1" colspan="1">HC <break></break>Mean (SD)</th><th align="center" rowspan="1" colspan="1">PD <break></break>Mean (SD)</th><th align="center" rowspan="1" colspan="1">PDDS <break></break>Mean (SD)</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1">Stroop color word test (number of words)</td><td align="center" rowspan="1" colspan="1">48,77 (10,57)</td><td align="center" rowspan="1" colspan="1">48,64 (6,64)</td><td align="center" rowspan="1" colspan="1">44,18 (7,40)</td><td align="center" rowspan="1" colspan="1"><sup>a</sup>NS</td></tr><tr><td align="left" rowspan="1" colspan="1">Stroop color word test (number of errors)</td><td align="center" rowspan="1" colspan="1">0,38 (0,77)</td><td align="center" rowspan="1" colspan="1">1,36 (1,57)</td><td align="center" rowspan="1" colspan="1">1,17 (1,53)</td><td align="center" rowspan="1" colspan="1">NS</td></tr><tr><td align="left" rowspan="1" colspan="1">Color trail-making test A</td><td align="center" rowspan="1" colspan="1">34,08 (8,98)</td><td align="center" rowspan="1" colspan="1">36,10 (13,76)</td><td align="center" rowspan="1" colspan="1">44,85 (17,44)</td><td align="center" rowspan="1" colspan="1">NS</td></tr><tr><td align="left" rowspan="1" colspan="1">Hayling</td><td align="center" rowspan="1" colspan="1">4,58 (1,88)</td><td align="center" rowspan="1" colspan="1">3,73 (1,74)</td><td align="center" rowspan="1" colspan="1">3,83 (1,64)</td><td align="center" rowspan="1" colspan="1">NS</td></tr><tr><td align="left" rowspan="1" colspan="1">London tower (number of errors)</td><td align="center" rowspan="1" colspan="1">0,46 (0,52)</td><td align="center" rowspan="1" colspan="1">0,58 (0,67)</td><td align="center" rowspan="1" colspan="1">3,15 (3,39)</td><td align="center" rowspan="1" colspan="1">PDDS*</td></tr><tr><td align="left" rowspan="1" colspan="1">Brixton spatial anticipation test</td><td align="center" rowspan="1" colspan="1">7,00 (2,27)</td><td align="center" rowspan="1" colspan="1">4,75 (2,01)</td><td align="center" rowspan="1" colspan="1">4,69 (2,10)</td><td align="center" rowspan="1" colspan="1">PDDS*, PD*</td></tr></tbody></table><table-wrap-foot><fn><p>All tests were performed without dopaminergic medication.</p></fn><fn><p><sup>a</sup>NS (non-significant); **<italic>P</italic> < 0.01; *<italic>P</italic> < 0.05.</p></fn><fn><p>No results are significantly different between PDDS and PD except for the Tower of London (number of errors; <italic>P</italic> < 0.05).</p></fn></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Tremblay, Christina" sort="Tremblay, Christina" uniqKey="Tremblay C" first="Christina" last="Tremblay">Christina Tremblay</name></noRegion><name sortKey="Hudon, Carol" sort="Hudon, Carol" uniqKey="Hudon C" first="Carol" last="Hudon">Carol Hudon</name><name sortKey="Hudon, Carol" sort="Hudon, Carol" uniqKey="Hudon C" first="Carol" last="Hudon">Carol Hudon</name><name sortKey="Macoir, Joel" sort="Macoir, Joel" uniqKey="Macoir J" first="Joël" last="Macoir">Joël Macoir</name><name sortKey="Macoir, Joel" sort="Macoir, Joel" uniqKey="Macoir J" first="Joël" last="Macoir">Joël Macoir</name><name sortKey="Monchi, Oury" sort="Monchi, Oury" uniqKey="Monchi O" first="Oury" last="Monchi">Oury Monchi</name><name sortKey="Monetta, Laura" sort="Monetta, Laura" uniqKey="Monetta L" first="Laura" last="Monetta">Laura Monetta</name><name sortKey="Monetta, Laura" sort="Monetta, Laura" uniqKey="Monetta L" first="Laura" last="Monetta">Laura Monetta</name><name sortKey="Tremblay, Christina" sort="Tremblay, Christina" uniqKey="Tremblay C" first="Christina" last="Tremblay">Christina Tremblay</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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