24-Epibrassinolide, a Phytosterol from the Brassinosteroid Family, Protects Dopaminergic Cells against MPP+-Induced Oxidative Stress and Apoptosis
Identifieur interne : 000F25 ( Ncbi/Merge ); précédent : 000F24; suivant : 000F2624-Epibrassinolide, a Phytosterol from the Brassinosteroid Family, Protects Dopaminergic Cells against MPP+-Induced Oxidative Stress and Apoptosis
Auteurs : Julie Carange [Canada] ; Fanny Longpré [Canada] ; Benoit Daoust [Canada] ; Maria-Grazia MartinoliSource :
- Journal of Toxicology [ 1687-8191 ] ; 2011.
Abstract
Oxidative stress and apoptosis are frequently cited to explain neuronal cell damage in various neurodegenerative disorders, such as Parkinson' s disease. Brassinosteroids (BRs) are phytosterols recognized to promote stress tolerance of vegetables via modulation of the antioxidative enzyme cascade. However, their antioxidative effects on mammalian neuronal cells have never been examined so far. We analyzed the ability of 24-epibrassinolide (24-Epi), a natural BR, to protect neuronal PC12 cells from 1-methyl-4-phenylpyridinium- (MPP+-) induced oxidative stress and consequent apoptosis in dopaminergic neurons. Our results demonstrate that 24-Epi reduces the levels of intracellular reactive oxygen species and modulates superoxide dismutase, catalase, and glutathione peroxidase activities. Finally, we determined that the antioxidative properties of 24-Epi lead to the inhibition of MPP+-induced apoptosis by reducing DNA fragmentation as well as the Bax/Bcl-2 protein ratio and cleaved caspase-3. This is the first time that the potent antioxidant and neuroprotective role of 24-Epi has been shown in a mammalian neuronal cell line.
Url:
DOI: 10.1155/2011/392859
PubMed: 21776258
PubMed Central: 3135132
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PMC:3135132Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Oxidative stress and apoptosis are frequently cited to explain neuronal cell damage in various neurodegenerative disorders, such as Parkinson' s disease. Brassinosteroids (BRs) are phytosterols recognized to promote stress tolerance of vegetables via modulation of the antioxidative enzyme cascade. However, their antioxidative effects on mammalian neuronal cells have never been examined so far.
We analyzed the ability of 24-epibrassinolide (24-Epi), a natural BR, to protect neuronal PC12 cells from 1-methyl-4-phenylpyridinium- (MPP<sup>+</sup>
-) induced oxidative stress and consequent apoptosis in dopaminergic neurons. Our results demonstrate that 24-Epi reduces the levels of intracellular reactive oxygen species and modulates superoxide dismutase, catalase, and glutathione peroxidase activities. Finally, we determined that the antioxidative properties of 24-Epi lead to the inhibition of MPP<sup>+</sup>
-induced apoptosis by reducing DNA fragmentation as well as the Bax/Bcl-2 protein ratio and cleaved caspase-3. This is the first time that the potent antioxidant and neuroprotective role of 24-Epi has been shown in a mammalian neuronal cell line.</p>
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<double pmid="21776258"><pmc><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">24-Epibrassinolide, a Phytosterol from the Brassinosteroid Family, Protects Dopaminergic Cells against MPP<sup>+</sup>
-Induced Oxidative Stress and Apoptosis</title>
<author><name sortKey="Carange, Julie" sort="Carange, Julie" uniqKey="Carange J" first="Julie" last="Carange">Julie Carange</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry, Neurosciences Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada G9A 5H7</nlm:aff>
<country>Canada</country>
<wicri:regionArea>Department of Biochemistry, Neurosciences Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Longpre, Fanny" sort="Longpre, Fanny" uniqKey="Longpre F" first="Fanny" last="Longpré">Fanny Longpré</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry, Neurosciences Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada G9A 5H7</nlm:aff>
<country>Canada</country>
<wicri:regionArea>Department of Biochemistry, Neurosciences Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Daoust, Benoit" sort="Daoust, Benoit" uniqKey="Daoust B" first="Benoit" last="Daoust">Benoit Daoust</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry, Neurosciences Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada G9A 5H7</nlm:aff>
<country>Canada</country>
<wicri:regionArea>Department of Biochemistry, Neurosciences Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martinoli, Maria Grazia" sort="Martinoli, Maria Grazia" uniqKey="Martinoli M" first="Maria-Grazia" last="Martinoli">Maria-Grazia Martinoli</name>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
</author>
</titleStmt>
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<idno type="pmid">21776258</idno>
<idno type="pmc">3135132</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3135132</idno>
<idno type="RBID">PMC:3135132</idno>
<idno type="doi">10.1155/2011/392859</idno>
<date when="2011">2011</date>
<idno type="wicri:Area/Pmc/Corpus">000A27</idno>
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<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A02</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">24-Epibrassinolide, a Phytosterol from the Brassinosteroid Family, Protects Dopaminergic Cells against MPP<sup>+</sup>
-Induced Oxidative Stress and Apoptosis</title>
<author><name sortKey="Carange, Julie" sort="Carange, Julie" uniqKey="Carange J" first="Julie" last="Carange">Julie Carange</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry, Neurosciences Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada G9A 5H7</nlm:aff>
<country>Canada</country>
<wicri:regionArea>Department of Biochemistry, Neurosciences Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Longpre, Fanny" sort="Longpre, Fanny" uniqKey="Longpre F" first="Fanny" last="Longpré">Fanny Longpré</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry, Neurosciences Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada G9A 5H7</nlm:aff>
<country>Canada</country>
<wicri:regionArea>Department of Biochemistry, Neurosciences Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Daoust, Benoit" sort="Daoust, Benoit" uniqKey="Daoust B" first="Benoit" last="Daoust">Benoit Daoust</name>
<affiliation wicri:level="1"><nlm:aff id="I1">Department of Biochemistry, Neurosciences Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada G9A 5H7</nlm:aff>
<country>Canada</country>
<wicri:regionArea>Department of Biochemistry, Neurosciences Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Martinoli, Maria Grazia" sort="Martinoli, Maria Grazia" uniqKey="Martinoli M" first="Maria-Grazia" last="Martinoli">Maria-Grazia Martinoli</name>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
<affiliation><nlm:aff>NONE</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Toxicology</title>
<idno type="ISSN">1687-8191</idno>
<idno type="eISSN">1687-8205</idno>
<imprint><date when="2011">2011</date>
</imprint>
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<front><div type="abstract" xml:lang="en"><p>Oxidative stress and apoptosis are frequently cited to explain neuronal cell damage in various neurodegenerative disorders, such as Parkinson' s disease. Brassinosteroids (BRs) are phytosterols recognized to promote stress tolerance of vegetables via modulation of the antioxidative enzyme cascade. However, their antioxidative effects on mammalian neuronal cells have never been examined so far.
We analyzed the ability of 24-epibrassinolide (24-Epi), a natural BR, to protect neuronal PC12 cells from 1-methyl-4-phenylpyridinium- (MPP<sup>+</sup>
-) induced oxidative stress and consequent apoptosis in dopaminergic neurons. Our results demonstrate that 24-Epi reduces the levels of intracellular reactive oxygen species and modulates superoxide dismutase, catalase, and glutathione peroxidase activities. Finally, we determined that the antioxidative properties of 24-Epi lead to the inhibition of MPP<sup>+</sup>
-induced apoptosis by reducing DNA fragmentation as well as the Bax/Bcl-2 protein ratio and cleaved caspase-3. This is the first time that the potent antioxidant and neuroprotective role of 24-Epi has been shown in a mammalian neuronal cell line.</p>
</div>
</front>
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<pubmed><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">24-Epibrassinolide, a Phytosterol from the Brassinosteroid Family, Protects Dopaminergic Cells against MPP-Induced Oxidative Stress and Apoptosis.</title>
<author><name sortKey="Carange, Julie" sort="Carange, Julie" uniqKey="Carange J" first="Julie" last="Carange">Julie Carange</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Neurosciences Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada G9A 5H7.</nlm:affiliation>
<country>Canada</country>
<wicri:regionArea>Department of Biochemistry, Neurosciences Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Longpre, Fanny" sort="Longpre, Fanny" uniqKey="Longpre F" first="Fanny" last="Longpré">Fanny Longpré</name>
</author>
<author><name sortKey="Daoust, Benoit" sort="Daoust, Benoit" uniqKey="Daoust B" first="Benoit" last="Daoust">Benoit Daoust</name>
</author>
<author><name sortKey="Martinoli, Maria Grazia" sort="Martinoli, Maria Grazia" uniqKey="Martinoli M" first="Maria-Grazia" last="Martinoli">Maria-Grazia Martinoli</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2011">2011</date>
<idno type="RBID">pubmed:21776258</idno>
<idno type="pmid">21776258</idno>
<idno type="doi">10.1155/2011/392859</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">24-Epibrassinolide, a Phytosterol from the Brassinosteroid Family, Protects Dopaminergic Cells against MPP-Induced Oxidative Stress and Apoptosis.</title>
<author><name sortKey="Carange, Julie" sort="Carange, Julie" uniqKey="Carange J" first="Julie" last="Carange">Julie Carange</name>
<affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, Neurosciences Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC, Canada G9A 5H7.</nlm:affiliation>
<country>Canada</country>
<wicri:regionArea>Department of Biochemistry, Neurosciences Research Group, Université du Québec à Trois-Rivières, Trois-Rivières, QC</wicri:regionArea>
<wicri:noRegion>QC</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Longpre, Fanny" sort="Longpre, Fanny" uniqKey="Longpre F" first="Fanny" last="Longpré">Fanny Longpré</name>
</author>
<author><name sortKey="Daoust, Benoit" sort="Daoust, Benoit" uniqKey="Daoust B" first="Benoit" last="Daoust">Benoit Daoust</name>
</author>
<author><name sortKey="Martinoli, Maria Grazia" sort="Martinoli, Maria Grazia" uniqKey="Martinoli M" first="Maria-Grazia" last="Martinoli">Maria-Grazia Martinoli</name>
</author>
</analytic>
<series><title level="j">Journal of toxicology</title>
<idno type="eISSN">1687-8205</idno>
<imprint><date when="2011" type="published">2011</date>
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<front><div type="abstract" xml:lang="en">Oxidative stress and apoptosis are frequently cited to explain neuronal cell damage in various neurodegenerative disorders, such as Parkinson' s disease. Brassinosteroids (BRs) are phytosterols recognized to promote stress tolerance of vegetables via modulation of the antioxidative enzyme cascade. However, their antioxidative effects on mammalian neuronal cells have never been examined so far. We analyzed the ability of 24-epibrassinolide (24-Epi), a natural BR, to protect neuronal PC12 cells from 1-methyl-4-phenylpyridinium- (MPP(+)-) induced oxidative stress and consequent apoptosis in dopaminergic neurons. Our results demonstrate that 24-Epi reduces the levels of intracellular reactive oxygen species and modulates superoxide dismutase, catalase, and glutathione peroxidase activities. Finally, we determined that the antioxidative properties of 24-Epi lead to the inhibition of MPP(+)-induced apoptosis by reducing DNA fragmentation as well as the Bax/Bcl-2 protein ratio and cleaved caspase-3. This is the first time that the potent antioxidant and neuroprotective role of 24-Epi has been shown in a mammalian neuronal cell line.</div>
</front>
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