La maladie de Parkinson au Canada (serveur d'exploration)

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Dopamine, reward, and frontostriatal circuitry in impulse control disorders in Parkinson's disease: insights from functional imaging.

Identifieur interne : 000C77 ( Ncbi/Merge ); précédent : 000C76; suivant : 000C78

Dopamine, reward, and frontostriatal circuitry in impulse control disorders in Parkinson's disease: insights from functional imaging.

Auteurs : Nicola Ray [Canada] ; Antonio P. Strafella

Source :

RBID : pubmed:20521491

English descriptors

Abstract

Dopamine agonists have been implicated in the development of impulse control disorders (ICDs). This may be due to the ability of agonists to tonically stimulate dopamine receptors. Recent neuroimaging data provided evidence that dopamine agonists induce significant changes in those frontostriatal circuits that process reward and mediate our ability to control impulses. Tonic stimulation of dopamine receptors via agonists may impair reward processing and inhibitory control mechanisms in ways that promote pathological repetition of behaviors. We will provide an overview of the current understanding of the neurobiology underlying ICDs in Parkinson's disease (PD).

DOI: 10.1177/155005941004100208
PubMed: 20521491

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pubmed:20521491

Le document en format XML

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   |clé=     pubmed:20521491
   |texte=   Dopamine, reward, and frontostriatal circuitry in impulse control disorders in Parkinson's disease: insights from functional imaging.
}}

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