Dopamine alters tactile perception in Parkinson's disease.
Identifieur interne : 001076 ( Ncbi/Merge ); précédent : 001075; suivant : 001077Dopamine alters tactile perception in Parkinson's disease.
Auteurs : Aimee J. Nelson [Canada] ; Azra Premji ; Navjot Rai ; Tasnuva Hoque ; Mark Tommerdahl ; Robert ChenSource :
- The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques [ 0317-1671 ] ; 2012.
English descriptors
- KwdEn :
- Adult, Aged, Analysis of Variance, Dopamine Agents (pharmacology), Dopamine Agents (therapeutic use), Female, Humans, Judgment (drug effects), Judgment (physiology), Levodopa (pharmacology), Levodopa (therapeutic use), Male, Middle Aged, Neuropsychological Tests, Parkinson Disease (complications), Perceptual Disorders (drug therapy), Perceptual Disorders (etiology), Physical Stimulation (methods), Psychophysics, Retrospective Studies, Touch Perception (drug effects).
- MESH :
- chemical , pharmacology : Dopamine Agents, Levodopa.
- chemical , therapeutic use : Dopamine Agents, Levodopa.
- complications : Parkinson Disease.
- drug effects : Judgment, Touch Perception.
- drug therapy : Perceptual Disorders.
- etiology : Perceptual Disorders.
- methods : Physical Stimulation.
- physiology : Judgment.
- Adult, Aged, Analysis of Variance, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Psychophysics, Retrospective Studies.
Abstract
Abnormal somatosensory processing may contribute to motor impairments observed in Parkinson's disease (PD). Dopaminergic medications have been shown to alter somatosensory processing such that tactile perception is improved. In PD, it remains unclear whether the temporal sequencing of tactile stimuli is altered and if dopaminergic medications alter this perception.
PubMed: 22384496
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Nelson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Kinesiology, University of Waterloo, Waterloo, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Premji, Azra" sort="Premji, Azra" uniqKey="Premji A" first="Azra" last="Premji">Azra Premji</name></author><author><name sortKey="Rai, Navjot" sort="Rai, Navjot" uniqKey="Rai N" first="Navjot" last="Rai">Navjot Rai</name></author><author><name sortKey="Hoque, Tasnuva" sort="Hoque, Tasnuva" uniqKey="Hoque T" first="Tasnuva" last="Hoque">Tasnuva Hoque</name></author><author><name sortKey="Tommerdahl, Mark" sort="Tommerdahl, Mark" uniqKey="Tommerdahl M" first="Mark" last="Tommerdahl">Mark Tommerdahl</name></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="RBID">pubmed:22384496</idno><idno type="pmid">22384496</idno><idno type="wicri:Area/PubMed/Corpus">000B15</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000B15</idno><idno type="wicri:Area/PubMed/Curation">000B15</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000B15</idno><idno type="wicri:Area/PubMed/Checkpoint">000B15</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000B15</idno><idno type="wicri:Area/Ncbi/Merge">001076</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Dopamine alters tactile perception in Parkinson's disease.</title><author><name sortKey="Nelson, Aimee J" sort="Nelson, Aimee J" uniqKey="Nelson A" first="Aimee J" last="Nelson">Aimee J. Nelson</name><affiliation wicri:level="1"><nlm:affiliation>Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Kinesiology, University of Waterloo, Waterloo, Ontario</wicri:regionArea><wicri:noRegion>Ontario</wicri:noRegion></affiliation></author><author><name sortKey="Premji, Azra" sort="Premji, Azra" uniqKey="Premji A" first="Azra" last="Premji">Azra Premji</name></author><author><name sortKey="Rai, Navjot" sort="Rai, Navjot" uniqKey="Rai N" first="Navjot" last="Rai">Navjot Rai</name></author><author><name sortKey="Hoque, Tasnuva" sort="Hoque, Tasnuva" uniqKey="Hoque T" first="Tasnuva" last="Hoque">Tasnuva Hoque</name></author><author><name sortKey="Tommerdahl, Mark" sort="Tommerdahl, Mark" uniqKey="Tommerdahl M" first="Mark" last="Tommerdahl">Mark Tommerdahl</name></author><author><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name></author></analytic><series><title level="j">The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques</title><idno type="ISSN">0317-1671</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Dopamine Agents (pharmacology)</term><term>Dopamine Agents (therapeutic use)</term><term>Female</term><term>Humans</term><term>Judgment (drug effects)</term><term>Judgment (physiology)</term><term>Levodopa (pharmacology)</term><term>Levodopa (therapeutic use)</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Parkinson Disease (complications)</term><term>Perceptual Disorders (drug therapy)</term><term>Perceptual Disorders (etiology)</term><term>Physical Stimulation (methods)</term><term>Psychophysics</term><term>Retrospective Studies</term><term>Touch Perception (drug effects)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Dopamine Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Dopamine Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Judgment</term><term>Touch Perception</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Perceptual Disorders</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Perceptual Disorders</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Physical Stimulation</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Judgment</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Analysis of Variance</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Psychophysics</term><term>Retrospective Studies</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abnormal somatosensory processing may contribute to motor impairments observed in Parkinson's disease (PD). Dopaminergic medications have been shown to alter somatosensory processing such that tactile perception is improved. In PD, it remains unclear whether the temporal sequencing of tactile stimuli is altered and if dopaminergic medications alter this perception.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">22384496</PMID><DateCreated><Year>2012</Year><Month>03</Month><Day>02</Day></DateCreated><DateCompleted><Year>2012</Year><Month>03</Month><Day>20</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0317-1671</ISSN><JournalIssue CitedMedium="Print"><Volume>39</Volume><Issue>1</Issue><PubDate><Year>2012</Year><Month>Jan</Month></PubDate></JournalIssue><Title>The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques</Title><ISOAbbreviation>Can J Neurol Sci</ISOAbbreviation></Journal><ArticleTitle>Dopamine alters tactile perception in Parkinson's disease.</ArticleTitle><Pagination><MedlinePgn>52-7</MedlinePgn></Pagination><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Abnormal somatosensory processing may contribute to motor impairments observed in Parkinson's disease (PD). Dopaminergic medications have been shown to alter somatosensory processing such that tactile perception is improved. In PD, it remains unclear whether the temporal sequencing of tactile stimuli is altered and if dopaminergic medications alter this perception.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Somatosensory tactile perception was investigated using temporal order judgment in patients with Parkinson's disease on and off dopaminergic medications and in aged-matched healthy controls. Measures of temporal order judgment were acquired using computer controlled stimulation to digits 2 and 3 on the right hand and subjects were required to determine which stimuli occurred first. Two experimental tasks were compared, temporal order judgment without and with synchronization whereby digits 2 and 3 were vibrated synchronously in advance of the temporal order judgment sequence of stimuli.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Temporal order judgment in PD patients of and on medications were similar to controls. Temporal order judgment preceded by synchronous vibration impaired tactical acuity in controls and in PD patients off medications to similar degrees, but this perceptual impairment by synchronous vibration was not present in PD patients on medications.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These findings suggest that dopamine in PD reduces cortico-cortical connectivity with SI and this leads to changes in tactical sensitivity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Nelson</LastName><ForeName>Aimee J</ForeName><Initials>AJ</Initials><AffiliationInfo><Affiliation>Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Premji</LastName><ForeName>Azra</ForeName><Initials>A</Initials></Author><Author ValidYN="Y"><LastName>Rai</LastName><ForeName>Navjot</ForeName><Initials>N</Initials></Author><Author ValidYN="Y"><LastName>Hoque</LastName><ForeName>Tasnuva</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Tommerdahl</LastName><ForeName>Mark</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Chen</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Can J Neurol Sci</MedlineTA><NlmUniqueID>0415227</NlmUniqueID><ISSNLinking>0317-1671</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D015259">Dopamine Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>46627O600J</RegistryNumber><NameOfSubstance UI="D007980">Levodopa</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015259" MajorTopicYN="N">Dopamine Agents</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007600" MajorTopicYN="N">Judgment</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007980" MajorTopicYN="N">Levodopa</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName><QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009483" MajorTopicYN="N">Neuropsychological Tests</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010300" MajorTopicYN="N">Parkinson Disease</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010468" MajorTopicYN="N">Perceptual Disorders</DescriptorName><QualifierName UI="Q000188" MajorTopicYN="Y">drug therapy</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010812" MajorTopicYN="N">Physical Stimulation</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011601" MajorTopicYN="N">Psychophysics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055698" MajorTopicYN="N">Touch Perception</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>3</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>3</Month><Day>6</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2012</Year><Month>3</Month><Day>21</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">22384496</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Canada</li></country></list><tree><noCountry><name sortKey="Chen, Robert" sort="Chen, Robert" uniqKey="Chen R" first="Robert" last="Chen">Robert Chen</name><name sortKey="Hoque, Tasnuva" sort="Hoque, Tasnuva" uniqKey="Hoque T" first="Tasnuva" last="Hoque">Tasnuva Hoque</name><name sortKey="Premji, Azra" sort="Premji, Azra" uniqKey="Premji A" first="Azra" last="Premji">Azra Premji</name><name sortKey="Rai, Navjot" sort="Rai, Navjot" uniqKey="Rai N" first="Navjot" last="Rai">Navjot Rai</name><name sortKey="Tommerdahl, Mark" sort="Tommerdahl, Mark" uniqKey="Tommerdahl M" first="Mark" last="Tommerdahl">Mark Tommerdahl</name></noCountry><country name="Canada"><noRegion><name sortKey="Nelson, Aimee J" sort="Nelson, Aimee J" uniqKey="Nelson A" first="Aimee J" last="Nelson">Aimee J. 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