Long-term effect of unilateral pallidotomy on levodopa-induced dyskinesia.
Identifieur interne : 000C83 ( Ncbi/Merge ); précédent : 000C82; suivant : 000C84Long-term effect of unilateral pallidotomy on levodopa-induced dyskinesia.
Auteurs : Galit Kleiner-Fisman [Canada] ; Andres Lozano ; Elena Moro ; Yu-Yan Poon ; Anthony E. LangSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2010.
English descriptors
- KwdEn :
- Antiparkinson Agents (adverse effects), Child, Child, Preschool, Deep Brain Stimulation (methods), Dyskinesia, Drug-Induced (surgery), Female, Functional Laterality (physiology), Humans, Levodopa (adverse effects), Longitudinal Studies, Male, Pallidotomy (methods), Parkinson Disease (drug therapy), Parkinson Disease (surgery), Severity of Illness Index, Statistics, Nonparametric.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- drug therapy : Parkinson Disease.
- methods : Deep Brain Stimulation, Pallidotomy.
- physiology : Functional Laterality.
- surgery : Dyskinesia, Drug-Induced, Parkinson Disease.
- Child, Child, Preschool, Female, Humans, Longitudinal Studies, Male, Severity of Illness Index, Statistics, Nonparametric.
Abstract
Unilateral pallidotomy has been effectively used to treat parkinsonism and reduce levodopa induced dyskinesia (LID). We sought to determine the long-term effects of pallidotomy on LID in 10 patients who had initial benefit from pallidotomy but went on to require DBS surgery for symptom progression. The Dyskinesia Rating Scale (DRS) was used to rate and quantify LID in a blinded fashion. Though sample size was small, there was a trend towards a reduction in LID lasting up to 12 years suggesting that posteroventral pallidotomy may provide sustained benefit in reducing LID.
DOI: 10.1002/mds.23155
PubMed: 20568091
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pubmed:20568091Le document en format XML
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<author><name sortKey="Poon, Yu Yan" sort="Poon, Yu Yan" uniqKey="Poon Y" first="Yu-Yan" last="Poon">Yu-Yan Poon</name>
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<term>Dyskinesia, Drug-Induced (surgery)</term>
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<front><div type="abstract" xml:lang="en">Unilateral pallidotomy has been effectively used to treat parkinsonism and reduce levodopa induced dyskinesia (LID). We sought to determine the long-term effects of pallidotomy on LID in 10 patients who had initial benefit from pallidotomy but went on to require DBS surgery for symptom progression. The Dyskinesia Rating Scale (DRS) was used to rate and quantify LID in a blinded fashion. Though sample size was small, there was a trend towards a reduction in LID lasting up to 12 years suggesting that posteroventral pallidotomy may provide sustained benefit in reducing LID.</div>
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