Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human pons.
Identifieur interne : 000B28 ( Ncbi/Merge ); précédent : 000B27; suivant : 000B29Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human pons.
Auteurs : Andrew S. Lim [Canada] ; Elena Moro ; Andres M. Lozano ; Clement Hamani ; Jonathan O. Dostrovsky ; William D. Hutchison ; Anthony E. Lang ; Richard A. Wennberg ; Brian J. MurraySource :
- Annals of neurology [ 1531-8249 ] ; 2009.
English descriptors
- KwdEn :
- Aged, Deep Brain Stimulation (methods), Female, Humans, Male, Middle Aged, Parkinson Disease (complications), Parkinson Disease (therapy), Polysomnography (methods), Pons (physiology), REM Sleep Behavior Disorder (etiology), REM Sleep Behavior Disorder (therapy), Supranuclear Palsy, Progressive (complications), Supranuclear Palsy, Progressive (therapy).
- MESH :
- complications : Parkinson Disease, Supranuclear Palsy, Progressive.
- etiology : REM Sleep Behavior Disorder.
- methods : Deep Brain Stimulation, Polysomnography.
- physiology : Pons.
- therapy : Parkinson Disease, REM Sleep Behavior Disorder, Supranuclear Palsy, Progressive.
- Aged, Female, Humans, Male, Middle Aged.
Abstract
Animal studies suggest that rapid eye movement (REM) sleep is governed by the interaction of REM-promoting and REM-inhibiting nuclei in the pontomesencephalic tegmentum. The pedunculopontine nucleus is proposed to be REM promoting. Using polysomnography, we studied sleep in five parkinsonian patients undergoing unilateral pedunculopontine nucleus deep brain stimulation (DBS). We demonstrated a near doubling of nocturnal REM sleep between the DBS "off" and DBS "on" states, without significant changes in other sleep states. This represents the first demonstration that DBS can selectively modulate human sleep, and it supports an important role for the pedunculopontine nucleus region in modulating human REM sleep. Ann Neurol 2009;66:110-114.
DOI: 10.1002/ana.21631
PubMed: 19670451
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Lim</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name></author><author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name></author><author><name sortKey="Dostrovsky, Jonathan O" sort="Dostrovsky, Jonathan O" uniqKey="Dostrovsky J" first="Jonathan O" last="Dostrovsky">Jonathan O. Dostrovsky</name></author><author><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D" last="Hutchison">William D. Hutchison</name></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name></author><author><name sortKey="Wennberg, Richard A" sort="Wennberg, Richard A" uniqKey="Wennberg R" first="Richard A" last="Wennberg">Richard A. Wennberg</name></author><author><name sortKey="Murray, Brian J" sort="Murray, Brian J" uniqKey="Murray B" first="Brian J" last="Murray">Brian J. 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Lim</name><affiliation wicri:level="4"><nlm:affiliation>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Division of Neurology, Department of Medicine, University of Toronto, Toronto, Ontario</wicri:regionArea><orgName type="university">Université de Toronto</orgName><placeName><settlement type="city">Toronto</settlement><region type="state">Ontario</region></placeName></affiliation></author><author><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name></author><author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name></author><author><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name></author><author><name sortKey="Dostrovsky, Jonathan O" sort="Dostrovsky, Jonathan O" uniqKey="Dostrovsky J" first="Jonathan O" last="Dostrovsky">Jonathan O. Dostrovsky</name></author><author><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D" last="Hutchison">William D. Hutchison</name></author><author><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name></author><author><name sortKey="Wennberg, Richard A" sort="Wennberg, Richard A" uniqKey="Wennberg R" first="Richard A" last="Wennberg">Richard A. Wennberg</name></author><author><name sortKey="Murray, Brian J" sort="Murray, Brian J" uniqKey="Murray B" first="Brian J" last="Murray">Brian J. Murray</name></author></analytic><series><title level="j">Annals of neurology</title><idno type="eISSN">1531-8249</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Deep Brain Stimulation (methods)</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (complications)</term><term>Parkinson Disease (therapy)</term><term>Polysomnography (methods)</term><term>Pons (physiology)</term><term>REM Sleep Behavior Disorder (etiology)</term><term>REM Sleep Behavior Disorder (therapy)</term><term>Supranuclear Palsy, Progressive (complications)</term><term>Supranuclear Palsy, Progressive (therapy)</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Parkinson Disease</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>REM Sleep Behavior Disorder</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Deep Brain Stimulation</term><term>Polysomnography</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Pons</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Parkinson Disease</term><term>REM Sleep Behavior Disorder</term><term>Supranuclear Palsy, Progressive</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Animal studies suggest that rapid eye movement (REM) sleep is governed by the interaction of REM-promoting and REM-inhibiting nuclei in the pontomesencephalic tegmentum. The pedunculopontine nucleus is proposed to be REM promoting. Using polysomnography, we studied sleep in five parkinsonian patients undergoing unilateral pedunculopontine nucleus deep brain stimulation (DBS). We demonstrated a near doubling of nocturnal REM sleep between the DBS "off" and DBS "on" states, without significant changes in other sleep states. This represents the first demonstration that DBS can selectively modulate human sleep, and it supports an important role for the pedunculopontine nucleus region in modulating human REM sleep. Ann Neurol 2009;66:110-114.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">19670451</PMID><DateCreated><Year>2009</Year><Month>08</Month><Day>24</Day></DateCreated><DateCompleted><Year>2009</Year><Month>09</Month><Day>04</Day></DateCompleted><DateRevised><Year>2009</Year><Month>08</Month><Day>24</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1531-8249</ISSN><JournalIssue CitedMedium="Internet"><Volume>66</Volume><Issue>1</Issue><PubDate><Year>2009</Year><Month>Jul</Month></PubDate></JournalIssue><Title>Annals of neurology</Title><ISOAbbreviation>Ann. Neurol.</ISOAbbreviation></Journal><ArticleTitle>Selective enhancement of rapid eye movement sleep by deep brain stimulation of the human pons.</ArticleTitle><Pagination><MedlinePgn>110-4</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/ana.21631</ELocationID><Abstract><AbstractText>Animal studies suggest that rapid eye movement (REM) sleep is governed by the interaction of REM-promoting and REM-inhibiting nuclei in the pontomesencephalic tegmentum. The pedunculopontine nucleus is proposed to be REM promoting. Using polysomnography, we studied sleep in five parkinsonian patients undergoing unilateral pedunculopontine nucleus deep brain stimulation (DBS). We demonstrated a near doubling of nocturnal REM sleep between the DBS "off" and DBS "on" states, without significant changes in other sleep states. This represents the first demonstration that DBS can selectively modulate human sleep, and it supports an important role for the pedunculopontine nucleus region in modulating human REM sleep. 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Dostrovsky</name><name sortKey="Hamani, Clement" sort="Hamani, Clement" uniqKey="Hamani C" first="Clement" last="Hamani">Clement Hamani</name><name sortKey="Hutchison, William D" sort="Hutchison, William D" uniqKey="Hutchison W" first="William D" last="Hutchison">William D. Hutchison</name><name sortKey="Lang, Anthony E" sort="Lang, Anthony E" uniqKey="Lang A" first="Anthony E" last="Lang">Anthony E. Lang</name><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name><name sortKey="Moro, Elena" sort="Moro, Elena" uniqKey="Moro E" first="Elena" last="Moro">Elena Moro</name><name sortKey="Murray, Brian J" sort="Murray, Brian J" uniqKey="Murray B" first="Brian J" last="Murray">Brian J. Murray</name><name sortKey="Wennberg, Richard A" sort="Wennberg, Richard A" uniqKey="Wennberg R" first="Richard A" last="Wennberg">Richard A. Wennberg</name></noCountry><country name="Canada"><region name="Ontario"><name sortKey="Lim, Andrew S" sort="Lim, Andrew S" uniqKey="Lim A" first="Andrew S" last="Lim">Andrew S. Lim</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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